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Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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Neural Regeneration research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi Pradeepkiran Priyanka Rawat Arubala P.Reddy Erika Orlov PHemachandra Reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of Pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of Public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAP-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

Emerging open-channel droplet arrays for biosensing

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National Science Review 2023年第10期10卷 172-186页

作者： Yongchao Song Lirong Wang Tailin Xu Guangyao Zhang Xueji Zhang School of Biomedical Engineering Health Science CenterShenzhen University Intelligent Wearable Engineering research center of Qingdao Research Center for Intelligent and Wearable Technology College of Textiles and ClothingState Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao University

Open-channel droplet arrays have attracted much attention in the fields of biochemical analysis,biofluid monitoring,biomarker recognition and cell interactions,as they have advantages with regard to miniaturization,parallelization,high-throughput,simplicity and *** droplet arrays not only improve the sensitivity and accuracy of a biosensor,but also do not require sophisticated equipment or tedious processes,showing great potential in next-generation miniaturized sensing *** review summarizes typical examples of open-channel micro droplet arrays and focuses on diversified biosensing integrated with multiple signal-output approaches(fluorescence,colorimetric,surface-enhanced Raman scattering(SERS),electrochemical,etc.).The limitations and development prospects of open-channel droplet arrays in biosensing are also discussed with regard to the increasing demand for biosensors.

关键词： open-channel droplet wettable pattern mini-pillar platform liquid marbles multiple biosensing

Prominent cycling reversibility and kinetics enabled by CaTiO3 protective layer on Zn metal for aqueous Zn-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 245-258页

作者： Gaeun Lee Yong Nam Ahn Seongjoon So Chanwoo Park Jong-Seong Bae Taehyun Park Il Tae Kim Jaehyun Hur School of Chemical Biological and Battery Engineering Gachon University Seongnam Busan center Korea Basic Science Institute

Aqueous Zn-ion batteries （AZIBs） have received considerable attention owing to their various advantages such as safety,low cost,simple battery assembly conditions,and high ionic ***,they still suffer from serious problems,including uncontrollable dendrite growth,corrosion,hydrogen evolution reaction （HER） from water decomposition,electrode passivation,and unexpected *** creation of a uniform artificial nanocrystal layer on the Zn anode surface is a promising strategy for resolving these ***,we propose the use of a perovskite CaTiO3（CTO） protective layer on Zn（CTO@Zn） as a promising approach for improving the performance of *** CTO artificial layer provides an efficient pathway for Zn ion diffusion towards the Zn metal because of the high dielectric constant （εr=180） and ferroelectric characteristics that enable the alignment of dipole moments and redistribute the Zn2+ions in the CTO *** avoiding the direct contact of the Zn anode with the electrolyte solution,the uneven dendrite growth,corrosion,parasitic side reactions,and HER are mitigated,while CTO retains its mechanical and chemical robustness during ***,CTO@Zn demonstrates an improved lifespan in a symmetric cell configuration compared with bare ***@Zn shows steady overpotential （～68 m V） for 1500 h at 1 mA cm-2/0.5 mA h cm-2,excelling bare ***,when paired with the V2O5-C cathode,the CTO@Zn//V2O5-C full battery delivers 148.4 mA h g-1（based on the mass of the cathode） after 300 *** study provides new insights into Zn metal anodes and the development of high-performance AZIBs.

关键词： Perovskite

Unraveling the impacts of intermolecular interaction on morphology evolution for highly efficient organic solar cells and modules

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Science China Chemistry 2025年第01期 264-272页

作者： Xueqing Ma Yingying Cheng Yuqiang Liu Xinming Zheng Guangliu Ran Hongxiang Li Xinyue Cui Andong Zhang Wenkai Zhang Pei Cheng Wenchao Huang Zhishan Bo Beijing Key Laboratory of Energy Conversion and Storage Materials College of Chemistry Beijing Normal University College of Textiles and clothing State Key Laboratory of Bio-fibers and Eco-textiles Qingdao University Key State Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and EngineeringWuhan University of Technology Department of Physics and Applied Optics Beijing Area Major Laboratory Center for Advanced Quantum Studies Beijing Normal University State Key Laboratory of Polymer Materials Engineering College of Polymer Science and Engineering Sichuan University

Understanding the effect of intermolecular interaction on the growth dynamic of active layers is critical for advancing organic solar cells(OSCs). However, the diverse structure of donors and acceptors makes the research challenging. Additives with customizable structures and properties could simplify this complexity. Herein, we meticulously tailor two additives of 3,4-ethylenedioxythiophene(EDOT) and 2,5-dibromo-3,4-ethylenedioxythiophene(DBEDOT), possessing distinct intermolecular interaction features to elaborate the inherent relationship. It is found that varied interaction strengths can alter film formation processes. The enhanced intermolecular interaction between the DBEDOT and non-fullerene acceptor BTP-e C9-4F results in pre-aggregation and longer crystallization duration of BTP-e C9-4F, facilitating the formation of films with compact molecular packing and decent phase separation. Thus, exciton dissociation and charge transport become more efficient. Finally, devices processed with DBEDOT exhibit a remarkable power conversion efficiency of 19.35% in small-area OSCs and 14.11% in bladecoated 5 cm × 5 cm organic solar mini-modules. Especially, OSCs can maintain 80% of their initial efficiency after continuous annealing at 85 °C for over 2,100 h.

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MOF-derived Porous Carbon Nanofiber Assembly as High Efficiency ORR Electrocatalysts for Zinc-air Batteries

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Chinese Journal of Polymer Science 2023年第12期41卷 1889-1901,I0008页

作者： Jin-Liang Ma Long-Long Liu Ren-Hai Zhao Ding Yuan Xin Ning Industrial research Institute of Nonwovens&Technical Textiles Shandong Center for Engineered NonwovensCollege of Textiles&ClothingQingdao UniversityQingdao 266071China

Reasonable construction of high activity and low cost non-noble metal oxygen reduction reaction(ORR)catalyst is of great importance for the wide application of zinc-air batteries(ZABs).Using bimetallic MOF as a precursor combined with electrospinning,high-temperature carbonization and electrodeposition,we successfully developed a porous carbon nanofiber(Co@Fe-CNFs-1000)with bimetallic active center as an efficient catalyst for *** successful construction of this special core-shell structure directly explores the synergy between different active *** results showed that the synthesized Co@Fe-CNFs-1000 catalyst exhibited ORR performance comparable to that of Pt/C in 0.1 mol/L KOH electrolyte,high half-wave potential(E_(1/2)=0.81 V)and limiting current density(J_(L)=5.4 mA·cm^(-2)).In addition,homemade liquid ZABs with Co@Fe-CNFs-1000 as the air cathode showed excellent power density(155.8 mW·cm^(-2)),specific capacity(780.6 mAh·g_(Zn)^(-1))and long-term stability(over 100 h at 2 mA·cm^(-2)),surpassing even Pt/C-based *** addition,the flexible solid-state ZABs assembled based on Co@Fe-CNFs-1000 demonstrates excellent flexibility and *** work provides a new idea for constructing ORR catalysts with high activity centers.

关键词： Electrospinning Porous structure ORR Bimetallic MOFs Zinc-air battery

High fidelity virtual try-on network via semantic adaptation and distributed componentization

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Computational Visual Media 2022年第4期8卷 649-663页

作者： Chenghu Du Feng Yu Minghua Jiang Ailing Hua Yaxin Zhao Xiong Wei Tao Peng Xinrong Hu School of Computer Science and Artificial Intelligence Wuhan Textile UniversityWuhan 430200China Engineering research center of Hubei Province for clothing Information Wuhan 430200China

Image-based virtual try-on systems have significant commercial value in online garment ***,prior methods fail to appropriately handle details,so are defective in maintaining the original appearance of organizational items including arms,the neck,and in-shop *** propose a novel high fidelity virtual try-on network to generate realistic ***,a distributed pipeline is used for simultaneous generation of organizational ***,the in-shop garment is warped using thin plate splines(TPS)to give a coarse shape reference,and then a corresponding target semantic map is generated,which can adaptively respond to the distribution of different items triggered by different ***,organizational items are componentized separately using our novel semantic map-based image adjustment network(SMIAN)to avoid interference between body ***,all components are integrated to generatethe overall result by SMIAN.A priori dual-modalinformation is incorporated in the tail layers of SMIAN to improve the convergence rate of the *** demonstrate that the proposed method can retain better details of condition information than current *** method achieves convincing quantitative and qualitative results on existing benchmark datasets.

关键词： virtual try-on conditional image synthesis human parsing thin plate spline semantic adaptation

Local and Whole Ventilation of Rainwear with Different Aperture Designs

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Journal of Donghua University(English Edition) 2017年第1期34卷 32-37页

作者：柯莹张向辉李子琪李俊 HAVENITH George Jiangsu Non-material Culture Heritage Laboratory College of Textiles and Clothing Jiangnan University Wuxi 214122 China Fashion &Art Design Institute Donghua University Shanghai 200051 China protective clothing research center Donghua University Shanghai 200051 China Key Laboratory of clothing Design &Technology Ministry of Education Shanghai 200051 China College of Quartermaster Technology Jilin University Changchun 130062 China Environmental Ergonomics research center Loughborough University Loughborough LE113TU UK

Aperture design is very important in the design process of rainwear,as garment aperture is one of the main pathways for air exchange between clothing microclimate and the *** purpose of this study was to investigate the effects of aperture design on whole and local ventilations of *** was measured by a tester developed based on the steady-state method.A rainwear suit with top and bottom was chosen as the basic *** were added at the arm,chest,back and knee *** ventilation of the arm,chest,back and whole ventilation of the top and bottom in different walking and wind conditions were *** and whole ventilations at five aperture conditions for the top and four for the bottom were *** results indicated that local ventilation value of the chest was the biggest and the arm was the *** ventilation of the suit was the biggest when walking at 5.6 km/h,with all the designed apertures *** ventilation value was bigger when opening arm aperture than that of opening chest or back *** bottom ventilation was the highest when both front and back apertures were opened.

关键词： aperture design tracer gas local ventilation whole ventilation rainwear

Breathable Kirigami‑Shaped Ionotronic e‑Textile with Touch/Strain Sensing for Friendly Epidermal Electronics

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Advanced Fiber Materials 2022年第6期4卷 1525-1534页

作者： Ruidong Xu Minghua She Jiaxu Liu Shikang Zhao Hong Liu Lijun Qu Mingwei Tian State Key Laboratory of Bio‑Fibers and Eco‑Textiles Research Center for Intelligent and Wearable TechnologyCollege of Textiles and ClothingCollaborative Innovation Center for Eco‑Textiles of Shandong Province and the Ministry of EducationIntelligent Wearable Engineering Research Center of QingdaoQingdao UniversityQingdao 266071ShandongPeople’s Republic of China College of Textiles and clothing Qingdao UniversityQingdao 266071ShandongPeople’s Republic of China

Flexible ionotronic devices have great potential to revolutionize epidermal ***,the lack of breathability in most ionotronic devices is a significance barrier to practical ***,a breathable kirigami-shaped ionotronic e-textile with two functions of sensing(touch and strain)is designed,by integrating silk fabric and kirigami-shaped ionic *** kirigami-shaped ionic hydrogel,combined with fluffy silk fabric,allows the ionotronic e-textile to achieve excellent breathability and ***,the fabricated ionotronic e-textile can precisely perform the function of touch sensing and strain *** touch-sensing,the ionotronic e-textile can detect the position of finger touching point with a fast response time(3 ms)based on the interruption of the ion *** strain sensing,large workable strain range(>100%),inconspicuous drift(10,000 cycles)is *** the proof of concept,a fabric keyboard and game controlling sleeve have been designed to display touch and strain sensing *** ionotronic e-textile break through the bottlenecks of traditional wearable ionotronic devices,suggesting a great promising application in future wearable epidermal electronics.

关键词： Flexible ionotronic devices Breathable kirigami-shaped ionotronic e-textile Touch and strain sensing Wearable epidermal electronics

Effects of tetrakis (hydroxymethyl) phosphonium sulfate pretreatment on characteristics of sewage sludge

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Journal of Environmental Sciences 2019年第4期31卷 174-182页

作者： Yunping Han Wenzhe Zhang Xiao Yu Panfen Yu Benyi Xiao Hao Yi research center for Eco-Environmental Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences College of Textiles and clothing Qingdao University South China Institute of Environmental Sciences Ministry of Environmental Protection

Recently, tetrakis(hydroxymethyl)phosphonium sulfate(THPS) was found to play an important role in the sludge pretreatment process. However, the effects of THPS pretreatment on the characteristics of sewage sludge are still insufficiently *** properties of sludge after pretreatment with different concentrations of THPS were investigated in this study. The results showed that pH, dewatering ability, and particle size of sludge decreased with increase in THPS concentration. The volatile suspended solids(VSS) and total suspended solids(TSS) of sludge also decreased slightly with increase in THPS concentration. The specific oxygen uptake rate(SOUR) results suggested that lower THPS concentrations(≤ 1.87 mg/g VSS) enhanced the activity of sludge, but higher concentrations(≥ 1.87 mg/g VSS) inhibited it. Gram-negative bacteria with peritrichous flagellation(such as Pseudomonas, Escherichia, and Faecalibacterium) were extremely sensitive to THPS. The decrease in specific most probable numbers(MPNs) of pathogens(total coliforms and Escherichia coli) with the increase in THPS concentration also proved the sterilization ability of THPS in the sludge pretreatment process. Pretreatment of sludge with concentrations of THPS higher than 37.41 mg/g VSS would meet the pathogen requirements for land application of Class A biosolids.

关键词： Sewage sludge Tetrakis(hydroxymerhyl) phosphonium sulfate Physicochemical properties Microbial community Pathogens