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Implications of receptor for advanced glycation end products for progression from obesity to diabetes and from diabetes to cancer

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World Journal of Diabetes 2023年第7期14卷 977-994页

作者： Andrea Garza-Campos José Roberto Prieto-Correa José Alfredo Domínguez-Rosales Zamira Helena Hernández-Nazará programa de Doctorado en Ciencias en Biología Molecular en Medicina Universidad de GuadalajaraGuadalajara 44340JaliscoMexico departamento de Biología Molecular y genómica Instituto de Investigación en Enfermedades Crónico-DegenerativasUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico

Obesity and type 2 diabetes mellitus(T2DM)are chronic pathologies with a high incidence *** share some pathological mechanisms,including hyperinsulinemia,the production and release of hormones,and *** above,over time,affects other systems of the human body by causing tissue hypoxia,low-grade inflammation,and oxidative stress,which lay the pathophysiological groundwork for *** leading causes of death globally are T2DM and *** main alterations of this pathological triad include the accumulation of advanced glycation end products and the release of endogenous alarmins due to cell death(i.e.,damage-associated molecular patterns)such as the intracellular proteins high-mobility group box protein 1 and protein S100 that bind to the receptor for advanced glycation products(RAGE)-a multiligand receptor involved in inflammatory and metabolic and neoplastic *** review analyzes the latest advanced reports on the role of RAGE in the development of obesity,T2DM,and cancer,with an aim to understand the intracellular signaling mechanisms linked with cancer *** review also explores inflammation,oxidative stress,hypoxia,cellular senescence,RAGE ligands,tumor microenvironment changes,and the“cancer hallmarks”of the leading tumors associated with *** assimilation of this information could aid in the development of diagnostic and therapeutic approaches to lower the morbidity and mortality associated with these diseases.

关键词： Type 2 diabetes Cancer Obesity Advanced glycation end product receptor Receptor for advanced glycation end products Glycation end products,advanced

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Six forests in one:Tree species diversity in the Bosque Protector Chongón Colonche,a lowland mountain range in coastal Ecuadorian

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Forest Ecosystems 2022年第6期9卷 725-733页

作者： Oswaldo Jadan David ADonoso Edwin Ponce-Ramírez Franz Pucha-Cofrep Omar Cabrera Facultad de Ciencias Agropecuarias Universidad de Cuenca12 de Octubre y Diego de TapiaCuenca010107Ecuador programa de Doctorado en Conservacion de recursos Naturales Escuela Internacional de DoctoradoUniversidad Rey Juan CarlosMostolesMadridES-28933Spain departamento de Biología Escuela Politecnica NacionalLadron de Guevara E11⋅253Quito170525Ecuador Geoforest S.A 12 de febrero y Av.Franklin VegaMacas140150Ecuador Grupo de Investigacion Hidrología y Climatología Universidad Tecnica Particular de LojaSan Cayetano Alto S/NLoja110101Ecuador Brandenburg University of Technology(BTU)Cottbus-Senftenberg 03044CottbusGermany departamento de Ciencias Biologicas y Agropecuarias Universidad Tecnica Particular de LojaSan Cayetano Alto S/NLoja110101Ecuador

Tropical mountain ranges shape the structure of tree communities and promote highly diverse natural ***“Bosque Protector Chong on-Colonche”(BPCC),an 86,000-ha mountain formation situated on the coast of Ecuador,is biogeographically important for the region by connecting floristic elements of the wet Choco and the dry Tumbesian *** understanding of the factors that model tree and palm diversity and distribution in this mountain range are *** measured and identified all trees and palms(DBH≥10 cm)in 289 plots of0.2 ha,distributed throughout *** used generalized linear models to explain the relationship between forest diversity and structure and climatic variables(temperature,rain,aridity),and *** then used cluster and non-metric multidimensional scale(NMDS)analyses to search for distinct forest communities within the *** partition(varpart)was used to determine which predictor variables best explained these distinct forest communities.A species indicator analysis identified the species most likely to define these distinct forest ***,we carried out a niche modeling approach to identify the potential distribution of these forest communities within *** total,we identified 220 tree and palm species in our *** average number of species per plot was 17.8±5.8,ranging from 3 to 40 *** methods sorted the 289study plots into six different forest communities,three communities in the dry forest and three in the semi-humid Garúa *** and temperature,but not altitude or aridity,explained floristic *** results emphasize the high but little cataloged diversity in the lowland mountain rainforests of coastal Ecuador.

关键词： Chongón-Colonche Climatic variables Dry forest Forest communities Garúa forest

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Comparative transcriptomics reveals hidden issues in the plant response to arthropod herbivores

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Journal of Integrative Plant Biology 2021年第2期63卷 312-326页

作者： M.Estrella Santamaria Alejandro Garcia Ana Amaiz Irene Rosa-Diaz Gara Romero-Hernandez Isabel Diaz Manuel Martinez Centro de Biotecnologia y genomica de Plantas Instituto Nacional de Investigacion y Tecnologia Agraria y AlimentariaUniversidad Politecnica de MadridMadridSpain departamento de Biotecnologia-Biologia Vegetal Escuela Tecnica Superior de Ingenierfa AgronomicaAlimentaria y de BiosistemasUniversidad Politecnica de MadridMadridSpain

Plants experience different abiotic/biotic stresses,which trigger their molecular machinery to cope with them. Besides general mechanisms prompted by many stresses, specific mechanisms have been introduced to optimize the response to individual threats. However, these key mechanisms are difficult to identify. Here, we introduce an in-depth species-specific transcriptomic analysis and conduct an extensive meta-analysis of the responses to related species to gain more knowledge about plant responses. The spider mite Tetranychus urticae was used as the individual species, several arthropod herbivores as the related species for meta-analysis, and Arabidopsis thaliana plants as the common host. The analysis of the transcriptomic data showed typical common responses to herbivory, such as jasmonate signaling or glucosinolate biosynthesis. Also, a specific set of genes likely involved in the particularities of the Arabidopsis-spider mite interaction was discovered. The new findings have determined a prominent role in this interaction of the jasmonateinduced pathways leading to the biosynthesis of anthocyanins and tocopherols. Therefore, tandem individual/general transcriptomic profiling has been revealed as an effective method to identify novel relevant processes and specificities in the plant response to environmental stresses.

关键词： Arabidopsis thaliana arthropod herbivore comparative transcriptomics plant defense Tetranychus urticae

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The cold-induced factor CBF3 mediates root stem cell activity,regeneration,and developmental responses to cold

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Plant Communications 2023年第6期4卷 197-211页

作者： Pablo Perez-Garcia Ornella Pucciariello Alvaro Sanchez-Corrionero Javier Cabrera Cristina del Barrio Juan Carlos del Pozo Mariano Perales Krzysztof Wabnik Miguel A.Moreno-Risueno Centro de Biotecnologíay genómica de Plantas(Universidad Politécnica de Madrid(UPM)–Instituto Nacional de Investigacióny Tecnología Agraria y Alimentaria–CSIC(INIA-CSIC)) MadridSpain

Plant growth and development involve the specification and regeneration of stem cell niches(SCNs).Although plants are exposed to disparate environmental conditions,how environmental cues affect developmental programs and stem cells is not well *** stem cells are accommodated in meristems in SCNs around the quiescent center(QC),which maintains their *** a combination of genetics and confocal microscopy to trace morphological defects and correlate them with changes in gene expression and protein levels,we show that the cold-induced transcription factor(TF)C-REPEAT BINDING FACTOR 3(CBF3),which has previously been associated with cold acclimation,regulates root development,stem cell activity,and ***3 is integrated into the SHORT-ROOT(SHR)regulatory network,forming a feedback loop that maintains SHR ***3 is primarily expressed in the root endodermis,whereas the CBF3 protein is localized to other meristematic tissues,including root *** of cbf3-1 using a wild-type CBF3 gene and a CBF3 fusion with reduced mobility show that CBF3 movement capacity is required for SCN patterning and regulates root ***,cold induces CBF3,affecting QC ***,exposure to moderate cold around 10℃–12℃promotes root regeneration and QC respecification in a CBF3-dependent manner during the recuperation *** contrast,CBF3 does not appear to regulate stem cell survival,which has been associated with recuperation from more acute cold(-4℃).We propose a role for CBF3 in mediating the molecular interrelationships among the cold response,stem cell activity,and development.

关键词： stem cells regeneration organ patterning protein movement cell fate low temperature

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Impacts of fire severity and cattle grazing on early plant dynamics in old-growth Araucaria-Nothofagus forests

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Forest Ecosystems 2019年第4期6卷 298-311页

作者： Paola Arroyo-Vargas Andres Fuentes-Ramírez Bart Muys Aníbal Pauchard Laboratorio de Biometría Departamento de Ciencias ForestalesUniversidad de La FronteraCasilla 54-DTemucoChile programa de Magíster en Manejo de recursos Naturales Facultad de Ciencias Agropecuarias y ForestalesUniversidad de La FronteraCasilla 54-DTemucoChile Butamallin Research Center for Global Change Universidad de La FronteraTemucoChile Instituto de Ecología y Biodiversidad(IEB) SantiagoChile department of Earth and Environmental Sciences University of LeuvenCelestijnenlaan 200EBox 24113001 LeuvenBelgium Laboratorio de Invasiones Biológicas(LIB) Facultad de Ciencias ForestalesUniversidad de ConcepciónCasilla 160-CConcepciónChile.

Background: Fire has historically shaped the dynamics of Araucaria araucana-Nothofagus pumilio forests in the Andean region of South America. Nevertheless, human disturbances and stronger drought events have resulted in increased occurrence and severity of wildfires. Regardless of their conservation relevance, the initial response to fire of Araucaria-Nothofagus forests has not been well documented. Through this research we tested the hypothesis that plant composition of Araucaria-Nothofagus forest after fire will initially differ in its recovery depending on fire severity, but over time, plant similarity will increase among areas with different levels of fire severity. The study was carried out in old-growth Araucaria-Nothofagus forests in south-central Chile(38°S) that were burned in 2015. We studied vegetation response to three levels of fire severity(low(LS), moderate(MS) and high(HS) severity), also including an adjacent unburned forest(UN), which were assessed one, two and three years after fire. We also evaluated the impact of cattle on plant recovery after fire. We measured species richness, abundance, plant diversity and origin of all vascular plant ***: Species richness and plant abundance responded differently to fire severity. Time-since-fire had a significant effect on plant richness and abundance. Plant composition within LS areas was similar to UN areas, but MS and HS areas were significantly less diverse compared to UN and LS. In absence of other major disturbances, similarity in plant composition tended to increase over time across the different levels of fire severity, becoming more similar to UN. We also found a synergetic effect of cattle and fire on species richness. This interaction promotes the establishment of nonnative species and limits the recovery of native species following ***: Fire severity had a significant impact on the plant community of old-growth Araucaria-Nothofagus forests,especially in areas of high fir

关键词： Fire severity gradient Wildfire Post-fire plant recovery Cattle exclusion Synergistic effects of disturbances Araucaria araucana Nothofagus pumilio

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