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Microcephaly prevalence after the 2015 to 2016 Zika outbreak in Tangará da Serra, Brazil: a population-based study

Reproductive and developmental Medicine 2022年第2期6卷 98-103页

作者： Juliana Herrero da Silva Ana Claudia Pereira Tercas-Trettel Juliano Andre Boquett Giovanny Vinicius Araujo Franca Augusto Cesar Cardoso-dos-Santos Marina Atanaka Marcelo Zagonel Oliveira Anna Pires Terra Viviane Karoline Vivi Lucia Andreia Nunes de Oliveira Lucia Schaedler Ronaldo Fernandes Santos Alves Lavinia Schuler-Faccini Prefeitura Municipal de Tangara da Serra Secretaria de SaudeVigilancia EpidemiologicaTangara da SerraBrazil programa de pos-graduacao em Genetica e biologia Molecular Universidade Federal do Rio Grande do SulPorto AlegreBrazil Universidade do Estado de Mato Grosso Tangara da SerraBrazil programa de pos-Graduagcao em Saude Coletiva Universidade Federal de Mato GrossoCuiabaBrazil Instituto Nacional de Genetica Medica Populacional-INaGemP Servico de Genetica MedicaHospital de Clinicas de Porto Alegre(HCPA)Porto AlegreBrazil programa de pos-graduacao em Saude da Crianga e do Adolescente Universidade Federal do Rio Grande do SulPorto AlegreBrazil Secretaria de Vigilancia em Saude Ministerio da SaudeBrasiliaBrazil Laboratorio de Visualizacao Avangada e Geoinformatica(VIZLab) Programa de Pos-Graduacao em Computacao AplicadaUniversidade do Vale do Rio dos SinosSao LeopoldoBrazil programa de pos-graduacao em Ciencia da Informacao Universidade Federal do Rio Grande do SulPorto AlegreBrazil Clinica Santa Luzia Tangara da SerraBrazil

Objective::Prenatal infection with the Zika virus (ZIKV) can lead to congenital Zika syndrome (CZS), characterized by microcephaly and brain injury. However, there are questions regarding the prevalence of microcephaly/CZS after the ZIKV outbreak in defined geographic areas. This study aimed to identify adverse outcomes in live births of fetuses exposed in utero to the ZIKV, compared to unexposed births, as well as maternal sociodemographic, delivery, and birth characteristics.Methods::Here, we conducted a cross-sectional observational study to investigate the characteristics of all live births in the city of Tangará da Serra, Mato Grosso, Brazil, in 2016, after the outbreak of ZIKV infection in late 2015. All live births of children to women residing in the municipality of Tangará da Serra between January 1 and december 31, 2016, were evaluated, and head circumference was measured at birth and after 24 hours. Children born with microcephaly or a maternal history of confirmed or suspected prenatal ZIKV infection were evaluated by a multidisciplinary team. The outcomes of the exposed and non-exposed children were compared. Prevalence ratios and their respective 95% confidence intervals were calculated for sociodemographic, delivery, and live birth characteristics.Results::Of 1,441 live births, 106 (7.3%) were from mothers with confirmed or highly probable exposure to ZIKV. The prevalence of severe congenital microcephaly (41.7/10,000) in Tangará da Serra in 2016 was ten-fold higher than that in Latin America before 2015.Conclusion::This study may serve as a model to investigate possible outbreaks of infections in a defined geographical space in the future.

关键词： Epidemiology Live births Microcephaly Zika virus

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Competences for self-care and self-control in diabetes mellitus type 2 in primary health care

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World Journal of Diabetes 2019年第8期10卷 454-462页

作者： Maria Marta Amancio Amorim Alessandra Hugo de Souza Adriana Keller Coelho Centro de Estudos em Migracoes E Relacoes Interculturais Belo Horizonte 302240010Brazil programa de pos graduacao em biologia de vertebrados Pontificia Universidade Catolica de Minas GeraisBelo Horizonte 30535901Brazil Geriatric Unit Hospital do Instituto de Previdência dos Servidores do Estado de Minas GeraisBelo Horizonte 3010110Brazil

The purpose of the guidelines of self-care and self-control of type 2 diabetes mellitus proposed by the Brazilian Ministry of Health is to strengthen and qualify users and health care professionals through the integrality and longitudinality of care with this disease.This article aims to present the self-care and self-control of people with type 2 diabetes mellitus in objective terms,taking into account the current recommen-dations based on scientific evidence and also from the subjective point of view,that is,emphasizing the aspects related to experience and subjectivity of these people.Next,we present the essential skills for self-care and self-control of users and professionals working in primary health care.

关键词： Diabetes mellitus type 2 Self-care Primary health care

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How does zebrafish support new strategies for neuroprotection and neuroregeneration in hypoxia-related diseases?

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Neural Regeneration Research 2016年第7期11卷 1069-1070页

作者： emerson S.Silva Joao Batista T.Rocha Diogo O.Souza Marcos M.Braga programa de pos-graduacao em Bioquimica Departamento de Bioquimica Instituto de ciencias basicas da saude Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil programa de pos-graduacao em Bioquimica Toxicologica Departamento de Bioquimica e Biologia Molecular Centro de ciencias Naturais e Exatas Universidade Federal de Santa Maria Santa MariaRS Brazil Instituto Nacional de Ciencia e Tecnologia em Excitotoxicidade e Neuroprotecao Universidade Federal do Rio Grande do Sul PortoAlegre RS Brazil

Hypoxia is a condition found commonly in several disorders,such as ischemia,asthma,anemia and neonatal hypoxia.Individuals subjected suddenly to high altitude or extreme exercise are also challenged to low oxygen（O2）levels.Since the brain presents elevated basal O_2 consumption,this organ is readily affected by hypoxia.For this reason,

关键词： How does zebrafish support new strategies for neuroprotection and neuroregeneration in hypoxia-related diseases

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种子库和植被物种之间的差异有助于保持新热带稀树草原的功能多样性

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Journal of Plant Ecology 2021年第4期14卷 605-615页

作者： Evaldo Bde Souza Francielli Bao Geraldo A.Damasceno Junior Arnildo Pott programa de pos-graduacao em Ecologia e Conservacao Instituto de BiocienciasUniversidade Federal de Mato Grosso do SulCampo GrandeBrazil programa de pos-graduacao em biologia Vegetal Instituto de BiocienciasUniversidade Estadual PaulistaRio ClaroSPBrazil programa de pos-graduacao em biologia Vegetal Instituto de BiociênciasUniversidade Federal de Mato Grosso do SulCampo GrandeBrazil

本研究的目的是量化种子库和建立的植被对物种组成、功能组成和多样性的贡献,并讨论这些差异对冲积平原植物群落更新和稳定性的影响。我们在巴西潘塔纳尔湿地的一个周期性洪水泛滥的稀树大草原上,在旱季和雨季对分布在5个地点的25个地块... 详细信息

本研究的目的是量化种子库和建立的植被对物种组成、功能组成和多样性的贡献,并讨论这些差异对冲积平原植物群落更新和稳定性的影响。我们在巴西潘塔纳尔湿地的一个周期性洪水泛滥的稀树大草原上,在旱季和雨季对分布在5个地点的25个地块(10 m×1 m)的1.5 m高度的地面覆盖植被和种子库进行了采样。采用出苗法对土壤种子库进行了评价。研究结果表明,种子库物种具有赋予群落更新的特征,而植被则具有稳定性特征。种子库的功能丰富度高于植被,而功能均匀度则低于植被。由于种子库和植被的植物特征不同,使得具有不同功能稳定性和更新特性的物种得以共存,这将有助于维持植物的功能多样性。这可能会让植物种群在应对干旱、火灾和洪水等不同的环境选择时更具有弹性。

关键词：环境选择功能多样性水溶扩散潘塔纳尔湿地稳定性更新

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Concordance of the point-of-care circulating cathodic antigen test for the diagnosis of intestinal schistosomiasis in a low endemicity area

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Infectious Diseases of Poverty 2019年第3期8卷 99-100页

作者： Sergei Rodrigo Magalhaes de Sousa Isabelle Helena Lima Dias Alvaro Luan Santana Fonseca Bianca Rodrigues Contente Joyce Favacho Cardoso Nogueira Tatyellen Natasha da Costa Oliveira Stefan Michael Geiger Martin Johannes Enk programa de pos-graduacao Strictu Sensu em biologia Parasitaria na Amazonia da Universidade do Estado do Para Tv.Perebebui2623-MarcoBelemPA 66087Brazil Laboratorio de Parasitoses Intestinais Esquistossomose e Malacologia(LPIEM)Secgao de ParasitologiaInstituto Evandro Chagas/SVS/MSAnanindeuaParaBrazil

Background:The Kato-Katz technique is recommended worldwide for the diagnosis of intestinal schistosomiasis,detecting parasite eggs in feces of infected people.However,new tests have been developed in order to facilitate diagnosis,e.***.by detection of specific antigens secreted by schistosomes,such as the circulating cathodic antigen(CCA).The aim of this study was to evaluate the performance of the point-of-care circulating cathodic antigen test(POC-CCA)compared to the Kato-Katz technique in a low prevalence area in the Amazon Region,located in the municipality of Primavera,State of Para,Brazil.Methods:positivity rates of the POC-CCA test and the Kato-Katz technique were calculated.The sensitivity,specificity,accuracy and kappa coefficient were determined by comparing both methods.The reference standard was established using 16 Kato-Katz slides,12 of the first fecal sample,two of the second and two of the third one.The study also included the concordance between POC-CCA results and different numbers and combinations of Kato-Katz slides.Results:The prevalence of schistosomiasis according to the reference standard or POC-CCA test reached a rate of 9.4%or 23.9%,respectively,among a total of 372 participants.The positivity rates by the Kato-Katz technique increased from 2.4 to 9.4%,according to the increase in the number of slides examined and fecal samples colleaed.A sensitivity of 55.6%,specificity 76.9%,accuracy 76%and k coefficient of 0.06 was observed by comparing one slide of the first sample and POC-CCA.Comparing 6 slides from three different samples,two slides of each,with POC-CCA resulted in a sensitivity of 583%,specificity 78.4%,accuracy 77%and k coefficient of 0.16.Finally,the comparison of 16 slides from three different samples with POC-CCA revealed a sensitivity of 65.7%,specificity 80.4%,accuracy 79%,and k coefficient of 0.27.Conclusions:The immunochromatographic test has the potential to be an important tool to combat schistosomiasis because of its practicality and applicability but should be applied w

关键词： Schistosoma mansoni Kato-Katz POC-CCA Accuracy Diagnosis Low prevalence area

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Antibacterial enhancement of antibiotic activity by Enterolobium contortisiliquum(Vell.)Morong

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Asian Pacific Journal of Tropical Biomedicine 2017年第10期7卷 945-949页

作者： Zildene de Sousa Silveira Nair Silva Macêdo Thiago Sampaio de Freitas Ana Raquel Pereira da Silva Joycy Francely Sampaio dos Santos Maria Flaviana Bezerra Morais-Braga José Galberto Martins da Costa Raimundo Nonato Pereira Teixeira Jean Paul Kamdem Henrique Douglas Melo Coutinho Francisco Assis Bezerra da Cunha Laboratorio de Bioprospeccao do Semioarido Universidade Regional do CaririCratoBrazil Laboratorio de Microbiologia e biologia Molecular Universidade Regional do CaririCratoBrazil Laboratorio de Pesquisas de Produtos Naturais Universidade Regional do CaririCratoBrazil departamento de Ciencias biologicas Universidade Regional do Cariri-URCACratoCEP:63105-000Brazil programa de pos-graduacao em Bioprospeccao Molecular Universidade Regional do Cariri–URCACratoBrazil

Objective: To identify the main chemical classes of compounds from aqueous extract of Enterolobium contortisiliquum(E. contortisiliquum) seed bark and to evaluate its antibacterial activity, as well as its potential to increase the activity of antibiotics against strains of Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli.Methods: Different classes of compounds in the aqueous extract of E. contortisiliquum were evaluated based on the visual changes in the coloration and the formation of precipitate after the addition of specific reagents. The antibacterial activity of the extract and its potential to increase of antibiotic activity of antibiotics drugs, gentamicin and norfloxacin was determined by using the microdilution method.Results: Our results demonstrated that the following secondary metabolites were presented in E. contortisiliquum seed bark: flavones, flavonols, xanthones, flavononols,chalcones, aurones, flavones and catechins. The extract itself had very low antibacterial activity against all bacterial strains tested(MIC ≥ 1024 μg/m L), but there was an increase in the antibiotic activity of gentamicin and norfloxacin when combined in the subinhibitory concentration(i.e., MIC/8).Conclusions: Our data suggests that E. contortisiliquum seed bark may be an alternative source for new drugs with the potential to increase antibiotic activity against different strains of bacteria.

关键词： Antibiotic activity Enhancement Synergism Chemical compounds Bioactivity

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New Insights into Aluminum Tolerance in Rice： The ASR5 Protein Binds the STAR1 Promoter and Other Aluminum-Responsive Genes

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Molecular Plant 2014年第4期7卷 709-721页

作者： Rafael Augusto Arenhart Yang Bai Luiz Felipe Valter de Oliveira Lauro Bucker Neto Mariana Schunemann Felipe dos Santos Maraschin Jorge Mariath Adriano Silverio Gilberto Sachetto-Martins Rogerio Margis Zhi-Yong Wang Marcia Margis-Pinheiro programa de pos-graduacao em Genetica e biologia Molecular Avenida Bento Goncalves 9500 Departamento de Genetica sala 207 predio 43312 Universidade Federal do Rio Grande do Sul 91501-970 Porto Alegre Brasil department of Plant Biology Carnegie Institution for Science Stanford CA 94305 USA School of Computer Science and Technology Harbin Institute of Technology Harbin 150001 China departamento de Botanica Universidade Federal do Rio Grande do Sul Porto Alegre Brasil departamento de Genetica Universidade Federal do Rio de Janeiro Porto Alegre Brasil Centro de Biotecnologia Universidade Federal do Rio Grande do Sul Porto Alegre Brasil

Aluminum （AI） toxicity in plants is one of the primary constraints in crop production. Al3＋, the most toxic form of Al, is released into soil under acidic conditions and causes extensive damage to plants, especially in the roots. In rice, Al tolerance requires the ASR5 gene, but the molecular function of ASR5 has remained unknown. Here, we perform genome-wide analyses to identify ASR5-dependent Al-responsive genes in rice. Based on ASRS_RNAi silencing in plants, a global transcriptome analysis identified a total of 961 genes that were responsive to Al treatment in wildtype rice roots. Of these genes, 909 did not respond to Al in the ASR5_RNAi plants, indicating a central role for ASR5 in Al-responsive gene expression. Under normal conditions, without Al treatment, the ASR5 RNAi plants expressed 1.756 genes differentially compared to the wild-type plants, and 446 of these genes responded to AI treatment in the wild-type plants. Chromatin immunoprecipitation followed by deep sequencing identified 104 putative target genes that were directly regulated by ASR5 binding to their promoters, including the STAR1 gene, which encodes an ABC transporter required for AI tolerance. Motif analysis of the binding peak sequences revealed the binding motif for ASR5, which was confirmed via in vitro DNA-binding assays using the STAR1 promoter. These results demonstrate that ASR5 acts as a key transcription factor that is essential for AI-responsive gene expression and Al tolerance in rice.

关键词： Aluminum ChlP-Seq RNA-Seq rice ASR.

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Genetic diversity and population structure of Prochilodus costatus and Prochilodus argenteus preceding dam construction in the Paraopeba River,Sao Francisco River Basin,Minas Gerais,Brazil

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Open Journal of Genetics 2012年第2期2卷 121-130页

作者： Tatiana M.Barroca Fabio P.Arantes Barbara F.Magalhaes Flavia F.Siqueira Carolina C.R.Horta Isabella F.Pena Jorge A.dergam Evanguedes Kalapothakis departamento de biologia Geral Instituto de Ciencias BiologicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil programa de pos-graduacao em Zoologia de vertebrados Pontificia Universidade Catolica de Minas GeraisBelo HorizonteBrazil departamento de biologia Animal Centro de Ciencias Biologicas e da SaudeUniversidade Federal de VicosaVicosaBrazil

Curimat?-pioa (Prochilodus costatus) and curimat?-pacu (Prochilodus argenteus) are migratory fish species endemic to the S?o Francisco River Basin in Brazil. Both species play important roles in local fisheries and ecology in the Paraopeba River. A dam was recently constructed on this river and to help in the development and conservation programs, we characterized the genetic variation of both species before dam construction. Complex hypervariable repeats micro-satellite was used to asses genetic variation for both species within and between the five collection sites in order to detect population substructuring. Nucleotide substitutions and insertion/deletion polymorphisms (indels) resulted in 35 P. costatus haplotypes (sample size = 89) and 22 P. argenteus haplotypes (sample size = 32). Significant genetic diversity and population differentiation was detected between five sampling sites for both species. Therefore, each of the five sites should be regarded as a group comprising significant genetic differences in species conservation and maintenance plans. Comparing these results to genetic diversity measures after dam construction will be critical for future management in this region.

关键词： Freshwater Fish Complex Hypervariable Repeats Microsatellite Genetic Diversity Population Structure

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Historical Evolution of the Trophic and Limnological Relationships in the Itaipu Reservoir:Top-Down and Bottom-Up Effects upon Fish Production

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Advances in Bioscience and Biotechnology 2015年第6期6卷 390-407页

作者： Rinaldo Antonio Ribeiro Filho Miguel Petrere Junior Angelo Antonio Agostinho Simone Friderigi Benassi Julia Myriam de Almeida Pereira Edson Kiyoshi Okada Curso de Engenharia de Pesca Universidade Estadual Paulista(Unesp)RegistroBrazil programa de pos graduacao em Diversidade Bilogica e Conservacao Universidade Federal de Sao Carlos(UFSCar)SorocabaBrazil programa de pos graduacao em Sustentabilidade em Ecossistemas Marinhos e Costeiros UNISANTASantosBrazil departamento de biologia Nucleo de Pesquisas em LimnologiaIctiologia e AquiculturaUniversidade Estadual de MaringaParanaBrazil Divisao de Reservatorio(MARR.CD) Itaipu BinacionalFoz do IguaçuBrazil

Many experimental studies have contributed to the development of the theory of trophic chains in lacustrine habitats. They have revealed the important role played by fish, a subject that has been mostly ignored by limnological studies for the past few decades. Most of these studies were developed in Europe and in the United States. The general applicability of this theory has not yet been tested in subtropical and tropical habitats. In spite of controversies, the bottom-up: top-down trophic cascade hypotheses are the most adopted conceptual models. In this context, we examined if these hypotheses may be corroborated by data from the subtropical Itaipu Reservoir. A negative effect was verified between water transparency and total suspended solids. The detritivorous fish exerted a controlling effect on chlorophyll-a concentrations. Bottom-up effects were detected in four trophic levels, and top-down was detected in just one trophic level. The limnological variates influenced the chlorophyll-a concentration, which indicated that the lnTKN plus the effect of the quarter and the reservoir zone (and their interaction) were important.

关键词： Reservoir Trophic Cascade Top-Down Bottom-Up Limnology Biotic Community

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Recovery Process on Soft-Bottom Macrobenthic Communities after Artificial Disturbance in Tropical Polluted Estuary(Guanabara Bay,Rio de Janeiro,Brazil)

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Open Journal of Marine Science 2013年第4期3卷 161-166页

作者： Cecília do Valle Pinto Pereira Leandro Amaro Pessoa Marcos Aurélio Vasconcelos de Freitas Carlos Alejandro Echeverría Laboratório de Pesquisas Costeiras e Estuarinas—LABCOEST/UFRJmar(Coastal and Estuarine Research Laboratory)Federal University of Rio de Janeiro UFRJ Old Hidroplanes HangarFundaoBrazil programa de pos graduacao em Biodiversidade e biologia Evolutiva—PPGBBE/UFRJ Federal University of Rio de JaneiroRio de JaneiroBrazil programa de pos graduacao em biologia Marinha—PPGBM/UFF Fluminense Federal UniversityNiteroiBrazil Instituto Virtual Internacional de Mudancas Globais(International Virtual Institute of the Global Change—IVIG/COPPE-UFRJ) Rio de JaneiroBrazil

The regime of disturbance with natural or anthropogenic origin can lead to the destabilization or even to a mass mortality of benthic communities. Due to the heterogeneity of the disturbance there is a formation of patches in different stages of ecological succession. The aim of this study is to follow and describe the resilience in artificial disturbed sediment in a polluted bay in Rio de Janeiro. The sediment was collected, sterilized and placed inside corers (10 cmdiameter ×15 cmheight) in the same place where it was collected. We allocated the samples in two structures, the difference between them was that one was placed closed to the bottom and the other was placed50 cmheight. We found 2352 organisms distributed in 14 taxons. The class Polychaeta and the order Amphipoda showed the highest density in all the survey and treatments. We identified the factors influencing the scenarium: different mechanisms of dispersal, the position of the structures and life history of each group. Disturbance can be the main cause of the patch’s diversity found in estuaries and coastal areas. Because of this, monitoring of selected areas becomes an important tool to understand the regime of disturbance as a key factor structuring benthic communities in soft sediment, also suggesting a metapopulation dynamics.

关键词： Sucession Recolonization defaunation Metapopulation Dynamics Dispersion Processes

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