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Chinese chemical Letters 2024年第9期35卷 387-391页

作者： Jia Chen Yun Liu Zerong Long Yan Li Hongdeng Qiu Xinjiang Uygur Autonomous product Quality Supervision and Inspection Institute Urumqi 830000China CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for natural Medicine of Gansu Province Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

In this work,we established an exceptionally facile method for the preparation of Ni-CeO_(2)nanorods in a kind of deep eutectic solvents(DESs)composed of l-proline and Ce(NO_(3))_(3)·6H_(2)***,Ni-CeO_(2)nanorods were successfully prepared by adding Ni(NO_(3))_(3)·6H_(2)O to ***,we found that Ni-CeO_(2)nanorods prepared in DESs have more prominent oxidase-like activity than pure CeO_(2).The outstanding catalytic activity of Ni-CeO_(2)could be ascribed to its high Ce^(3+)/Ce^(4+)*** a proof-of-concept application,the Ni-CeO_(2)nanorods were successfully acted as a colorimetric platform for the sensitive determination of ascorbic acid andα-glucosidase activity,which displays excellent analytical ***,this sensing platform was applied for screening naturalα-glucosidase inhibitors,such as terpenoids from natural *** results indicated that ursolic acid and oleanolic acid had good inhibitory *** strategy not only provides a new way to construct more kinds of nanomaterials from DESs,but also offers a facile and effective tool to screen theα-glucosidase natural inhibitors as potential anti-diabetic drugs.

关键词： Ni-CeO_(2) Ascorbic acid α-Glucosidase Inhibitor screening Nanozyme

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Participatory Risk Governance for Seoul, South Korea's Flood Risk Management

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International Journal of Disaster Risk Science 2024年第3期15卷 317-331页

作者： Bokjin Ro Gregg Garfin School of Geography Development and Environment The University of Arizona Interdisciplinary program for Disaster Crisis and Risk Management Sungkyunkwan University School of natural Resources and the Environment The University of Arizona

Risk governance is a widely used framework in natural and societal risk management research. Risks from natural hazards in urban areas call for the establishment of rigorous and participatory urban risk governance. In this study, we examined participatory risk governance(PRG) of flood risk management(FRM) in Seoul, South Korea. We conducted key informant interviews and implemented a survey with citizens, to explore perceptions of flood risks and risk management, and to examine prospects for improving PRG in Seoul. We found a gap between the perceptions of key informants and *** informants believed that citizens' low awareness of flood risks hinders PRG. Yet our research found that citizens' risk awareness was not low, and risk awareness may not be the main barrier to participation in PRG. Instead, we found that citizens lacked knowledge of FRM actions, and they assigned government bodies a high level of responsibility for FRM,compared to the level of responsibility that citizens assigned to themselves. Moreover, the actors involved in FRM tended not to trust each other, which implies a lack of mutual understanding. To increase the eff ectiveness of PRG, we suggest a polycentric governance structure anchored by a leading actor group, and active promotion of the participation of actors at multiple levels of governance. Communication between government and citizen participants, designed to foster improved understanding and recognition of one another's roles and contributions to FRM, will enhance trust and improve the implementation of PRG in Seoul.

关键词： Citizen participation Flood risk management Participatory risk governance Risk awareness South Korea Urban flood risk

Direct Synthesis of α-Aminophosphonates from Amines,Alcohols,and White Phosphorus

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CCS Chemistry 2024年第1期6卷 91-99页

作者： Mengpei Bai Yinwei Cao Junwei Huang Yan Liu Guo Tang Yufen Zhao Department of Chemistry and Key Laboratory for chemical biology of Fujian Province College of Chemistry and Chemical EngineeringXiamen UniversityXiamenFujian 361005

Developing practical strategies for the synthesis of organophosphorus compounds(OPCs)from white phosphorus(P_(4))without the use of Cl_(2) and PCl_(3) remains a significant *** first multicomponent oxidative α-phosphonylation of amines with P_(4) and alcohols has been *** the use of copper(Ⅱ)as the catalyst and air as the safe oxidant,structurally sophisticated α-aminophosphonates have been prepared in high ***,this method is also suitable for selective construction of P-O-P *** reaction is characterized by a complete conversion of P_(4).The activation of P_(4) with transition metals often leads to formation of complexes[M_(x)P_(y)]_(n) associated with the deactivation of transition *** breakthrough showcases the potential of transition-metal-catalyzed reactions in elemental phosphorus chemistry.

关键词： white phosphorus P-C bonds dialkyl phosphites aminophosphonates pyrophosphates

chemical biology investigation of a triple-action,smart-decomposition antimicrobial booster based-combination therapy against“ESKAPE”pathogens

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Science China Chemistry 2024年第9期67卷 3071-3082页

作者： Min Wang Huangsheng Pu Yangfan Xu Chenxuan Wu Yuanxin Gu Qingyun Cai Guoxing Yin Peng Yin Chunhui Zhang Wing-Leung Wong Muyang Wan Yugang Bai Xinxin Feng State Key Laboratory of Chem-/Bio-Sensing and Chemometrics Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biologyand School of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China College of biology Hunan UniversityChangsha 410082China College of Advanced Interdisciplinary Studies&Hunan Provincial Key Laboratory of Novel Nano Optoelectronic Information Materials and Devices National University of Defense TechnologyChangsha 410073China Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China Key Laboratory of chemical biology and Traditional Chinese Medicine Research(Ministry of Education) College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China State Key Laboratory of chemical biology and Drug Discovery Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityHong Kong SAR 999077China Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs The Third Hospital of Changsha(The Affiliated Changsha Hospital of Hunan University)Changsha 410015China

The global antibiotic resistance crisis necessitates urgent *** innovative approach involves potentiating antibiotics and non-antibiotic drugs with adjuvants or boosters.A major drawback of these membrane-active boosters is their limited biocompatibility,as they struggle to differentiate between prokaryotic and eukaryotic *** study reports the chemical biology investigation of a dual-action oligoamidine(OA1)booster with a glutathione-triggered decomposition ***1,when combined with other antimicrobial molecules,exhibits a triple-targeting mechanism including cell membrane disruption,DNA targeting,and intracellular enzyme *** multi-targeting mechanism not only enhances the in vitro and in vivo eradication of antibiotic-resistant“ESKAPE”pathogens,but also suppresses the development of bacterial ***,OA1 maintains its activity in bacterial cells by creating an oxidative environment,while it quickly decomposes in mammalian cells due to high glutathione *** mechanistic insights and design principles may provide a feasible approach to develop novel antimicrobial agents and effective anti-resistance combination therapies.

关键词： antimicrobial booster oligoamidine membrane disruption DNA targeting triggered degradation anti-resistance

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Monitoring of Cell Membrane Microenvironment Based on DNA Nanodevices

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chemical Research in Chinese Universities 2024年第2期40卷 255-267页

作者： NAN Hexin CAI Ming KUANG Shi NIE Zhou State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan Provincial Key Laboratory of Biomacromolecular Chemical BiologyHunan UniversityChangsha410082P.R.China

The cell membrane is a critical barrier for cellular homeostasis,integral to signaling and intercellular communication,and vital for understanding cellular functions and disease *** its microenvironment is crucial for uncovering the molecular basis of physiological and pathological processes associated with the cell membrane,driving the development of bioanalytical toolkits capable of dynamically monitoring the cell surface *** the continuous advancement of functional nucleic acids and dynamic DNA nanotechnology,DNA nanodevices with controllable nanosized geometry,specific molecular recognition,and selective membrane-localization properties offer a versatile platform for probing the cell membrane *** this review,we summarize the current biosensing and membrane-anchoring mechanisms of DNA nanodevices and highlight their use in studying key cell membrane events,including membrane lipid dynamics,transmembrane transport,receptor dimerization,and signal ***,we discuss the challenges and potential future applications of DNA nanodevices in advancing cell membrane biology research and biomedical applications.

关键词： DNA nanodevice Cell membrane Cellular micro-environment Monitoring

A MOF built on 8-connected Y3 nodes demonstrates simultaneous reverse adsorptive separation: ethane over ethylene and propane over propylene

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Science China Chemistry 2024年第11期67卷 3657-3661页

作者： Lu-Lu Ma Jiaqi Liu Kang Zhou Zixuan Cao Jiafeng Miao Guo-Ping Yang Yao-Yu Wang Jing Li Hao Wang Key Laboratory of Synthetic and natural Functional Molecule Chemistry of the Ministry of Education Shaanxi Key Laboratory of PhysicoInorganic Chemistry College of Chemistry & Materials Science Northwest University Hoffmann Institute of Advanced Materials Shenzhen Polytechnic University Shenzhen Senior High School Department of Chemistry and chemical biology Rutgers University

Selective adsorption of paraffins over olefins（mostly C2 and C3） by porous solids could offer tremendous advantages for the purification of olefins, which is, however, challenging as it has stringent requirements on the pore dimensions and pore surface chemistry of the adsorbent. We report here a metal-organic framework（MOF） with novel topology, Y3（μ3-OH）(TCMPB)2(denoted as HIAM-316, TCMPB4-= 1,2,4,5-tetra（4-carboxy-3-methylphenyl）benzene), which shows reversed separation of C2H6/C2H4and C3H8/C3H6simultaneously. The ideal adsorbed solution theory（IAST） selectivities for equimolar binary mixtures of C2H6/C2H4and C3H8/C3H6were calculated to be 1.67 and 1.23 at 1 bar and 298 K for HIAM-316. Its capability of removing paraffines from paraffin/olefin mixtures is validated by breakthrough measurements. Molecular simulations reveal that the preferential adsorption of paraffins over olefins by HIAM-316 may be attributed to the abundant carboxylate oxygen atoms along its channel.

关键词： metal-organic framework adsorption separation

Inter-chromosomal insertions into wild-type chromosomes induced by SCRaMbLE

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Frontiers of chemical Science and Engineering 2024年第9期18卷 125-135页

作者： Sijie Zhou Junyanrui Li Xichen Cui Ying Wang Ying-Jin Yuan Frontiers Science Center for Synthetic biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Frontiers Research Institute for Synthetic biology Tianjin UniversityTianjin 300072China

Genomic rearrangements play a crucial role in shaping biological phenotypic diversity and driving species *** chromosome rearrangement and modification by LoxP-mediated evolution(SCRaMbLE)has been applied to explore large-scale genomic rearrangements,yet it has been observed that these rearrangements occur exclusively in genomic regions containing loxPsym ***,we found that SCRaMbLE of synthetic yeast harboring synthetic chromosome V and X can generate a variety of synthetic segment insertions into wild-type chromosomes,ranging from 1 to 300 ***,it was revealed that the novel insertions impacted the transcriptional level of neighboring regions and affected the production of exemplar pathway of ***,our results improve the understanding of the ability of SCRaMbLE to generate complex structural variations in nonsynthetic regions and provide a potential model to explore genomic transposable events.

关键词： genomic rearrangements synthetic yeast genome SCRaMbLE inter-chromosomal insertions synthetic biology

Cationic starch microparticles with integrated antibacterial and hemostatic performance

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Science China Technological Sciences 2024年第10期67卷 3235-3246页

作者： SU Yang NIU MengXin XU KaiDong XU Chen YANG PeiLang HU Yang XU Fu-Jian Key Lab of Biomedical Materials of natural Macromolecules (Beijing University of chemical Technology Ministry of Education)Beijing Laboratory of Biomedical MaterialCollege of Materials Science and EngineeringBeijing University of Chemical Technology Department of Burn Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

It is urgently demanded to develop biomaterials with balanced hemostatic/antibacterial ability and facile preparation methods. In this work, cationic starch microparticles(MSQP), prepared by the facile grafting of microporous starch particles(MS) with tunable quaternized polyethyleneimine, were readily constructed as promising hemostatic materials for integrated antibacterial and hemostatic performance. The cationic grafts not only endowed MSQP with good antibacterial ability, but also benefited from biocompatible MS to achieve favorable biocompatibility. Moreover, in vitro results confirmed the superior hemostatic property of MSQP2(with the medium content of cationic grafts) among three MSQP and pristine MS. After investigating the bloodmaterial interactions of MSQP/MS, the procoagulant mechanism of MSQP2 was revealed that the optimal amount of cationic grafts achieves highly balanced plasma-protein adhesion, platelet adhesion and blood coagulation system. In vivo artery-injury model further demonstrated the superior hemostatic performance of MSQP2 for potential severe hemorrhage. This work sheds light on the design of cationic polymer-based biomaterials for balanced antibacterial and hemostatic functions.

关键词： hemostasis antibacterial cationic polymer microparticles

Role of methoxy and C_(α)-based substituents in electrochemical oxidation mechanisms and bond cleavage selectivity of β-O-4 lignin model compounds

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Green Energy & Environment 2024年第1期9卷 114-125页

作者： Yang Zhou Qiang Zeng Hongyan He Kejia Wu Fuqiao Liu Xuehui Li School of Chemistry and chemical Engineering The Guangdong Provincial Key Laboratory of Green Chemical Product TechnologyState Key Laboratory of Pulp and Paper EngineeringSouth China University of TechnologyGuangzhouGuangdong510640China CAS Key Laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China

In order to better understand the specific substituent effects on the electrochemical oxidation process of β-O-4 bond, a series of methoxyphenyl type β-O-4 dimer model compounds with different localized methoxyl groups, including 2-(2-methoxyphenoxy)-1-phenylethanone, 2-(2-methoxyphenoxy)-1-phenylethanol, 2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)ethanone, 2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)ethanol, 2-(2,6-dimethoxyphenoxy)-1-(4-methoxyphenyl)ethanone, 2-(2,6-dimethoxyphenoxy)-1-(4-methoxyphenyl)ethanol have been selected and their electrochemical properties have been studied experimentally by cyclic voltammetry, and FT-IR spectroelectrochemistry. Combining with electrolysis products distribution analysis and density functional theory calculations, oxidation mechanisms of all six model dimers have been explored. In particular, a total effect from substituents of both para-methoxy(on the aryl ring closing to Cα) and Cα-OH on the oxidation mechanisms has been clearly observed, showing a significant selectivity on the Cα-Cβbond cleavage induced by electrochemical oxidations.

关键词： Lignin model compounds β-O-4 dimers Electrochemical oxidation Oxidation mechanisms Substituent effect

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Polygalacturonase-inhibiting proteins as an exogenously applied natural solution for prevention of postharvest fungal infections

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Synthetic and Systems Biotechnology 2024年第3期9卷 481-493页

作者： Tiffany Chiu Yanran Li Graduate program in Genetics Genomicsand Bioinformatics1140 Batchelor HallUniversity of California RiversideCalifornia92521USA program of chemical Engineering Department of NanoengineeringUniversity of CaliforniaSan DiegoCA92521USA

Polygalacturonase inhibiting proteins(PGIPs)are plant proteins involved in the inhibition of polygalacturonases(PGs),cell-wall degrading enzymes often secreted by phytopathogenic ***,we confirmed that PGIP2 from Phaseolus vulgaris(PvPGIP2)can inhibit the growth of Aspergillus niger and Botrytis cinerea on agar *** this study,we further validated the feasibility of using PGIP as an environmental and ecological friendly agent to prevent fungal infection *** found that application of either purified PGIP(full length PvPGIP2 or truncated tPvPGIP2_5-8),or PGIP-secreting Saccharomyces cerevisiae strains can effectively inhibit fungal growth and necrotic lesions on tobacco *** also examined the effective amount and thermostability of PGIP when applied on plants.A concentration of 0.75 mg/mL or higher can significantly reduce the area of *** *** activity of full-length PvPGIPs is not affected after incubation at various temperatures ranging from􀀀20 to 42◦C for 24 h,while truncated tPvPGIP2_5-8 lost some efficacy after incubation at 42◦***,we have also examined the efficacy of PGIP on tomato *** the purified PvPGIP2 proteins were applied to tomato fruit inoculated with *** at a concentration of roughly 1.0 mg/mL,disease inci-dence and area of disease had reduced by more than half compared to the controls without PGIP *** study explores the potential of PGIPs as exogenously applied,eco-friendly fungal control agents on fruit and vegetables post-harvest.

关键词： PGIP Antifungal agent Pest control Postharvest treatment