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Genome-wide identification and characterization of ACBP gene family in Populus reveal salinity alkali-responsive profiles

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Journal of Forestry Research 2023年第2期34卷 481-496页

作者： Yu Chang Xinru Xu Hongxia Zheng Hao Xie Bo Li Sixue Chen Ying Li Shaojun Dai Key Laboratory of Saline-Alkali Vegetation Ecology Restoration(Northeast Forestry University) Ministry of EducationCollege of Life SciencesNortheast Forestry UniversityHarbin 150040People’s Republic of China Development Center of Plant Germplasm Resources College of Life SciencesShanghai Normal UniversityShanghai 200234People’s Republic of China Department of Biology Genetics InstitutePlant Molecular and Cellular Biology ProgramInterdisciplinary Center for Biotechnology ResearchUniversity of FloridaGainesvilleFloridaUSA

Acyl-CoA-binding proteins(ACBPs)are important for the transport of acyl groups for macro molecular biosynthesis involved in plant growth,development,and diverse stress(e.g.,cold,drought,salinity,and heavy metals)***,we report the phylogeny and characteristics of the ACBP family in the woody plant Populus *** genes encoding ACBP proteins were identified,and they are distributed on eight chromosomes in *** PtACBP genes were divided into four subgroups according to gene structure,conserved motifs and phylogenetic *** analysis revealed that cis-elements were related to stress response,phytohormone response,and physical and reproductive growth *** levels of PtACBP genes varied among different organs,with the highest expression in leaves and the lowest in *** real-time PCR(qRT-PCR)analysis showed that under salinity-alkali stresses(i.e.,200 mM NaCl,75 mM Na2CO3,and 100 mM NaHCO3),four(PtACBP1,PtACBP3,PtACBP4 and PtACBP8)of eight PtACBP genes were significantly induced in roots and *** data provide a comprehensive analysis of the ACBPs family in ***,which could be useful for gene function analyses.

关键词： Acyl-CoA-binding proteins(ACBPs) Gene structure Expression pattern Stress response Populus trichocarpa

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Update on the use of 45S5 bioactive glass in the treatment of bone defects in regenerative medicine

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World Journal of Orthopedics 2024年第3期15卷 204-214页

作者： Dayane Maria Braz Nogueira Marcelie Priscila de Oliveira Rosso Daniela Vieira Buchaim Mariana Schutzer Ragghianti Zangrando Rogério Leone Buchaim Department of Prosthodontics and Periodontics Bauru School of DentistryUniversity of São PauloBauru 17012-901Brazil Department of Biological Sciences Bauru School of DentistryUniversity of São PauloBauru 17012-901Brazil Medical School University Center of AdamantinaAdamantina 17800-000Brazil Postgraduate program in Structural and Functional Interactions in Rehabilitation Postgraduate DepartmentUniversity of MaríliaMarília 17525-902Brazil

Bone regeneration is a critical area in regenerative medicine,particularly in orthopedics,demanding effective biomedical materials for treating bone defects.45S5 bioactive glass(45S5 BG)is a promising material because of its osteoconductive and bioactive *** research in this field continues to advance,keeping up-to-date on the latest and most successful applications of this material is *** achieve this,we conducted a comprehensive search on Pub-Med/MEDLINE,focusing on English articles published in the last *** search used the keywords“bioglass 45S5 AND bone defect”in *** found 27 articles,and after applying the inclusion criteria,we selected 15 studies for detailed *** of these studies compared 45S5 BG with other cement or scaffold *** comparisons demonstrate that the addition of various composites enhances cellular biocompatibility,as evidenced by the cells and their osteogenic ***,the use of 45S5 BG is enhanced by its antimicrobial properties,opening avenues for additional investigations and applications of this biomaterial.

关键词： Biocompatible materials Bioglass Bone regeneration

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Molecular determinants regulating the release of the egg during ovulation:Perspectives in piscine models

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Aquaculture and Fisheries 2022年第5期7卷 583-594页

作者： Soumyajyoti Ghosh Subhasri Biswas Sudipta Maitra Molecular and cellular Endocrinology Laboratory Department of ZoologyVisva-Bharati UniversitySantiniketan731235India

Reproduction in bony fish,specifically in the female teleost,encompasses well-defined stages,including growth and development,final oocyte maturation and finally ovulation-a pre-requisite for forming fertilizable female *** morphological changes encountered during ovulatory response engage a multitude of endocrine,autocrine,and paracrine *** include gonadal steroids,growth factors,inflammatory cytokines,prostaglandins,leukotrienes and matrix *** recent years,the active participation of prostaglandins and their receptors in LH-dependent ovulatory action has received much *** evidence also supports the participation of nitric oxide/nitric oxide synthase(NO/NOS)unit in regulating meiotic maturation and ovulatory ***,relatively less information is available on physiological relevance,the inter-relationship and the conjoined efforts of these molecular candidates to trigger ovulation in the fish *** prime objective of the present article is to summarize the potential cross-talk between major molecular candidates downstream of LH action in the follicular ***,the intraovarian role of prostaglandin(PG)vis-`a-vis NO/NOS system on mammalian and teleost ovulatory response has been emphasised.

关键词： Luteinizing hormone(LH) Ovulation Growth factors Inflammatory cytokines Prostaglandins Nitric oxide

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Author Correction:Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24

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cellular & Molecular Immunology 2024年第1期21卷 100-100页

作者： Zhengzhou Ying Swanand Hardikar Joshua B.Plummer Tewfik Hamidi Bin Liu Yueping Chen Jianjun Shen Yunxiang Mu Kevin M.McBride Taiping Chen Department of Epigenetics and Molecular Carcinogenesis The University of Texas MD Anderson Cancer Center Houston TX 77030 USA program in Genetics and Epigenetics The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Houston TX 77030 USA

In the sentence beginning‘To trace cell proliferation,FO and MZ B cells’and the sentence beginning‘For cell activation,naïve B cells or CH12F3 cells’in this article,the[10 ng/ml]‘F(ab’)_(2)fragment goat anti-mouse IgM’should have read‘10μg/ml F(ab’)_(2)fragment goat anti-mouse IgM’.The original article has been corrected.

关键词： immunodeficiency CD19 deficient

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Control of Directional Macromolecular Trafficking Across Specific cellular Boundaries:A Key to Integrative Plant Biology

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Journal of Integrative Plant Biology 2007年第8期49卷 1227-1234页

作者： BiaoDing AsukaItaya Department of Plant cellular and Molecular Biology and Plant Biotechnology Center Ohio State University ColumbusOhio 43210USA The OSU RNA GroupOhio State UniversityColumbusOhio 43210USA MolecularCellular and Developmental Biology ProgramOhio State UniversityColumbusOhio 43210USA

There is now solid evidence that cell-to-cell trafficking of certain proteins and RNAs plays a critical role in trans-cellular regulation of gene expression to coordinate cellular differentiation and development. Such trafficking also is critical for viral infection and plant defense. The mechanisms of trafficking remain poorly understood. Although some proteins may move between cells by diffusion, many proteins and RNAs move in a highly regulated fashion. Regulation is likely achieved through interactions between distinct protein or RNA motifs and cellular factors. Some motifs and factors have been identified. One of the major focuses for future studies is to identify all motifs and their cognate factors and further elucidate their roles in trafficking between specific cells. With increasing information from such studies, we should be able to develop an understanding of the mechanisms that regulate trafficking of various proteins and RNAs across all and specific cellular boundaries. On the basis of such mechanistic knowledge, we can further investigate how the trafficking machinery has evolved to regulate developmental and physiological processes in a plant, how pathogens have co-evolved to use this machinery for systemic spread in a plant, and how plants use this machinery for counterdefense.

关键词： CAPRICE GLABRA3 KNOTTED-I phloem plasmodesmata protein trafficking RNA trafficking SHORT-ROOT viral movementprotein viroid

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Carboxypeptidase E (NF-α1):a new trophic factor in neuroprotection

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Neuroscience Bulletin 2014年第4期30卷 692-696页

作者： Yong Cheng Niamh X.Cawley Y.Peng Loh Section on cellular Neurobiology Program on Developmental NeuroscienceEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institutes of Health BethesdaMD 20892USA

Carboxypeptidase E （CPE） is a prohormone-processing enzyme and sorting receptor that functions intracellularly. However, recent studies have demonstrated that CPE acts as atrophic factor extracellularly to up-regulate the expression of a pro-survival gene. This mini-review summarizes the roles of CPE in neuroprotection and the implications for neurodegenerative diseases.

关键词： carboxypeptidase E NF-α1 neuroprotection stress neurodegenerative disease

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β-Cyclodextrin-modified AuBi metallic aerogels enable efficient peroxidase mimicking for colorimetric sensing of urease-positive pathogenic bacteria

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Nano Research 2023年第7期16卷 9663-9671页

作者： Minghui Wang Peixian Wu Sha Yang Gui-long Wu Na Li Xiaofeng Tan Qinglai Yang Center for Molecular Imaging Probe Hunan Province Key Laboratory of Tumor Cellular and Molecular PathologyCancer Research InstituteHengyang Medical SchoolUniversity of South ChinaHengyang 421001China

The detection of pathogenic bacteria with improved accessibility,reduced analysis time,and increased sensitivity is of great importance for diagnosing the infected *** have attracted rising attention in the bioassay *** a model nanozyme needs the combined merit of sensible nanostructures and a large specific surface area to guarantee exceptional enzyme-mimic ***,aβ-cyclodextrin modified AuBi aerogel is prepared by a one-pot reduction *** introduction ofβ-cyclodextrin(featured with a hydrophobic cavity and hydrophilic surface)enhances the catalytic activity of AuBi aerogels by engendering host-guest complex and improving dispersity/*** on the specific urea hydrolysis,which could produce NH_(3)to raise pH by urease,the pH up-regulation would inhibit the peroxidase-mimicking performances ofβ-cyclodextrin/AuBi ***,the sensitive colorimetric detection platform for urease activity could be ***,the sensing platform can detect straightforwardly urease-positive Proteus mirabilis in urine circumstances with a wide detection range and a low limit of detection(LOD)of 4 colony-forming unit(CFU)·mL^(-1).The reproducibility,stability,and specificity of this approach are verified to be ***,as an inhibitor of urease activity,the fluoride ion could be detected by the constructed sensing platform sensitively and ***,this work provides a blueprint for designing an ideal nanozyme and paves a new roadway for detecting pathogenic bacteria.

关键词： metallic aerogels surface modification urea hydrolysis urease activity fluoride ion proteus mirabilis bacteria detection

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Unsynchronized butyrophilin molecules dictate cancer cell evasion of Vγ9Vδ2 T-cell killing

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cellular & Molecular Immunology 2024年第4期21卷 362-373页

作者： Zeguang Wu Qiezhong Lamao Meichao Gu Xuanxuan Jin Ying Liu Feng Tian Ying Yu Pengfei Yuan Shuaixin Gao Thomas S.Fulford Adam P.Uldrich Catherine C.L Wong Wensheng Wei Biomedical Pioneering Innovation Center Peking-Tsinghua Center for Life SciencesPeking University Genome Editing Research CenterState Key Laboratory of Protein and Plant Gene ResearchSchool of Life SciencesPeking University100871BeijingChina EdiGene Inc. Life Science ParkChangping District102206BeijingChina Center for Precision Medicine Multi-Omics Research Peking University Health Science CenterPeking University100191BeijingChina Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity The University of MelbourneParkvilleVIC3010Australia Cancer Immunology program Peter MacCallum Cancer CentreMelbourneVICAustralia State Key Laboratory for Complex Severe and Rare DiseasesClinical Research InstitutePeking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegePeking-Tsinghua Center for Life Sciences100871BeijingChina

Vγ9Vδ2 T cells are specialized effector cells that have gained prominence as immunotherapy agents due to their ability to target and kill cells with altered pyrophosphate *** our effort to understand how cancer cells evade the cell-killing activity of Vγ9Vδ2 T cells,we performed a comprehensive genome-scale CRISPR screening of cancer *** found that four molecules belonging to the butyrophilin(BTN)family,specifically BTN2A1,BTN3A1,BTN3A2,and BTN3A3,are critically important and play unique,nonoverlapping roles in facilitating the destruction of cancer cells by primary Vγ9Vδ2 T *** coordinated function of these BTN molecules was driven by synchronized gene expression,which was regulated by IFN-γsignaling and the RFX ***,an enzyme called QPCTL was shown to play a key role in modifying the N-terminal glutamine of these BTN proteins and was found to be a crucial factor in Vγ9Vδ2 T cell killing of cancer *** our research,we offer a detailed overview of the functional genomic mechanisms that underlie how cancer cells escape Vγ9Vδ2 T ***,our findings shed light on the importance of the harmonized expression and function of gene family members in modulating T-cell activity.

关键词： Butyrophilin Vγ9Vδ2 T-cell Cancer-specific immune evasion Glutaminyl-peptide cyclotransferase-like Pyrophosphate metabolite Immunotherapy

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Epigenomic reprogramming in peripheral nerve injury

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Neural Regeneration Research 2016年第12期11卷 1930-1931页

作者： Ki H.Ma John Svaren Waisman Center University of Wisconsin-Madison cellular and Molecular Pathology Graduate program University of Wisconsin-Madison Department of Comparative Biosciences University of Wisconsin-Madison

The regenerative capacity of peripheral nerve is significantly different from injury responses in the central nervous *** of injured axons,re-myelination and functional recovery are readily observed after injury to pe... 详细信息

关键词： gene cell Epigenomic reprogramming in peripheral nerve injury

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Resistance mechanism to cisplatin in NCI-H460 non-small cell lung cancer cell line:investigating apoptosis,autophagy,and cytogenetic damage

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Cancer Drug Resistance 2018年第1期1卷 72-81页

作者： Érica Ballestreri Daniel Simon Ana Paula de Souza Camila Schultz Grott Débora Dreher Nabinger Rafael Rodrigues Dihl Ivana Grivicich Laboratory of Cancer Biology Graduate Program in Cellular and Molecular Biology Applied to HealthLutheran University of BrazilCanoasRS 92425-900Brazil Laboratory of Human Molecular Genetics Graduate Program in Cellular and Molecular Biology Applied to HealthLutheran University of BrazilCanoasRS 92425-900Brazil Laboratory of Genetic Toxicity Graduate Program in Cellular and Molecular Biology Applied to HealthLutheran University of BrazilCanoasRS 92425-900Brazil

Aim:To investigate the effects of cisplatin on the human non-small cell lung carcinoma(NCI-H460)cell line regarding cytotoxicity,genotoxicity,and expression of genes associated with apoptosis(BIRC5)and autophagy(BECN1).Methods:Cell cultures were treated with cisplatin concentrations(0.16-33.3μmol/L)for 48 *** and acute and chronic cytotoxicities were assessed using the MTT,clonogenic,and cytokinesis-block micronucleus *** expression of BIRC5 and BECN1 was evaluated by reverse transcription-polymerase chain ***:Cisplatin IC50(0.33μmol/L)increased micronucleus frequency 2.50 *** was also cytotoxic in the 0.6-33.3μmol/L range,with reduced expression of the BIRC5 gene,suggesting induction of *** reducing the expression of the BIRC5 gene,33.3μmol/L cisplatin increased the expression of the BECN1 gene,suggesting that autophagy can be related to cisplatin ***:Cisplatin inhibited NCI-H460 growth,and cisplatin IC50 induced genotoxic *** higher cisplatin concentrations are used,the expression of genes associated with apoptosis and autophagy was *** results points to a further investigation of the role of autophagy in cisplatin resistance.

关键词： BECN1 BIRC5 cisplatin cytotoxicity lung cancer

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