检索结果-南通市图书馆

World Journal of Gastrointestinal Surgery 2025年第1期17卷 1-7页

作者： Liang Wang Sheng-Mei Zhang Xiao-Qian Chen Department of Gastrointestinal Oncology Surgery The Affiliated Hospital of Qinghai UniversityThe Affiliated Cancer Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina Department of Anorectal Surgery The Affiliated Hospital of Qinghai UniversityThe Affiliated Cancer Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina

Currently,the use of immune checkpoint inhibitors(ICIs)has shown notable clinical efficacy in treating various malignant tumors,significantly improving patient ***,while ICIs enhance the body’s anti-tumor effects,they can also trigger immune-related adverse events(irAEs),with ICI-associated colitis being one of the more prevalent *** condition can disrupt treatment,necessitate drug discontinuation,and adversely affect therapeutic *** severe cases,irAEs may even become life-threatening.A recent case report by Hong et al highlights the importance of vigilance for ICI-associated colitis in patients experiencing symptoms such as diarrhea and abdominal pain,which can arise both during and even after completion of ICI *** identification,multidisciplinary management,and continuous monitoring of patients are essential steps to further improve outcomes.

关键词： Immune checkpoint inhibitors Immune-related adverse events Immune checkpoint inhibitor-associated colitis Immunotherapy Multidisciplinary management

Targeted maintenance therapy for a young woman with cervical rhabdomyosarcoma:A case report and review of literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2025年第3期16卷 151-161页

作者： Huan-Ran Ma Dan Zhang Li Li Lin Qi Liang Wang Yi-Tong Li Ya-Ru Wang Department of Gynecologic Oncology Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina Department of Gastrointestinal Oncology Surgery Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina

BACKGROUND Rhabdomyosarcoma of the uterine cervix is a rare form of soft-tissue sarcoma predominantly affecting young women,with no established standard treatment *** SUMMARY This report presents a case of a 17-year-old female patient presenting with in-termittent,non-cyclical vaginal bleeding and associated lower abdominal *** magnetic resonance imaging and additional examinations led to the dia-gnosis of cervical *** primary treatment options for uterine cervical rhabdomyosarcoma include surgery,with or without adjuvant chemo-therapy and *** patient underwent surgery followed by a posto-perative chemotherapy regimen of gemcitabine combined with docetaxel and *** 19 months of follow-up,the patient showed no signs of re-currence and maintained good overall *** the rarity of cervix rhab-domyosarcoma,this case is presented to provide insights into the diagnosis and treatment of this *** This suggests that bevacizumab may demonstrate potential efficacy in the treat-ment of cervical *** the future,targeted therapy is expected to play an increasingly significant role in the management of rhabdomyosarcoma.

关键词： Rhabdomyosarcoma Cervical rhabdomyosarcoma Targeted therapy Chemo-therapy Prognosis Case report

lncRNA SNHG4 enhanced gastric cancer progression by modulating miR-409-3p/CREB1 axis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2025年第1期33卷 185-198页

作者： ZHOUYANG CHENG YUCHEN HUA YANG CAO JUN QIN Department of General Surgery Affiliated Hospital of Nantong UniversityNantong226001China Department of Surgery Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong226001China Department of Operation Affiliated Hospital of Nantong UniversityNantong226001China

Objective:Gastric cancer(GC)is a globally common cancer characterized by high incidence and mortality *** in the molecular understanding of GC provide promising targets for GC diagnosis and *** non-coding RNAs(lncRNAs)and their downstream regulators are regarded to be implicated in the progression of multiple types of *** have shown that the lncRNA small nucleolar RNA host gene 4(SNHG4)serves as a tumor promoter in various malignancies,while its function in GC has yet to be ***,our study aimed to explore the role and underlying mechanism of SNHG4 in ***:We used qRT-PCR to analyze SNHG4 expression in GC tissues and ***-Meier analysis was used to assess the correlation between SNHG4 expression and the survival rate of GC *** function experiments such as CCK-8,BrdU,colony formation,flow cytometry analysis,and transwell were performed to explore the effects of SNHG4 on GC cell proliferation,apoptosis,cell cycle,migration,and *** also established xenograft mouse models to explore the effect of SNHG4 on GC tumor ***,dual luciferase reporter assay was used to verify the interaction between SNHG4 and miR-409-3p and between miR-409-3p and cAMP responsive element binding protein 1(CREB1).Results:The results indicated that SNHG4 was overexpressed in GC tissues and cell lines,and was linked with poor survival rate of GC ***4 promoted GC cell proliferation,migration,and invasion while inhibiting cell apoptosis and cell cycle arrest in *** in vivo experiment indicated that SNHG4 facilitated GC tumor ***,SNHG4 was demonstrated to bind to ***,CREB1 was directly targeted by *** assays demonstrated that miR-409-3p deficiency reversed the suppressive impact of SNHG4 knockdown on GC cell ***,miR-409-3p was also revealed to inhibit GC cell proliferation,migration,and invasion by targeting CREB1

关键词： Gastric cancer Small nucleolar RNA host gene 4(SNHG4) MicroRNA-409-3p(miR-409-3p) cAMP responsive element binding protein 1(CREB1)

NIR driven catalytic enhanced acute lung injury therapy by using polydopamine@Co nanozyme via scavenging ROS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2025年第2期36卷 337-343页

作者： Xiaoshuai Wu Bailei Wang Yichen Li Xiaoxuan Guan Mingjing Yin Wenquan Lv Yin Chen Fei Lu Tao Qin Huyang Gao Weiqian Jin Yifu Huang Cuiping Li Ming Gao Junyu Lu Intensive Care Unit The Second Affiliated Hospital of Guangxi Medical University Department of Critical Care Medicine The Ninth Affiliated Hospital of Guangxi Medical University Life Sciences Institute Guangxi Medical University Department of Emergency The First Affiliated Hospital of Guangxi Medical University College & hospital of Stomatology Guangxi Medical University Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction Guangxi Medical University

Acute lung injury(ALI) was characterized by excessive reactive oxygen species(ROS) levels and inflammatory response in the lung. Scavenging ROS could inhibit the excessive inflammatory response, further treating ALI. Herein, we designed a novel nanozyme(P@Co) comprised of polydopamine(PDA) nanoparticles(NPs) loading with ultra-small Co, combining with near infrared(NIR) irradiation, which could efficiently scavenge intracellular ROS and suppress inflammatory responses against ALI. For lipopolysaccharide(LPS) induced macrophages, P@Co + NIR presented excellent antioxidant and anti-inflammatory capacities through lowering intracellular ROS levels, decreasing the expression levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α) as well as inducing macrophage M2 directional polarization. Significantly, it displayed the outstanding activities of lowering acute lung inflammation, relieving diffuse alveolar damage, and up-regulating heat shock protein 70(HSP70) expression, resulting in synergistic enhanced ALI therapy effect. It offers a novel strategy for the clinical treatment of ROS related diseases.

关键词： Acute lung injury M2 directional polarization Nanozyme NIR driven ROS scavenging

Early and accurate diagnosis and selection of appropriate treatment plans are crucial for patients with gastrointestinal hemangiomas

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2025年第2期17卷 303-307页

作者： Zhou Chen Liang Wang Peng-Jie Yu Department of Emergency Medicine The Second Affiliated Hospital of Guangdong UniversityZhanjiang 524000Guangdong ProvinceChina Department of Gastrointestinal Oncology Surgery Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina Department of Anorectal Surgery The Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina

Gastrointestinal hemangioma(GIH)is clinically rare,accounting for 7%-10%of benign gastrointestinal tumors and 0.5%of systemic *** can occur as either solitary or multiple lesions,with gastrointestinal bleeding as a significant clinical *** the clinical and endoscopic features of GIH is essential for improving diagnostic accuracy,particularly through endoscopy and selective arteriography,which are highly effective in diagnosing GIH and preventing misdiagnosis and inappropriate *** confirmed diagnosis,it is essential to thoroughly evaluate the patient's condition to determine the most suitable treatment modality—whether surgical,endoscopic,or minimally invasive *** minimally invasive interventional partial embolization therapy using polyvinyl alcohol particles,proposed and implemented by Pospisilova et al,has achieved excellent clinical *** approach reduces surgical trauma and the inherent risks of traditional surgical treatments.

关键词： Hemangioma Gastrointestinal hemangioma Gastrointestinal hemorrhage Minimally invasive interventional treatment Selective embolization

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang Tang Daochen Wen Bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First affiliated hospital of Chongqing Medical university ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

维普期刊数据库

Preparation of hierarchical MoS_(2)microsphere/BN composites for microwave absorption and thermal management

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第3期32卷 718-727页

作者： Haoliang Wen Weidong Zhang College of Chemical Engineering Qinghai UniversityXining 810016China

The increase in the utilization of infrared heat detection technology in military applications necessitates research on composites with improved thermal transmission performance and microwave absorption *** study satisfactorily fabricated a series of MoS_(2)/BN-xyz composites(which were characterized by the weight ratio of MoS_(2)to BN,denoted by xy:z)through chemical vapor depos-ition,which resulted in their improved thermal stability and thermal transmission *** results show that the remaining mass of MoS_(2)/BN-101 was as high as 69.25wt%at 800℃under air atmosphere,and a temperature difference of 31.7℃was maintained between the surface temperature and the heating source at a heating temperature of 200℃.Furthermore,MoS_(2)/BN-301 exhibited an im-pressive minimum reflection loss value of-32.21 dB at 4.0 mm and a wide effective attenuation bandwidth ranging from 9.32 to 18.00 GHz(8.68 GHz).Therefore,these simplified synthesized MoS_(2)/BN-xyz composites demonstrate great potential as highly efficient con-tenders for the enhancement of microwave absorption performance and thermal conductance.

关键词： microwave absorbers thermal transmission hierarchical molybdenum disulfide microsphere boron nitride nanosheets

维普期刊数据库

Tumor inflammation-specific self-amplifying fluorescent molecular probes induce an anti-tumor immune response

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第1期68卷 273-287页

作者： Shuguang Yang Lijun Hu Hong Xiao Zecong Xiao Xintao Shuai PCFM Lab of Ministry of Education School of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou 510275China Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Medical Ultrasound The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Ultrasound The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China

Enhancing the concentration of exogenous molecular drugs within the tumor microenvironment through enzyme-catalyzed polymerization presents a novel strategy for cancer ***,the optimization of the catalytic efficiency is often impeded by the inefficient expression of ***,we reported a self-amplifying fluorescent molecular probe,Bis-HTPICG,for photodynamic therapy(PDT)and subsequent PDT-induced *** Bis-HTP-ICG probe possesses a noticeable enzyme-catalyzed polymerization facilitated by myeloperoxidase(MPO),a crucial enzyme secreted by neutrophils at inflammation *** exposure to laser irradiation,Bis-HTP-ICG showed a high PDT efficacy,inducing an acute inflammatory response that stimulates further recruitment of neutrophils and then elevated MPO *** heightened level of MPO enhances the accumulation of the Bis-HTP-ICG via self-polymerization or binding with intratumoral proteins following MPO enzyme catalysis,instigating a self-amplifying chain reaction cycle involving Bis-HTP-ICG,neutrophils and ***,PDT efficiently incites immunogenic cell death(ICD)in tumor cells,initiating an anti-tumor immune response including dendritic cells(DCs)maturation,T cell proliferation and reprogramming of tumor-associated neutrophils(TANs).This work portrays a promising strategy for self-amplification of fluorescent molecular probes through adjustable enzyme levels,potentially offering a unique avenue to enhance the tumor accumulation of molecular drugs for improved tumor therapy.

关键词： fluorescent molecular probes self-amplifying myeloperoxidase photodynamic therapy

维普期刊数据库

HNRNPC as a pan-cancer biomarker and therapeutic target involved in tumor progression and immune regulation

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2025年第1期33卷 83-102页

作者： YUEZHOU ZHANG ZHAO ZHANG JINXIN DONG CHANGAN LIU Department of Hepatobiliary Surgery The Second Affiliated Hospital of Chongqing Medical UniversityChongqing400016China Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing400016China

Background:Aberrant expression of RNA-binding proteins(RBPs)has been linked to a variety of diseases,including hematological disorders,cardiovascular diseases,and multiple types of *** nuclear ribonucleoprotein C(HNRNPC),a member belonging to the heterogeneous nuclear ribonucleoprotein(hnRNP)family,plays a pivotal role in nucleic acid *** studies have underscored the significance of HNRNPC in tumorigenesis;however,its specific role in malignant tumor progression remains inadequately ***:We leveraged publicly available databases,including The Cancer Genome Atlas(TCGA),to explore the potential involvement of HNRNPC across various ***,we performed experimental validation studies focused on liver ***:Our analysis revealed that HNRNPC is overexpressed in a wide range of common malignancies,including liver and lung cancers,and is strongly linked to unfavorable ***,HNRNPC was observed to be closely linked to tumor *** immune checkpoint analysis and immune cell infiltration assessment,HNRNPC emerged as a potential target for modulating tumor ***,silencing of HNRNPC markedly inhibited the proliferation,metastasis,and infiltration of liver cancer ***:In summary,our findings highlight HNRNPC as a prognostic marker in various cancers,including liver cancer,and suggest its involvement in shaping the tumor immune *** insights offer potential avenues for improving clinical outcomes in tumors with elevated HNRNPC expression,particularly through immunotherapeutic strategies.

关键词： Heterogeneous nuclear ribonucleoprotein C(HNRNPC) Pan-cancer analysis Tumor immunity Prognostic biomarker Immunotherapeutic target Hepatocellular carcinoma

Nd@C3N4-photoredox/chlorine dual catalyzed synthesis and evaluation of antitumor activities of 4-alkylated sulfonyl ketimines

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2025年第2期36卷 412-416页

作者： Hong-Tao Ji Yu-Han Lu Yan-Ting Liu Yu-Lin Huang Jiang-Feng Tian Feng Liu Yan-Yan Zeng Hai-Yan Yang Yong-Hong Zhang Wei-Min He Department of Ophthalmology The Affiliated Nanhua Hospital Hengyang Medical School University of South China School of Chemistry and Chemical Engineering University of South China Department of Lung Cancer and Gastroenterology Hunan Cancer Hospital The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University

The first example of Nd@C3N4-photoredox/chlorine dual catalyzed alkylation with unactivated alkanes as the alkyl sources has been developed,which allows for the synthesis of various 4-alkylated cyclic sulfonyl *** this process,chlorine functions as both a redox and hydrogen atom transfer *** synergism of the reversible Nd2+/Nd3+and Clˉ/Cl˙redox pairs significantly enhances overall photocatalytic *** in vitro anticancer activity of 4-alkylated products was evaluated by using the CCK8assay against both human choroidal melanoma （MUM-2B） and lung cancer （A549） *** 3da showed approximately triple the potency of 5-fluorouracil.

关键词： Chlorine Dual catalysis Hydrogen atom transfer Redox catalyst Semiconductor