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Dietary isoflavones,the modulator of breast carcinogenesis:Current landscape and future perspectives

Asian Pacific Journal of Tropical Medicine 2018年第3期11卷 186-193页

作者： Javed Iqbal Banzeer Ahsan Abbasi Ali Talha Khalil Barkat Ali Tariq Mahmood Sobia Kanwal Sayed Afzal Shah Wajid Ali Department of Plant Sciences Quaid-i-Azam University Department of Eastern Medicine and Surgery Qarshi University UNESCO UNISA Africa chair in nanoscience and nanotechnology Nanosciences African Network(NANOAFNET) Department of Zoology University of GujratSub Campus

Breast cancer is a frightful disease and serious concern in women around the world causing significant health care burden in both developed and developing countries. Extensive research work has shown that breast cancer provides strong resistance to chemical agents, U V radiation,and hormonal treatments. It is generally accepted that cell genetics is not the only main reason for breast cancer and genetic risk factors, for example, mutations in RRCAI and BRCA2 genes constitute 5%-10% of all breast cancer rates. Other related factors include age, gender,race, ethnicity, weight, reproductive factors, exo-and endogenous hormonal exposures, oral contraceptives use, ultraviolet radiation, diet, and night work(circadian disruption). Many studies have revealed that dietary isoflavones regulate breast cancer occurrence, recurrence and prognosis. Dietary isoflavones have long been part of Asian population diet and there is a significant increase as compared to dietary isoflavones intake among other populations. Dietary isoflavones are natural phytoestrogens having both estrogenic and anti-estrogenic potentials on breast cancer cells in culture, animal models and in experimental trials. This literature survey provides a comprehensive overview on the tumor preventive and tumor promoting potentials of dietary isoflavones on breast cancer. In addition, this paper provides a literature review of dietary isoflavones and their effects on up-regulation and down-regulation of different signaling pathways, genes and proteins. Finally, future perspectives of dietary isoflavones and breast cancer researchers are also critically discussed, which will provide a deeper insight regarding the inner molecular mechanisms of action.

关键词： Dietary isoflavones Breast cancer Signaling pathways Natural phytoestrogens

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Plant-derived anticancer agents: A green anticancer approach

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Asian Pacific Journal of Tropical Biomedicine 2017年第12期7卷 1129-1150页

作者： Javed Iqbal Banzeer Ahsan Abbasi Tariq Mahmood Sobia Kanwal Barkat Ali Sayed Afzal Shah Ali Talha Khalil Department of Plant Sciences Quaid-i-Azam University Islamabad45320Pakistan Department of Zoology University of GujratSub Campus RawalpindiPakistan Department of Eastern Medicine and Surgery Qarshi UniversityLahorePakistan UNESCO UNISA Africa chair in nanoscience and nanotechnology South Africa Nanosciences African Network(NANOAFNET) South Africa

Cancer is a frightful disease and represents one of the biggest health-care issues for the human race and demands a proactive strategy for cure. Plants are reservoirs for novel chemical entities and provide a promising line for research on cancer. Hitherto, being effective, chemotherapy is accompanied by certain unbearable side effects. Nevertheless,plants and plant derived products is a revolutionizing field as these are Simple, safer, ecofriendly, low-cost, fast, and less toxic as compared with conventional treatment *** are selective in their functions and acts specifically on tumor cells without affecting normal cells. Carcinogenesis is complex phenomena that involves many signaling cascades. Phytochemicals are considered suitable candidates for anticancer drug development due to their pleiotropic actions on target events with multiple manners. The research is in progress for developing potential candidates(those can block or slow down the growth of cancer cells without any side effects) from these phytochemicals. Many phytochemicals and their derived analogs have been identified as potential candidates for anticancer therapy. Effort has been made through this comprehensive review to highlight the recent developments and milestones achieved in cancer therapies using phytomolecules with their mechanism of action on nuclear and cellular factors. Furthermore, drugs for cancer treatment and their limitations have also been discussed.

关键词： Cancer Limitations of anticancer drugs Phytochemicals Analogs

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Role of dietary phytochemicals in modulation of miRNA expression:Natural swords combating breast cancer

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Asian Pacific Journal of Tropical Medicine 2018年第9期11卷 501-509页

作者： Banzeer Ahsan Abbasi Javed Iqbal Tariq Mahmood Ali Talha Khalil Barkat Ali Sobia Kanwal Sayed Afzal Shah Riaz Ahmad Department of Plant Sciences Quaid-i-Azam University Nanosciences African Network(NANOAFNET) iThemba LABS-National Research Foundation Somerset West Department of Zoology University of GujratSub Campus Department of Eastern Medicine and Surgery Qarshi University UNESCO UNISA Africa Chair in Nanoscience and Nanotechnology College of Graduate StudiesUniversity of South Africa College of Life Sciences Shaanxi Normal University

The National Cancer Institute had projected breast cancer(BC) as one of the topmost prevalent malignancies around the *** many cases,BC becomes resistant to chemotherapy,radiation and hormonal *** BC therapies are associated with adverse side effects,drug resistance and *** research work has shown that these dietary phytochemicals(DPs) may exert therapeutic effects by regulating the miRNA expression.A large number of DPs have been researched as miRNA regulatory agents against BC and some other DPs have not yet been tested against *** have discussed the effects of curcumin,diallyl disulphide,3,3′ diindolylmethane,ellagic acid,genistein,indole-3-carbinol,quercetin,resveratrol,and sulforaphane on regulation of expression of BC miRNAs in a wide range of in vitro and in vivo *** have also shown some of the possible DPs(Oleanolic acid,capsaicin,benzyl isothiocyanate,epigallocatechin gallate,phenethyl isothiocyanate and ursolic acid) that have shown miRNA regulatory activities and have not yet been tested against BC ***,current limitations,challenges,future perspectives of DPs and BC research are also critically discussed.

关键词： Breast cancer miRNAs Dietary phytochemicals In vitro In vivo

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DNA Fingerprinting of Essential Commercialized Medicinal Plants from Pakistan

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American Journal of Plant Sciences 2017年第9期8卷 2119-2132页

作者： Waqar Ahmad Khushi Muhammad Altaf Hussain Habib Ahmad Khalid Kahn Iqbal Ahmed qarshi Kamran Iqbal Shinwari Muhammad Shahid Nadeem Youxiong Que Ayaz Khan Javed Iqbal Department of Genetics Hazara University Mansehra Pakistan qarshi university Lahore and Qarshi Industries Hattar Pakistan School of Biological Sciences University of the Punjab Lahore Pakistan Key Lab of Sugarcane Biology and Genetic Breeding Ministry of Agriculture Fujian Agriculture and Forestry University Fuzhou China Department of Biochemistry Faculty of Science King Abdulaziz University Jeddah Saudi Arabia Women university Swabi Pakistan

Development of fingerprints based on DNA markers is necessary for proper identification and standardization of plant species. These techniques are widely used to develop an unquestionable method of plant identification to protect the patents and quality control for industry. In this study, fifteen commercially important medicinal plants of Pakistan were collected from botanical garden of qarshi Industries (Pvt.) Ltd, Pakistan. The objective was to optimize the extraction of genomic DNA for use in a PCR-based random amplified polymorphic DNA marker approach. The initial protocol used 60 decamers to amplify scorable amplicons;only nine markers produced significant bands in genomic DNA of medicinal plants. These markers generated 51 bands ranging between 250 and 1600 bp. The most important property of genomic markers is polymorphism to enable specific identification;all the used markers showed 100% polymorphism across 15 different plants. Further, six decamers amplified specific bands to reliably identify 8 species. The amplified bands were arranged in a binary matrix and analyzed by DNAMAN version 5.2.2 statistical software. A homology tree was constructed using binary data for nine markers, and four major clusters/clades were observed. The Rose, Mentha and Stevia accessions had shown clear clustering and grouped in major clusters/clads I, II and III respectively. Sixty decamers amplified 51 polymorphic loci in the genomes of 15 commercially valuable accessions. Moreover clear phylogenetic construction was observed in the generation of homolog tree. This protocol could therefore be useful to provide a baseline to authenticate, identify and perform phylogenetic analysis of important medicinal plants used in the Pakistani herbal medicine industry.

关键词： RAPD Decamers Medicinal Plants DNA Fingerprinting

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