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National survey of the awareness and implementation status of early pulmonary rehabilitation for patients with critical illness in departments of pulmonary and critical care medicine in 2019

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Chinese Medical Journal 2023年第2期136卷 227-229页

作者： Qing Zhao Liyuan Tao Quanguo Li Sinan Wu Dingyi Wang Peng Feng Nan Luo Yuxiao Xie Siyuan Wang Cunbo Jia Gang Zeng Hongmei Zhao Department of pulmonary and critical care medicine Center of Respiratory MedicineChina–Japan Friendship HospitalBeijing 100029China National Clinical Research Center for Respiratory Diseases Beijing 100029China Institute of Respiratory medicine Chinese Academy of Medical SciencesBeijing 100029China National Center for Respiratory medicine Beijing 100029China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100091China Department of pulmonary and critical care medicine Weifang Respiratory Disease HospitalWeifang No.2 Renmin HospitalWeifangShandong 261041China Department of Clinical Research and Data management Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Department of Hospital Development Office China–Japan Friendship HospitalBeijing 100029China Department of Medical Rehabilitation China–Japan Friendship HospitalBeijing 100029China Department of Respiratory medicine North District of Suzhou Municipal HospitalNanjing Medical UniversitySuzhouJiangsu 215000China

To the Editor:The aim of early pulmonary rehabilitation(PR)in the intensive care unit(ICU)is to reduce the incidence of post-ICU syndrome,increase the number of ventilator-free days,reestablish and improve functional capacity,improve health-related life quality,promote mental health,and enhance participation in everyday *** in the ICU is highly effective and plays an important role in recovery of patients with reduced exercise endurance,functional capacity,and health-related life *** surveys outside China have assessed the implementation of early rehabilitation in the ICU,[1]but there are few data from *** study aimed to investigate the awareness and implementation of early PR in secondary-and tertiary-class hospitals with pulmonary and critical care medicine(PCCM)standardized *** staff members were recruited to fill out a selfdesigned *** defined early PR as PR within 5 days of ICU admission.

关键词： critical survey everyday

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Calling for improved pulmonary and critical care medicine in China and beyond

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Chinese Medical Journal pulmonary and critical care medicine 2023年第1期1卷 1-2页

作者： Chen Wang Xiuyuan Hao Simiao Chen Chinese Academy of Medical Sciences&Peking Union Medical College Beijing 100730China Editorial Department of Chinese Medical Journal pulmonary and critical care medicine Chinese Medical AssociationBeijing 100052China Heidelberg Institute of Global Health Faculty of Medicine and University HospitalHeidelberg UniversityHeidelbergGermany

Infectious and chronic respiratory diseases place a high burden on both individual patients and the health *** instance,lower respiratory infections count among the leading causes of death worldwide.1 The emergence wi... 详细信息

关键词： respiratory diseases death

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PKHD1L1 blocks the malignant behavior of lung adenocarcinoma cells and restricts tumor growth by regulating CBX7

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BIOCELL 2024年第8期48卷 1209-1221页

作者： KEWEI CHENG LEI SHI CAIWEN SHI SHUANSHUAN XIE CHANGHUI WANG Department of pulmonary and critical care medicine The Affiliated Changzhou Second People’s Hospital of Nanjing Medical UniversityChangzhou213004China Department of pulmonary and critical care medicine Shanghai Tenth Clinical Medical College of Nanjing Medical UniversityShanghai200072China

Objective:To explore the role of polycystic kidney and hepatic disease 1-like 1(PKHD1L1)in lung adenocarcinoma(LUAD).Methods:Bioinformatics tools were utilized to examine the clinical profile of PKHD1L1 and chromobox protein homolog 7(CBX7)in *** Cell Counting Kit-8,colony formation,terminal deoxynucleotidyl transferase dUTP nick end labeling,Transwell,and wound-healing assays were carried out to assess the proliferative,apoptotic,invasive,and migrative capacities of the ***,the interrelation between PKHD1L1 and CBX7 was validated using a co-immunoprecipitation assay.A LUAD mice model was constructed by subcutaneous injection of A549 ***,immunohistochemical staining was performed to evaluate CBX7 and Ki67 ***:PKHD1L1 was downregulated in LUAD and predicted dismal outcomes in patients with ***1L1 upregulation repressed the proliferative,invasive,and migrative capabilities of A549 cells and exacerbated the apoptotic ***,PKHD1L1 may bind to CBX7 and positively modulate CBX7 ***7 deletion partly abrogated the effects of PKHD1L1 upregulation on the cellular biological activities in A549 ***,the PKHD1L1/CBX7 axis regulates the Hippo signaling pathway in A549 ***1L1 restricted tumor growth in LUAD xenograft mice;this was partly abolished by CBX7 ***:PKHD1L1 can hinder LUAD progression by regulating CBX7-mediated Hippo signaling.

关键词： Lung adenocarcinoma Polycystic kidney and hepatic disease 1-like 1 CBX7 Hippo signaling

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Severe aspiration pneumonia in the elderly

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Journal of Intensive medicine 2024年第3期4卷 307-317页

作者： Sebastian Ocrospoma Marcos I.Restrepo Division of pulmonary Diseases&critical care medicine University of Texas Health San AntonioSan AntonioTXUSA Section of pulmonary&critical care medicine South Texas Veterans Health Care SystemSan AntonioTXUSA

The global population is aging at an unprecedented rate,resulting in a growing and vulnerable elderly population in need of efficient comprehensive healthcare services that include long-term care and skilled nursing *** this context,severe aspiration pneumonia,a condition that carries substantial morbidity,mortality,and financial burden,especially among elderly patients requiring admission to the intensive care unit,has attracted greater *** pneumonia is defined as a pulmonary infection related to aspiration or dysphagia in *** episodes of coughing on food or liquid intake,a history of relevant underlying conditions,abnormalities on videofluoroscopy or water swallowing,and gravity-dependent shadow distribution on chest imaging are among the clues that suggest *** with aspiration pneumonia tend to be elderly,frail,and suffering from more comorbidities than those without this ***,we comprehensively address the epidemiology,clinical characteristics,diagnosis,treatment,prevention,and prognosis of severe aspiration community-acquired pneumonia in the elderly to optimize care of this high-risk demographic,enhance outcomes,and minimize the healthcare costs associated with this *** preventive measures and effective management strategies is vital in ensuring the well-being of our aging population.

关键词： Aspiration pneumonia Aged critical illness Swallowing disorders Frailty Antibacterial agents

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Research progress of viral sepsis:etiology,pathophysiology,diagnosis,and treatment

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Emergency and critical care medicine 2024年第2期4卷 74-81页

作者： Jianping Li Yiqi Luo Hao Li Yunhong Yin Yi Zhang Department of pulmonary and critical care medicine Qilu Hospital of Shandong UniversityJinanShandongChina

Sepsis is a common systemic disease characterized by various physiological and pathological *** can result from infection by various pathogens,such as bacteria,viruses,and *** rate of culture-negative sepsis is almost 42%,indicating that most patients may have nonbacterial *** the outbreak of coronavirus disease 2019,viral sepsis has attracted growing attention because many critically ill patients develop *** sepsis can be caused by viral infections and combined with,or secondary to,bacterial *** the common types of viral sepsis and the main characteristics of its pathogenesis will be helpful for effective diagnosis and treatment,thereby reducing *** identification of the causative agent of viral sepsis can help reduce the overuse of broad-spectrum *** this article,we reviewed the common viruses of sepsis,their potential pathophysiology,targets of diagnosis,and remedies for viral sepsis.

关键词： Acute gastrointestinal injury Acute kidney injury Acute lung injury Cytokine storm Diagnosis Treatment of viral sepsis Viral sepsis

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DNA of neutrophil extracellular traps promote NF-κBdependent autoimmunity via cGAS/TLR9 in chronic obstructive pulmonary disease

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3040-3055页

作者： Jun Chen Tao Wang Xiaoou Li Lijuan Gao Ke Wang Mengxin Cheng Zijian Zeng Lei Chen Yongchun Shen Fuqiang Wen Department of Respiratory and critical care medicine West China HospitalWest China School of Medicineand Division of Pulmonary DiseasesState Key Laboratory of BiotherapySichuan UniversityChengduSichuan 610041China

Chronic obstructive pulmonary disease(COPD)is characterised by persistent airway inflammation even after cigarette smoking *** extracellular traps(NETs)have been implicated in COPD severity and acute airway inflammation induced by short-term cigarette smoke(CS).However,whether and how NETs contribute to sustained airway inflammation in COPD remain *** study aimed to elucidate the immunoregulatory mechanism of NETs in COPD,employing human neutrophils,airway epithelial cells(AECs),dendritic cells(DCs),and a long-term CS-induced COPD mouse model,alongside cyclic guanosine monophosphate-adenosine monophosphate synthase and toll-like receptor 9 knockout mice(cGAS-^(−/−)TLR9^(−/−));Additionally,bronchoalveolar lavage fluid(BALF)of COPD patients was *** from COPD patients released greater cigarette smoke extract(CSE)-induced NETs(CSE-NETs)due to mitochondrial respiratory chain *** CSE-NETs,containing oxidatively-damaged DNA(NETs-DNA),promoted AECs proliferation,nuclear factor kappa B(NF-κB)activation,NF-κB-dependent cytokines and type-I interferons production,and DC maturation,which were ameliorated/reversed by silencing/inhibition of cGAS/*** the COPD mouse model,blocking NETs-DNA-sensing via cGAS^(−/−)and TLR9^(−/−)mice,inhibiting NETosis using mitoTEMPO,and degrading NETs-DNA with DNase-I,respectively,reduced NETs infiltrations,airway inflammation,NF-κB activation and NF-κBdependent cytokines,but not type-I interferons due to IFN-α/βreceptor *** NETs components(myeloperoxidase and neutrophil elastase activity)in BALF of COPD smokers correlated with disease severity and NF-κB-dependent cytokine levels,but not type-I interferon *** conclusion,NETs-DNA promotes NF-κB-dependent autoimmunity via cGAS/TLR9 in long-term CS exposure-induced ***,targeting NETs-DNA and cGAS/TLR9 emerges as a potential strategy to alleviate persistent airway inflammation in COPD.

关键词： inflammation TLR9 neutrophil

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lmpact of non-canonical ALK fusion on the efficacy of targeted therapy in non-small cell lung cancer

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Chinese Medical Journal 2024年第12期137卷 1468-1470页

作者： Hao Zeng Qi Wei Yuan Tang Yuanyuan Zhang Sihan Tan Qin Huang Xin Pu Yalun Li Panwen Tian Department of pulmonary and critical care medicine West China HospitalSichuan UniversityChengduSichuan 610041China Department of Pathology West China HospitalSichuan UniversityChengduSichuan 610041China Department of pulmonary and critical care medicine Lung Cancer CenterWest China HospitalSichuan UniversityChengduSichuan 610041China Department of pulmonary and critical care medicine State Key Laboratory of Respiratory Health and MultimorbidityPrecision Medicine Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduSichuan 610041China

To the Editor:With the wide application of next-generation sequencing(NGS),a number of EML4-ALK fusion partners or coexisting(non)-EML4-ALK and non-EML4-ALK have been detected in non-small cell lung cancer(NSCLC).Although targeted therapies for patients with metastatic NSCLC and actionable mutations dramatically change how these patients are treated,studies have demonstrated differences in progression-free survival(PFS)among patients based on different ALK fusion partners.

关键词： targeted lung NSCLC

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Whole-exome sequencing identified novel DNAH5 homozygous variants in two consanguineous families with primary ciliary dyskinesia

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中华医学杂志(英文版) 2024年第1期137卷 115-116页

作者： Yang Binyi Lei Cheng Xu Yingjie Yang Danhui Lu Chenyang Liu Ying Guo Ting Luo Hong Department of pulmonary and critical care medicine The Second Xiangya Hospital 3. Central South University 4. Changsha 5. Hunan 410011 6. China

Primary ciliary dyskinesia (PCD) is a rare autosomal recessive inherited disease characterized by dysfunction of the motile cilia. DNAH5, the most frequently mutated gene in PCD, encodes a heavy chain of the ciliary outer dynein arms (ODAs). Herein, we report two patients with Kartagener syndrome (sinusitis, bronchiectasis, and situs inversus) in two consanguineous families carrying two novel homozygous DNAH5 variants [Supplementary Figures 1A and 1B, http://***/CM9/B598].

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Reflections on COPD comorbidities

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Chinese Medical Journal 2024年第12期137卷 1504-1506页

作者： Zhenming He Yue Wang Lin Shan Yan Mou Yunhuan Liu Guanhua Ma Yanxu Wu Huili Zhu Jeffrey L.Curtis Shilei Cui Haiyan Ge Department of pulmonary and critical care medicine Huadong HospitalFudan UniversityShanghai 200040China Medical Service VA Ann Arbor Healthcare SystemAnn ArborMI 48105USA pulmonary&critical care medicine Division Department of Internal MedicineUniversity of MichiganAnn ArborMI 48109USA Graduate Program in Immunology University of MichiganAnn ArborMI 48109USA

To the Editor:Chronic obstructive pulmonary disease(COPD)is a common disease among the elderly,affecting over one-third of the elderly population *** progressive decline in lung function characteristic of COPD significantly impacts the quality of life and employability of affected individuals,resulting in a substantial direct and indirect socioeconomic *** frequently has comorbidities involving other organ *** all elderly COPD patients present with one or more comorbid conditions,collectively exacerbating health and economic *** viral and bacterial infections remain the most common triggers for COPD exacerbations(ECOPD).

关键词： morbid lung collective

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Fangji Fuling Decoction Alleviates Sepsis by Blocking MAPK14/FOXO3A Signaling Pathway

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Chinese Journal of Integrative medicine 2024年第3期30卷 230-242页

作者： WANG Yi CHEN Ming-qi DAI Lin-feng ZHANG Hai-dong WANG Xing Department of critical care medicine Changzhou Hospital of Traditional of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineChangzhouJiangsu Province213000China Department of critical care medicine Jiangsu Province Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing210029China

Objective:To examine the therapeutic effect of Fangji Fuling Decoction(FFD) on sepsis through network pharmacological analysis combined with in vitro and in vivo ***:A sepsis mouse model was constructed through intraperitoneal injection of 20 mg/kg lipopolysaccharide(LPS).RAW264.7 cells were stimulated by 250 ng/m L LPS to establish an in vitro cell *** pharmacology analysis identified the key molecular pathway associated with FFD in *** ectopic expression and depletion experiments,the effect of FFD on multiple organ damage in septic mice,as well as on cell proliferation and apoptosis in relation to the mitogen-activated protein kinase 14/Forkhead Box O 3A(MAPK14/FOXO3A) signaling pathway,was ***:FFD reduced organ damage and inflammation in LPS-induced septic mice and suppressed LPS-induced macrophage apoptosis and inflammation in vitro(P<0.05).Network pharmacology analysis showed that FFD could regulate the MAPK14/FOXO signaling pathway during *** confirmed by in vitro cell experiments,FFD inhibited the MAPK14 signaling pathway or FOXO3A expression to relieve LPS-induced macrophage apoptosis and inflammation(P<0.05).Furthermore,FFD inhibited the MAPK14/FOXO3A signaling pathway to inhibit LPS-induced macrophage apoptosis in the lung tissue of septic mice(P<0.05).Conclusion:FFD could ameliorate the LPS-induced inflammatory response in septic mice by inhibiting the MAPK14/FOXO3A signaling pathway.

关键词： sepsis Fangji Fuling Decoction mitogen-activated protein kinase 14/Forkhead Box O 3A signaling pathway inflammatory response apoptosis lung injury Chinese medicine

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