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劳埃晶体学时代的到来

生物物理学报 2001年第3期17卷 419-434页

作者： REN Zhong Dominique Bourgeois John R.Helliwell Keith Moffat VukicaSrajer Barry L.Stoddard 沈月全杨晓静任匡一顾茵任重 Department of Biochemistry and Molecular biology and Consortium for Advanced Radiation Sources The University of Chicago European Synchrotron Radiation Facility Department of Chemistry University of Manchester programin structural biology Division of Basic SciencesFred Hutchinson Cancer Research Center 中国科学院生物物理研究所 Renz ResearchInc.任氏研究所 Ben May Institute The University of Chicago

近年来 ,人们对古老的劳埃衍射技术重新产生了浓厚的兴趣。这主要是因为世界各地新的同步辐射光源的建成;各种先进的插入件,诸如波形器(wiggler)、波荡器(undulator)的飞速发展 ;以及利用这类光源通过时间分辨晶体学来研究分子结构动态... 详细信息

近年来 ,人们对古老的劳埃衍射技术重新产生了浓厚的兴趣。这主要是因为世界各地新的同步辐射光源的建成;各种先进的插入件,诸如波形器(wiggler)、波荡器(undulator)的飞速发展 ;以及利用这类光源通过时间分辨晶体学来研究分子结构动态变化的前景。在过去的十年中 ,理论研究已经阐明了多波长衍射几何学的特征 ,在很大程度上加深了我们对劳埃法的认识。劳埃数据处理方法及其软件开发也因此有所创新。曾在相当长的时间内限制这项技术应用的劳埃数据处理中的大部分问题现在已经得到解决 ;同步辐射光源 ,束线光学器件及X射线探测器等方面也都取得了显著的进步。静态劳埃实验得到的结构因子振幅在质量上已同单波长数据相当。晶体中反应易于启动的时间分辨劳埃实验已经开始在一系列生物分子体系中得到成功的实践。由此得到的关于结构动力学的信息是任何其它传统的衍射方法所无能为力的。这些静态的及时间分辨的实验说明了劳埃法已经开始走向成熟 ,并指明了今后发展的方向 ,即对晶体的镶嵌度和劳埃衍射点的相应能量宽度的正确处理、扩散散射的考虑、时间分辨实验中低浓度瞬态中间物结构的测定等等。

关键词：劳埃衍射时间分辨晶体学生物分子

Mechanisms of Avian Magnetic Orientation

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Zoological Research 2009年第2期30卷 221-224页

作者： Joshua Dominic Rizak 车轶 Interdisciplinary programin Neuroscience Medical College University of British Columbia 苏州大学医学部

Among the most fascinating mysteries of life is the interaction between biological systems and the earth＇s magnetic field. Although earth＇s magnetism may have an under appreciated role in biological interpretations, it has been most extensively studied in the processes of avian orientation and migration. Many species of bird are known to have behavioral responses to the earth＇s and artificial magnetic fields. These responses may be mediated by a number of potential magneto-biochemical processes. The two most commonly investigated include a magnetosensitive magnetite rich region in the upper beak area and a photo/magnetoreception process in the eyes of various bird species. In addition to external magnetic stimuli, recent findings in visually restricted birds have described a hemispherically lateralized interpretation of this information within the brain. Even with these findings, a considerable amount of work is needed to clarify what information is processed and how it is used to create the bird＇s magnetic compass. This review focuses these recently published findings as a means to assess this intriguing phenomenon.

关键词： Avian Earth's magnetic field Orientation

脐带钳夹时机对于墨西哥婴幼儿体内铁含量的影响:一项随机化对照临床试验

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世界核心医学期刊文摘（儿科学分册） 2006年第11期2卷 3-4页

作者： Chaparro C.M. Neufeld L.M. Tena Alavez G. K.G. Dewey 张振 Department of Nutrition Programin International and Community Nutrition University of California Davis CA United States Dr.Prof.

Background: Delayed clamping of the umbilical cord incr-eases the infant’s iron endowment at birth and haemoglobin concentration at 2 months of age. We aimed to assess whether a 2-minute delay in the clamping of the umbilical cord of normal-weight, full-term infants improved iron and haematological status up to 6 months of age. Methods: 476 mother-infant pairs were recruited at a large obstetrics hospital in Mexico City, Mexico,randomly assigned to delayed clamping (2 min after delivery of the infant’s shoulders) or early clamping (around 10 s after delivery), and followed up until 6 months *** outcomes were infant haematological status and iron status at 6 months of age, and analysis was by intention-to-treat. This study is registered with Clinical ***, number NCT00298051. Findings: 358(75%) mother-infant pairs completed the trial. At 6 months of age, infants who had delayed clamping had significantly higher mean corpuscular volume (81.0 fL vs 79.5 fL 95%CI -2.5 to -0.6, P=0.001), ferritin (50.7 μg/L vs 34.4 μg/L95%CI -30.7 to -1.9, P=0.0002), and total body iron. The effect of delayed clamping was significantly greater for infants born to mothers with low ferritin at delivery, breastfed infants not receiving iron-fortified milk or formula, and infants born with birthweight between 2500 g and 3000 g. Acord clamping delay of 2 minutes increased 6-month iron stores by about 27-47 mg. Interpretation: Delay in cord clamping of 2 minutes could help prevent iron deficiency from developing before 6 months of age, when iron-fortified complementary foods could be introduced.

关键词：脐带钳随机化临床试验血红蛋白水平足月产儿对母出生后正常体重母乳喂养肩部

线粒体DNAT1095C突变的耳聋患者的临床特征及mtDNA序列分析

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中华耳科学杂志 2005年第4期3卷 253-259页

作者：赵立东杨伟炎李荣华王秋菊钱亚萍管敏鑫中国人民解放军总医院耳鼻咽喉科研究所北京100853 Division and programin Human Genetics and Center for Hearing and Deafness Research Cincinnati Children’s Hospital Medical CenterCincinnatiOhioUSA Division and programin Human Genetics and Center for Hearing and Deafness Research Cincinnati Children’s Hospital Medical CenterCincinnatiOhioUSA Department of PediatricsUniversity of Cincinnati College of MedicineCincinnatiOhioUSA

目的分析3例携带线粒体12SrRNA基因T1095C突变的耳聋患者的临床特征、其线粒体基因组的全序列特征以及T1095C突变与对非综合征型—耳聋之间的关系。方法对从门诊收集的188例耳聋患者的血样进行线粒体DNA12SrRNA基因突变筛查,发现三例携... 详细信息

目的分析3例携带线粒体12SrRNA基因T1095C突变的耳聋患者的临床特征、其线粒体基因组的全序列特征以及T1095C突变与对非综合征型—耳聋之间的关系。方法对从门诊收集的188例耳聋患者的血样进行线粒体DNA12SrRNA基因突变筛查,发现三例携带T1095C突变,推测T1095C突变所引起的12SrRNA二级结构变化及其可能的线粒体功能的变化。对这三例患者的线粒体基因组进行全序列测定,同时对其临床资料进行分析。结果从门诊收集的188例患者的血样中,发现3例患者携带线粒体12SrRNAT1095C突变,临床表现型的评估表明,这些患者的听力损失(包括发病年龄,听力图)的类型不一。序列分析表明这三个患者的线粒体基因组除都有T1095C的突变之外,其线粒体DNA的多态位点还显示独特的多态性。在364个国人的正常对照组中,没有发现该突变。结论T1095C在这些遗传背景不同的有听力损失的家庭中出现强烈的提示这个突变是导致听力损失的致病因素,T1095C突变可能与非综合征型耳聋有关。在这些线粒体DNA中,还有一些碱基突变,如16SrRNA中的A2238G和T2885C以及在CO2(氧化磷酸化复合体2)基因中的第175位氨基酸由Ile变成Val,在ATP合成酶6基因中的第16位氨基酸由Phe变成Leu,以及在ND6基因中的第112位氨基酸由Val变成Met都位于进化上高度保守的区域,这些突变可能对这3位患者耳聋的临床表型起了一部分作用。

关键词：耳聋线粒体DNA 突变氨基糖甙类抗生素

Effects of music therapy in depression and anxiety disorder

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Life Research 2019年第2期2卷 64-70页

作者： Ednaldo Antonio dos Santos Esperanza Marchant Sanchez Maria Angeles Niguez Ortiz Maria Amparo Oliver Germes Doctoral programin Promotion of Autonomy and Social Healthcare in the Unit University of Valencia.

Mental disorders are considerate "the evil of the century" by renowned researchers, because a large part of the population in many countries is a diagnosticated, and currently afect youth and children. Among the numerous therapeutic interventions, the music therapy is a non-invasive approach. However, there are very few people who are professionally engaged in research and studies on the subject. Therefore, this article is a literature to talk about the benefits of music therapy sessions for people with stress, depression and anxiety disorders.

关键词： music therapy anxiety disorder depression disorders stresses non-invasive techniques

Interleukin-6 mediates neutrophil mobilization from bone marrow in pulmonary hypertension

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Cellular & Molecular Immunology 2021年第2期18卷 374-384页

作者： Jonathan Florentin Jingsi Zhao Yi-Yin Tai Sathish Babu Vasamsetti Scott P.O’Neil Rahul Kumar Anagha Arunkumar Annie Watson John Sembrat Grant C.Bullock Linda Sanders Biruk Kassa Mauricio Rojas Brian B.Graham Stephen Y.Chan Partha Dutta Center for Pulmonary Vascular biology and Medicine Pittsburgh HeartLungBloodand Vascular Medicine InstituteDivision of CardiologyDepartment of MedicineUniversity of Pittsburgh School of MedicineUniversity of Pittsburgh Medical CenterPittsburghPA15213USA Division of Pulmonary and Critical Care Medicine Zuckerberg San Francisco General Hospital and Trauma CenterUniversity of California San FranciscoBuilding 1002nd floor1001 Potrero AveSan FranciscoCAUSA Division of Pulmonary Allergy and Critical Care MedicineUniversity of PittsburghPittsburghPA15261USA Division of Hematopathology Pittsburgh HeartLungBloodand Vascular Medicine Institute University of Pittsburgh School of MedicineUniversity of Pittsburgh Medical CenterPittsburghPA15213USA Department of Medicine Anschutz Medical CampusBuilding RC29th floor12700 E 19th AveAuroraCO80045USA Department of Immunology University of Pittsburgh School of MedicinePittsburghPA15213USA

Myeloid cells,such as neutrophils,are produced in the bone marrow in high quantities and are important in the pathogenesis of vascular diseases such as pulmonary hypertension(PH).Although neutrophil recruitment into sites of inflammation has been well studied,the mechanisms of neutrophil egress from the bone marrow are not well *** computational flow cytometry,we observed increased neutrophils in the lungs of patients and mice with ***,we found elevated levels of IL-6 in the blood and lungs of patients and mice with *** observed that transgenic mice overexpressing Il-6 in the lungs displayed elevated neutrophil egress from the bone marrow and exaggerated neutrophil recruitment to the lungs,resulting in exacerbated pulmonary vascular remodeling,and dysfunctional ***,we found that IL-6-induced neutrophil egress from the bone marrow was dependent on interferon regulatory factor 4(IRF-4)-mediated CX3CR1 expression in ***,Cx3cr1 genetic deficiency in hematopoietic cells in Il-6-transgenic mice significantly reduced neutrophil egress from bone marrow and decreased neutrophil counts in the lungs,thus ameliorating pulmonary remodeling and *** summary,these findings define a novel mechanism of IL-6-induced neutrophil egress from the bone marrow and reveal a new therapeutic target to curtail neutrophil-mediated inflammation in pulmonary vascular disease.

关键词： neutrophil IL-6 pulmonary hypertension CX3CR1 inflammation