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Aquatic exercise program-modulated oxidative stress markers in patients with Parkinson's disease

Neural Regeneration Research 2020年第11期15卷 2067-2072页

作者： Caroline Dani Isabel Teixeira Proenca Jessica Marinho Pamela Peccin Ivy Reichert Vital da Silva Simone Nique Vera Striebel Daniela Pochmann Viviane Rostirola Elsner programa de pos graduacao em Biociencias e Reabilitacao do Centro Universitario Metodista-IPA Porto AlegreRSBrazil Curso de Fisioterapia do Centro Universitario Metodista-IPA Porto AlegreRSBrazil programa de pos graduacao em ciencias biologicas:fisiologia Universidade Federal do Rio Grande do SulPorto AlegreRSBrazil programa de pos graduacao em Farmacologia e Terapeutica Universidade Federal do Rio Grande do SulPorto AlegreRSBrazil

Parkinson's disease is a neurodegenerative disease.Oxidative stress,i.e.,the imbalance between the generation of reactive oxygen species and the antioxidant defense capacity of the body,plays an important role in the pathogenesis of this disease.Physical exercise can regulate oxidative stress.The purpose of this study was to analyze the short-and long-term effects of an aquatic exercise program on oxidative stress levels in patients with Parkinson's disease.The aquatic exercise program was carried out during 1 month with two sessions per week(1 hour/session).Blood samples were collected at four different time points:pre-intervention,immediately,48 hours,and 30 days after the first session of aquatic exercise program.Our results revealed that water-based programs modulated antioxidant enzyme activity,increased superoxide dismutase activity,reduced catalase activity,and increased the ratio of superoxide dismutase activity to catalase activity in patients with Parkinson's disease.Compared with pre-intervention and 48 hours after the first session of aquatic exercise program,superoxide dismutase activity was higher and catalase activity was lower immediately and 30 days after the first session.Our results demonstrated that aquatic exercise program could modulate oxidative stress,mainly by the effect of antioxidant enzyme activity.These results could better help understand the target of oxidative stress in Parkinson's disease.This study was approved by the Ethics Committee of Centro Universitário Metodista IPA(approval No.1.373.911)on August 9,2019 and registered with REBEC(registration number:RBR-6 NJ4 MK).

关键词： antioxidant enzyme antioxidants aquatic exercise exercise therapies neurodegenerative disease oxidative stress Parkinson's disease

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Targeting the guanine-based purinergic system in Alzheimer's disease

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Neural Regeneration Research 2017年第2期12卷 212-213页

作者： Débora Lanznaster Carla I.Tasca departamento de Bioquimica Programa de Pos-graduacao em Neurociencias Centro de Ciencias Biologicas Universidade Federal de Santa Catarina Florianopolis Brazil

Alzheimer’s disease（AD）is the main cause of dementia worldwide and affects approximately 5%of people with 65 years or older.The estimated increase in the elderly population suggests that cases of AD will rise in th... 详细信息

关键词： Targeting the guanine-based purinergic system in Alzheimer’s disease

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Assessing physical habitat structure and biological condition in eastern Amazonia stream sites

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Water Biology and Security 2023年第2期2卷 23-31页

作者： Jady Vivia Almeida da Silva Santos Myllena Lima Josinete Sampaio Monteles Daiany Larissa Ribeiro Carrera Ana Paula Justino de Faria Leandro Schlemmer Brasil Leandro Juen Faculdades de ciencias biologicas Instituto de Ciencias BiologicasUniversidade Federal do Para/Rua Augusto CorreiaNº1Bairro GuamaCEP66075-110BelemParaBrazil Laboratorio de Ecologia e Conservacao Universidade Federal do Para/Rua Augusto CorreiaNº1Bairro GuamaCEP66075-110BelemParaBrazil programa de pos-graduacao em Zoologia Universidade Federal do Para/Museu Paraense Emílio GoeldiRua Augusto CorreiaNº1Bairro GuamaCEP66075-110BelemParaBrazil programa de pos-graduacao em Ecologia Universidade Federal do Para e Embrapa Amazonia OrientalRua Augusto CorreiaNº1Bairro GuamaCEP66075-110BelemParaBrazil programa de pos-graduacao em Agricultura e Ambiente Laboratorio de Ciencias Ambientais e BiodiversidadeUniversidade Estadual do MaranhaoSao LuísBrazil Instituto de ciencias Biologicas e Saúde Universidade Federal do Mato GrossoCampus AraguaiaPontal do AraguaiaMato GrossoBrazil

The advance of agricultural frontiers and industrialization in Amazonia has increased natural resource deterioration,resulting in degraded physical habitat structure and reduced local aquatic biodiversity.We evaluated the relative sensitivities of the Biological Monitoring Working Party(BMWP)and Average Score Per Taxon(ASPT)biotic indexes based on EPT(Ephemeroptera,Plecoptera,Trichoptera)versus EPT taxa richness,EPT abundance,and Shannon-Wiener EPT diversity for evaluating anthropogenic impacts on Amazonian streams.We expected that EPT-BMWP and EPT-ASPT would be more sensitive in detecting environmental changes on stream biota than the other measures.We sampled 32 stream sites in eastern Amazonia distributed along an environmental gradient resulting from different land use intensities.All the biological metrics except EPT-ASPT were significantly responsive to anthropogenic pressures;however,EPT taxa richness was slightly more responsive.

关键词： Land use Aquatic insects Biotic index Environmental monitoring

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Evaluation of the 5-HTTLPR and 5-HTTVNTR Polymorphisms in the Serotonin Transporter Gene in Women with postpartum depression

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Neuroscience & Medicine 2012年第3期3卷 275-280页

作者： Josi Maria Zimmermann-Peruzatto Silvana Almeida Aldo Bolten Lucion Jean Pierre Oses Luciana Avila Quevedo Karen Amaral Tavares Pinheiro Ricardo Azevedo da Silva Ricardo Tavares Pinheiro Marcia Giovenardi programa de pos-graduacao em ciencias biologicas FisiologiaUniversidade Federal do Rio Grande do SulPorto AlegreBrazil programa de pos-graduacao em ciencias da Saude Universidade Federal de Ciencias da Saúde de Porto AlegrePorto AlegreBrazil programa de Pós-graduacao em Saúde&Comportamento Centro de Ciencias da Vida e da SaúdeUniversidade Católica de PelotasPelotasBrazil

Objective: The purpose of the present study was to evaluate the association between the 5-HTTLPR and 5-HTTVNTR polymorphisms in the serotonin transporter gene (SLC6A4) in Brazilian women with diagnosed postpartum depression (PPD) and the presence of depressive symptoms. Method: The cohort consisted of 128 white women who were charac-terized based on skin color and morphological characteristics. The Beck depression Inventory was used to diagnose PPD and to score the depressive symptoms. The 5-HTTLPR and 5-HTTVNTR polymorphisms were analyzed by PCR-based methods. Results: No association was observed between the PPD diagnosis and either the 5-HTTLPR (p = 0.48) or the 5-HTTVNTR (p = 0.77) polymorphism. When the polymorphisms were analyzed together with haplotype data, the analyses demonstrated that women carriers of the L-12/L-12 diplotype have lower Beck depression Inventory scores than women carrying other diplotypes (p = 0.04). Discussion: Few studies have investigated the association of SLC6A4 polymorphisms with PPD, and the role of 5-HTTLPR and 5-HTTVNTR polymorphisms in PPD susceptibility has not been established to date. Therefore, our findings link the haplotypes of these two variants with depression symptoms, thereby contributing to our understanding of PPD susceptibility.

关键词： postpartum depression Serotonin Transporter 5-HTTLPR 5-HTTVNTR Polymorphisms

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Small river basin and estuarine sediment fluxes:The magnitude necessary for coastal dispersion and siltation effects on a coral reef

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International Journal of Sediment Research 2019年第6期34卷 591-599页

作者： Paula Sagili?o Isacksson Eduardo Guilherme Gentil de Farias Francisco José Dias Roberto Nascimento de Farias Anandra Machado Francisco de Assis Esteves Mauricio Mussi Molisani Instituto de Biodiversidade e Sustentabilidade (NUPem/UFRJ) Universidade Federal do Rio de Janeiro Grupo de Gestao Ecologia e Tecnologia Marinha (GTMar)Departamento de Engenharia de Pesca a Ciencias Biologicas (DEPB)Universidade do Estado de Santa Catarina (UESC) Laboratorio de Hidrodinamica Costeira Estuarina e de Aguas Interiores (LHiCEAI)Departamento de Oceanografia e Limnologia (DEOLI)Universidade Federal do Maranhao (UFMA) programa de pos-graduacao em ciencias Ambientais e Conservacao-PPGCIAC Instituto de Biodiversidade e Sustentabilidade (NUPEM/UFRJ)

Increasing continental suspended sediment influx to coral reefs is an example of land-sea coupling that requires the identification of sources,magnitude of transport,and controlling processes.In Brazil,a small coastal basin(Macae River) was identified as a source of suspended sediment to a coral reef on the coast of Cape Armacao dos Buzios.Biannual suspended sediment loads were measured at the basin as were fluxes within the estuary and towards the coast during eight tidal cycles.Particle load and yield from this basin were typical of small coastal basins,showing high to moderate slopes and transitional land management.However,the magnitude of the river loads was lower than the sediment transport within the estuary,indicating that the estuary amplifies river fluxes and sustains the transference of suspended sediment alongshore to the coral reef.Nonetheless,the estuary displays both suspended particle retention and export capacity and,therefore,fluxes to the coast and the coral reef occur as episodic events.

关键词： Suspended matter Watershed Mass-balance budget Campos Basin

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Antibacterial enhancement of antibiotic activity by Enterolobium contortisiliquum(Vell.)Morong

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Asian Pacific Journal of Tropical Biomedicine 2017年第10期7卷 945-949页

作者： Zildene de Sousa Silveira Nair Silva Macêdo Thiago Sampaio de Freitas Ana Raquel Pereira da Silva Joycy Francely Sampaio dos Santos Maria Flaviana Bezerra Morais-Braga José Galberto Martins da Costa Raimundo Nonato Pereira Teixeira Jean Paul Kamdem Henrique Douglas Melo Coutinho Francisco Assis Bezerra da Cunha Laboratorio de Bioprospeccao do Semioarido Universidade Regional do CaririCratoBrazil Laboratorio de Microbiologia e Biologia Molecular Universidade Regional do CaririCratoBrazil Laboratorio de Pesquisas de Produtos Naturais Universidade Regional do CaririCratoBrazil departamento de ciencias biologicas Universidade Regional do Cariri-URCACratoCEP:63105-000Brazil programa de pos-graduacao em Bioprospeccao Molecular Universidade Regional do Cariri–URCACratoBrazil

Objective: To identify the main chemical classes of compounds from aqueous extract of Enterolobium contortisiliquum(E. contortisiliquum) seed bark and to evaluate its antibacterial activity, as well as its potential to increase the activity of antibiotics against strains of Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli.Methods: Different classes of compounds in the aqueous extract of E. contortisiliquum were evaluated based on the visual changes in the coloration and the formation of precipitate after the addition of specific reagents. The antibacterial activity of the extract and its potential to increase of antibiotic activity of antibiotics drugs, gentamicin and norfloxacin was determined by using the microdilution method.Results: Our results demonstrated that the following secondary metabolites were presented in E. contortisiliquum seed bark: flavones, flavonols, xanthones, flavononols,chalcones, aurones, flavones and catechins. The extract itself had very low antibacterial activity against all bacterial strains tested(MIC ≥ 1024 μg/m L), but there was an increase in the antibiotic activity of gentamicin and norfloxacin when combined in the subinhibitory concentration(i.e., MIC/8).Conclusions: Our data suggests that E. contortisiliquum seed bark may be an alternative source for new drugs with the potential to increase antibiotic activity against different strains of bacteria.

关键词： Antibiotic activity Enhancement Synergism Chemical compounds Bioactivity

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Stem cell therapy in intracerebral hemorrhage rat model

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World Journal of Stem Cells 2015年第3期7卷 618-629页

作者： Marcos F Cordeiro Ana P Horn programa de pos-graduacao em ciencias Fisiologicas-fisiologia Animal Comparada Universidade Federal do Rio Grande Rio Grande RS 96210-900 Brazil Laboratorio de Histologia Instituto de Ciencias Biologicas Universidade Federal do Rio Grande Rio Grande RS 96210-900 Brazil Laboratorio de Neurociencias Instituto de Ciencias Biologicas Universidade Federal do Rio Grande Rio Grande RS 96210-900 Brazil

Intracerebral hemorrhage(ICH) is a very complex pathology, with many different not fully elucidated etiologies and prognostics. It is the most severe subtype of stroke, with high mortality and morbidity rates. Unfortunately, despite the numerous promising preclinical assays including neuroprotective, anti-hypertensive,and anti-inflammatory drugs, to this moment only symptomatic treatments are available, motivating the search for new alternatives. In this context, stem cell therapy emerged as a promising tool. However, more than a decade has passed, and there is still much to be learned not only about stem cells, but also about ICH itself, and how these two pieces come together. To date, rats have been the most widely used animal model in this research field, and there is much more to be learned from and about them. In this review, we first summarize ICH epidemiology, risk factors, and pathophysiology. We then present different methods utilized to induce ICH in rats, and examine how accurately they represent the human disease. Next, we discuss the different types of stem cells used in previous ICH studies, also taking into account the tested transplantation sites. Finally, we summarize what has been achieved in assays with stem cells in rat models of ICH, and point out some relevant issues where attention must be given in future efforts.

关键词： Cell therapy Intracerebral hemorrhage Preclinical assays Rat Stem cells

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Genetic diversity and population structure of Prochilodus costatus and Prochilodus argenteus preceding dam construction in the Paraopeba River,Sao Francisco River Basin,Minas Gerais,Brazil

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Open Journal of Genetics 2012年第2期2卷 121-130页

作者： Tatiana M.Barroca Fabio P.Arantes Barbara F.Magalhaes Flavia F.Siqueira Carolina C.R.Horta Isabella F.Pena Jorge A.dergam Evanguedes Kalapothakis departamento de Biologia Geral Instituto de Ciencias BiologicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil programa de pos-graduacao em Zoologia de Vertebrados Pontificia Universidade Catolica de Minas GeraisBelo HorizonteBrazil departamento de Biologia Animal Centro de Ciencias Biologicas e da SaudeUniversidade Federal de VicosaVicosaBrazil

Curimat?-pioa (Prochilodus costatus) and curimat?-pacu (Prochilodus argenteus) are migratory fish species endemic to the S?o Francisco River Basin in Brazil. Both species play important roles in local fisheries and ecology in the Paraopeba River. A dam was recently constructed on this river and to help in the development and conservation programs, we characterized the genetic variation of both species before dam construction. Complex hypervariable repeats micro-satellite was used to asses genetic variation for both species within and between the five collection sites in order to detect population substructuring. Nucleotide substitutions and insertion/deletion polymorphisms (indels) resulted in 35 P. costatus haplotypes (sample size = 89) and 22 P. argenteus haplotypes (sample size = 32). Significant genetic diversity and population differentiation was detected between five sampling sites for both species. Therefore, each of the five sites should be regarded as a group comprising significant genetic differences in species conservation and maintenance plans. Comparing these results to genetic diversity measures after dam construction will be critical for future management in this region.

关键词： Freshwater Fish Complex Hypervariable Repeats Microsatellite Genetic Diversity Population Structure

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The Role of CD4+ and CD8+ T-Cells during Angiostrongylus vasorum Infection in Dogs

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Open Journal of Animal Sciences 2014年第5期4卷 285-290页

作者： Thales Augusto Barcante Lis Ribeiro do Valle Antonelli Kenneth Gollob Thiago Pasqua Narciso Silvio Divino de Oliveira Junior Vitor Marcio Ribeiro Ricardo Toshio Fujiwara Ana Paula Peconick debora Negrao-Correa Walter dos Santos Lima Joziana Muniz de Paiva Barcante Laboratorio de Biologia Parasitaria(BIOPAR) Departamento de Medicina VeterinariaSetor PreventivaUniversidade Federal de Lavras(UFLA)LavrasBrazil Instituto de ciencias biologicas Universidade Federal de Minas GeraisBelo HorizonteBrazil programa de pos-graduacao em ciencias Veterinarias Departamento de Medicina VeterinariaUniversidade Federal de Lavras(UFLA)LavrasBrazil

A determinant factor in the pathology of canine angiostrongylosis seems to be related to the location of the parasite in the definitive host. Their presence inside the arteries and its branches, promoting mechanical and metabolic action on the wall of the vessels, may alter its homeostasis. Bronchoalveolar lavage (BAL) is a procedure that retrieves cells and other elements from de lungs for evaluation, and helps in the diagnosis of many pulmonary diseases. The aim of this study was to evaluate CD4+/CD8+ lymphocyte profile during the infection by Angiostrongylus vasorum, using cells retrieved using BAL. The identification of subpopulations of T lymphocytes by evaluating the co-expression of CD4 and CD8 receptor proteins has shown that despite the increase in both populations, there was a predominance of CD4+ T-cells, instead of CD8+ T-cells. These increases of CD4+ T-cells associated with the increase of the ratio between CD4+/CD8+ suggest polarization of a Th2 response. However, the immune cells, signaling factors, and cytokines that mediate such immunity and how and where they act within the body remain largely undefined during angiostrongylosis.

关键词： Citometria Angiostrongyliasis Brochoalveolar Lavage

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Historical Evolution of the Trophic and Limnological Relationships in the Itaipu Reservoir:Top-Down and Bottom-Up Effects upon Fish Production

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Advances in Bioscience and Biotechnology 2015年第6期6卷 390-407页

作者： Rinaldo Antonio Ribeiro Filho Miguel Petrere Junior Angelo Antonio Agostinho Simone Friderigi Benassi Julia Myriam de Almeida Pereira Edson Kiyoshi Okada Curso de Engenharia de Pesca Universidade Estadual Paulista(Unesp)RegistroBrazil programa de pos graduacao em Diversidade Bilogica e Conservacao Universidade Federal de Sao Carlos(UFSCar)SorocabaBrazil programa de pos graduacao em Sustentabilidade em Ecossistemas Marinhos e Costeiros UNISANTASantosBrazil departamento de Biologia Nucleo de Pesquisas em LimnologiaIctiologia e AquiculturaUniversidade Estadual de MaringaParanaBrazil Divisao de Reservatorio(MARR.CD) Itaipu BinacionalFoz do IguaçuBrazil

Many experimental studies have contributed to the development of the theory of trophic chains in lacustrine habitats. They have revealed the important role played by fish, a subject that has been mostly ignored by limnological studies for the past few decades. Most of these studies were developed in Europe and in the United States. The general applicability of this theory has not yet been tested in subtropical and tropical habitats. In spite of controversies, the bottom-up: top-down trophic cascade hypotheses are the most adopted conceptual models. In this context, we examined if these hypotheses may be corroborated by data from the subtropical Itaipu Reservoir. A negative effect was verified between water transparency and total suspended solids. The detritivorous fish exerted a controlling effect on chlorophyll-a concentrations. Bottom-up effects were detected in four trophic levels, and top-down was detected in just one trophic level. The limnological variates influenced the chlorophyll-a concentration, which indicated that the lnTKN plus the effect of the quarter and the reservoir zone (and their interaction) were important.

关键词： Reservoir Trophic Cascade Top-Down Bottom-Up Limnology Biotic Community

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