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High-risk screening combined with family screening for Fabry disease in adult hemodialysis population-a family report of GLA IVS4+919G>A mutation in Fabry disease

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China Medical Abstracts(Internal Medicine) 2024年第2期41卷 113-113页

作者：陈冰蓉 dept Nephrol Children's HospZhejiang Univ Med SchNatl Clin Child Health Res CenterHangzhou 310052

Objective To explore the combination of high risk screening and family screening for potential patients with Fabry disease in adult hemodialysis population,and to improve the diagnostic efficiency of the *** It was a cross-sectional investigation ***-risk screening for Fabry disease was performed on adult hemodialysis patients with end-stage kidney disease who were admitted to Yongkang First People's Hospital of Zhejiang Province between November 2022 and February *** blood paperα-galactosidase A(α-Gal A)detection assay was performedin males,or glycosphingolipids(Lyso-CL-3)detection assay was performed in *** genetic assay was performed for further diagnosis after abnormal screening *** screening was carried out on the family members of the confirmed Fabry disease patients,andα-Gal A activity and Lyso-GL-3 of peripheral blood were ***,urine routine,blood biochemistry,eye examination,hearing test,cranial magnetic resonance imaging,and electrocardiogram were performed to assess organ *** Among 244 hemodialysis patients,139(56.97%)were males and 105(43.03%)were females.

关键词： admitted GLA routine

Does Periconceptional Fish Consumption by Parents Affect the Incidence of Autism Spectrum Disorder and Intelligence Deficiency?A Case-control Study in Tianjin,China

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Biomedical and Environmental Sciences 2016年第12期29卷 885-892页

作者： GAO Lei CUI Shan Shan HAN Yu DAI Wei SU Yuan Yuan ZHANG Xin dept.Maternal child&Adolescence health of School of Public health Tianjin Medical UniversityTianjin 300070China Department of Nutrition and Food Science Sehool of Public HealthTianjin Medical UniversityTianjin 300070China

Objective This study aimed to explore the association between periconceptional fish consumption by parents and autism spectrum disorder （ASD） and intelligence deficiency （ID）. Methods A case-control study was conducted through a questionnaire with 108 ASD cases, 79 ID cases, and 108 controls. The ASD and ID cases were students from special educational schools in Tianjin from 2012 to 2014. The age- and sex-matched controls were from a high school, three primary schools, and a kindergarten in Tianjin. Multivariate logistic regression was performed. Results Paternal habit of eating hairtail before fertilization, maternal preference for fruits during pregnancy, and maternal habit of eating grass carp during pregnancy were preventive factors for ASD. Paternal habit of drinking alcohol before fertilization was a risk factor for ID, whereas maternal preference for fruits during pregnancy and maternal habit of eating crucian carp during pregnancy were protective factors for ID. Conclusion Parental fish consumption is beneficial for the prevention of ASD and ID. Meanwhile, the protective effects of fish consumption on ASD and ID differ. More attention should be paid to the combined effect of other food when eating fish.

关键词： Parental fish consumption Periconception Autism spectrum disorder Intelligencedeficiency

EVALUATION ON THE EFFECT OF A SHORT-TERM INTERVENTION OF SEXUAL/REPRODUCTIVE health EDUCATION AMONG RURAL MIDDLE SCHOOL STUDENTS

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Academic Journal of Xi'an Jiaotong University 2001年第2期13卷 89-93页

作者：李燕琴郑全庆李学成路平王芝芳王懿 dept. of Maternal and child health Xi' an Jiaotong University Xi' an 710061 China

Objective To analyze and evaluate the impact of adolescents’ sexual and reproductive health education on students’ sexual knowledge,attitude and *** A short term intervention was conducted among high school students in two schools in Xixiang county,Shaanxi *** intervention was carried out in the forms of manual,video,discussion,consultation,and so on .The contents of intervention consisted of the knowledge about adolescent physiology,care,conception,STD/HIV, and so on. Results The results showed that students’ knowledge increased significantly(11.92±4.61 before intervention vs 19.81±4.8 after intervention, P =0.000).The sexual attitude and behavior changed insignificantly,especially the change of *** The intervention is significantly effective in increasing knowledge,but less effective in the change of attitude and almost ineffective in the behavior change.

关键词： middle school student sexual/reproductive health health education intervention

THE ANALYSIS OF child′S GROWTH TREND DURING 1958～1995 IN XI′AN CITY

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Journal of Pharmaceutical Analysis 1999年第2期13卷 182-185页

作者： Hou Rulan,Tang Xiaohongdept. of Epidemiology, Xi′an Medical University, Xi′an 710061 Department of child and Adolescent health, Xi′an Medical University, Xi′an 710061 dept. of child and Adolescent health Xi'an Medical University Xi'an 710061 China

The paper analyzed the growth level and velocity to find the growth trend with the data collected in 8 investigations on growth of children aged 7～17 years in 1958～1995 in Xi′an. The results showed that child′s growth level was elevated with the passage of years and was the lowest in 1962, the highest in 1995 during the 38 years. The height of boy of the same age in 1995 has average increased by 9 59 cm over 1958 and girl 8 38 cm. The weight of boy of the same age in 1995 has averagely increased by 8 35 kg over 1958 and girl 5 90 kg. The chest girth of boy of the same age in 1995 has average increased by 5 69 cm over 1958 and girl 4 66 cm. The growth level of children aged 9～15 years had greater increase than others in 7～17 years of age. The average increment per 10 years of boy's height was 2 57 cm and girl's 2 26 cm. The average increment of per 10 years of boy's weight was 2 17 kg and girl's 1 56 kg. The average increment of per 10 years of boy's chest girth was 1 50 cm and girl's 1 23 cm. The analysis of the growth velocity in different period during 38 years showed the velocity in 1958～1962 was a negative value and indicated a growth retard, but the velocity in 1962～1964 was the fastest and indicated a catch up growth. And then, growth velocities of height, weight and chest girth were different in different period. The analysis of the growth curves of height, weight and chest girth showed that the 2 cross ages were 1～3 years of age ahead of time and menarche and emission also were ahead of time that during the 38 years indicated there is a child's growth acceleration in Xi′an and the trend of child's growth acceleration could continue if there are more and better nourishment, sports requisites, health care and housing conditions.

关键词： child growth growth retard catch up growth growth trend

呼吸道合胞病毒感染住院的早产学龄前患儿卫生保健使用情况的评估

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世界核心医学期刊文摘（儿科学分册） 2005年第4期1卷 21-22页

作者： Greenough A. Alexander J. Burgess S. 刘健 prof.dept. of child health King's College Hospital London SE5 9RS United Kingdom

背景:有慢性肺脏疾病(CLD)早产儿,其因呼吸道合胞病毒(RSV)感染而住院治疗与其生后前两年的使用卫生保健和花费的增加有关。本文目的在于确定患慢性肺脏疾病的早产儿生后前两年的因RSV住院治疗是否与其学龄前的慢性呼吸系统疾病发病有... 详细信息

背景:有慢性肺脏疾病(CLD)早产儿,其因呼吸道合胞病毒(RSV)感染而住院治疗与其生后前两年的使用卫生保健和花费的增加有关。本文目的在于确定患慢性肺脏疾病的早产儿生后前两年的因RSV住院治疗是否与其学龄前的慢性呼吸系统疾病发病有关。方法:回顾性分析患儿2-4岁及5岁时再次住院治疗。

关键词：卫生保健呼吸道合胞病毒住院治疗合胞平均胎龄 gestational birth median 生活质量 versus

Acceptability and associated factors of preexposure prophylaxis based on different sexual purpose among human immunodeficiency virus male sero-discordant couples

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China Medical Abstracts (Internal Medicine) 2017年第4期 206-207页

作者：覃寿学 dept child health Care Guigang Maternal & Child Health Care Hosp

Objective To study the acceptability and associated factors of pre-exposure prophylaxis(PrEP)based on different sexual purpose among human immunodeficiency virus(HIV)male serodiscordant *** HIVnegative female spouses of HIV-positive male in Guigang,Guiping and Pingnan county in Guangxi Zhuang Autonomous Region were recruited by the existing epidemic database and the method of cluster random

关键词： HIV Acceptability and associated factors of preexposure prophylaxis based on different sexual purpose among human immunodeficiency virus male sero-discordant couples

Comparing maternal and neonatal outcomes between hands-and-knees delivery position and supine position

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International Journal of Nursing Sciences 2016年第2期3卷 178-184页

作者： Hong-Yu Zhang Rong Shu Ning-Ning Zhao Yu-Jing Lu Min Chen Ying-Xia Li Jun-Qin Wu Li-Hua Huang Xiao-Lan Guo Yu-Hong Yang Xiao-Li Zhang Xiao-Yu Zhou Ren-Fei Guo Jing Li Wen-Zhi Cai Nursing dept.of Hainan Medical University Haikou 571119China Nanfang Medical University Guangzhou 520000China dept.of Obstetric Cangxian HospitalCangzhou 061000China dept.of Obstetric Dongchang Maternal and Child Health HospitalLiaocheng 252000China dept.of Obstetric Gongan People's HospitalJingzhou 434300China dept.of Obstetric Yanshan People's HospitalCangzhou 061300China dept.of Obstetric Dongguan Maternal and Child Health HospitalDongguan 523002China dept.of Obstetric Baoan Maternal and Child Health HospitalShenzhen 518101China dept.of Obstetric Juxian People's HospitalRizhao 276500China dept.of Obstetric East Part of the Fourth Hospital of Hebei Medical UniversityShijiazhuang 050035China dept.of Obstetric Nanhai People's HospitalFoshan 528200China dept.of Obstetric Haikou Maternal and Child Health HospitalHaikou 571100China dept.of Obstetric Jiangmen Wuhu Chinese Medicine HospitalJiangmen 529020China

Background:The supine position is the most common birth position adopted in China,but the World health Organization recommends non-supine positions for *** handsand-knees position shows several advantages,such as wide pelvic diameter and easy fetal rotation during *** trials conducted in China in 2011 revealed that the handsand-knees position resulted in improved maternal and neonate outcomes than those in the supine ***,a comprehensive study must be conducted before the handsand-knees position can be introduced into clinical ***,we conducted this multicenter trial to comprehensively examine the benefits of the hands-and-knees position over the supine position during ***:Our clinical study was conducted in 11 hospitals in China from May to December 2012.A total of 446 pregnant women who gave birth in the hands-and-knees position were assigned into the experimental group,and 440 women who gave birth in the supine position were classified into the control *** rate was evaluated as the primary outcome,and perineum laceration degree was considered the secondary ***:Women in the experimental group achieved lower rates of episiotomy and higher rates of intact perineum and first-degree perineum lacerations compared with those in the *** bleeding amount,neonatal asphyxia,and APGAR scores at 1 and 5 min were not significantly different between the two ***:This study proves that women who delivered in the hands-and-knees position achieved low rates of episiotomy and intact ***,the rates of neonatal asphyxia and postpartum bleeding did not *** patients who prefer to adopt the hands-and-knees position should be assisted in assuming such position during delivery.

关键词： Supine delivery position Hands-and-knees delivery position Episiotomy

The enhancing effect and promoting mechanisms of the stereoisomeric monoterpene alcohol esters as enhancers for drugs with different physicochemical properties

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Asian Journal of Pharmaceutical Sciences 2022年第1期17卷 139-152页

作者： Heping Wang Yan Li Chunyan Wang Jing Wang Bo Ren Xiaona Li Mingzhu Li Dandan Geng Chensi Wu Ligang Zhao School of Pharmacy North China University of Science and TechnologyTangshan 063000China dept of Pharmacy Tangshan Maternal and Child Health HospitalTangshan 063000China Tangshan key laboratory of novel preparations and drug release technology Tangshan 063000China

To explore the structure-activity connections of amphiphilic permeation enhancers containing the length of the hydrophobic chains as well as the properties of the polar head,O-acylgeraniol and O-acylnerol derivatives were synthesized from geraniol/nerol(cis-isomer of geraniol) and pharmaceutical excipient acids in this research. Their promotion of the percutaneous absorption of three drugs as the model, flurbiprofen(FP), isosorbide dinitrate(ISDN) and donepezil(DNP), which were selected based on their physicochemical properties,was tested by in vitro skin penetration and in vivo. Molecular simulation, ATR-FTIR, CLSM and histological observation were implement to evaluate the mode of action of the *** results indicated that(E)-3,7-dimethyl-2,6-octadien-1-yl tetradecanoate(GER-C14, trans-)achieved the highest enhancement ability for the three drugs;additionally, the in vivo results obtained were in good correlation with the in vitro data. Molecular docking results suggested that enhancers loosen the hydrogen bonds between ceramides, and the results of molecular simulation indicated that GER-C14, NER-C14 could insert into the middle of the lipid bilayer to form an independent phase. According to ATR-FTIR and histological evaluation, the enhancers extracted lipids and influenced the protein region, thereby disturbing the skin array. In addition, CLSM described the dynamic effects of enhancers on lipids between stratum corneum(SC) cells. In conclusion, GER-C14 had a better penetration promotion effect, which broadened our understanding of stereoisomeric penetration enhancers.

关键词： O-acylgeraniol derivatives O-acylnerol derivatives Transdermal drug delivery system In vitro and in vivo correlation Enhancing mechanism

Long-term outcome of percutaneous balloon aortic valvuloplasty for children with congenital aortic valve stenosis

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China Medical Abstracts(Internal Medicine) 2021年第1期38卷 33-34页

作者： HAN Yong dept Peadatric Cardiol Liuzhou Maternal&Child Health HospLiuzhou 545001

Objective To assess the efficacy and long-term outcome of percutaneous balloon aortic valvuloplasty(PBAV) for children with congenital aortic stenosis(CAS) and to explore risk factors for significant aortic regurgitat... 详细信息

关键词： balloon aortic stenosis