检索结果-南通市图书馆

Clinical Performances of Pure TB-lamp Kit for <i>M. tuberculosis</i>Complex detection in Sputum Samples

Journal of Tuberculosis Research 2017年第2期5卷 129-138页

作者： Kouassi N’guessan Jacob Adegbele Ibrahima Coulibaly Natacha Kouame-N’takpé Hortense Seck-Angu André Guei Jacquemin Kouakou Mireille Dosso laboratoire nationale de Référence de la tuberculose Institut Pasteur de C&ocirc te d’Ivoire Abidjan C&ocirc te d’Ivoire Centre Antituberculeux de Yopougon Abidjan C&ocirc te d’Ivoire programme national de lutte contre la tuberculose Abidjan C&ocirc te d’Ivoire

Tuberculosis represents a main concern for public health worldwide. In poor countries, the most prevalent method for bacteriological confirmation re- mains Smear Sputum Microscopy (SSM). This study objective was to assess clinical performances of Loop Mediated Isothermal Amplification for TB detection (lamp-TB). Sputum of patients presenting symptoms consistent with tuberculosis were collected according to the national Tuberculosis Control programme guidelines in Centre Antituberculeux de Yopougon. SSM after Ziehl-Neelsen staining and TB-lamp were blindly performed with spot sputum specimen. Samples, transported at Institut Pasteur de Cote d’Ivoire were decontaminated according to N-acetyl-L-cystein (NALC) method. In Mycobacteria Growth Indicator Tube (MGIT), 500 μl of pellet were inoculated and incubated in MGIT 960 instrument. MPT64 antigen was detected on positive culture. Of 500 patients enrolled, 469 were included. Clinical isolates of M. tuberculosis Complex were detected for 157 (33.5%). Comparatively to culture, Sensitivity and Specificity of SSM were 86% (95% Confidence interval (CI): 81% - 91%) 96% (95%IC: 94% - 98%) respectively. TB-lamp Sensitivity was 92% (95%CI: 88% - 96%), and Specificity 94% (95%CI: 91% - 97%). Positive Predictive Value of SSM and TB-lamp was 91.8% and 88.8% respectively. Negative Predictive Value of TB-lamp assay was 95.7% whereas this of SSM was 93.3%. Positive Likelihood Ratio was 15.3 for TB-lamp and 21.5 for SSM 21.5 whereas negative Likelihood of TB-lamp was lower than SSM. Active tuberculosis was detected in162/469 (34.5%) with TB-lamp and 147 (31.3%) with SSM. TB-lamp assay performances estimated from sputum samples may improve detection of active TB cases in routine.

关键词： Tuberculosis Ziehl-Neelsen TB-lamp Assay

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

低收入国家常规条件下抗酸杆菌痰涂片标准记录方法的评价

引用

国际结核病与肺部疾病杂志 1998年第1期 34-39页

作者： H.L.Rieder Th.Arnadottir A.A.TardencillaGutierrez A.C.Kasalika F.L.M.Salaniponi F.Ba A.H.Diop S.Anagonou M.Gninafon T.Ringdal A.Trébucq D.A.Enarson 李传友 Intemational Union Against Tuberculosis and Lung Disease France national Tuberculosis programme Nicaragua national Tuberculosis Progrmme Malawi programme national de lutte contre la tuberculose Senegal programme national de lutte contre la tuberculose Benin

背景:贝宁、马拉维、尼加拉瓜和塞内加尔的实验室开展的结核菌痰涂片检查。方法:通过实验室登记进行计算机分析确定工作量、连续痰涂片的检出率及受检人群的人口分布特征结果:42个实验室的60000多个受检查者的资料显示,每个国家每天涂... 详细信息

背景:贝宁、马拉维、尼加拉瓜和塞内加尔的实验室开展的结核菌痰涂片检查。方法:通过实验室登记进行计算机分析确定工作量、连续痰涂片的检出率及受检人群的人口分布特征结果:42个实验室的60000多个受检查者的资料显示,每个国家每天涂片检测的数量一般为4—19(平均6)。发现一例结核病人平均检查可疑者痰涂片21个(8—50)。所有至少一次阳性结果的病例中,87％的病例在第一次检测中就呈阳性结果。病例人群分布的不同在国家和性别之间变化很大。在42个实验室中的35个实验室里,男性病例的检出率要高于女性。随着年龄的增长,女性要比男性更多数量的可疑者检查方能确诊为一个病例。结论:该研究证实抗酸杆菌涂片结果标准化记录系统具有很好的用途,它能为规程实施和了解受检人群的分布特征方面提供必要的信息。

关键词：结核病诊断显微镜计划流行病学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

荧光显微术与萋-尼氏染色技术在检查痰抗酸杆菌方面的比较

引用

国际结核病与肺部疾病杂志 2000年第Z1期 60-64页

作者： F.Ba H.L.Rieder 吴雪琼 laboratoire national de Reference pour la tuberculose Programme National de lutte contre la Tuberculose Dakar Senegal 。Tubercolosis

背景:塞内加尔达喀尔国家结核病参比实验室。目的:比较荧光显微镜和明视野显微镜检查抗酸杆菌的结果。方法:1996年1月至1998年6月期间2630份痰标本被同时制备2种涂片,在1000倍物镜下分别进行萋-尼氏染色和荧光显微术检查,并应用这两种... 详细信息

背景:塞内加尔达喀尔国家结核病参比实验室。目的:比较荧光显微镜和明视野显微镜检查抗酸杆菌的结果。方法:1996年1月至1998年6月期间2630份痰标本被同时制备2种涂片,在1000倍物镜下分别进行萋-尼氏染色和荧光显微术检查,并应用这两种方法同时检查一例标本的68张涂片来确定判断一张涂片为阴性所需的检查时间。结果:诊断和随访检查时两者的符合率分别为96.9％和92.3％。当标本中每100个视野至少10条菌时,两者的检出率相似,但当标本中每100个视野少于10条菌时,荧光显微术的检出率较高。在同倍物镜下,荧光显微术判断一张涂片为阴性所需的检查时间平均为3分34秒,而萋-尼氏染色技术需7分44秒。结论:两者的检查结果非常相似。对于含菌量少的病例,荧光显微镜似比明视野显微镜的检出率更高,而且所需检查时间少一半多。

关键词：抗酸染色金胺O 荧光显微镜结核病萋-尼氏染色

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Schistosomiasis control in Senegal:results from community data analysis for optimizing preventive chemotherapy intervention with praziquantel

引用

Infectious Diseases of Poverty 2023年第6期12卷 101-102页

作者： Boubacar Diop Khadime Sylla NDèye MBackéKane Oumou Kaltoum Boh Babacar Guèye Mady Ba Idrissa Talla Malang Mané Rose Monteil Boniface Kinvi Honorat Gustave Marie Zoure Jorge Cano Ortega Pauline Mwinzi Moussa Sacko Babacar Faye programme national de lutte contre les Bilharzioses et les Géo-Helminthiases Direction de la Lutte Contre la Maladie (DLM) Ministère de la Santé et de l’Action Sociale (MSAS) Dakar Senegal department of Parasitology and Mycology Faculty of Medicine Pharmacy and Odontology Université Cheikh Anta Diop de Dakar (UCAD) Dakar Senegal WHO Country Office Dakar Senegal Département de Santé Publique Faculté des Sciences de la Santé Université Amadou Hampathé Ba Dakar Senegal FHI 360 Chargé des Enquêtes et Evaluation des Maladies et des Campagnes de DMM Dakar Senegal Expanded Special Project for Elimination of Neglected Tropical Diseases (ESPEN) WHO Africa Regional Office Brazzaville Congo Service de Parasitologie Institut National de Santé Publique (INSP) Bamako Mali

Background Over the past two decades,preventive chemotherapy(PC)with praziquantel(PZQ)is the major strategy for controlling schistosomiasis in *** objective of this analysis was to update the endemicity of schistosomiasis at community level for better targeting mass treatment with PZQ in *** demographic and epidemiological data from 1610 community health areas were analyzed using the schistosomiasis community data analysis tool of Expanded Special Project for Elimination of Neglected Tropical Diseases which developed by World Health Organization/Africa Ofce(WHO/AFRO).The tool uses a WHO/AFRO decision tree for areas without epidemiological data to determine whether mass treatment should be continued at community *** analysis was *** Overall,the endemicity of 1610 community health areas were updated based on the data from the district endemicity(33.5%)and the form of Join request for selected PC medicine(40.5%).Up to 282(17.5%)and 398(24.7%)of community health areas were classifed as moderate and high endemicity.41.1%of communities were non *** endemicity was more important in Tambacounda,Saint Louis,Matam,Louga and Kedougou.A change in endemicity category was observed when data was disagregted from district level to community *** units classifed non endemic were more important at community level(n=666)compared to district level(n=324).Among 540 areas previously classifed high endemic at district level,392(72.6%)remained high prevalence category,while 92(17.0%)became moderate,43(8.0%)low and 13(2.4%)non-endemics at community *** of implementation units requiring PC was more important at district level(1286)compared to community level(944).Number of school aged children requiring treatment was also more important at district level compared to community *** The analysis to disaggregate data from district level to community level using the WHO/AFRO schistosomiasis sub-distric

关键词： Schistosomiasis Community data analysis Endemicity Praziquantel Senegal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

First Use of Bedaquiline in democratic Republic of Congo: Two Case Series of Pre Extensively Drug Resistant Tuberculosis

引用

Journal of Tuberculosis Research 2018年第2期6卷 125-134页

作者： Murhula Innocent Kashongwe Leopoldine Mbulula Brian Bakoko Pamphile Lubamba Murielle Aloni Simon Kutoluka Pierre Umba Luc Lukaso Michel Kaswa Jean Marie Ntumba Kayembe Zacharie Munogolo Kashongwe Kinshasa University Hospital Kinshasa Democratic Republic of Congo Action Damien Centre d’Excellence Damien Kinshasa Democratic Republic of Congo Coordination Provinciale de lutte contre la tuberculose Kinshasa Democratic Republic of Congo national Tuberculosis Program Kinshasa Democratic Republic of Congo

In this manuscript the authors have studied the first two patients who were successfully treated with the treatment regimen containing Bedaquiline as second-line drug. The patients were diagnosed with pre-extensively drug-resistant tuberculosis (preXDR TB) whose prognosis was fatal in democratic Republic of Congo (DRC). Bedaquiline is arguably one of the molecules of the future in the management of ultra-resistant tuberculosis. However, a larger cohort study may help to establish its effectiveness. Case report: Patients 1, 29 years old, with a history of multidrug-resistant TB (MDR-TB) one year previously. He showed signs of TB impregnation again 6 months after the last treatment. Bascilloscopy was positive again. The pre-extensively tuberculosis (pre-XDR TB) diagnosis was made by the Hain test (GenoType®MTBDRsl, Hain Lifescience). Patient 2, brother of the first patient, with a history of MDR TB a year before. He had low back pain with right parietal dorso swelling four months after the last treatment. The x-ray of the column showed L4-L5 disc disease. Parietal ultrasound showed a parietal abscess to the right of thoracic vertebrae with fistulization. Surgical biopsy and pus culture confirmed the diagnosis of Pre-XDR Extrapulmonary TB. The treatment regimen was the same for both patients: 6 months with Amikacin (Am) Bedaquiline (Bdq) Prothionamide (Pto) Paraamino Salicylic acid (PAS) Linezolid (Lzd) Cycloserine (Cs) Pyrazinamide (Z) and 14 months with PAS Lzd Cs Z. The side effects were minor. Bacteriological controls (smears and cultures) after 20 months of treatment are negative to date.

关键词： Pre-XDR TB Pott’s Disease Bedaquiline Molecular Technique Loweinstein Culture

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Malaria and Lymphatic Filariasis Co-Transmission in Endemic Health Districts in Burkina Faso

引用

Advances in Entomology 2021年第4期9卷 155-175页

作者： Sanata Coulibaly Simon Péguédwindé Sawadogo Aristide Sawdetuo Hien Achille Sindimbasba Nikièma Ibrahim Sangaré Bamogo Rabila lassane Koala Clarisse Bougouma Roland Windtaré Bougma Georges Anicet Ouedraogo Roch Kounbobr Dabiré Institut de Recherche en Sciences de la Santé/Direction Régionale de l’Ouest Bobo-Dioulasso Burkina Faso Université Nazi Boni Bobo-Dioulasso Burkina Faso programme national de lutte contre les Maladies Tropicales Négligées Ministère de la Santé Ouagadougou Burkina Faso

Introduction: Lymphatic filariasis (LF) and malaria are two vector-borne diseases which parasites can simultaneously infect human or mosquito. In Burkina Faso, studies mainly focused on the control of these diseases independently. Hence, there is a lack of information on their co-transmission of to both human and vector. The present study aimed at providing baseline data from endemic areas in Burkina Faso towards a successful integrated management of both diseases. Methods: The study was carried out in six sites distributed in the East, Center-East and South-West regions of Burkina Faso. Data were collected in August 2014 and September 2015. The infection rates in human and vector populations, vector diversity, trophic and resting behavior were investigated. To determine the disease prevalence nocturnal finger- prick blood sample and microscopic observations were performed. Vectors collected by human landing catches and pyrethrum spray collections. Biochemical and molecular analyses were performed to identify Anopheles gambiae sensu lato

关键词： Wuchereria bancrofti Plasmodium falciparum Mosquitoes Co-Infection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Diagnosis and Treatment Outcomes of Tuberculosis in Relation to Gender and HIV STATUS in South Benin

引用

Journal of Tuberculosis Research 2017年第3期5卷 189-200页

作者： Ablo Prudence Wachinou Serge Ade Gildas Agodokpessi Berenice Awanou Dissou Affolabi Wilfried Bekou Marius Esse Gabriel Ade Severin Anagonou Anthony D. Harries programme national contre la tuberculose (PNT) Cotonou Bénin Faculté des Sciences de la Santé (FSS) Université d’Abomey-Calavi Cotonou Bénin Faculté de Médecine de Parakou Université de Parakou Parakou Bénin International Union against Tuberculosis and Lung Disease Paris France London School of Tropical Medicine and Hygiene London UK

Background: In Benin, little is known about the influence of both gender and HIV-status on diagnostic patterns and treatment outcomes of Tuber-culosis (TB) patients. Objective: To assess whether differences in gender and HIV status affect diagnostic patterns and treatment outcomes of TB patients. Methods: Retrospective cohort study of patients registered in 2013 and 2014 in the three largest TB Basic Management Units in south Benin. Results: Of 2694 registered TB patients, 1700 (63.1%) were male. Case notification rates were higher in males compared with females (96 vs 53/100,000 inhabitants). The male to female ratio was 1:1 in HIV positive patients, but was 2:1 among HIV negative cases. In HIV-positive patients, there were no differences in TB types between men and women. In HIV-negative patients, there were significantly higher proportions of females with clinically diagnosed pulmonary TB (p = 0.04) and extrapulmonary TB (p ders in the HIV positive group;but significantly more unfavorable outcomes were reported among HIV negative males, with higher rates of failure (p < 0.001) and loss-to-follow up (p = 0.02). Conclusion: The study has shown that overall TB notification rates were higher in males than in females in south Benin, with more females co-infected with HIV. Unfavorable outcomes were more common in HIV-negative males.

关键词： Tuberculosis Diagnosis Treatment Outcomes Gender HIV

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

贝宁-科托努地区初治和复治肺结核患者抗结核药物耐药研究

引用

国际结核病与肺部疾病杂志 2008年第2期3卷 69-72页

作者： D. Affolabi O. A. B. G. Adjagba B. Tanimomo-Kledjo M. Gninafon S.Y. Anagonou F. Portaels 徐彩红（译）刘宇红（校）何广学（审） programme national contre la tuberculose Cotonou Benin Mycobacteriology Unit Institute of TropicalMedicine Antwerp Belgium 不详

目的:评估贝宁最大的结核病中心科托努地区目前抗结核药物的耐药形势。方法:共计分析从肺结核患者分离出的470株结核分枝杆菌复合群:其中244株来自新病人, 226株来自复治病人。使用比例法对分离菌株进行一线药物的敏感性试验。结果:原... 详细信息

目的:评估贝宁最大的结核病中心科托努地区目前抗结核药物的耐药形势。方法:共计分析从肺结核患者分离出的470株结核分枝杆菌复合群:其中244株来自新病人, 226株来自复治病人。使用比例法对分离菌株进行一线药物的敏感性试验。结果:原发耐多药情况与患者的来源有关:若分析所有的患者,则新病人中耐多药相对较高(1.6%);若仅考虑贝宁常住人口,该比例则较低(0.5%),并与1994年国家的耐药监测结果比较。复治患者的耐多药率(11.1%),也与贝宁1994年的耐药监测结果持平。没有发现合并感染人类免疫缺陷病毒与抗结核药物的耐药性相关。结论:本研究表明在流行病学调查中正确的区分患者的重要性,研究人口不同,结果就可能不相同。

关键词：耐药分枝杆菌,结核科托努

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

在布隆迪系统性痰涂片复染有助于痰检质量控制

引用

国际结核病与肺部疾病杂志 2003年第3期 89-93页

作者： T.Buzingo M.Sanders J-P.Masabo S.Nyandwi A.Van deun 马玙 programme national contre la Lepre et la tuberculose Bujumbura Burundi Institute of Tropical Medicine Mycobacteriology Antwerpen Belgium

背景:布隆迪的常规结核病控制服务。目标:判定在质量复核前进行系统痰涂片复染的必要性。设计:双盲法复核周边地区常规检查的痰涂片,比较复染前后检查结果的不一致性。结果:如果不复染,852份原阴性的涂片及 189份原阳性的涂片中复核后... 详细信息

背景:布隆迪的常规结核病控制服务。目标:判定在质量复核前进行系统痰涂片复染的必要性。设计:双盲法复核周边地区常规检查的痰涂片,比较复染前后检查结果的不一致性。结果:如果不复染,852份原阴性的涂片及 189份原阳性的涂片中复核后被判定为错误者,即假阴性和假阳性各有10份(1.2％)及59份(31.2％)。复染后 34份(4.1％)为假阴性,13份(6.9％)为假阳性,两者均有显著性改变。复染前阳性涂片的定级通常认为太高,而复染后发现42份中有41份定级太低。结论:虽然布隆迪气候温暖,在复核前需要复染全部涂片的重要性未被认识,普遍存在的问题是假阴性而不是假阳性。从无复染的结果推论,需重新严格评价冷染色法的标准程序而不是涂片的复染问题。在国家结核病规划实施中(NTP)为了控制导致错误结果的可能原因,在复核前复染全部涂片可能是需要的。在现场规划中应避免采用冷染色法,因为其操作常受到一些不良因素的影响。

关键词：结核病涂片显微镜检查质量控制染色剂及染色法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Capacity gaps in health facilities for case management of intestinal schistosomiasis and soil-transmitted helminthiasis in Burundi

引用

Infectious Diseases of Poverty 2018年第1期7卷 645-653页

作者： Paul Bizimana Katja Polman Jean-Pierre Van Geertruyden Frederic Nsabiyumva Celine Ngenzebuhoro Elvis Muhimpundu Giuseppina Ortu Global Health Institute Department of Epidemiology and Social MedicineFaculty of Medicine and Health SciencesUniversity of AntwerpGouverneur KinsbergencentrumDoornstraat 331Wilrijk2610 AntwerpBelgium departement des Sciences de la SantePublique Direction de la FormationInstitut National de SantePubliqueB.P6807 BujumburaBurundi departement de Medecine Communautaire Facultede Medecine de BujumburaUniversitedu BurundiBujumburaBurundi Medical Helminthology Unit Department of Biomedical SciencesInstitute of Tropical MedicineAntwerpBelgium departement de Medecine Interne Facultede Medecine de BujumburaUniversitedu BurundiBujumburaBurundi departement des Sciences de la SantePublique Institut Universitaire des Sciences de la Santeet de Developpement CommunautaireBujumburaBurundi programme national Integrede lutte contre les Maladies Tropicales Negligees et la Cecite Departement des programmes de santeMinistere de la SantePublique et de la Lutte contre le SidaBujumburaBurundi department of Infectious Diseases and Epidemiology Schistosomiasis Control InitiativeImperial CollegeLondonUK

Background:Schistosomiasis and soil-transmitted helminthiasis(STH)are endemic diseases in *** control is integrated into health facilities(HF)across the country,but schistosomiasis control is *** present study aimed to assess the capacity of HF for integrating intestinal schistosomiasis case management into their routine *** addition,the current capacity for HF-based STH case management was ***:A random cluster survey was carried out in July 2014,in 65 HF located in Schistosoma mansoni and STH endemic *** were collected by semi-quantitative *** with different functions at the HF were interviewed(managers,care providers,heads of laboratory and pharmacy and data clerks).Data pertaining to knowledge of intestinal schistosomiasis and STH symptoms,human and material resources and availability and costs of diagnostic tests and treatment were ***:Less than half of the 65 care providers mentioned one or more major symptoms of intestinal schistosomiasis(abdominal pain 43.1%,bloody diarrhoea 13.9%and bloody stool 7.7%).Few staff members(15.7%)received higher education,and less than 10%were trained in-job on intestinal schistosomiasis case *** guidelines and laboratory protocols for intestinal schistosomiasis diagnosis and treatment were available in one third of the *** was performed by direct smear *** was not available in any of the *** results for STH were similar,except that major symptoms were more known and cited(abdominal pain 69.2%and diarrhoea 60%).Clinical guidelines were available in 61.5%of HF,and albendazole or mebendazole was available in all ***:The current capacity of HF for intestinal schistosomiasis and STH detection and management is *** was not available for *** issues need to be addressed to create an enabling environment for successful integration of intestinal schistosomiasis and STH case mana

关键词： Capacity gap Health facility Case management Intestinal schistosomiasis Soil-transmitted helminthiasis Burundi

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：