检索结果-南通市图书馆

The secondary injury cascade after spinal cord injury: an analysis of local cytokine/chemokine regulation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第6期19卷 1308-1317页

作者： Daniel J.Hellenbrand Charles M.Quinn Zachariah J.Piper Ryan T.Elder Raveena R.Mishra Taylor L.Marti Phoebe M.Omuro Rylie M.Roddick Jae Sung Lee William L.Murphy Amgad S.Hanna department of Neurosurgery University of Wisconsin-Madison School of Medicine and Public Health department of Biomedical engineering University of Wisconsin-Madison department of Orthopedics and Rehabilitation University of Wisconsin-Madison department of Materials Science and engineering University of Wisconsin-Madison Forward BIO Institute University of Wisconsin-Madison

After spinal cord injury, there is an extensive infiltration of immune cells, which exacerbates the injury and leads to further neural degeneration. Therefore, a major aim of current research involves targeting the immune response as a treatment for spinal cord injury. Although much research has been performed analyzing the complex inflammatory process following spinal cord injury, there remain major discrepancies within previous literature regarding the timeline of local cytokine regulation. The objectives of this study were to establish an overview of the timeline of cytokine regulation for 2 weeks after spinal cord injury, identify sexual dimorphisms in terms of cytokine levels, and determine local cytokines that significantly change based on the severity of spinal cord injury. Rats were inflicted with either a mild contusion, moderate contusion, severe contusion, or complete transection, 7 mm of spinal cord centered on the injury was harvested at varying times post-injury, and tissue homogenates were analyzed with a Cytokine/Chemokine 27-Plex assay. Results demonstrated pro-inflammatory cytokines including tumor necrosis factor α, interleukin-1β, and interleukin-6 were all upregulated after spinal cord injury, but returned to uninjured levels within approximately 24 hours post-injury, while chemokines including monocyte chemoattractant protein-1 remained upregulated for days post-injury. In contrast, several anti-inflammatory cytokines and growth factors including interleukin-10 and vascular endothelial growth factor were downregulated by 7 days post-injury. After spinal cord injury, tissue inhibitor of metalloproteinase-1, which specifically affects astrocytes involved in glial scar development, increased more than all other cytokines tested, reaching 26.9-fold higher than uninjured rats. After a mild injury, 11 cytokines demonstrated sexual dimorphisms; however, after a severe contusion only leptin levels were different between female and male rats. In conclus

关键词： astrocytes chemokines cytokines inflammation macrophages microglia secondary damage spinal cord injury

Predicting Hurricane Evacuation Decisions with Interpretable Machine Learning Methods

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Disaster Risk Science 2024年第1期15卷 134-148页

作者： Yuran Sun Shih‑Kai Huang Xilei Zhao department of Civil and Coastal engineering University of FloridaGainesvilleFL 32611USA department of Emergency Management and public Administration Jacksonville State UniversityJacksonvilleAL 36265USA

Facing the escalating effects of climate change,it is critical to improve the prediction and understanding of the hurricane evacuation decisions made by households in order to enhance emergency *** studies in this area often have relied on psychology-driven linear models,which frequently exhibited limitations in *** present study proposed a novel interpretable machine learning approach to predict household-level evacuation decisions by leveraging easily accessible demographic and resource-related predictors,compared to existing models that mainly rely on psychological *** enhanced logistic regression model(that is,an interpretable machine learning approach) was developed for accurate predictions by automatically accounting for nonlinearities and interactions(that is,univariate and bivariate threshold effects).Specifically,nonlinearity and interaction detection were enabled by low-depth decision trees,which offer transparent model structure and robustness.A survey dataset collected in the aftermath of Hurricanes Katrina and Rita,two of the most intense tropical storms of the last two decades,was employed to test the new *** findings show that,when predicting the households’ evacuation decisions,the enhanced logistic regression model outperformed previous linear models in terms of both model fit and predictive *** outcome suggests that our proposed methodology could provide a new tool and framework for emergency management authorities to improve the prediction of evacuation traffic demands in a timely and accurate manner.

关键词： Artifcial Intelligence(AI) Decision-making modeling Hurricane evacuation Interpretable machine learning Nonlinearity and interaction detection

Generation of lossy mode resonances(LMR)using perovskite nanofilms

在线全文

学校读者我要写书评

暂无评论

Opto-Electronic Advances 2024年第2期7卷 33-40页

作者： Dayron Armas Ignacio R.Matias M.Carmen Lopez-Gonzalez Carlos Ruiz Zamarreño Pablo Zubiate Ignacio del Villar Beatriz Romero Electrical Electronic and Communications Engineering DepartmentPublic University of NavarraPamplona 31006Spain Institute of Smart Cities(ISC) Public University of NavarraPamplona 31006Spain Experimental Science and Technology School Rey Juan Carlos UniversityMostoles 28933Spain

The results presented here show for the first time the experimental demonstration of the fabrication of lossy mode resonance(LMR) devices based on perovskite coatings deposited on planar waveguides. Perovskite thin films have been obtained by means of the spin coating technique and their presence was confirmed by ellipsometry, scanning electron microscopy, and X-ray diffraction testing. The LMRs can be generated in a wide wavelength range and the experimental results agree with the theoretical simulations. Overall, this study highlights the potential of perovskite thin films for the development of novel LMR-based devices that can be used for environmental monitoring, industrial sensing, and gas detection, among other applications.

关键词： perovskite thin films slab waveguide lossy mode resonance

Finite element analysis and experimental validation of polymer-metal contacts in block-on-ring configuration

在线全文

学校读者我要写书评

暂无评论

Friction 2024年第3期12卷 554-568页

作者： K.Y.Eayal AWWAD Khosro FALLAHNEZHAD B.F.YOUSIF Ahmad MOSTAFA Omar ALAJARMEH A.SHALWAN Xuesen ZENG Mechanical engineering department Faculty of EngineeringTafila Technical UniversityTafila 66110Jordan Medical Device Research Institute College of Science and EngineeringFlinders UniversitySouth Australia 5042Australia Centre for Future Materials University of Southern QueenslandToowoomba 4350Australia department of Manufacturing engineering Technology Public Authority for Applied Education and TrainingKuwait 13092Kuwait

The wear profile analysis,obtained by different tribometers,is essential to characterise the wear ***,most of the available methods did not take the stress distribution over the wear profile in consideration,which causes inaccurate *** this study,the wear profile of polymer–metal contact,obtained by block-on-ring configuration under dry sliding conditions,was analysed using finite element modelling(FEM)and experimental ***’s wear equation was integrated into a developed FORTRAN-UMESHMOTION code linked with Abaqus software.A varying wear coefficient(k)values covering both running-in and steady state regions,and a range of applied loads involving both mild and severe wear regions were measured and implemented in the *** FEM was in good agreement with the *** model reproduced the stress distribution profiles under variable testing conditions,while their values were affected by the sliding direction and maximum wear depth(hmax).The largest area of the wear profile,exposed to the average contact stresses,is defined as the normal *** the critical zones were characterized by high stress concentrations reaching up to 10 times of that at the normal *** wear profile was mapped to identify the critical zone where the stress concentration is the key point in this *** surface features were examined in different regions using scanning electron microscope(SEM).Ultimately,SEM analysis showed severer damage features in the critical zone than that in the normal zone as proven by ***,the literature data presented and considered the wear features the same at any point of the wear *** this study,the normal zone was determined at a stress value of about 0.5 MPa,whereas the critical zone was at about 5.5 *** wear behaviour of these two zones showed totally different features from one another.

关键词： polymer-to-metal contact block-on-ring wear profile wear model

Characterization of a smog chamber for studying formation of gas-phase products and secondary organic aerosol

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第2期136卷 570-582页

作者： Qi Yuan Zhuozhi Zhang Meng Wang Kin Fai Ho Tao Wang Shuncheng Lee department of Civil and Environmental engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina School of public Health and Primary Care The Chinese University of Hong KongShatinHong KongChina

Smog chambers provide a potent approach to explore the secondary organic aerosol formation under varied *** study describes the construction and characterization of a new smog chamber facility for studying the formation mechanisms of gas-phase products and secondary organic aerosol from the photooxidation of volatile organic *** chamber is a 5.4 m^(3) Fluorinated Ethylene Propylene(FEP)Teflon reactor with the potential to perform photooxidation experiments at controlled temperature and relative *** characterizations were conducted for evaluation of stability of environmental parameters,mixing time,background contamination,light intensity,and wall losses of gases and *** photolysis rate of NO_(2)(J_(NO2))ranged from(1.02-3.32)×10^(-3)sec^(-1),comparable to the average J_(NO2)in ambient *** wall loss rates for NO,NO_(2),and O_(3)were 0.47×10^(-4),0.37×10^(-4),and 1.17×10^(-4)min^(-1),while wall loss of toluene was obsoletely found in a 6 hr *** particle number wall loss rates are(0.01-2.46)×10^(-3)min^(-1)for 40-350 nm with an average lifetime of more than one day.A series of toluene photooxidation experiments were carried out in absence of NO_xunder dry *** results of the simulation experiments demonstrated that the chamber is well designed to simulate photolysis progress in the atmosphere.

关键词： Smog chamber Gas-phase oxidation Chamber characterization Chemical mechanism

Metabolite acetyl-L-carnitine participates in Bifidobacterium animalis F1-7 to ameliorate atherosclerotic inflammation by downregulating theTLR4/NF-κB pathway

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第2期13卷 813-822页

作者： Xi Liang Zhe Zhang Xiaoying Tian Qingyu Cui Haiyan Lu Maozhen Zhao Tongjie Liu Huaxi Yi Pimin Gong Lanwei Zhang department of Nutrition and Food Hygiene School of public healthQingdao UniversityQingdao 266071China College of Food Science and engineering Ocean University of ChinaQingdao 266003China

This study aimed to explore the effect of Bifidobacterium animalis F1-7 on the improvement of atherosclerotic *** model ApoE^(-/-)mice were orally administered with *** F1-7 for 12 *** probiotic intervention reduced the plaque areas in aorta and the accumulation of macrophages,and downregulated the expression of toll-like receptor 4(TLR4)/nuclear factorκB(NF-κB)pathway to reduce the levels of inflammatory *** widely-targeted metabolomics analysis showed that acetyl-L-carnitine(ALC)in the intestine of atherosclerotic mice was significantly increased after *** F1-7 *** analysis proved that ALC was associated with atherosclerotic inflammatory *** using oxidized low density lipoprotein induced macrophage foam cells,we further verified that ALC could reduce lipid accumulation and inflammatory response in foam cells by downregulating the TLR4/NF-κB ***,our results revealed that *** F1-7 upregulated the metabolite ALC to downregulate the inflammatory responses,leading to the reduction of plaque accumulation of atherosclerosis.

关键词： Bifidobacterium animalis F1-7 Atherosclerosis Inflammation Metabonomics Acetyl-L-carnitine

A risk assessment method considering risk attributes and work safety informational needs and its application

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical engineering 2024年第4期68卷 253-262页

作者： Cong Luo Yunsheng Zhao Ke Xu School of Political Science and public Administration Shandong UniversityQingdao 266200China Faculty of engineering China University of GeosciencesWuhan 430074China department of Emergency Management of Hubei Province Wuhan 430064China

The technological revolution has spawned a new generation of industrial systems,but it has also put forward higher requirements for safety management accuracy,timeliness,and *** assessment needs to evolve to address the existing and future challenges by considering the new demands and advancements in safety *** study aims to propose a systematic and comprehensive risk assessment method to meet the needs of process system safety *** methodology first incorporates possibility,severity,and dynamicity(PSD)to structure the“51X”evaluation indicator system,including the inherent,management,and disturbance risk ***,the four-tier(risk point-unit-enterprise-region)risk assessment(RA)mathematical model has been established to consider supervision *** in conclusion,the application of the PSD-RA method in ammonia refrigeration workshop cases and safety risk monitoring systems is presented to illustrate the feasibility and effectiveness of the proposed PSD-RA method in safety *** findings show that the PSD-RA method can be well integrated with the needs of safety work informatization,which is also helpful for implementing the enterprise's safety work responsibility and the government's safety supervision responsibility.

关键词： Risk assessment Safey “51X”evaluation indicator system Four-tier risk assessment model Risk attributes Process system

Novel Sustainable Cellulose Acetate Based Biosensor for Glucose Detection

在线全文

学校读者我要写书评

暂无评论

Journal of Renewable Materials 2024年第2期12卷 369-380页

作者： M.F.Elkady E.M.El-Sayed Mahmoud Samy Omneya A.Koriem H.Shokry Hassan Chemical and Petrochemical engineering department Egypt-Japan University of Science and TechnologyNew Borg El-ArabAlexandriaEgypt Fabrication Technology Research department Advanced Technology and New Materials Research InstituteCity of Scientific Research and Technological Applications(SRTA-City)New Borg El-ArabAlexandria21934Egypt department of public works engineering Faculty of EngineeringMansoura UniversityMansoura35516Egypt Environmental engineering department Egypt-Japan University of Science and TechnologyNew Borg El-ArabAlexandriaEgypt Electronic Materials Research department Advanced Technology and NewMaterials Research InstituteCity of Scientific Research and Technological Applications(SRTA-City)New Borg El-ArabAlexandria21934Egypt

In this study,green zinc oxide(ZnO)/polypyrrole(Ppy)/cellulose acetate(CA)film has been synthesized via solvent *** film was used as supporting material for glucose oxidase(GOx)to sensitize a glucose *** nanoparticles have been prepared via the green route using olive leaves extract as a ***/Ppy nanocomposite has been synthesized by a simple in-situ chemical oxidative polymerization of pyrrole(Py)monomer using ferric chloride(FeCl3)as an oxidizing *** produced materials and the composite films were characterized using X-ray diffraction analysis(XRD),scanning electron microscope(SEM),Fourier transform infrared(FTIR)and thermogravimetric analysis(TGA).Glucose oxidase was successfully immobilized on the surface of the prepared film and then ZnO/Ppy/CA/GOx composite was sputtered with platinum electrode for the current determination at different initial concentrations of *** measurements proved the suitability and the high sensitivity of the constructed biosensor for the detection of glucose levels in different *** performance of the prepared biosensor has been assessed by measuring and comparing glucose concentrations up to 800 *** results affirmed the reliability of the developed biosensor towards real samples which suggests the wide-scale application of the proposed biosensor.

关键词： Biosensors composite films glucose polypyrrole green ZnO cellulose acetate

Synergistic effect of adsorption and photocatalytic degradation of oilfield-produced water by electrospun photocatalytic fibers of Polystyrene/Nanorod-Graphitic carbon nitride

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第7期141卷 287-303页

作者： Parisa Azmoon Mehrdad Farhadian Alireza Pendashteh Amir H.Navarchian department of Chemical engineering Faculty of EngineeringUniversity of IsfahanIsfahanIran department of Chemical engineering Faculty of EngineeringUniversity of GuilanRashtIran department of Water and Environmental engineering Caspian Sea Basin Research CenterUniversity of GuilanRashtIran

Graphitic carbon nitride with nanorod structure(Nr-GCN)was synthesized using melamine as a precursor without any other reagents by hydrothermal pretreatment ***,FTIR,SEM,N_(2)adsorption-desorption from BET,UV-Vis DRS spectroscopy,and photoluminescence were used to characterize the prepared ***,the photoelectrochemical behavior of nanoparticles was studied by photocurrent transient response and cyclic voltammetry ***(PS)fibrous mat was fabricated by electrospinning technique and used as a support for the stabilization of the *** performance of the synthesized nanoparticles and photocatalytic fibers(PS/Nr-GCN)was evaluated in oilfield-produced water treatment under visible light *** this process,oil contaminants were adsorbed by hydrophobic polystyrene fibers and simultaneously degraded by *** removal efficiency of chemical oxygen demand(COD)has been obtained 96.6%and 98.4%by Nr-GCN and PS/Nr-GCN,respectively,at the optimum conditions of pH4,photocatalyst dosage 0.5 g/L,COD initial concentration 550 mg/L,and illumination time 150 *** gas chromatography-mass spectroscopy analysis results showed 99.3%removal of total petroleum hydrocarbons using photocatalytic fibers of PS/*** results demonstrated that the GCN has outstanding features like controllable morphology,visible-light-driven,and showing high potential in oily wastewater ***,the synergistic effect of adsorption and photocatalytic degradation is an effective technique in oilfield-produced water treatment.

关键词： Graphitic carbon nitride(GCN) Nanorod structure Polystyrene fibrous mat Photocatalytic fibers Oilfield-produced water(OPW)