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Neural Regeneration Research 2024年第3期19卷 657-662页

作者： Hang Yu Mingting Shao Xi Luo Chaoqin Pang Kwok-Fai So Jiandong Yu Li Zhang Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina Department of Neurosurgery The First Affiliated Hospital of Bengbu Medical CollegeBengbuShandong ProvinceChina School of psychology Shanghai University of SportShanghaiChina

Epilepsy frequently leads to cognitive dysfunction and approaches to treatment remain *** regular exercise effectively improves learning and memory functions across multiple neurological diseases,its application in patients with epilepsy remains ***,we adopted a 14-day treadmill-exercise paradigm in a pilocarpine injection-induced mouse model of *** assays confirmed the improvement of object and spatial memory after endurance training,and electrophysiological studies revealed the maintenance of hippocampal plasticity as a result of physical *** of the mechanisms underlying this effect revealed that exercise protected parvalbumin interneurons,probably via the suppression of neuroinflammation and improved integrity of blood-brain *** summary,this work identified a previously unknown mechanism through which exercise improves cognitive rehabilitation in epilepsy.

关键词： blood-brain barrier cognition hippocampus interneurons long-term potentiation microglial cell neuroinflammation spatial memory temporal epilepsy treadmill exercise

Models and detection of spontaneous recurrent seizures in laboratory rodents

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Zoological Research 2017年第4期38卷 171-179页

作者： Bin Gu Katherine A. Dalton Department of Cell Biology and Physiology University of North Carolina Chapel Hill NC 27599 USA psychology & Neuroscience program University of North Carofina Chapel Hill NC 27599 USA

Epilepsy, characterized by spontaneous recurrent seizures （SRS）, is a serious and common neurological disorder afflicting an estimated 1% of the population worldwide. Animal experiments, especially those utilizing small laboratory rodents, remain essential to understanding the fundamental mechanisms underlying epilepsy and to prevent, diagnose, and treat this disease. While much attention has been focused on epileptogenesis in animal models of epilepsy, there is little discussion on SRS, the hallmark of epilepsy. This is in part due to the technical difficulties of rigorous SRS detection. In this review, we comprehensively summarize both genetic and acquired models of SRS and discuss the methodology used to monitor and detect SRS in mice and rats.

关键词： Spontaneous recurrent seizures Animal model Epilepsy

单配制啮齿动物PairBond形成的神经调节机制(英文)

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兽类学报 2004年第2期24卷 160-172页

作者： Brandon J.Aragona J.Thomas Curtis 刘彦汪作新 Department of psychology and program in Neuroscience Florida State University

单配制啮齿动物社会结构的神经生物学原理可以通过实验室研究Socialbonding而获得。在本文中,我们探讨了如何利用单配制的草原田鼠(Microtusochrogaster)作为研究模型揭示pairbond形成的神经调控机制。我们进而探讨了单配制与多配制田... 详细信息

单配制啮齿动物社会结构的神经生物学原理可以通过实验室研究Socialbonding而获得。在本文中,我们探讨了如何利用单配制的草原田鼠(Microtusochrogaster)作为研究模型揭示pairbond形成的神经调控机制。我们进而探讨了单配制与多配制田鼠之间神经解剖学的差异以及神经化学物质的调节是怎样影响pairbond的。本篇综述还讨论了与pairbond形成有关的神经化学系统之间的相互影响以及pairbond形成过程中的两性差异。最后,我们预测了这一研究领域的未来研究方向以及研究socialbonding的神经调控对人类健康的重要性。

关键词：多巴胺加压素催产素肾上腺皮质素单配制田鼠 Pair bond 神经调节机制

Brain weight predicts yawn duration across domesticated dog breeds

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Current Zoology 2020年第4期66卷 401-405页

作者： Andrew C.Gallup Lea Moscatello Jorg J.M.Massen psychology program Department of Social and Behavioral SciencesSUNY Polytechnic InstituteUticaNY13502USA Department of psychology SUNY College at OneontaOneontaNY13820USA Animal Ecology Group Department of BiologyUtrecht UniversityPadualaan 8Utrecht CH3584The Netherlands

Previous research shows that yawning enhances intracranial circulation and regulates brain temperature. Consistent with these functional outcomes, yawn duration correlates positively with interspecies variation in brain weight across mammals, with robust relationships documented at both the taxonomic rank of class and the more restricted scale of family (e.g., Felidae). This study provides the first investigation into whether differences in brain weight within a single species, domesticated dogs Canis lupus familiaris, can predict intraspecific variation in yawn duration. Measures of yawn duration were obtained from public videos available online and then paired with previously published brain and body weight data of different dog breeds. The final sample consisted of 272 yawns from 198 dogs across 23 breeds. Consistent with recent studies, we find robust correlations between yawn duration and brain weight across breeds. Moreover, these correlations remain significant after controlling for differences in body weight across breeds. These findings replicate and extend upon past work in this area and provide further support that yawns evolved to serve an important and large-scale neurophysiologic function.

关键词： brain cooling brain size cortical arousal neuroanatomy

Estimation of the density of neural,glial,and endothelial lineage cells in the adult mouse dentate gyrus

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Neural Regeneration Research 2022年第6期17卷 1286-1292页

作者： Joshua D.Rieskamp Patricia Sarchet Bryon M.Smith Elizabeth D.Kirby Neuroscience Graduate program The Ohio State UniversityColumbusOHUSA Department of psychology The Ohio State UniversityColumbusOHUSA Department of Neuroscience The Ohio State UniversityColumbusOHUSA Chronic Brain Injury program The Ohio State UniversityColumbusOHUSA

The dentate gyrus subregion of the mammalian hippocampus is an adult neural stem cell niche and site of lifelong *** regarding the role of adult-born neuron synaptic integration in hippocampal circuit function are framed by robust estimations of adultborn versus pre/perinatally-born neuron *** contrast,the non-neurogenic functions of adult neural stem cells and their immediate progeny,such as secretion of bioactive growth factors and expression of extracellular matrix-modifying proteins,lack similar framing due to few estimates of their number versus other prominent secretory ***,we apply immunohistochemical methods to estimate cell density of neural stem/progenitor cells versus other major classes of glial and endothelial cell types that are potentially secretory in the dentate gyrus of adult *** the cell types quantified,we found that GFAP^(+)SOX2^(+)stellate astrocytes were the most numerous,followed by CD31^(+)endothelia,GFAP-SOX2^(+)intermediate progenitors,Olig2^(+)oligodendrocytes,Iba1+microglia,and GFAP^(+)SOX2^(+)radial glia-like neural stem *** did not observe any significant sex differences in density of any cell ***,neural stem/progenitor cells were present at a similar density as several cell types known to have potent functional roles via their *** findings may be useful for refining hypotheses regarding the contributions of these cell types to regulating hippocampal function and their potential therapeutic *** experimental protocols were approved by the Ohio State University Institutional Animal Care and Use Committee(protocol#2016A00000068)on July 14,2016.

关键词： adult neurogenesis dentate gyrus endothelia glia hippocampus neural stem cell secretome stereology

Insight into endoplasmic reticulum-mitochondria contacts in human amyotrophic lateral sclerosis

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Neural Regeneration Research 2024年第7期19卷 1407-1408页

作者： Naomi Hartopp Andrea Markovinovic Christopher CJ Miller Patricia Gomez-Suaga Sheffield Institute for Translational Neuroscience University of SheffieldSheffieldUK Department of Basic and Clinical Neuroscience Institute of PsychiatryPsychology and NeuroscienceLondonUK Universidad de Extremadura.Departamento de Bioquímica y Biología Molecular y Genética Facultad de Enfermería y Terapia OcupacionalCáceresSpain Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas-Instituto de Salud Carlos Ⅲ(CIBER-CIBERNED-ISCⅢ) MadridSpain Instituto Universitario de Investigación Biosanitaria de Extremadura(INUBE) CáceresSpain

Amyotrophic lateral sclerosis(ALS) is a fastprogressing fatal neurodegenerative disease and the most common form of motor neuron *** is currently no cure and approximately 90% of cases are *** shares genetic causes,clinical and neuropathological features with frontotemporal dementia,the second most common form of presenile *** and frontotemporal dementia are therefore considered a disease spectrum(Abramzon et al.,2020).

关键词： senile sclerosis

Adolescent social isolation influences cognitive function in adult rats

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Neural Regeneration Research 2013年第11期8卷 1025-1030页

作者： Feng Shao Xiao Han Shuang Shao Weiwen Wang Department of psychology Peking University Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences

Adolescence is a critical period for neurodevelopment. Evidence from animal studies suggests that isolated rearing can exert negative effects on behavioral and brain development. The present study aimed to investigate the effects of adolescent social isolation on latent inhibition and brain-derived neurotrophic factor levels in the forebrain of adult rats. Male Wistar rats were randomly divided into adolescent isolation （isolated housing, 38-51 days of age） and social groups. Latent inhibition was tested at adulthood. Brain-derived neurotrophic factor levels were measured in the medial prefrontal cortex and nucleus accumbens by an enzyme-linked immunosorbent assay. Adolescent social isolation impaired latent inhibition and increased brain-derived neurotrophic factor levels in the medial prefrontal cortex of young adult rats. These data suggest that adolescent social isolation has a profound effect on cognitive function and neurotrophin levels in adult rats and may be used as an animal model of neurodevelopmental disorders.

关键词： neural regeneration adolescence social isolation latent inhibition brain-derived neurotrophicfactor medial prefrontal cortex nucleus accumbens adult cognitive function neurodevelopmentaldisorders grants-supported paper neuroregeneration

Safety and efficacy of modified endoscopic ultrasound-guided selective N-butyl-2-cyanoacrylate injections for gastric variceal hemorrhage in left-sided portal hypertension

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World Journal of Gastrointestinal Endoscopy 2024年第1期16卷 29-36页

作者： Yan Zeng Jian Yang Jun-Wen Zhang Department of psychology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Gastroenterology Changdu People's Hospital of XizangChangdu 854000Tibet Autonomous RegionChina Department of Gastroenterology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Gastric variceal hemorrhage is one of the primary manifestations of left-sided portal hypertension(LSPH).The hemorrhage is fatal and requires safe and effective *** To evaluate the clinical safety and efficacy of modified endoscopic ultrasound(EUS)-guided selective N-butyl-2-cyanoacrylate(NBC)injections for gastric variceal hemorrhage in *** A retrospective observational study of patients with LSPH-induced gastric variceal hemorrhage was *** EUS evaluations were *** patients were divided into modified and conventional groups according to the NBC injection *** final selection of NBC injection technique depended on the patients’preferences and clinical *** technical and clinical success rates,operation time,NBC doses,perioperative complications,postoperative hospital stay,and recurrent bleeding rates were analyzed,*** A total of 27 patients were *** statistically significant differences were observed between the two groups regarding baseline *** comparison to patients in the conventional group,patients in the modified group demonstrated significantly reduced NBC doses(2.0±0.6 mL vs 3.1±1.0 mL;P=0.004)and increased endoscopic operation time(71.9±11.9 min vs 22.5±6.7 min;P<0.001).Meanwhile,the two groups had no significant difference in the technical and clinical success rates,perioperative complications,postoperative hospital stay,and recurrent bleeding *** Modified EUS-guided selective NBC injections demonstrated safety and efficacy for LSPH-induced gastric variceal hemorrhage,with advantages of reduced injection dose and no radiation *** were time consumption and technical challenge.

关键词： Endoscopic ultrasound Selective N-butyl-2-cyanoacrylate Gastric varices Hemorrhage Left-sided portal hypertension

Explosion of research on psychopathology and social media use after COVID-19:A scientometric study

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World Journal of Psychiatry 2024年第5期14卷 742-759页

作者： Meng-Di Zhang Rong-Quan He Jia-Yuan Luo Wan-Ying Huang Jing-Yu Wei Jian Dai Hong Huang Zhen Yang Jin-Liang Kong Gang Chen Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Clinical psychology Jiangbin Hospital of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina Division of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Despite advances in research on psychopathology and social media use,no comprehensive review has examined published papers on this type of research and considered how it was affected by the coronavirus disease 2019(COVID-19)*** To explore the status of research on psychopathology and social media use before and after the COVID-19 *** We used Bibliometrix(an R software package)to conduct a scientometric analysis of 4588 relevant studies drawn from the Web of Science Core Collection,PubMed,and Scopus *** Such research output was scarce before COVID-19,but exploded after the pandemic with the publication of a number of high-impact *** authors and institutions,located primarily in developed countries,maintained their core positions,largely uninfluenced by COVID-19;however,research production and collaboration in developing countries increased significantly after *** the analysis of keywords,we identified commonly used methods in this field,together with specific populations,psychopathological conditions,and clinical *** have devoted increasing attention to gender differences in psychopathological states and linked COVID-19 strongly to depression,with depression detection becoming a new *** in research on psychopathology and social media use are unbalanced and uncoordinated across countries/regions,and more indepth clinical studies should be conducted in the *** After COVID-19,there was an increased level of concern about mental health issues and a changing emphasis on social media use and the impact of public health emergencies.

关键词： Psychopathology Social media Bibliometrics Web of Science PubMed Scopus

Effects of Neurokinin-1 Receptor Inhibition on Anxiety Behavior in Neonatal Rats Selectively Bred for an Infantile Affective Trait

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Pharmacology & Pharmacy 2014年第9期5卷 859-864页

作者： Amanda L. Schott Betty Zimmerberg Department of psychology and program in Neuroscience Williams College Williamstown USA

Interest in understanding the etiology and developing new treatments for anxiety disorders in children and adolescents has led to recent studies of neurotransmitters not traditionally associated with neural pathways for fear and anxiety. The binding of the neurotransmitter substance P (SP) to its neurokinin-1 (NK1) receptor may be a crucial component in mediating the anxiety response. While previous studies using rodent models have documented the anxiolytic effects of SP antagonists, the role of individual differences in affective temperament has not yet been examined in studies of drug response. This study used intracerebroventricular injections of the NK1 antagonist Spantide II at concentrations of 10 and 100 pmol to examine the consequences of blocking the SP-NK1 pathway in high and low line rats selectively bred for high or low levels of ultrasonic distress calls after a brief maternal separation. Affective temperament was a significant factor in determining drug response. Spantide II resulted in a significant reduction of distress calls in subjects in the high anxiety line, while low line subjects with low anxiety were resistant to the drug. These data indicate that the SP-NK1 pathway could be an important therapeutic target for the treatment of various stress disorders, but drug response might be influenced by the individual’s state anxiety or history of chronic stress.

关键词： Anxiety Substance P Neurokinin Receptor Spantide Ultrasonic Vocalizations