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烟酰胺和N-乙酰葡萄糖胺改善色斑效果观察

临床皮肤科杂志 2007年第10期36卷 628-631页

作者：吴艳仲少敏 Joe Kaczvinsky 赵俊郁乔圆邓琳 Chieko Soh Cindy Berge Michael Marmor Donald Bissett Larry Robinson 朱学骏北京大学第一医院皮肤科 The procter & gamble Company Sharon Woods Technical CenterCincinnati OHUSA 45241 宝洁公司北京技术中心 procter & gamble Company R&D Kobe Technical CenterHyogo 658-0032Japan The procter & gamble Company Miami Valley Innovation CenterCincinnati OH USA 45202

目的:比较含烟酰胺和N-乙酰葡萄糖胺的护肤品在改善色素沉着方面的效果。方法:双盲、基质对照人体试验。采用REAL3.0系统采集所有图像,用相关软件分析色斑面积百分比、L*a*b值、黑素相关的色斑面积百分比、平均黑素含量(灰度)和黑素相... 详细信息

目的:比较含烟酰胺和N-乙酰葡萄糖胺的护肤品在改善色素沉着方面的效果。方法:双盲、基质对照人体试验。采用REAL3.0系统采集所有图像,用相关软件分析色斑面积百分比、L*a*b值、黑素相关的色斑面积百分比、平均黑素含量(灰度)和黑素相关的皮肤颜色均匀度;Chromameter测量非色斑部位皮肤颜色改变;由皮肤科专家分析使用护肤品前后照片改善情况和受试者自我比较进行主观评价。结果:与基质相比,含烟酰胺和N-乙酰葡萄糖胺的护肤品可以抑制色斑面积的增加,减轻紫外线引起的肤色加深和肤色不均匀。结论:正常人皮肤对含烟酰胺和N-乙酰葡萄糖胺的护肤品有良好的耐受性,与基质相比,该护肤品有一定的减轻色素沉着的效果。

关键词：烟酰胺 N-乙酰葡萄糖胺色素沉着护肤品

A MULTI-SCALE APPROACH TO MODELING AND SIMULATION OF PARTICLE FORMATION AND HANDLING PROCESSES IN CONSUMER GOODS MAKING

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A MULTI-SCALE APPROACH TO MODELING AND SIMULATION OF PARTICL...

Expanded Follicle-Sulcus-Crack Complex Is an Early Warning Sign of Facial Skin Aging: Improvement by Application of Galactomyces Ferment Filtrate-Containing Skin Product

中国颗粒学会第七届学术年会暨海峡两岸颗粒技术研讨会

作者： Paul R Mort procter ＆ gamble Co. CincinnatiOhioUSA

＜正＞In considering how discrete particles interact to influence bulk powder behavior,one faces the challenge of connecting across many orders of magnitude in length *** attempting to bridge across these gaps in scale,it is convenient to consider a *** meso-scale can be defined according to a relevant set of properties or other distributed aspects that are key to making the *** processes commonly include a number of distinct transformations that may overlap in the process to make the analysis and modeling of the system more *** this case,it may be more convenient to describe the meso-scale in terms of empirical relationships, e.g.,a set of constitutive relationships that link the mechanical energy of the process to the material properties of the *** the other hand,it may be possible to develop more fundamental models for individual product *** this case,it may be advantageous to consider meso-scale models that are based on the distributed features of the particles or particle mixture.

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Journal of Cosmetics, Dermatological Sciences and Applications 2023年第2期13卷 91-106页

作者： Kukizo Miyamoto Bandara Dissanayake Shenal Wanigasekara Keisuke Fujii Xianghong Yan Masutaka Furue Research and Development Kobe Innovation Center Procter and Gamble Innovation GK Kobe Japan Department of Research and Development Beauty Technology Division P&G Company Cincinnati USA Department of Dermatology Graduate School of Medical Sciences Kyushu University Fukuoka Japan

Background: Wrinkles, pigmented spots, and roughness are representative parameters reflecting facial skin aging. Sulci cutis connecting to follicular orifices frequently form perifollicular cracks, which join together adjacent sulci. This follicle-sulcus-crack complex (FSCC) is exacerbated by dehydration. Purpose: Although dehydration is associated with facial skin aging, FSCC’s implications in facial skin aging remain unresolved. Method: We measured facial skin parameters in 1999 and 2010 in 108 Japanese women, and in 2006 and 2016 in 182 Chinese women. We addressed whether expansion of FSCC is associated with other skin aging parameters. We also examined whether skin moisturizer can reverse the expanded FSCC. Results: In both clinical studies, FSCC severity as well as wrinkles, spots, and roughness significantly deteriorated with age. Notably, FSCC significantly increased as early as in subjects in their 20s, whereas wrinkles, spots, and roughness became conspicuous in those in their 40s or older. Moreover, subjects with more severe FSCC in the initial measurement exhibited significantly worse wrinkles, spots, and roughness in the second measurement a decade later. Dehydration was significantly correlated with expanded FSCC. Furthermore, FSCC expansion was reversed after appropriate moisturization by daily application of Galactomyces ferment filtrate (GFF)-containing skincare product (SK-II Skin Power Cream) for 4 weeks in 37 women. Conclusion: The expanded FSCC is likely to be an early indicator of facial skin aging. Appropriate moisturization may reduce FSCC formation and decelerate facial skin aging.

关键词： Facial Skin Aging Follicle-Sulcus-Crack Complex Dehydration Hyperpigmented Spot Wrinkle Galactomyces Ferment Filtrate

Two-Dimensional Correlation Spectroscopy—A Decade of Fruitful Collaboration and Friendship in China

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Two-Dimensional Correlation Spectroscopy—A Decade of Fruitf...

Sensitive Skin in China

第十五届全国分子光谱学术报告会

作者： Isao Noda The procter ＆ gamble Company 8611 Beckett Road West Chester

＜正＞Two-dimensional（2D）correlation spectroscopy is a versatile analytical technique,where a spectrum is obtained as a function of two independent spectral values,such as IR *** are spread over a- long the second dimension,thereby enhancing the spectral resolution and simplifying the visualization of com- plex spectra consisting of many overlapped *** among various spectral bands are characterized by the presence of cross *** technique is applicable to the analysis of a wide range of spectral data un- der various experimental *** is a leading country where the use of 2D correlation spectroscopy has flourished in the last 10 years.A number of important development and clever applications have been re- *** of the exciting 2D correlation spectroscopy work carried out by colleagues and friends in China are highlighted.

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Journal of Cosmetics, Dermatological Sciences and Applications 2012年第3期2卷 184-195页

作者： Miranda A. Farage Christian P. Mandl Enzo Berardesca Howard I. Maibach Department of Dermatology University of San Francisco Medical School San Francisco USA San Gallicano Dermatological Institute Rome Italy The procter & gamble Company Schwalbach Germany The procter & gamble Company Winton Hill Business Center Cincinnati USA

Background: Many consumers in the USA and Europe define themselves as having sensitive skin, a phenomenon whose etiology appears to include both physiological and psychosocial factors. Objectives: Sensitive skin data from the developing world is sparse. This study evaluates the prevalence and characteristics of sensitive skin in China and compares data collected to existing data from the western world. Patients/Materials/Methods: A total of 408 Chinese women voluntarily completed a survey on sensitive skin. Results: Some degree of skin sensitivity was claimed by 94 (23%) of respondents;most (90.4%) said their skin was only slightly or moderately sensitive. Facial sensitivity was claimed by 21% of Chinese women, sensitivity of the body surface by 9% and genital sensitivity by only 6%. Small numbers of respondents reported a history of skin allergy (3%) or a familial history of sensitive skin (2%). Many reported making buying decisions based on product claims. Conclusions: Only 23% of Chinese women claimed any degree of sensitive skin, a prevalence substantially lower than that observed in most Western countries. Sensitivity of the genital skin, in particular, was dramatically lower, suggesting at least some cultural component to perceptions of sensitive skin.

关键词： Sensitive Skin Genital Skin Irritation Skin Sensitivity Stinging Erythema Feminine Hygiene Fabrics Sensory

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不同程度慢性牙周炎患者病情的二年自然进展

中华口腔医学杂志 2004年第3期39卷 193-196页

作者：欧阳翔英曹采方 Henry Liu 胡文杰 J Leslie Winston 北京大学口腔医学院牙周科 100081 procter and gamble Company

目的　观察不同程度慢性牙周炎的自然进展规律。方法　纵向观察 16 9例轻、中、重度慢性牙周炎患者在 2年中的疾病自然进展 ,检查除第三磨牙外的全口牙 ,每颗牙 6个位点 ,以探诊深度、附着丧失为指标 ,两次检查之间附着丧失加重≥ 3mm... 详细信息

目的　观察不同程度慢性牙周炎的自然进展规律。方法　纵向观察 16 9例轻、中、重度慢性牙周炎患者在 2年中的疾病自然进展 ,检查除第三磨牙外的全口牙 ,每颗牙 6个位点 ,以探诊深度、附着丧失为指标 ,两次检查之间附着丧失加重≥ 3mm的牙位定为活动性进展。结果　活动性发生率依基线时疾病的轻、中、重程度而逐渐增高 ,按位点活动性的发生率分别为 0 14 %、0 39%及0 73% ,按个体活动性的发生率分别为 15 5 6 %、2 9 89%及 4 3 2 4 % ,差异有统计学意义。结论　重度牙周炎患者是牙周破坏活动性进展的高危人群。

关键词：慢性牙周炎病情自然进展诊断治疗

Application of ultra-sonication, acid precipitation and membrane filtration for co-recovery of protein and humic acid from sewage sludge

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Frontiers of Environmental Science & Engineering 2016年第2期10卷 327-335页

作者： Liangliang WEI Kun WANG Xiangjuan KONG Guangyi LIU Shuang CUI Qingliang ZHAO Fuyi CUI Key Laboratory of Songliao Aquatic Environment (Ministry of Education) Jilin Jianzhu University Changchun 130118 China School of Mu-nicipal & Environmental Engineering Harbin Institute of Technology Harbin 150090 China Center of Science & Technology of Construction of the Ministry of Housing and Urban Rural Development of E R. China Beijing 100835 China procter & gamble Company Guangzhou 510620 China

A novel method was applied to co-recover proteins and humic acid from the dewatered sewage sludge for liquid fertilizer and animal feed. The proteins in sewage sludge were first extracted using the processes of ultra- sonication and acid precipitation, and then the humic acid was recovered via membrane filtration. The extraction efficiency was 125.9mg humic acid-gWSS volatile suspended solids （VSS） and 123.9 mg proteins-g-1 VSS at the optimal ultrasonic density of 1.5 W·mL-1. FT-IR spectrum results indicated that the recovered proteins and humic acid showed similar chemical characteristic to the natural proteins and humic acid. The acidic solution （pH 2） could be recycled and used more than 10 times during the co-recovery processes. In addition, the dewatered sludge could be easily biodegraded when the humic acid and proteins are extracted, which was essential for further utilization. These findings are of great significance for recovering valuable nutrient fi＇om sewage sludge.

关键词： sewage sludge co-recovery proteins humicacid recycling biodegradation rate

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高等学校化学学报 2002年第8期23卷 1627-1631页

作者：田格吴琼孙素琴野田勇夫陈国强清华大学生物科学与技术系北京100084 清华大学化学系分析中心北京100084 The procter and gamble Company.8256 Union centre Boulevard

应用新型二维傅里叶变换红外 (2 D FTIR)相关光谱研究细菌合成聚羟基丁酸酯 (PHB)在升温时的预熔行为以及降温后的重结晶过程 .在 2 5～ 2 2 0℃的变温过程中测得动态红外光谱 .着重讨论了在热力学干扰导致红外谱图中羰基峰 (1 70 0～ 1... 详细信息

应用新型二维傅里叶变换红外 (2 D FTIR)相关光谱研究细菌合成聚羟基丁酸酯 (PHB)在升温时的预熔行为以及降温后的重结晶过程 .在 2 5～ 2 2 0℃的变温过程中测得动态红外光谱 .着重讨论了在热力学干扰导致红外谱图中羰基峰 (1 70 0～ 1 770 cm- 1 )和醚键 (1 2 3 0～ 1 3 1 0 cm- 1 )吸收强度的波动 .结果表明 ,这种影响来自样品中 PHB的结晶态和非晶态之间的相态变化 .二维谱图分析表明 ,在热熔过程中 ,结晶态的消失并不同时引起完全非晶态的出现 ,暗示在分子排列高度有序的晶态和非晶态之间存在某种中间态 ,PHB晶体向非晶态转变时必须经过一个预熔过程 .在红外谱图上这个中间态很可能对应着由二维分析显示出来的位于 1 73 0 cm- 1 的吸收峰 .同时 ,在

关键词：二维傅里叶红外光谱聚羟基丁酸酯熔融结晶预熔过程生物可降解塑料

ATP生物荧光增幅法在微生物检测中的可行性研究——应用于化妆品领域

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食品与发酵工业 2020年第21期46卷 201-206页

作者：翟磊葛媛媛洪海军刘吉泉李婷沈颖林雅芳蔡俊松刘骥刘瑞娜王旭姚粟中国食品发酵工业研究院有限公司北京100015 联合利华(中国)有限公司上海200335 procter&gamble International Operations 新加坡138547 北京宝洁技术有限公司北京101312 查士利华微生物应用技术(上海)有限公司上海201708

为探究ATP生物荧光增幅法在化妆品微生物检测中应用的可行性,开展了富集培养基促生长能力测试和产品适用性试验。收集了与化妆品原料及其生产环境相关的47株代表性菌株,在富集培养基MTAT中生长良好,ATP生物荧光增幅检测结果均为阳性。... 详细信息

为探究ATP生物荧光增幅法在化妆品微生物检测中应用的可行性,开展了富集培养基促生长能力测试和产品适用性试验。收集了与化妆品原料及其生产环境相关的47株代表性菌株,在富集培养基MTAT中生长良好,ATP生物荧光增幅检测结果均为阳性。分别选取了清洁类、护理类、美容修饰类中6种化妆品,接种6株《中国药典》(2020版)参考菌株,进行了产品适用性试验。样品影响测试结果表明:培养基空白的信号值在167~285 RLU,6种产品的本底信号值在87~199 RLU,远低于3倍培养基空白信号值的要求;ATP回收率在73.8%~106.8%,均高于25%的推荐值,符合检测方法的要求。接菌试验结果表明,供试样品的检测结果均为阳性,化妆品的抑菌作用可被有效消除。因此,ATP生物荧光增幅法具有在化妆品及相关领域开展微生物快速筛选与检测的良好应用前景。

关键词： ATP生物荧光增幅法化妆品微生物检测促生长能力