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A novel responsive stabilizing Janus nanosilica as a nanoplugging agent in water-based drilling fluids for exploiting hostile shale environments

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Petroleum Science 2024年第2期21卷 1190-1210页

作者： Alain Pierre Tchameni Lv-Yan Zhuo Lesly Dasilva Wandji Djouonkep Robert Dery Nagre Lu-Xin Chen Lin Zhao Chao Ma Bin-Qiang Xie College of Petroleum engineering Yangtze UniversityWuhan430100HubeiChina Key Laboratory of Drilling and production engineering for Oil and Gas HubeiChina Lost Circulation Control Laboratory National Engineering Laboratory for Petroleum Drilling EngineeringYangtze UniversityWuhan430100HubeiChina College of Petroleum engineering Shandong Institute of Petroleum and Chemical TechnologyDongying257061ShandongChina Petroleum Engineer Research Institute of Petrochina Dagang Oilfield Tianjin300280China Department of Chemical engineering Kumasi Technical UniversityP.O.Box 854KumasiGhana

Thermo-responsive nanocomposites have recently emerged as potential nanoplugging agents for shale stabilization in high-temperature water-based drilling fluids(WBDFs). However, their inhibitory properties have not been very effective in high-temperature drilling operations. Thermo-responsive Janus nanocomposites are expected to strongly interact with clay particles from the inward hemisphere of nanomaterials, which drive the establishment of a tighter hydrophobic membrane over the shale surface at the outward hemisphere under geothermal conditions for shale stabilization. This work combines the synergistic benefits of thermo-responsive and zwitterionic nanomaterials to synchronously enhance the chemical inhibitions and plugging performances in shale under harsh conditions. A novel thermoresponsive Janus nanosilica(TRJS) exhibiting zwitterionic character was synthesized, characterized,and assessed as shale stabilizer for WBDFs at high temperatures. Compared to pristine nanosilica(Si NP)and symmetrical thermo-responsive nanosilica(TRS), TRJS exhibited anti-polyelectrolyte behaviour, in which electrolyte ions screened the electrostatic attraction between the charged particles, potentially stabilizing nanomaterial in hostile shaly environments(i.e., up to saturated brine or API brine). Macroscopically, TRJS exhibited higher chemical inhibition than Si NP and TRS in brine, prompting a better capability to control pressure penetration. TRJS adsorbed onto the clay surface via chemisorption and hydrogen bonding, and the interactions became substantial in brine, according to the results of electrophoretic mobility, surface wettability, and X-ray diffraction. Thus, contributing to the firm trapping of TRJS into the nanopore structure of the shale, triggering the formation of a tight hydrophobic membrane over the shale surface from the outward hemisphere. The addition of TRJS into WBDF had no deleterious effect on fluid properties after hot-treatment at 190℃, implying that TRJ

关键词： Janus nanosilica Thermo-responsive copolymer Anti-polyelectrolyte effect Shale stabilizer Inhibition Plugging Drilling fluid

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SARS-CoV2 Nsp3 protein triggers cell death and exacerbates amyloid β42-mediated neurodegeneration

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Neural Regeneration Research 2024年第6期19卷 1385-1392页

作者： Aditi Singh Anuradha Venkatakrishnan Chimata Prajakta Deshpande Soumya Bajpai Anjali Sangeeth Mrigendra Rajput Amit Singh Department of Biology University of DaytonDaytonOHUSA Premedical program University of DaytonDaytonOHUSA Center for Tissue Regeneration and engineering at Dayton(TREND) University of DaytonDaytonOHUSA The Integrative Science and engineering Center University of DaytonDaytonOHUSA Center for Genomic Advocacy(TCGA) Indiana State UniversityTerre HauteINUSA

Infection caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV2)virus,responsible for the coronavirus disease 2019(COVID-19)pandemic,induces symptoms including increased inflammatory response,severe acute respiratory syndrome(SARS),cognitive dysfunction like brain fog,and cardiovascular ***-term effects of SARS-CoV2 COVID-19 syndrome referred to as post-COVID-19 syndrome on age-related progressive neurodegenerative disorders such as Alzheimer's disease remain *** the targeted misexpression of individual SARS-CoV2 proteins in the retinal neurons of the Drosophila melanogaster eye,we found that misexpression of nonstructural protein 3(Nsp3),a papain-like protease,ablates the eye and generates dark necrotic *** misexpression of Nsp3 in the eye triggers reactive oxygen species production and leads to apoptosis as shown by cell death reporters,terminal deoxynucleotidyl transferase(TdT)dUTP Nick-end labeling(TUNEL)assay,and dihydroethidium ***,Nsp3 misexpression activates both apoptosis and autophagy mechanism(s)to regulate tissue *** expression of SARS-CoV2 Nsp3 in murine neuroblastoma,Neuro-2a cells,significantly reduced the metabolic activity of these cells and triggers cell *** of SARS-CoV2 Nsp3 in an Alzheimer's disease transgenic fly eye model(glass multiple repeats[GMR]>amyloidβ42)further enhances the neurodegenerative rough eye phenotype due to increased cell *** findings suggest that SARS-CoV2 utilizes Nsp3 protein to potentiate cell death response in a neurodegenerative disease background that has high pre-existing levels of neuroinflammation and cell death.

关键词： Alzheimer's disease apoptosis autophagy COVID-19 Drosophila necrosis Neuro-2a cells neurodegeneration post COVID-19 syndrome SARS-CoV2

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Science China(Life Sciences) 2024年第9期67卷 1970-1988页

作者： Jiayi Yu Changbing Zheng Qiuping Guo Yulong Yin Yehui Duan Fengna Li CAS Key Laboratory of Agro-ecological Processes in Subtropical Region Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic ProcessNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China University of Chinese Academy of Sciences Beijing 100049China College of Animal Science and Technology Hunan Agricultural UniversityChangsha 410128China

We previously demonstrated that lipopolysaccharide(LPS)injection-induced immune stress could impair muscle growth in weaned piglets,but the precise mechanisms behind this remain ***,we found that chronic immune stress induced by LPS resulted in a significant reduction of 36.86%in the total muscle mass of piglets at 5 d post-treatment compared with the control *** 1 d,prior to muscle mass loss,multiple alterations were noted in response to LPS *** included a reduction in the abundance of Bacteroidetes,an increase in serum concentrations of pro-inflammatory cytokines,compromised mitochondrial morphology,and an upregulation in the expression of dynamin-related protein 1(Drp1),a critical protein involved in mitochondrial *** highlight a strong negative correlation between Bacteroidetes abundance and the levels of serum pro-inflammatory cytokines,corroborated by in vivo intervention strategies in the musculature of both pig and mouse ***,the effects of Bacteroidetes on inflammation and muscle mass loss may involve the signaling pathway of the tauro-β-muricholic acid-fibroblast growth factor ***,the induction of overexpression of inflammatory cytokines,achieved without LPS treatment through oral administration of recombinant human IL-6(rh IL-6),led to increased levels of circulating cytokines,subsequently causing a decrease in muscle ***,pre-treatment with Mdivi-1,an inhibitor of Drp-1,markedly attenuated the LPS-induced elevation in reactive oxygen species levels and rescued the associated decline in muscle ***,these data indicate that LPS-induced muscle mass loss was linked to the reduction of Bacteroidetes abundance,increased inflammation,and the disruption of mitochondrial *** insights offer promising avenues for the identification of potential therapeutic targets aimed at mitigating muscle mass loss.

关键词： Bacteroidetes inflammation mitochondrial morphology muscle mass loss piglets

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Phase separation and domain crystallinity control enable open-air-printable highly efficient and sustainable organic photovoltaics

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InfoMat 2024年第3期6卷 131-143页

作者： Jie Lv Xiaokang Sun Hua Tang Fei Wang Guangye Zhang Liangxiang Zhu Jiaming Huang Qianguang Yang Shirong Lu Gang Li Frédéric Laquai Hanlin Hu Hoffmann Institute of Advanced Materials Shenzhen Polytechnic UniversityShenzhenthe People's Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhenthe People's Republic of China School of Materials Science and engineering Xiangtan UniversityXiangtanthe People's Republic of China KAUST Solar Center Physical Sciences and Engineering Division(PSE)Materials Science and Engineering Program(MSE)King Abdullah University of Science and Technology(KAUST)ThuwalKingdom of Saudi Arabia College of New Materials and New Energies Shenzhen Technology UniversityShenzhenthe People's Republic of China Department of Electronic and Information engineering The Hong Kong Polytechnic UniversityHong Kong SARthe People's Republic of China Department of Material Science and Technology Taizhou UniversityTaizhouthe People's Republic of China

Organic solar cells(OSCs)have emerged as a promising solution for sustainable energy production,offering advantages such as a low carbon footprint,short energy payback period,and compatibility with ***,the use of hazardous solvents continues to dominate the best-performing OSCs,mainly because of the challenges of controlling phase separation and domain crystallinity in *** this study,we combined the solvent vapor treatment of CS2 and thermal annealing to precisely control the phase separation and domain crystallinity in PM6:M-Cl and PM6:O-Cl systems processed with the eco-solvent *** method resulted in a maximum power conversion efficiency(PCE)of 18.4%,which is among the highest values reported for sustainable binary ***,the fabrication techniques were transferred from spin coating in a nitrogen environment to blade printing in ambient air,retaining a PCE of 16.0%,showing its potential for high-throughput and scalable *** addition,a comparative analysis of OSCs processed with hazardous and green solvents was conducted to reveal the differences in phase *** work not only underscores the significance of sustainability in OSCs but also lays the groundwork for unlocking the full potential of open-air-printable sustainable OSCs for commercialization.

关键词： open-air printable organic solar cells sustainability

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Fluid flow simulation of industrial fixed bed mixed-flow grain dryer using k-ω SST turbulence model

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International Journal of Agricultural and Biological engineering 2021年第2期14卷 226-230页

作者： Anderson Rodrigo Visconcini Cid Marcos Gonçalves Andrade Alexandre Marconi de Souza Costa post-graduation Department of Mechanical engineering University of MaringáAv.Colombo3790-Bloco 14-Sala 2487020-900Maringá-PRBrazil

The fluid dynamics analysis on industrial,mixed-flow grain dryers with fixed bed using computational techniques is necessary to assist the design of such equipment contributing to cost reduction in the dryer projects and agricultural drying operations that involve the production of grains in the *** study presents a Computational Fluid Dynamic(CFD)solution for air flow analysis in an industrial *** air flow at the inlet and outlet of the dryer was investigated using the k-ωSST turbulence *** dryer region with soybean was considered as a laminar porous medium flow in the permanent and isothermal regime,having for the model a simplified geometry with the tower considered as a porous medium and the air inlet and outlet as a turbulent fluid *** flow was treated with a permanent and isothermal *** flow and pressures were used according to design *** validate the k-ωSST turbulence model,the velocity profile at the dryer inlet was obtained experimentally,which presented results with good agreement between the numerical and the experimental *** model obtained satisfactory results of the computational validation of the air flow in the dryer with good convergence requiring a minimum of computational effort,being suitable for the simulation of industrial-scale dryers,as to its air flow through a tower,operating with fixed bed soybean in the steady and isothermal regime.

关键词： computational methods fixed bed porous medium soybean dryer turbulent flow

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Soil Erodibility Rates through a Hydraulic Flume Erosometer: Test Assembly and Results in Sandy and Clayey Soils

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Open Journal of Civil engineering 2023年第1期13卷 155-170页

作者： Cleyton Stresser Larissa de Brum Passini program of post-graduation in Civil engineering (PPGEC) Federal University of Parana (UFPR) Curitiba Brazil

This paper presents a proposal for erodibility quantitative evaluation through a hydraulic flume based on the Inderbitzen erosion test. The equipment scheme and procedures for result calculation are described, following a review of literature. Through the proposed procedure, 24 tests are conducted, in order to study the erodibility of a sandy soil and a clayey soil, in undeformed and reconstituted conditions. These are conducted using grass roots in controlled quantities, to quantify root effects on erodibility. The results of soil loss by elapsed time and the definition of the erodibility K factor shows that clayey soil is 90% less erodible compared with sandy soil. Also, roots show no significant relationship with K factor and the undeformed sample is less erodible, compared with reconstituted sample. The test methodology and the results allowed soil classification, analytical data and comparative results between different cases.

关键词： Erosion Rates Procedures Low-Cost Criteria

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Dynamic Routing Combined to Forecast the Behavior of Traffic in the City of Sao Paulo Using Neuro Fuzzy Network

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Computer Technology and Application 2011年第1期2卷 36-41页

作者： Ricardo Pinto Ferreira Carlos de Oliveira Affonso Renato Jose Sassi Industrial engineering post graduation program Nove de Julho University Sao Paulo 05001-100 Brazil

The challenge of keeping and getting new customers drives the development of new practices to meet the consumption needs of increasingly tends to micro-segmentation of product and consumer market. The new consumption habits of brazilians brought new prospects for market. The objective of this paper is to develop of a dynamic vehicle routing system supported by the behavior of urban traffic in the city ofSao Paulo using Neuro Fuzzy Network. The methodology of this paper consists in the capture of relevant events that interfere with the flow of traffic of the city of Sao Paulo and implementation of a Fuzzy Neural Network trained with these events in order to foresee the traffic behavior. The system offers three labels of hierarchical routing, thus is possible to consider not only the basic factors of routing, but too external factors that directly influence on the flow of traffic and the disruption which may be avoided in large cities, through alternative routes （dynamic vehicle routing）. Predicting the behavior of traffic represents the strategic level routing, dynamic vehicle routing is the tactical level, and routing algorithms to the operational level. This paper will not be discussed the operational level.

关键词： Traffic behavior dynamic vehicle routing neuro fuzzy network fuzzy logic.

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The Microclimatic Influence of a Water Body on an Urban Environment

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Journal of Environmental Science and engineering(B) 2013年第8期2卷 453-459页

作者： Erico Masierc Lea Cristina Lucas de Souza Department of Civil engineering Federal University of Sao Carlos PhD-Post Graduation Program of Urban Engineering Sao Carlos 13560 000 Brazil Department of Civil engineering Federal University of Sao Carlos Professor of Post Graduation Program of Urban Engineering Sao Carlos 13560 000 Brazil

The paper aims to investigate the potential of a water body to influence in lowering the warmth in the city of Sao Jose do Rio Preto, Brazil, due to the evaporative cooling effects. In order to verify its potential, three collecting points of temperature and humidity were placed in an urban area close to the municipal dam. The first one was placed on the dam margin, the second one, 50 m distant of the margin and, the third one, 100 m distant. The data were taken during December 2010 and then compared to the climate data of the Climate Station of CIIAGRO-Integrated Center of Agro Meteorological. The results show that the closer the collection point is to the water body, and the lower is the temperature variation. The humidity taxes verified at the closest point to the water body indicate values higher than those ones collected at the most distant point. The insertion of moisture through the water bodies in an urban environment demonstrated to be a strategy that improved the thermal conditions and has to be considered for urban planners to establish strategies of urban occupation.

关键词： Water body thermal comfort evaporative cooling.

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Ecological Costs Applied in the Bleaching of Cotton： A Study for an Optimized Process

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Journal of Chemistry and Chemical engineering 2013年第7期7卷 633-636页

作者： Rosa Jorge Marcos Tambourgi Elias Basile Santana Jose Carlo Curvelo Carmo Renee Simoes Argolo Arafjo Mauricio de Campos College of Chemistry engineering State University of Campinas Sao Paulo 03008-020 Brazil post graduation Department College of Technology Antoine Skaf Sao Paulo 03008-202 Brazil production engineering post graduation program Nine o f July University Sao Paulo 5001-100 Brazil Textile and Fashion post graduation program Sao Paulo University S6o Paulo 03828-000 Brazil

The aim of this paper was to study three variables in hydrogen peroxide bleaching of cotton fabrics： the amount of hydrogen peroxide （H2O2）, peroxide stabilizer （Na2SiO3） and the process temperature. The factorial planning of two levels and three factors was done in order to obtain an optimized recipe for subsequent comparison with commons recipes used in industry. Were evaluated the brightness （DL）, energy consumption （dQ）, H2O2 residual （Rox）, processing time and ecological costs.

关键词： Cotton bleaching factorial planning ecological costs.

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Assessment of the Total Organic Carbon and Conductivity in Consecutive Dyeings with Reactive Dyestuffs Using Treated Effluent by UV/H202 Photocatalysis

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Journal of Chemistry and Chemical engineering 2014年第2期8卷 139-144页

作者： Leite Adilson da SilvaI Barco Luiz Trindade Nelson Barros Araujo Mauricio de Campos Rosa Jorge Marcos Tambourgi Elias Basile Santana José Carlos Curvelo Chemical Textile post graduation Department College of Technology SENAI Antoine Skaf $6o Paulo 03008-020 Brazil Textile and Fashion post graduation program S6o Paulo University S6o Paulo 03828-000 Brazil College of Chemical engineering State University of Campinas Campinas 13083-852 Brazil production engineering post graduation program Nove de Julho University Sao Paulo 05001-100 Brazil

The paper was monitored the conductivity （g.L＂l of NaCI）, the absorbances values （Abs） and the amount of TOC （total organic carbon）, before and after five consecutive dyeings made with reuse water, obtained from treated effluent by UV/H202 photocatalysis. All rates of decolorization were above 92%, the removal of total organic carbon was above 89% in all treatments and the economy of NaCI was from 3.10 in the first recipe, 3.17 in the second, 3.49 in the third, 3.79 in the fourth and 4.05 in the fifth recipe. The five dyeings compared with same dyeings made with deionized water presented a color deviation （AE＊） below 1. The conventional dyeings would consume 80 L/kg against 40 L/kg used in the dyeing process proposed in this study, representing a great economy of water, with no discharge of effluents.

关键词： Conductivity reactive dyestuffs reuse of water photocatalysis textile effluent.

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