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第三届营养与保健食品专业会议

作者： Joanne R.Lupton Regents William W.Allen Ph.D. endowed chair in nutrition texas a&m university professor endowed chair in nutrition texas a&m university

讨论的内容1)定义“膳食纤维”的准备工作2)纤维定义小组进行定义的过程3)已经提出的定义4)加拿大和美国目前对纤维摄入量的推荐

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Adoptive transfer of Pfkfb3-disrupted hematopoietic cells to wild-type mice exacerbates diet-induced hepatic steatosis and inflammation

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Liver Research 2020年第3期4卷 136-144页

作者： Xin Guo Bilian Zhu Hang Xu Honggui Li Boxiong Jiang Yina Wang Benrong Zheng Shannon Glaser Gianfranco Alpini Chaodong Wu Department of nutrition Texas A&M UniversityCollege StationTXUSA Department of nutrition and Food Hygiene School of Public HealthCheeloo College of MedicineShandong UniversityJinanChina Department of VIP medical Service Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina medical Physiology Texas A&M University College of MedicineBryanTXUSA Hepatology and Gastroenterology MedicineIndiana UniversityIndianapolisINUSA Richard L.Roudebush VA medical Center IndianapolisINUSA

Background and objectives:Hepatic steatosis and inflammation are key characteristics of non-alcoholic fatty liver disease(NAFLD).However,whether and how hepatic steatosis and liver inflammation are differentially regulated remains to be *** that disruption of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3(Pfkfb3/iPfk2)dissociates fat deposition and inflammation,the present study examined a role for Pfkfb3/iPfk2 in hematopoietic cells in regulating hepatic steatosis and inflammation in ***:Pfkfb3-disrupted(Pfkfb3^(+/-))mice and wild-type(WT)littermates were fed a high-fat diet(HFD)and examined for NAFLD ***,bone marrow cells isolated from Pfkfb3^(+/-)mice andWT mice were differentiated into macrophages for analysis of macrophage activation status and for bone marrow transplantation(BmT)to generate chimeric(WT/BmT-Pfkfb3^(+/-))mice in which Pfkfb3 was disrupted only in hematopoietic cells and control chimeric(WT/BmT-WT)*** latter were also fed an HFD and examined for NAFLD *** vitro,hepatocytes were co-cultured with bone marrowderived macrophages and examined for hepatocyte fat deposition and proinflammatory ***:After the feeding period,HFD-fed Pfkfb3^(+/-)mice displayed increased severity of liver inflammation in the absence of hepatic steatosis compared with HFD-fed WT *** inflammatory activation was analyzed,Pfkfb3^(+/-)macrophages revealed increased proinflammatory activation and decreased anti-proinflammatory *** NAFLD phenotype was analyzed in the chimeric mice,WT/BmT-Pfkfb3^(+/-) mice displayed increases in the severity of HFD-induced hepatic steatosis and inflammation compared with WT/BmT-WT *** the cellular level,hepatocytes co-cultured with Pfkfb3^(+/-) macrophages revealed increased fat deposition and proinflammatory responses compared with hepatocytes co-cultured with WT ***:Pfkfb3 disruption only in hematopoietic cells exacerbates HFD-induce

关键词： 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3(Pfkfb3/iPfk2) Hematopoietic cells Hepatic steatosis Inflammation macrophages

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Necrotizing Fasciitis Secondary to Emphysematous Cholecystitis and Cholecystocutaneous Fistula: A Rare Case Report Presentation

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Surgical Science 2023年第5期14卷 388-397页

作者： Alexandra N. Dominianni Samantha A. Delapena Luis G. Fernandez mostaffa T. Jabassini Sean F. O’Keefe Rachel L. Villanueva marc R. matthews College of medicine-Phoenix University of Arizona Phoenix AZ USA Creighton university Arizona Health Education Alliance Phoenix AZ USA Department of Surgery Division of Trauma Surgery/Surgical Critical Care The University of Texas Health Science Center Tyler TX USA The university of texas-Tyler School of medicine Bill Barrett endowed chair in Trauma Surgery Tyler TX USA Trauma Wound Care UT Health East Tyler TX USA Department of Surgery University of Texas Medical Branch Galveston TX USA Adjunct Clinical professor of medicine and Nursing University of Texas Arlington TX USA Past Commanding General TXSG medical Brigade Austin TX USA Surgical Resident Abrazo Health Network General Surgery Residency Glendale AZ USA Area Sales manager Miach Orthopedics Surgical Acute Account manager 3M Minneapolis MN USA Clinical professor of Surgery Banner University of Arizona/University Medical Center Tucson AZ USA

Emphysematous cholecystitis is a rare subtype of acute cholecystitis characterized by the presence of gas in the gallbladder wall secondary to ischemia. Typically, this is a result of cystic artery vascular compromise with a concomitant infection from gas-forming organisms such as Clostridium species, Klebsiella species, or Escherichia coli. The mortality rate of acute emphysematous cholecystitis is 15% - 20% compared with 1.4% in uncomplicated acute cholecystitis. The subsequent development of a cholecystocutaneous fistula, an abnormal connection between the gallbladder and the skin, is also a rare complication of gallbladder disease. We describe a case of a 77-year-old male who presented with right flank necrotizing fasciitis which developed from a cholecystocutaneous fistula secondary to emphysematous cholecystitis. Once the necrotic tissues were adequately debrided, the large open wound was treated with negative pressure wound therapy with instillation (NPWT-i) utilizing hypochlorous acid (HOCL). The wound was closed with a split-thickness skin graft.

关键词： Emphysematous Cholecystitis Gangrenous Cholecystitis Cholecystocutaneous Fistula Necrotizing Fasciitis Sepsis

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