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A flexible,thin-film microchannel electrode array device for selective subdiaphragmatic vagus nerve recording

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Microsystems & Nanoengineering 2024年第1期10卷 115-128页

作者： Jongcheon Lim Peter A.Zoss Terry L.Powley Hyowon Lee Matthew P.Ward Weldon School of Biomedical Engineering Purdue UniversityWest LafayetteINUSA Birck Nanotechnology Center Purdue UniversityWest LafayetteINUSA Center for Implantable Devices Purdue UniversityWest LafayetteINUSA Department of Psychological Sciences Purdue UniversityWest LafayetteINUSA purdue institute of integrative neuroscience Purdue UniversityWest LafayetteINUSA Indiana University School of Medicine IndianapolisINUSA

The vagus nerve(VN)plays an important role in regulating physiological conditions in the gastrointestinal(GI)tract by communicating via the parasympathetic pathway to the enteric nervous system(ENS).However,the lack of knowledge in the neurophysiology of the VN and GI tract limits the development of advanced treatments for autonomic dysfunctions related to the *** better understand the complicated underlying mechanisms of the VN-GI tract neurophysiology,it is necessary to use an advanced device enabled by microfabrication *** several candidates including intraneural probe array and extraneural cuff electrodes,microchannel electrode array devices can be used to interface with smaller numbers of nerve fibers by securing them in the separate channel *** microchannel electrode array devices to interface teased nerve structures are relatively bulky with thickness around 200µ*** thick design can potentially harm the delicate tissue structures,including the nerve *** this paper,we present a flexible thin film based microchannel electrode array device(thickness:11.5µm)that can interface with one of the subdiaphragmatic nerve branches of the VN in a *** demonstrated recording evoked compound action potentials(ECAP)from a transected nerve ending that has multiple nerve ***,our analysis confirmed that the signals are from C-fibers that are critical in regulating autonomic neurophysiology in the GI tract.

关键词： electrode recording film

Could non-invasive brain-stimulation prevent neuronal degeneration upon ion channel re-distribution and ion accumulation after demyelination?

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Neural Regeneration Research 2020年第11期15卷 1977-1980页

作者： Friederike Pfeiffer Alia Benali Werner Reichardt Centre for integrative neuroscience(CIN) University of TubingenTubingenGermany Section for Computational Sensomotorics Department of Cognitive NeurologyHertie-Institute for Clinical Brain Research and Centre for Integrative NeuroscienceUniversity of TubingenTubingenGermany

Fast and efficient transmission of electrical signals in the nervous system is mediated through myelinated nerve *** neuronal diseases such as multiple sclerosis,the conduction properties of axons are disturbed by the removal of the myelin sheath,leaving nerve cells at a higher risk of *** some cases,the protective myelin sheath of axons can be rebuilt by remyelination through oligodendroglial *** any case,however,changes in the ion channel organization occur and may help to restore impulse conduction after *** the other hand,changes in ion channel distribution may increase the energy demand of axons,thereby increasing the probability of axonal *** attempts have been made or discussed in recent years to increase remyelination of affected axons in demyelinating diseases such as multiple *** approaches range from pharmacological treatments that reduce inflammatory processes or block ion channels to the modulation of neuronal activity through electrical cortical ***,these treatments either affect the entire organism(pharmacological)or exert a very local effect(electrodes).Current results show that neuronal activity is a strong regulator of oligodendroglial *** bridge the gap between global and very local treatments,non-invasive transcranial magnetic stimulation could be *** magnetic stimulation is externally applied to brain areas and experiments with repetitive transcranial magnetic stimulation show that the neuronal activity can be modulated depending on the stimulation parameters in both humans and *** this review,we discuss the possibilities of influencing ion channel distribution and increasing neuronal activity by transcranial magnetic stimulation as well as the effect of this modulation on oligodendroglial cells and their capacity to remyelinate previously demyelinated *** the physiological mechanisms underlying the effects of transcrani

关键词： ion channel multiple sclerosis neuronal activity oligodendrocyte (re-)myelination repetitive transcranial magnetic stimulation transcranial magnetic stimulation

Does sexual dimorphism vary by population? Laryngeal and ear anatomy in cricket frogs

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Current Zoology 2019年第3期65卷 343-352页

作者： Blinda E.MCCLELLAND Michael J.RYAN Walter WILCZYNSKI Department of integrative Biology University of Texas at Austin Austin TX 78712 USA neuroscience institute and Center for Behavioral neuroscience Georgia State University Atlanta GA 30303 USA

Acoustic communication in many anuran species can show the effects of both natural and sexual selection. This is reflected in the sexually dimorphic an atomy of the lary nx and ear structures, as well as the allometric relationship of these morphological traits to head or body size. In this study, we examined laryngeal and ear structures of cricket frogs Acris crepitans not only as sexually dimorphic characteristics, but also as they differ across populations in environmentally different habitats. We used 2-way ANOVA to determine whether the volumetric or linear measurements of these structures differed by sex and population. Females have significantly larger body, head, and ear sizes, but significantly smaller larynges than males. Furthermore, females as well as males show larger body and head sizes, ears, and larynges in a dryer open habitat. An ANCOVA analysis shows that males, but not females, differ in laryngeal size across populations beyond the allometric changes attributable to head size alone indicating that males have a greater degree of laryngeal population variation. In contrast, our covariate analysis found that in both sexes many of the ear differences are non-sigrdficant once head size is accounted for, suggesting that most of the population-level ear variation is due to allometric effects of body size. We conclude that although both sexes show size differences in the larynx related to selection for larger body size in dry, open habitats, selection on males for larger larynx size related to the production of lower frequency calls in those habitats does not result in correlated changes in the female larynx. The results suggest that in anurans, selection for changes in body and head size affects both sexes equally, male calls and the vocal structures responsible for them can further diversify without concordant changes in females.

关键词： acoustic communication allometry amphibians population variation sex differences

A call for international research on COVID-19-induced brain dysfunctions

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National Science Review 2021年第12期8卷 13-14页

作者： Pedro A.Valdes-Sosa Alan C.Evans Mitchell J.Valdes-Sosa Mu-ming Poo Global Brain Consortium University of Electronic Sciences and Technology of China (UESTC) Cuban neuroscience Center (CNEURO) Cuban Academy of Sciences Global Brain Consortium Royal Society of CanadaMc Gill Center for Integrative Neuroscience Mc Gill University Center for Excellence in Brain Science and Intelligence Technology Institute of NeuroscienceChinese Academy of Sciences

The COVID-19 pandemic, still raging worldwide, imposes staggering human and economic costs. These will only increase as many convalescent patients suffer consequences for many *** the virus can target multiple organ s...

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Mitochondrial homeostasis in Parkinson＇s disease-a triumvirate rule？

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Neural Regeneration Research 2017年第8期12卷 1270-1272页

作者： Chee-Hoe Ng Liting Hang Kah-Leong Lim National neuroscience institute Singapore neuroscience & Behavioral Disorders Program Duke-NUSMedical School Singapore Department of Physiology National University of SingaporeSingapore NUS Graduate School for integrative Sciences and Engineering Singapore

Mitochondrial dysfunction in Parkinson＇s disease：Mitochondria are the primary energy generator of the cell and they are important for cell survival and *** mitochondrial homeostasis is frequently reported in human d... 详细信息

关键词： PPAR PD cell PGC AMPK Mitochondrial homeostasis in Parkinson’s disease-a triumvirate rule

A signal-substrate match in the substrate-borne component of a multimodal courtship display

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Current Zoology 2010年第3期56卷 370-378页

作者： Damian O.ELIAS Andrew C.MASON Eileen A.HEBETS Department of Environmental Science Policy and ManagementUniversity of California integrative Behaviour and neuroscience Group University of Toronto Scarborough School of Biological Sciences University of Nebraska

The environment can impose strong limitations on the efficacy of signal transmission. In particular, for vibratory communication, the signaling environment is often extremely heterogeneous at small scales. Nevertheless, natural selection is expected to select for signals well-suited for effective transmission. Here, we test for substrate-dependent signal efficacy in the wolf spider Schizocosa stridulans Strattou 1991. We first explore the transmission characteristics of this important signaling mo- dality by playing recorded substrate-bome signals through three different substrates （leaf litter, pine litter, and red clay） and measuring the propagated signal. We found that the substrate-bome signal of S. stridulans attenuates the least on leaf litter, the substrate upon which the species is naturally found. Next, by assessing mating success with artificially muted and non-muted males across different signaling substrates （leaf litter, pine litter, and sand）, we explored the relationship between substrate-bome signaling and signaling substrate for mating success. We found that muted males were unsuccessful in obtaining copulations re- gardless of substrate, while mating success was dependent on the signaling substrate for non-muted males. For non-muted males, more males copulated on leaf litter than any other substrate. Taken together, these results confLrm the importance of sub- strate-bome signaling in S. stridulans and suggest a match between signal properties and signal efficacy - leaf litter transmits the signal most effectively and males are most successful in obtaining copulations on leaf litter [Current Zoology 56 （3）： 370-378, 2010].

关键词： Environmental heterogeneity Sensory drive Mate choice Communication

Behavioral and neural auditory thresholds in a frog

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Current Zoology 2019年第3期65卷 333-341页

作者： Ryan C.TAYLOR Karin AKRE Walter WILCZYNSKI Michael J.RYAN Department of integrative Biology University of Texas at Austin Austin TX USA Department of Biological Sciences Salisbury University Salisbury MD USA Smithsonian Tropical Research institute Balboa Republic of Panama neuroscience institute and Center for Behavioral neuroscience Georgia State University Atlanta GA USA

Vocalizations play a critical role in mate recognition and mate choice in a number of taxa, especially, but not limited to, orthopterans, frogs, and birds. But receivers can only recognize and prefer sounds that they can hear. Thus a fundamental question linking neurobiology and sexual selection asks-what is the threshold for detecting acoustic sexual displays? In this study, we use 3 methods to assess such thresholds in tdngara frogs: behavioral responses, auditory brainstem responsesz and multi unit electrophysiological recordi ngs from the *** show that thresholds are lowest for multiunit recordings (ca. 45 dB SPL), and then for behavioral responses (ca. 61 dB SPL), with auditory brainstem responses exhibiting the highest thresholds (ca. 71 dB SPL). We discuss why these estimates differ and why, as with other studies, it is unlikely that they should be the same. Although all of these studies estimate thresholds they are not measuring the same thresholds;behavioral thresholds are based on signal salienee whereas the 2 neural assays estimate physiological thresholds. All 3 estimates, however, make it clear that to have an appreciation for detection and salienee of acoustic signals we must listen to those signals through the ears of the receivers.

关键词： anurans auditory brainstem responses auditory thresholds mate choice Physalaemus pustulosus signal recog nition thresholds sexual selection tungara frogs vocalizations

Role of the Anterior Cingulate Cortex in Translational Pain Research

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neuroscience Bulletin 2021年第3期37卷 405-422页

作者： Xiao Xiao Ming Ding Yu-Qiu Zhang Key Laboratory of Computational neuroscience and Brain-Inspired Intelligence Ministry of EducationInstitute of Science and Technology for Brain-Inspired IntelligenceBehavioral and Cognitive Neuroscience CenterFudan UniversityShanghai 200433China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Department of Translational NeuroscienceJing’an District Centre Hospital of ShanghaiInstitutes of Brain ScienceInstitute of Integrative MedicineFudan UniversityShanghai 200032China

As the most common symptomatic reason to seek medical consultation,pain is a complex experience that has been classified into different categories and *** pain processing,noxious stimuli may activate the anterior cingulate cortex(ACC).But the function of ACC in the different pain conditions is not well *** this review,we elaborate the commonalities and differences from accumulated evidence by a variety of pain assays for physiological pain and pathological pain including inflammatory pain,neuropathic pain,and cancer pain in the ACC,and discuss the cellular receptors and signaling molecules from animal *** further summarize the ACC as a new central neuromodulation target for invasive and non-invasive stimulation techniques in clinical pain *** comprehensive understanding of pain processing in the ACC may lead to bridging the gap in translational research between basic and clinical studies and to develop new therapies.

关键词： Anterior cingulate cortex Deep brain stimulation Transcranial magnetic stimulation Transcranial direct current stimulation Pathological pain Inflammatory pain Neuropathic pain Cancer pain

Morphological structure and peripheral innervation of the lateral line system in the Siberian sturgeon (Acipenser baerii)

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integrative Zoology 2012年第1期7卷 83-93页

作者： Wei SONG Jiakun SONG institute for Marine Biosystem and neuroscience Shanghai Ocean UniversityShanghaiChina

Light and scanning electron microscopy(SEM)were used to study the epidermal lateral line system of the Si-berian sturgeon(Acipenser baerii Brandt,1869).This system consists of mechanoreceptive neuromasts,ampul-lae and the electroreceptive *** neuromasts are located in 5 pairs of cephalic and 1 pair of trunk canals and superficially in the middle and posterior pit lines that lie dorsomedially along the top of the skull immedi-ately adjacent to the otic ampullae *** canal neuromasts and pit organ superficial neuromasts have oppo-site polarized hair cells that are parallel along the axis of the canal and pit line,***,they dif-fer in both size and shape and in the density and length of the hair *** ampullae are confined on the head,adjacent to the neuromast *** morphological structure of the ampullae in the Siberian sturgeon is similar to the ampullae in elasmobranchs and other primitive ***,it has a relatively large mucus-filled ampulla,and a shorter and narrower canal leading to a small opening to the outer epidermal *** also present new information concerning the peripheral innervation of lateral line receptors in *** re-ceptors of the lateral line system are innervated by 2 pairs of cranial nerves:anterior and posterior lateral line *** peripheral processes of the anterior lateral line nerve form superficial ophthalmic,buccal,otic and anteroventral *** peripheral processes of the posterior lateral line nerve form middle,supratemporal and lateral rami.

关键词： canal neuromasts electroreceptors lateral line nerves mechanoreceptors pit organ superficial neuromasts sturgeon