检索结果-南通市图书馆

Residual Risk of Transmission of HIV and Hepatitis B and C by blood transfusion in bukavu in the Democratic Republic of Congo

引用

Open Journal of Epidemiology 2014年第3期4卷 157-163页

作者： Jeff Maotela Kabinda André Nyandwe Bulabula Philippe Donnen Réné Fiasse Jeff Van den Ende Daniel Sondag-Thull Dramaix-Wilmet Michèle Catholic University of bukavu Bukavu Congo provincial blood transfusion centre of bukavu Bukavu Congo

The aim of this study was to determine the incidence rates of HIV1/2 antibodies, HBV and HCV antibodies among voluntary blood donors and to estimate the residual risk of HIV, HBV and HCV infection among blood donors in bukavu. We conducted a follow-up cohort study of volunteer blood donors who have made at least two blood donations in bukavu (DRC) between January 2010 and December 2012. We recorded 2986 volunteer blood donors during the study period. The residual risk of viral transmission associated with the serological window was considered as equals to the incidence rate multiplied by the duration of the serological window period divided by 365. Seroprevalence in volunteer blood donors in bukavu was 1.1% for HIV 1/2 antibodies, 4.0% for HBs Ag and 2.1% for hepatitis C antibody. The number of conversion between two blood donations (incident cases) were observed is 8, 12 and 37 donors respectively for HIV 1/2, HCV and hepatitis B between 2010 and 2012. Incidence rates reported for 1000 person-years were 11.0 for HIV, 51.7 for HBV and 17.1 for HCV. The residual risk as estimated from the window was 0.6 per 1000 donations or 1/1.515 donations for HIV, 3.1 per 1000 donations or 1/329 for HCV and 7.9 per 1000 donations or 1/126 donations for hepatitis B. The residual risk is high. The screening tests are not enough to ensure safe blood. The reduction of residual risk would be achieved through the effectiveness of preventive measures taken for transfusion chain, before and after the biological qualification of blood donation.

关键词： Residual Risk Hepatitis HIV blood Donation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assessment of Knowledge, Attitude and Practice of the General Population of bukavu in the Democratic Republic of Congo on blood Donation and blood transfusion

引用

Health 2014年第18期6卷 2525-2534页

作者： Jeff Maotela Kabinda Serge Ahuka Miyanga Sylvain Yuma Ramazani Michèle-Wilmet Dramaix provincial blood transfusion centre of bukavu Bukavu Democratic Republic of Congo Catholic University of bukavu Bukavu Democratic Republic of Congo Research centre in Biostatistics and Epidemiology Brussels Belgium National blood transfusion centre of Kinshasa Kinshasa Democratic Republic of Congo Free University of Brussels Brussels Belgium School of Public Health Brussels Belgium

Objective: To assess the knowledge, attitudes and practices regarding blood donation in the general population. Methods: A cross-sectional study was conducted and enrolled 416 people between 18 and 65 years old at random, living in three health zones in the city of bukavu in eastern DRC. These subjects responded to a questionnaire on knowledge, attitudes and practices regarding blood donation. Results: Our sample consisted of 61.5% men, 70.9% of people from one level of education at the secondary level and 60% unemployed. According to the surveyed subjects blood was considered as a fuel of the body in 44.6% and as a source of life in 44.1%. Sixty-one percent of the population did not know the practice of blood donation;this knowledge differed significantly (p blood had negative effects and 27.4% did not know where the blood bags were stored. Channels of knowledge about blood donation practices were associations of blood donors (30.9%), awareness campaigns (18.2%), school (17.3%) and media (15.5%), churches (10%), and friends (8.1%). Approximately 85% of subjects who knew blood donation agreed with blood donation and blood transfusion but only 54.9% had donated blood in their lifetime, with a proportion of loyalty to blood donation (31.8%). In the population 59.4% were willing to donate blood. Motivation to donate blood most common (66%) was volunteerism while 19.1% were willing to donate blood for a family member and 12.6% willing to donate blood against money. The reasons for refusal to donate blood identified were fear of contracting diseases especially HIV, lack of information, religious beliefs, the sale of the collected blood by medical staff, and fear of test result for HIV. Conclusion: Factors of refusal to donate blood were identified. Efforts and new strategies tailored to these factors must be developed and implemented to increase blood donation.

关键词： blood Donation bukavu transfusion blood Donor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatitis B, Hepatitis C and HIV among Children 6 to 59 Months in the Community in the Democratic Republic of Congo

引用

Open Journal of Pediatrics 2015年第2期5卷 171-178页

作者： Jeff Maotela Kabinda Tony Shindano Akilimali Ahuka Serge Miyanga Philippe Donnen Dramaix-Wilmet Michèle provincial blood transfusion centre of bukavu Bukavu Congo Catholic University of bukavu Bukavu Congo Research centre in Biostatistics and Epidemiology Brussels Belgium Free University of Brussels Brussels Belgium School of Public Health Brussels Belgium centre for Policy and Health Systems/International Health Brussels Belgium

Objectives: To determine the prevalence of HBV, HCV and HIV among children 6 to 59 months and determine the risk factors. Materials and Methods: Descriptive and analytical study on children aged 6 to 59 months of community Maniema (DRC) conducted between 24 June and 24 July 2013. We enrolled 781 children aged 6 to 59 months. For association between the presence of viral markers and potential risk factors the chi-square test of Pearson was applied, the odds ratios (OR) and their 95% confidence intervals (95% CIs) were calculated. The Fisher exact test was used when the conditions for application of the chi-square test of Pearson were not met. Results: The median age of the children was 34 months, 51% of female children. Ten percent of children had a history of blood transfusion;6.6% and 64% had fever and anemia. The prevalence of HBsAg was 3.6%, the prevalence of antibodies against hepatitis C was 2.8% and HIV was 3.7%. The risk factors were HBsAg, male gender (5.5% male vs 2.0 % female;OR = 2.8(1.3 - 6.9) p = 0.001) and urban areas (5.0% rural vs 0.5% urban, OR = 0.1 (0.01 - 0.72), p = 0.01). For HCV and HIV, these factors were the history of blood transfusion in the child and the mother. For HCV 7.6% of children with blood transfusion history;OR = 3.2 (1.1 - 8.5);p = 0.05 and 11.1% history’s mother blood transfusion, OR = 5.6 (2.1 - 14.1). For HIV 11.4% of children with blood transfusion history, OR = 3.8, p = 0.005 and 9.8% history’s mother blood transfusion, OR = 2.9, p = 0.04. Conclusion: Vaccination against hepatitis B in children must be widespread, educational messages to the population must target the risk factors for these viruses. A screening of hepatitis in pregnant women must be coupled with rigorous selection policy for blood donors before each donation and qualification of any unit of blood.

关键词： HBV HCV HIV Child

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatitis B, Hepatitis C and HIV in Pregnant Women in the Community in the Democratic Republic of Congo

引用

World Journal of AIDS 2015年第2期5卷 124-130页

Objectives: To determine the prevalence of HBV, HCV and HIV in pregnant women and identify risk factors. Materials and Methods: Descriptive and analytical study on pregnant women in the community Maniema (DRC) between 24 June and 24 July 2013. We enrolled a total of 581 pregnant women. Results: Prevalence among pregnant women was 4.1% (2.5% to 6.3%) for HIV, 5.9% (3.9% to 8.4%) for the HBsAg and 4.1% (2.5% to 6.4%) for hepatitis C. The risk factor was for HIV, blood transfusion history in women. For HBsAg the main risk factor was the tattoo history and no statistically significant factor was found for hepatitis C. Conclusion: To reduce the risk of transmission of hepatitis from mother to child, all pregnant women should be screened prenatally. A strengthening of routine screening of blood products must be done and a health education of the population on the mode of contamination should be conducted.

关键词： HBV HCV HIV Pregnancy Risk Factors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Knowledge, Attitudes and Practices of Medical and Paramedical Staff in blood transfusion in the Democratic Republic of Congo

引用

Open Journal of Preventive Medicine 2014年第8期4卷 672-680页

作者： Jeff Maotela Kabinda Serge Ahuka Miyanga Philippe Donnen Jeff Van den Ende Michèle-Wilmet Dramaix Free University of Brussels Brussels Belgium School of Public Health Brussels Belgium Centre for Policy and Health Systems/International Health Brussels Belgium Institute of Tropical Medicine Antwerp Belgium provincial blood transfusion centre of bukavu Bukavu Democratic Republic of Congo provincial blood transfusion centre of bukavu Bukavu Democratic Republic of Congo Catholic University of Bukavu Bukavu Democratic Republic of Congo Research Centre in Biostatistics and Epidemiology Brussels Belgium Research centre in Biostatistics and Epidemiology Brussels Belgium Free University of Brussels Brussels Belgium School of Public Health Brussels Belgium

Objective: To assess the knowledge, attitudes and practices of providers in blood transfusion, HIV infections and hepatitis B and C in the province of South Kivu (eastern DRC). Methods: This study is comparative cross-sectional. It covered all the staff care. Our sample was composed by doctors, nurses, midwives, and agents’ rapid training in activity in health sector in South Kivu between 1 December 2011 and 30 December 2011. Those medical and paramedical staffs came from 12 general reference hospitals, 11 hospitals and 65 health centers in the province of South Kivu. Three hundred and ninety three people were interviewed including 6.5% of physicians, 87.4% of nurses and 5.1% of midwives. Among them, 25.5% had received training in blood transfusion. Results: Overall, 11.7% of providers responded correctly to questions on knowledge and attitude on blood safety. The proportion of correct answers on the knowledge and attitude on exposure accidents was 53.8%. The frequency of caregivers who responded well to the basics of HIV and hepatitis B and C was 15.5%. Notions about the type of donor blood and the risk of blood transfusion received an overall rating of 17.8% and the proportion of correct answers on the knowledge and practice base of blood transfusion was 16.7%. During the six months following the survey, 54.4% of providers have experienced accidental exposure to blood. Conclusion: The lack of knowledge of the medical staff in transfusion is obvious. We must therefore have the possibility of organizing regular training and follow-up activities.

关键词： Health Personnel transfusion Hepatitis HIV

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cytotoxicity of anti-tumor herbal Marsdeniae tenacissimae extract on erythrocytes

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第7期18卷 597-604页

作者： Ke HAO Bing-yu CHEN Kai-qiang LI Yu ZHANG Cai-xia LI Ying WANG Lu-xi JIANG Jiang SHEN Xiang-chai GUO Wei ZHANG Meng-hua ZHU Zhen WANG Research Center of blood transfusion Medicine Ministry of Education Key Laboratory of Laboratory Medicine Department of Blood Transfusion Zhejiang Provincial People's Hospital People's Hospital of Hangzhou Medical College Department of blood transfusion Lishui People's Hospital

Marsdeniae tenacissimae extract （MTE） has been used as an adjuvant medicine for cancer therapy for a long time. Although massive studies demonstrated its considerable anti-cancer effect, there is no research on its influence on erythrocytes, which are firstly interacted with MTE in the circulation. To investigate the influence of MTE on erythrocytes, we used a flow cytometer to detect the MTE-treated alternations of morphology, calcium concentration, and reactive oxygen species （ROS） level in erythrocytes. We used hemolysis under different osmotic solutions to evaluate the fragility of erythrocytes. Data showed that MTE treatment dose-dependently increased the ratio of erythrocyte fragmentation （P〈0.001） and shrinking, and elevated the forward scatter （FSC） value （P〈0.001） and calcium accumulation （P〈0.001）. MTE induced ROS production of erythrocytes under the high glucose condition （P〈0.01） and consequently caused a rise in fragility （P〈0.05）. These results suggest that MTE induces cytotoxicity and aging in erythrocytes in a dose-dependent manner, and presents the possibility of impairment on cancer patients＇ circulating erythrocytes when MTE is used as an anti-cancer adjuvant medicine.

关键词： Marsdeniae tenacissimae extract Erythrocyte Calcium Reactive oxygen species (ROS) Fragility

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

TSR:A User-friendly R Shiny Application for Assessment of Optimal blood Product Selection in ABO-incompatible Hematopoietic Stem Cell Transplantation

引用

Current Medical Science 2023年第4期43卷 716-722页

作者： Juan WANG Lin-feng DENG Quan ZHANG Lei HE Department of blood transfusion Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Laboratory Medicine Hubei Provincial Hospital of Integrated Chinese&Western MedicineWuhan 430015China

Objective:Patients undergoing hematopoietic stem cell transplant(HSCT)need frequent transfusions,until their red blood cells(RBCs)and platelets start to *** safe transfusion for patients who receive ABO-incompatible HSCT is essential to the transplant *** date,there is no user-friendly tool to choose the right blood product for transfusion treatment,despite the number of guidelines and expert advice on the ***:R/shiny is a powerful programming language for clinical data analysis and *** can create interactive web applications that work in *** web application named TSR was built using R programming,simplifying blood transfusion practice for ABO-incompatible HSCT witha one-click ***:The TSR is divided into four main *** home tab provides an overview of the application,while RBC,plasma and platelet transfusion tabs offer tailored suggestions for blood product selection in each *** traditional methods that rely on treatment guidelines and specialist consensus,TSR leverages the power of the R/Shiny interface to extract critical content based on user-specified parameters,providing an innovative approach to improve transfusion ***:The present study highlights that the TSR enables real-time analysis,and promotes transfusion practice byoffering a unique and efficient one-key output for blood product selection to ABO-incompatible *** has the potential to become a widely-utilized tool for transfusion services,providing a reliable and user-friendly solution that enhances transfusion safety in clinical practice.

关键词： transfusion practice peripheral blood stem cell transplant transfusion risks

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Clinical Characteristics and Genotype of HCV infection in Northwest China Running title: The characteristic of HCV infection

The Clinical Characteristics and Genotype of HCV infection i...

引用

2018年中国肿瘤标志物学术大会暨第十二届肿瘤标志物青年科学家论坛

作者： Rui Guo Chaojun Wei Hui Xu Yonghong Li Yanjuan Jia Jing Jia Yu Wu Yuanting Li Zhenghong Wei Xiaoming Qi Xiaoling Gao The Institute of Clinical Research and Translational Medicine Gansu Provincial Hospital blood transfusion Department Gansu Provincial Hospital

Background: Hepatitis C virus(HCV) is a major human liver pathogen. HCV patients are at a high risk for progressive liver disease, leading to liver fibrosis, cirrhosis and eventually hepatocellular carcinoma(HCC).The features of HCV infection and genotype characteristics, as well as its association with HCV viral loads, liver function were investigated in current ***: 507 patients with positive anti-HCV IgG were enrolled in our study. The serum HCV RNA levels and the HCV genotypes were measured by qualitative commercial reverse transcription-polymerase chain reaction and reverse dot blot hybridization, respectively. The liver function tests were analyzed on auto biochemical analyzer. Results: Of all the 507 anti-HCV IgG positive patients in this study, only 42.21%patients have detectable HCV-RNA in their serum. Genotype 2 a and 1 b were predominant in northwest China. The positive rates of HCV-RNA were distributed evenly among males and females, while varied in different age groups. Particularly high incidence but a lower RNA replication level had been found in senior patients. Abnormalities of liver function tests were significantly related to HCV-RNA positivity. Accordingly, there was dramatical difference of the abnormality rate of ALT, AST and GGT between HCV-RNA positive and negative group. In AST abnormal group, the HCV-RNA viral load was significantly lower than that in the AST normal group. Logistic regressions showed that HCV RNA positivity was associated with age and AST. Conclusions: HCV genotypes 2 a and 1 b were prevalent in northwest China. The positive rates of HCV-RNA had been found increased with aging. The individuals with HCV-RNA replication had poor liver function. The peripheral RNA levels could not indicate liver function status, which implied that serum RNA levels may not precisely consist with the liver viral loads.

关键词： Hepatitis C Age distribution Genotype Liver function Tests

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Purifying chylous plasma by precluding triglyceride via carboxylated polyethersulfone microfiltration membrane

引用

Chinese Journal of Chemical Engineering 2022年第9期35卷 130-139页

作者： Yang Liu Qiu Han Guiliang Li Haibo Lin Fu Liu Gang Deng Dingfeng Lv Weijie Sun Ningbo Institute of Materials Technology&Engineering Chinese Academy of SciencesNingbo 315000China University of Chinese Academy of Sciences Beijing 100049China The Ningbo Central blood Station Ningbo 315099China Department of blood transfusion Ningbo First HospitalNingbo 315010China

Precluding the excessive lipoproteins from plasma rapidly and effectively is highly needed for biomedical detection and reducing plasma product scrap in blood donation *** current centrifugation procedure is high-cost and ***,we fabricated an anionic microfiltration polyethersulfone(PES)membrane modified by interface swelling and implanting of acrylic acid(AA)for screening out large particle lipoprotein chylomicron(CM)and adsorbing cationic very low-density lipoproteins(VLDL).To improve the separation efficiency,a two-stage filtration through carboxylated polyethersulfone microfiltration membranes with the mean pore size of 0.45 and 0.22μm respectively were *** total reflection Fourier transform infrared technique(ATR-FTIR),water contact angle(WCA),Zeta potential and scanning electron microscope(SEM)were employed to characterize the modified *** test the effectiveness of this membrane,plasma flux and concentration variation of plasma components were examined to study the purification ***,the hemocompatibility of modified membranes was tested to confirm its practicability on bloodcontacting *** carboxylated polyethersulfone microfiltration membrane shows its promising potential application to purify chylous plasma.

关键词： Chylous plasma Chylomicrons Very low-density lipoproteins Carboxylated polyethersulfone microfiltration membrane

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Protection of plasma transfusion against lipopolysaccharide/D-galactosamine-induced fulminant hepatic failure through inhibiting apoptosis of hepatic cells in mice

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2018年第6期19卷 436-444页

作者： Bing-yu CHEN Lu-xi JIANG Ke HAO Lu WANG Ying WANG Yi-wei XIE Jian SHEN Meng-hua ZHU Xiang-ming TONG Kai-qiang LI Zhen WANG Research Center of blood transfusion Medicine Ministry of Education Key Laboratory of Laboratory Medicine Department of Blood Transfusion Zhejiang Provincial People’s Hospital People’s Hospital of Hangzhou Medical College Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province Department of Nephrology Zhejiang Provincial People’s Hospital People’s Hospital of Hangzhou Medical College

Fulminant hepatic failure is a severe clinical condition associated with extremely poor outcomes and high mortality. A number of studies have demonstrated the ability of plasma transfusion to successfully treat fulminant hepatic failure, but the underlying mechanisms are not well understood. The aim of the present study is to define the mechanisms of plasma transfusion treatment in lipopolysaccharide/D-galactosamine(LPS/D-Gal N)-induced mice. LPS/D-Gal N treatment in mice causes significant hepatic failure, including increasing serum aspartate aminotransferase(AST) and alanine aminotransferase(ALT) levels, histopathological changes in centrilobular necrosis and inflammatory cells, and the up-regulation of inflammation(tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6)). When LPS/D-Ga IN-induced mice were treated with plasma, these changes were halted. Results showed that plasma transfusion significantly reduced mortality, and decreased the levels of AST, ALT, and inflammation factors such as TNF-α and IL-6. The expression levels of cleaved Caspase-3, BAX, and p53 were down-regulated and Bcl-2 was up-regulated, suggesting that plasma can reduce LPS/D-Gal N-induced apoptosis. The protective mechanism of plasma against LPS/D-Gal N-induced fulminant hepatic failure is related to the inhibition of the inflammatory response and the reduction in apoptosis through the down-regulation of the p53-induced apoptotic pathway.

关键词： Fulminant hepatic failure Plasma Inflammation Apoptosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：