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Predictors of the placebo response in a nutraceutical randomized controlled trial for depression

Journal of Integrative Medicine 2024年第1期22卷 46-53页

作者： Rosemary Arnold Jenifer Murphy-Smith Chee H.Ng David Mischoulon Gerard J.Byrne Chad A.Bousman Con Stough Michael Berk Jerome Sarris professorial unit the Melbourne ClinicDepartment of PsychiatryUniversity of MelbourneRichmond 3121Australia Depression Clinical and Research Program Department of PsychiatryMassachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA Faculty of Medicine Discipline of PsychiatryCentre for Clinical ResearchRoyal Brisbane&Women’s HospitalHerstonthe University of QueenslandBrisbane 4006Australia Departments of Medical Genetics PsychiatryPhysiology&Pharmacology and Community Health SciencesUniversity of CalgaryCalgaryAB T2N 1N4Canada Department of Psychiatry the University of MelbourneMelbourne 3052Australia Centre for Human Psychopharmacology Swinburne UniversityMelbourne 3122Australia The Institute for Mental and Physical Health and Clinical Translation School of MedicineBarwon HealthDeakin UniversityGeelong 3220Australia The Centre of Excellence in Youth Mental Health the University of MelbourneParkville 3052Australia Florey Institute of Neuroscience and Mental Health the University of MelbourneParkville 3052Australia NICM Health Research Institute Western Sydney UniversityWestmeadNSW 2145Australia

Objective The placebo response in depression studies is the change in symptoms amongst those who receive an inactive *** well-designed randomized controlled trials(RCTs)of depression have a high proportion of placebo responders,with little understanding as to *** present study assesses characteristics associated with the placebo response in a nutraceutical trial with a large proportion of placebo *** This is a secondary analysis of a nutraceutical depression RCT which identified no overall treatment benefit relative to placebo(n=69 in placebo group).We investigated participant characteristics such as socio-demographics,clinical features,and recruitment methods,and their association with the placebo *** genetic polymorphisms were also *** response was measured based on change in Montgomery-Asberg Depression Rating Scale *** association of these hypothesis-driven variables of interest and the placebo response was examined using linear mixed effects *** Greater levels of education,particularly pursuing post-high school education,better self-reported general health,marriage/de facto,greater improvement in the first trial week,and more failed antidepressant therapies in the current depressive episode were associated with greater placebo *** increased placebo response was not found in those recruited via social media nor in those with concomitant antidepressant *** nucleotide polymorphisms from the tryptophan hydroxylase 1(TPH1)gene(A779C and A218C)were weakly associated with greater placebo response,although the evidence was attenuated after accounting for multiple *** This is,to our knowledge,the first study within nutraceutical research for depression to assess the association between participant characteristics and variation in the placebo *** variables appeared to predict the placebo *** findings may encourage future trial design

关键词： Randomized controlled trial Placebo Depression Nutraceutical Psychiatry

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Pseudoainhum Associated With Lepromatous Leprosy:A Very Rare Association in Modern World

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International Journal of Dermatology and Venereology 2023年第2期6卷 110-111页

作者： Ahangama Arachchige Nilanga Nishad Mahathevan Pathman Seyed Ahamed Uwyse Ashan Mendis Prabath Kularathne Abeysundara Arjuna P.de Silva professorial Medical unit Colombo North Teaching HospitalColombo 11010Sri Lanka Department of Dermatology National Hospital of Sri LankaColombo 01000Sri Lanka Department of Dermatology Colombo North Teaching HospitalColombo 11010Sri Lanka Department of Clinical Medicine General HospitalAmpara 32350Sri Lanka Department of Clinical Medicine Faculty of MedicineUniversity of KelaniyaKelaniya 11300Sri Lanka.

Introduction:Pseudoainhum(dactylolysis spontanea)is characterized by the development of a fibrous band around the digit that gradually leads to *** pain associated with Pseudoainhum may not be evident in patients with neuropathic ***,we present a rare case of pseudoainhum patient,which describes a very rare association of pseudoainhum with *** presentation:A 48 year old male with lepromatous leprosy,with resorption of digits,charcot joints and tropical ulcers was seen in the *** forth digit of the left hand had a narrowing due to a fibrous band at the 2nd inter phalangeal joint with shiny tethering distal *** could not recall the duration of the *** was not suffering from any ***:The current report describes a very rare association of pseudoainhum with *** case involved a 48-year-old man in the dermatology ward with lepromatous leprosy presenting with a ***:This case highlights the possibility of delayed presentation of patients with pseudoainhum to physicians when the patients have underlying neuropathic conditions that prevent feeling finger pain and cause abnormal appearance of the digits,especially in leprosy.

关键词： pseudoainhum leprosy lepromatous leprosy case report

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Animal Nutrition and Feed Science

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Engineering 2017年第5期3卷 586-587页

作者： Adrian R. Egan Fellow of the Australian Academy of Technological Sciences and Engineering Emeritus Professor and Honorary professorial Research Fellow Faculty of Veterinary and Agricultural Sciences The University of Melbourne

1.引言动物营养和饲料科学学科可简单地分为以下两类:(1)研究动物对特定吸收物质的数量和平衡的生理需求(即营养需求);(2)天然植物和动物产品或合成物质提供全部或部分营养物质的能力(即饲料组成和营养成分利用率)。为了平衡饲料供应以... 详细信息

1.引言动物营养和饲料科学学科可简单地分为以下两类:(1)研究动物对特定吸收物质的数量和平衡的生理需求(即营养需求);(2)天然植物和动物产品或合成物质提供全部或部分营养物质的能力(即饲料组成和营养成分利用率)。为了平衡饲料供应以满足动物的需求。

关键词：饲料科学动物营养动物模型生理需求营养学家营养成分饲料供应饲料组 feeding nutrients

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Analysis of comparative genomic hybridization and loss of heterozygosity in 43 primary gastric carcinomas

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Chinese Medical Journal 2003年第4期116卷 517-523页

作者：王琦王柏秋关新元高慧程慧张岂凡黄承斌李璞傅松滨 Laboratory of Medical Genetics Department of BiologyHarbin Medical University Queen Mary Hospital The university of Hong KongRoom 129 Professorial BlockPokfulam Road The Third Affiliated Hospital Harbin Medical University

To investigate common chromosomal changes and the LOH frequency of microsatellite loci in primary gastric cancer samples in order to locate the deleted regions in which human gastric cancer related genes might exist Methods Comparative genomic hybridization (CGH) was used to define global chromosomal aberrations in 43 primary gastric tumors Based on the results of CGH, analysis of loss of heterozygosity (LOH) was performed in chromosome 19 in which the loss was first discovered in the gastric cancers The PCR-based approach was used to investigate 22 loci, which are spaced at 1 1-10 9 cM intervals throughout chromosome 19 The amplified PCR fragments were subjected to electrophoresis in PAGE gel and analyzed with Genescan TM and Genotyper TM Results CGH analysis revealed gains in chromosome 3p(8/43), 8q(8/43), 20 [20 (9/43), 20p(7/43), 20q(4/43)], 12q(16/43), 13q(12/43) and losses in 19 [19 (15/43)], 7 [17 (8/43), 17p (10/43)], 16 (10/43) and 1p (11/43) Among the 43 evaluated samples, the most frequent LOH was detected at locus D19S571 (27 81%) Conclusions The tumorigenesis of gastric cancer includes several chromosomal changes The aberration of chromosome 19 was the first common change founded in gastric cancer The region near the D19S571 might harbor potential genes related to the tumorigenesis of gastric cancer

关键词： comparative genome hybridization · loss of hetero zygosity · gastric cancer

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Review of Coeliac Plexus Blockade for the Management of Chronic Pancreatitis Pain at Tallaght University Hospital (TUH)

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Pain Studies and Treatment 2022年第3期10卷 21-34页

作者： Paul Ryan Kevin C. Conlon Philip Hu Paul Ridgway Marie Egan Camillus Power Department of Anaesthesia Intensive Care and Pain Medicine Tallaght University Hospital Dublin Ireland professorial Surgical unit Department of Surgery Trinity College Dublin and Tallaght University Hospital Dublin Ireland Department of Surgery Trinity College Dublin and Tallaght University Hospital Dublin Ireland Department of Anaesthesia Intensive Care and Pain Medicine Trinity College Dublin and Tallaght University Hospital Dub-lin Ireland

Background: Pain is a major problem for patients suffering from chronic pancreatitis. Unfortunately, medical therapy often fails to adequately control pain. Coeliac plexus block (CPB) is sometimes performed to treat intractable pain in patients with chronic pancreatitis. Aims: Our primary objective was to determine the effect of CPB for pain management in a cohort of patients with chronic pancreatitis. We also sought to quantify opioid use in patients with chronic pancreatitis. Methods: We reviewed the database of pain referrals for chronic pancreatitis and recorded opioid use for each patient. We interviewed all patients who underwent CPB for chronic pancreatitis at TUH from January 2018-December 2020. Effect of the block, duration of pain relief, analgesia requirements, complications and patient satisfaction were recorded. Results: 62 inpatient referrals were made to the pain service over a 3-year period regarding pain management in chronic pancreatitis. 76% of patients referred for chronic pancreatitis pain management require regular long-term opioids. Mean daily oxycodone requirement in this group was 52 mg. 11 of these patients underwent CPB over a 3-year period. Mean age of patients who underwent CPB was 44 years. Effective reduction in pain scores (>50% improvement) was achieved in 7 of 11 patients. The mean NRS pain score decreased from 9.2 (±0.9) to 4.4 (±3.1). Mean duration of pain relief experienced was 69 days. Transient diarrhoea was reported by 1 patient. 4 patients reported a temporary decrease in oral analgesia requirement, while 3 patients reported a sustained decrease in analgesia requirement post CPB. For those who had further CPBs, the effect of repeated interventions was comparable to the initial procedure. Conclusion: High regular opioid consumption is common in patients with chronic pancreatitis. CPB can provide significant improvement in pain control and quality of life in appropriately selected patients. CPB can assist with opioid reduction

关键词： Coeliac Plexus Block Chronic Pancreatitis Chronic Pain Opioid Analgesia Opioid Reduction

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Pathogenesis of overactive bladder and surgical treatment according to the Integral Theory Paradigm

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Gynecology and Obstetrics Clinical Medicine 2021年第2期1卷 55-61页

作者： Peter Petros Formerly University of NSW professorial Dept of Surgery St Vincent’s Hospital SydneyAustralia School of Mechanical and Mathematical Engineering University of Western AustraliaPerthWAAustralia

Overactive bladder(OAB is a definition by the International Continence Society(ICS).It comprises three symptoms,urge,frequency and *** is a major problem for up to 30%of women,more so for elderly *** is generally assumed to be a paradigm,but it cannot meet the criteria of a paradigm,as its causation is said to be"idiopathic"(unknown)and is said to have no known *** 1993,it was demonstrated that the sequence of events in urodynamically diagnosed detrusor overactivity(now"DO")was identical with what occurred in normal micturition,which led to the conclusion that frequency,urgency,nocturia were in effect,an uncontrolled but otherwise normal *** from a 1997 experiment indicated the control mechanism of the bladder was binary,either closed or open,regulated by a peripheral musculoligamentous system under cortical *** Integral Theory paradigm's view of OAB is based on and is compatible with,ICS definitions and *** Integral Theory paradigm(ITP)views OAB pathogenesis as anatomical,caused by defects anywhere along the control mechanism pathway,but mainly damage in its weakest link,collagen defects in the peripheral musculoligamentous *** tests to prove causation consist of mechanically supporting suspensory ligaments,pubourethral ligament(PUL)or uterosacral ligament(USL),"simulated operations";PUL support prevents urine loss on coughing;USL support by inserting the lower blade of a bivalve speculum into the vagina diminishes urge and *** ITP specifies treatment of correctible causes:squatting-based exercises to strengthen the reflex pelvic muscles,ligament repair by plication for premenopausal women,slings for postmenopausal women.

关键词： bladder treatment otherwise

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Sludge Pollution Control from Crude Oil Tank Cleaning

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Journal of Water Resource and Protection 2022年第9期14卷 632-649页

作者： Christopher C. Adigwe Ify L. Nwaogazie Ejikeme Ugwoha Adekunle O. David Ndubuisi G. Elemuo Department of Civil and Environmental Engineering University of Port Harcourt Choba Nigeria Department of Civil Engineering Olabisi Onabanjo Univesity Ibogun Campus Ibogun Nigeria Research Fellow at SPDC JV-ARET ADAMS professorial Chair in Petroleum Engineering University of Port Harcourt Choba Nigeria

This study investigated the use of microbial analysis as a bioremediation option for remediating petroleum sludge, which is part of the waste stream generated in the petroleum industry. The aim is to reduce environmental burden caused by the discharge of untreated sludge. Sludge sample was cultured in other to isolate microorganisms for the sludge treatment. The selected strain of the organisms after screening were Aspergillus flavus, Aspergillus niger, Verticillus sp, Penicillum sp, and Microsporium audouinii. Bioreactors (labeled A, B, C, D and O) were designed for the treatment of petroleum sludge. These reactors contain 2.0 × 10-2 m3 of the diluted sludge samples and the isolated organisms for the treatment process. On a weekly basis, the control reactors received 1.5 × 10-3 m3 of fresh and saline water respectively. After 12 weeks of treatment, sludge physicochemical characteristics showed distinct variations. From the result, reactor D was the best in terms of remediating the sludge as compared to other reactors. Friedman non-parametric test was performed to check if the weeks of treatment affected the reduction of the total hydrocarbon content (THC) in the five reactors and also checked for significant differences in the THC after treatments. The drop in the THC of the treated sludge ranged from 56.0% to 67.3%. These results showed the possibility of enhanced biodegradation of petroleum sludge by hydrocarbon utilizing microorganisms (fungi).

关键词： Petroleum Sludge Sludge Pollution Control Crude Oil Tank Cleaning Microbial Analysis Bioremediation Bioreactor

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Global Challenges for Chemical Engineering Education and the Impact from the “New World”

Global Challenges for Chemical Engineering Education and the...

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The 12th Asian Pacific Confederation of Chemical Engineering Congress

作者： David G Wood Chair of the World Chemical Engineering Council Executive Emeritus Professor ＆ professorial Fellow Department of Chemical and Biomolecular EngineeringUniversity of Melbourne

＜正＞Countries having the most impact on chemical engineering education for its first one hundred years include the USA,united Kingdom,Germany and France and yet the undergraduate pro- grams in each of these countries are very different in structure and to a lesser extent in curricula. For the purposes of this paper these countries and those that have developed similar education sys- tems *** and Australia are regarded as "Old World".

关键词： Global Challenges for Chemical Engineering Education and the Impact from the New World

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Maternal Perception on Obesity;Its Complications and Gestational Weight Gain in Pregnant Mothers Presenting to Antenatal Clinics in a South Asian Teaching Hospital (De Soyza Hospital for Women Colombo—DSHW)

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Advances in Reproductive Sciences 2019年第2期7卷 21-30页

作者： Wijemunige Chamara Charith Gunathilaka Surangi Nilanka Jayakody Senani Hemantha Dodampahala Thavendra Kumaran Senior House Officer De Soyza Hospital for Women Colombo Sri Lanka Lecturers in Community Medicine Faculty of Medical Sciences University of Sri Jayewardenepura Colombo Sri Lanka Obstetrics and Gynecology Professorial Unit De Soyza Hospital for Women Colombo Sri Lanka Faculty of Medicine University of Colombo Colombo Sri Lanka

The rates of overweight and obesity are rising to epidemic proportions globally, especially among women. Obesity is increasingly common in the obstetric population as well. Sri Lanka is not an exception to this regard. There is limited published data on maternal perceptions on obesity in pregnancy, gestational weight gain and its complications. The current study aimed to describe the maternal perception on obesity, their knowledge on complications of obesity in pregnancy and gestational weight gain in pregnant mothers. Hospital based descriptive cross sectional study was conducted among a systematic sample of 416 pregnant women registered for antenatal clinic care at De Soyza Maternity Hospital. Pre-tested interviewer administered questionnaire was used for data collection. Maternal BMI at booking visit was taken from the pregnancy record to assess the overweight/obesity prevalence among the study population. Nearly one third (32.2%) of the study population were overweight and 11.8% were obese. Fifty three percent (53%) of overweight women identified themselves as such, but 45% of them considered themselves to be normal weight. Most of the pregnant women in the study sample (59.6%) were unable to estimate the recommended weight gain in pregnancy. Women’s knowledge on the specific risks associated with maternal obesity was poor. Pregnant mother’s knowledge on obesity, gestational weight gain and its consequences were unsatisfactory. Bridging this knowledge gap is an important step towards improving perinatal outcomes for all pregnant mothers in the current obesity epidemic.

关键词： Overweight Obesity Gestational Weight Gain Maternal Complications Medical Nutrition Therapy South Asia

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Dietary intake in patients with chronic pancreatitis:A systematic review and meta-analysis

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World Journal of Gastroenterology 2021年第34期27卷 5775-5792页

作者： Qurat Ul Ain Yasir Bashir Linda Kelleher David M Bourne Suzanne M Egan Jean McMahon Laura Keaskin Oonagh M Griffin Kevin C Conlon Sinead N Duggan professorial Surgical unit Department of SurgeryTrinity College DublinDublin 24 D24 NR0AIreland Department of Nutrition and Dietetics Tallaght University HospitalDublin 24 D24 NR0AIreland Department of Newcastle Nutrition Freeman HospitalNewcastle Upon Tyne NE77DNUnited Kingdom Library and Information Services Tallaght Tallaght University HospitalDublin 24 D24 NR0AIreland Department of Nutrition and Dietetics St.Vincent’s University HospitalDublin 4 D04 T6F4Ireland

BACKGROUND A progressive reduction in the secretion of pancreatic enzymes in patients with chronic pancreatitis(CP)results in malabsorption and ultimate ***,the pathogenesis of malnutrition is multifactorial and other factors such as chronic inflammation,alcohol excess and poor dietary intake all *** may restrict their dietary intake due to poor appetite or to avoid gastrointestinal symptoms and abdominal *** up to half of patients with chronic pancreatitis are reportedly malnourished,the dietary intake of patients with CP is relatively understudied and has not been systematically reviewed to *** To perform a systematic review and meta-analysis of the dietary intakes of patients with CP compared to healthy controls,and to compare the dietary intake of patients with alcohol-related CP and non-alcohol-related *** A systematic literature search was performed using EMBASE,MEDLINE,and Cochrane review on studies published between 1946 and August 30th,*** subjects with a diagnosis of CP who had undergone dietary assessment were included in the systematic review(qualitative analysis).Studies on patients with other pancreatic diseases or who had undergone pancreatic surgery were not *** comparing the dietary intake of patients with CP to that of healthy controls were included in the meta-analysis(quantitative analysis).Metaanalysis was performed using Review Manager *** Ottawa Scale(NOS)was used to assess quality of *** Of 6715 studies retrieved in the search,23 were eligible for qualitative analysis while 12 were eligible for quantitative *** the meta-analysis,the total energy(calorie)intake of patients with CP was similar to that of healthy controls[mean difference(MD):171.3;95%confidence interval(CI):-226.01,568.5;P=0.4],however patients with CP consumed significantly fewer non-alcohol calories than controls[MD:-694.1;95%CI:-1256.1,(-132.1);P=0.02].CP patients consumed m

关键词： Systematic review Meta-analysis Chronic pancreatitis Dietary intake Undernutrition Alcohol-related chronic pancreatitis

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