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Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China Life Sciences 2025年第1期 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng Yan Kun Jiang Bingbing Song He Li Maomao Cao Dianqin Sun Fan Yang Xinxin Yan Shaoli Zhang Yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan center for Disease Control and Prevention Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrend<0.001). Four predictors, including male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

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Virtual anthropology-a brief review of the literature and history of computed tomography

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Forensic Sciences Research 2017年第4期2卷 165-173页

作者： Tanya Uldin Department of Medicine and community health University Center of Legal Medicine Lausanne-GenevaUniversity Hospital of LausanneLausanneSwitzerland

Computed tomography(CT)has influenced numerous fields since its inception in the *** field of palaeoanthropology significantly benefited from this efficient and non-invasive medium in terms of the conservation,reconstruction and analysis of fossil human *** the past decade,there has been a steady increase in the number of forensic anthropological studies incorporating virtual osteological *** of the increasing importance of these modern cross-sectional imaging techniques and the requirement for standardized parameters in forensic science,we deemed it important to outline the history and development of CT applications in these related academic *** present paper outlines the history of“virtual anthropology”and osteological multi-detector CT in the context of palaeoanthropology and forensic anthropology.

关键词： Forensic science forensic anthropology virtual anthropology palaeoanthropology computed tomography MDCT bone imaging

Prevalence and risk factors of diabetes mellitus among elderly patients in the Lugu community

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World Journal of Diabetes 2024年第4期15卷 638-644页

作者： Li-Zhen Zhao Wei-Min Li Ying Ma Lugu community health Service center West Campus Beijing Chao-yang Hospital Affiliated to Capital Medical UniversityBeijing 100043China

BACKGROUND Age is a significant risk factor of diabetes mellitus(DM).With the develop of population aging,the incidence of DM remains *** the epidemiology of DM among elderly individuals in a certain area contributes to the DM interventions for the local elderly individuals with high risk of *** To explore the prevalence of DM among elderly individuals in the Lugu community and analyze the related risk factors to provide a valid scientific basis for the health management of elderly *** A total of 4816 elderly people who came to the community for physical examination were retrospectively *** prevalence of DM among the elderly was *** individuals were divided into a DM group and a non-DM group according to the diagnosis of DM to compare the differences in diastolic blood pressure(DBP)and systolic blood pressure(SBP),fasting blood glucose,body mass index(BMI),waist-to-hip ratio(WHR)and incidence of hypertension(HT),coronary heart disease(CHD),and chronic kidney disease(CKD).RESULTS DM was diagnosed in 32.70%of the 4816 elderly *** BMI of the DM group(25.16±3.35)was greater than that of the non-DM group(24.61±3.78).The WHR was 0.90±0.04 in the non-DM group and 0.90±0.03 in the DM group,with no significant *** left SBP and SBP in the DM group were 137.9 mmHg±11.92 mmHg and 69.95 mmHg±7.75 mmHg,respectively,while they were 126.6 mmHg±12.44 mmHg and 71.15 mmHg±12.55 mmHg,respectively,in the non-DM *** findings indicate higher SBP and lower DBP in DM patients than in those without *** the DM group,1274 patients were diagnosed with HT,accounting for 80.89%.Among the 3241 non-DM patients,1743(53.78%)were hypertensive and 1498(46.22%)were *** DM group had more cases of HT than did the non-DM *** were more patients with CHD or CKD in the DM group than in the non-DM *** were more patients who drank alcohol more frequently(≥3 times)in the DM group than in the no

关键词： Diabetes mellitus Type 2 diabetes mellitus Elderly Risk factors

Micro RNA-320 family is downregulated in colorectal adenoma and affects tumor proliferation by targeting CDK6

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World Journal of Gastrointestinal Oncology 2016年第7期8卷 532-542页

作者： Toshihiro Tadano Yoichi Kakuta Shin Hamada Yosuke Shimodaira Masatake Kuroha Yoko Kawakami Tomoya Kimura Hisashi Shiga Katsuya Endo Atsushi Masamune Seiichi Takahashi Yoshitaka Kinouchi Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine community Gastroenterology (Iwaki Kyoritsu Hospital) Tohoku University Graduate School of Medicine health Administration center Center for the Advancement of Higher Education Tohoku University

AIM: To investigate the microR NA(miR NA) expression during histological progression from colorectal normal mucosa through adenoma to carcinoma within a lesion. METHODS: Using microarray, the sequential changes in miR NA expression profiles were compared in colonic lesions from matched samples; histologically, nonneoplastic mucosa, adenoma, and submucosal invasive carcinoma were microdissected from a tissue sample. Cell proliferation assay was performed to observe the effect of miR NA, and its target genes were predicted using bioinformatics approaches and the expression profile of SW480 transfected with the miR NA mimics. mR NA and protein levels of the target gene in colon cancer cell lines with a mimic control or miR NA mimics were measured using qR TPCR and Western blotting. The expression levels of miR NA and target gene in colorectal tissue samples were also ***: Microarray analysis identified that the miR-320 family, including miR-320 a, miR-320 b, miR-320 c, miR-320 d and miR-320 e, were differentially expressed in adenomaand submucosal invasive carcinoma. The mi R-320 family, which inhibits cell proliferation, is frequently downregulated in colorectal adenoma and submucosal invasive carcinoma tissues. Seven genes including CDK6 were identified to be common in the results of gene expression array and bioinformatics analyses performed to find the target gene of the miR-320 family. We confirmed that mR NA and protein levels of CDK6 were significantly suppressed in colon cancer cell lines with miR-320 family mimics. CDK6 expression was found to increase from non-neoplastic mucosa through adenoma to submucosal invasive carcinoma tissues and showed an inverse correlation with miR-320 family ***: MiR-320 family affects colorectal tumor proliferation by targeting CDK6, plays important role in its growth, and is considered to be a biomarker for its early detection.

关键词： CDK6 Colorectal cancer Mi R-320 family Colorectal adenoma Laterally spreading type

Sugar intake from sweetened beverages and diabetes:A narrative review

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World Journal of Diabetes 2021年第9期12卷 1530-1538页

作者： Tung-Sung Tseng Wei-Ting Lin Gabrielle V Gonzalez Yu-Hsiang Kao Lei-Shih Chen Hui-Yi Lin Behavioral and community health Sciences School of Public HealthLouisiana State University Health Sciences CenterNew OrleansLA 70112United States Department of Global community health and Behavioral Sciences School of Public Health&Tropical MedicineTulane UniversityNew OrleansLA 70112United States Department of health and Kinesiology Texas A&M UniversityCollege StationTX 77843United States Biostatistics Program School of Public HealthLouisiana State University Health Sciences CenterNew OrleansLA 70112United States

Type 2 diabetes mellitus(T2DM)is one of the fastest growing public health concerns around the ***-sweetened beverage(SSB)consumption has been proven to be associated with adverse health consequences in the diabetic *** SSB consumption,body weight control,healthy diets,and increased physical activity have been suggested as strategies to improve diabetes prevention and *** literature review provides an overview of:(1)The association between SSB consumption and the risk of T2DM;(2)Types of SSB consumption and T2DM;(3)The effect of obesity and inflammation on the association between SSB consum-ption and risk of T2DM;and(4)SSB consumption in T2DM *** is still work to be done to determine how SSB consumption is related to T2DM,but the current research on identifying the association between SSB consumption and T2DM is promising,with the most promising studies confirming the connection between SSBs,T2DM risk,and diabetes *** studies should explore more effective SSB related diabetes prevention and management interventions.

关键词： Sugar-sweetened beverages Type 2 diabetes mellitus Inflammation Obesity Diabetes management

Gene-Environment Interactions between Environmental Noise and Apo E4 Causes AD-Like Neuropathology in the Hippocampus in Male Rats

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Biomedical and Environmental Sciences 2022年第3期35卷 270-275页

作者： LI Wen Long LI Yuan Yuan LI Yu Xin FU Yu HE Xian Zhi TAO Fei Yan YOU Ruo Lan ZHANG Ruo Yu ZHONG Ming Qing CHI Hui Min ZHAI Qing Feng School of Public health Weifang Medical UniversityWeifang 261042ShandongChina community healthcare center of Baoshan Street Office Health Bureau of Licheng DistrictJinan 250000ShandongChina Weifang Maternal and Child health Hospital Weifang 261042ShandongChina

Experimental evidence has demonstrated that environmental hazards can induce neurodegeneration such as Alzheimer's disease(AD)^([1]).The pathogenesis of AD,characterized by a gradual cognitive decline,overproduction ofβ-amyloid(Aβ),and hyperphosphorylated tau in specific brain areas,is considered to involve the interaction of several internal(individual)and external environmental factors.

关键词： Alzheimer Aβ tau

Investigation of lacrimal sac space-occupying lesions using color doppler ultrasound, computed tomography, and computed tomography dacryocystography

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1224-1230页

作者： Zhen-Bin Qian Bo Yu Ye Yang Wei Fang Jian-Li Dong Li-Qing Wei National Clinical Research center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Sijiqing Street community health Service center Hangzhou 310000Zhejiang ProvinceChina

AIM:To observe the imaging features of color Doppler ultrasound(CDU)and computed tomography(CT)or computed tomography dacryocystography(CT-DCG)in different types of lacrimal sac space-occupying lesions(SOLs).METHODS:This retrospective case series study included 21 patients with lacrimal sac SOLs who underwent lacrimal sac surgery between January 2018 and March *** imaging features of CDU and CT or CT-DCG in these patients were extracted from the examination cloud *** images were observed and ***:The detection rate of lacrimal SOLs between CDU(21/21,100%)and CT or CT-DCG(20/21,95.2%)had no statistically significant difference(P=1.0).CDU could detect the blood flow signals in all SOLs except mucocele and mucopeptide *** them,polyps had characteristic imaging changes on CDU and *** mucoceles and mucopeptide concretions had characteristic imaging changes on CDU,which could provide more information for differential ***:The morphology and internal blood flow signals of lacrimal sac SOLs can be observed using *** or CT-DCG has advantages in observing structural damage around the lacrimal sac ***,CDU may be used as a routine examination to exclude lacrimal sac SOLs before dacryocystorhinostomy in the absence of preoperative CT or CT-DCG.

关键词： lacrimal sac computed tomography computed tomography dacryocystography color Doppler ultrasound space-occupying lesions

Teicoplanin combined with conventional vancomycin therapy for the treatment of pulmonary methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis infections

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World Journal of Clinical Cases 2021年第34期9卷 10549-10556页

作者： Wei Wu Min Liu Jia-Jing Geng Mei Wang Laboratory Medicine Bejing Tongren HospitalCapital Medical UniversityBeijing 100176China Department of General Practice The Community Health Services Center in LumenBeijing 100080China

BACKGROUND Vancomycin and teicoplanin are both antibiotics that have significant antimicrobial effects on Gram-positive *** To explore the value of teicoplanin combined with conventional(vancomycin only)anti-infective therapy for the treatment of methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis pulmonary *** A total of 86 patients with methicillin-resistant Staphylococcus aureus or methicillin-resistant Staphylococcus epidermidis pulmonary infections,treated in our hospital between January 2018 and February 2020,were assigned to the study and control groups using a random number table method,with 43 patients in each *** control group received conventional treatment(vancomycin),and the study group received both teicoplanin and conventional *** following indicators were assessed in both groups:the time required for symptom relief,treatment effectiveness,serum levels of inflammatory factors(procalcitonin,interleukin-1β,tumor necrosis factor-α,C-reactive protein),clinical pulmonary infection scores before and after treatment,and the incidence of adverse *** Patients in the study group were observed to have faster cough and expectoration resolution,white blood cell count normalization,body temperature normalization,and rales disappearance than patients in the control group(all P<0.05);the total rate of effectiveness was 93.02%in the study group,higher than the 76.74%in the control group(P<0.05).The pre-treatment serum levels of procalcitonin,interleukin-1β,tumor necrosis factor-α,and C-reactive protein as well as the clinical pulmonary infection scores were similar among the patients in both ***,the post-treatment serum levels of procalcitonin,interleukin-1β,tumor necrosis factor-α,and C-reactive protein as well as the clinical pulmonary infection scores were significantly lower in the study group than in the control group(P<0.05).There was no significant difference in the incidence o

关键词： Vancomycin Teicoplanin Methicillin-resistant Staphylococcus aureus Methicillin-resistant Staphylococcus epidermidis Lung infection

Population-based survey of prevalence,causes,and risk factors for blindness and visual impairment in an aging Chinese metropolitan population

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International Journal of Ophthalmology(English edition) 2017年第1期10卷 140-147页

作者： Jian-Yan Hu Liang Yan Yong-Dong Chen Xin-Hua Du Ting-Ting Li De-An Liu Dong-Hong Xu Yi-Min Huang Qiang Wu Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 200233China community health center Xietu StreetXuhui DistrictShanghai 200233China

AIM： To assess the prevalence, causes, and risk factors for blindness and visual impairment among elderly （〉60 years of age） Chinese people in a metropolitan area of Shanghai, China. METHODS： Random cluster sampling was conducted to identify participants among residents ≥60 years of age living in the Xietu Block, Xuhui District, Shanghai, China. Presenting visual acuity （PVA） and best-corrected visual acuity （BCVA） were checked by the Early Treatment Diabetic Retinopathy Study （ETDRS） visual chart. All eligible participants underwent a comprehensive eye examination. Blindness and visual impairment were defined according to World health Organization （WHO） criteria. RESULTS： A total of 4190 persons （1688 men and 2502 women） participated in the study, and the response rate was 91.1%. Based on PVA, the prevalence of blindness was 1.1% and that of visual impairment was 7.6%. Based on BCVA, the prevalence of blindness and visual impairment decreased to 0.9% and 3.9%, respectively. Older （〉80 years of age） women, with low educational levels and smoking habits, exhibited a significantly greater chance for blindness and visual impairment than did those with high educational levels and no smoking habits （P〈0.05）. Based on PVA and BCVA, the main causes of blindness were cataract, myopic maculopathy, and age-related macular degeneration （AMD）. CONCLUSION： Our findings help to identify the population in need of intervention, to highlight the need for additional eye healthcare services in urban China.

关键词： blindness visual impairment prevalence riskfactor cross-sectional study