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Neuroscience & Medicine 2022年第3期13卷 91-102页

作者： Wolfgang Heide Birgit Adlung Cornelia Körtke Robert Hoerr Department of Neurology General Hospital Celle Celle Germany private practice for radiology Bad Zwischenahn Germany private practice for Neurology Lübeck-St. Lorenz Süd Germany Research & Development Dr. Willmar Schwabe GmbH & Co. KG Karlsruhe Germany

Background: Ginkgo biloba extract EGb 761® is widely used to treat various types of vertigo. Aims: An exploratory trial was conducted to evaluate the efficacy of EGb 761® in addition to vestibular exercises in central vestibular vertigo caused by vertebro-basilar ischaemia. Subjects and Methods: In this randomised, placebo-controlled, double-blind trial, 40 patients were enrolled in the vertigo clinic of a neurological university hospital and treated with daily doses of 240 mg EGb 761® or placebo for a period of 180 days. All patients regularly performed vestibular exercises in addition. Efficacy was assessed using: a visual analogue scale for the patients to rate the overall intensity of vertigo;a numeric scale for physician-rated change;a vertigo score based on intensity, duration, and frequency of vertigo;and electronystagmography. Results: Until day 180, the mean patient-rated intensity of vertigo decreased by 46% during EGb 761® treatment and by 19% with placebo (p ® group compared to the placebo group. Nystagmus or other eye movement disorders were present only in small subgroups of patients without sufficient statistical power to detect differences between treatment groups. Conclusions: EGb 761® alleviated vertigo caused by ischaemic lesions in the brainstem or cerebellum in patients undergoing vestibular exercises.

关键词： Ginkgo biloba Extract EGb 761® Randomised Controlled Trial (RCT) Vertigo Dizziness Vestibular Exercises

Colorectal cancer,screening and primary care: A mini literature review

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World Journal of Gastroenterology 2017年第33期23卷 6049-6058页

作者： Athanasios Hadjipetrou Dimitrios Anyfantakis Christos G Galanakis Miltiades Kastanakis Serafim Kastanakis Primary Health Care Centre of Kissamos First Department of Surgery Saint George General Hospital of Chania private Family practice Unit in Chania Department of Internal Medicine Saint George General Hospital of Chania

Colorectal cancer(CRC) is a common health problem,representing the third most commonly diagnosed cancer worldwide and causing a significant burden in terms of morbidity and mortality,with annual deaths estimated at 700000. The western way of life,that is being rapidly adopted in many regions of the world,is a well discussed risk factor for CRC and could be targeted in terms of primary prevention. Furthermore,the relatively slow development of this cancer permits drastic reduction of incidence and mortality through secondary prevention. These facts underlie primary care physicians(PCPs) being assigned a key role in health strategies that enhance prevention and prompt diagnosis. Herein,we review the main topics of CRC in the current literature,in order to better understand its pathogenesis,risk and protective factors,as well as screening techniques. Furthermore,we discuss preventive and screening policies to combat CRC and the crucial role served by PCPs in their successful implementation. Relevant articles were identified through electronic searches of MEDLINE and through manual searches of reference lists.

关键词： Colorectal cancer Prevention Diagnosis Screening Primary care

Is Use of Radiation Hormesis the Missing Link to a Better Cancer Treatment?

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Journal of Cancer Therapy 2015年第7期6卷 601-605页

作者： Paul A. Oakley private practice Innovative Spine & Wellness Newmarket Canada

Radiation hormesis is a concept that pervades radiobiological exposures;low doses enhance immune response, while higher doses inhibit immune response. Low-dose Total-Body Irradiation (TBI) therapy offers radiation treatment to cancer patients using the concepts of radiation hormesis and show very good success rates. This phenomenon has been reported elsewhere as the “abscopal effect” and considering the marginal success rates of other treatment agents, like the immunotherapy drug Ipilimumab, TBI therapy may prove to be the missing link to a better cancer treatment.

关键词： Cancer Radiation Hormesis Abscopal Effect Therapy

Student Conceptions of Assessment:Regulatory Responses to Our practices

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ECNU Review of Education 2022年第1期5卷 116-139页

作者： Gavin T.L.Brown Development&Professional practice The Faculty of Education and Social WorkThe University of AucklandPrivate Bag 92019Victoria Street WestAuckland 1142New Zealand

Purpose:Universities assess and evaluate students concerning competence in essential disciplinary knowledge and *** assessments impact learners’attitudes,beliefs,and *** impacts may be overcome if students regulate their responses to assessment and ***/Approach/Methods:This article systematically locates research studies that cite three key early papers around student conceptions of assessment(SCoA).A narrative synthesis is based on 22 ***:In addition to the SCoA,11 different research inventories reveal a variety of regulatory responses that are enhanced when assessments are deliberately formative,fair,and *** is broad interest in this phenomenon but little consistency in methods,and even the SCoA has little consistency in factor structure across *** one study provided an objective behavioral measure to validate self-reports,which are the dominant form of ***/Value:This review gives readers insights into how assessment influences student thinking and how student cognition can regulate success.

关键词： Conceptions of assessment higher education learners self-regulated learning

A novel nomogram for predicting the prognosis of hepatocellular carcinoma patients following immune checkpoint inhibitors treatment beyond progression:a single center study based on Chinese population

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 771-787页

作者： Chao Chen Xiaoyuan Chu Hong Liu Mingzhen Zhou Zhan Shi Anfeng Si Ying Zhao Xiufeng Liu Jie Shen Baorui Liu Comprehensive Cancer Center Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjingChina Department of Oncology Jinling HospitalNanjing Medical UniversityNanjingChina Department of Cardiothoracic Surgery Nanjing Hospital Affiliated to Nanjing University of Chinese MedicineNanjingChina Department of Surgical Oncology of PLA Cancer Center Jinling HospitalNanjing Medical UniversityNanjingChina Department of radiology Jinling HospitalNanjing Medical UniversityNanjingChina

Background:Hepatocellular carcinoma(HCC)persists as a dominant cause of cancer-related mortality globally,with a notably rapid escalation in mortality *** advent of immunotherapy,particularly immune checkpoint inhibitors(ICIs),has ushered in a new era in the management of liver cancer,albeit with unresolved challenges in the context of treatment beyond progression(TBP)and stratified prognosis in diverse *** study aimed to develop and validate a novel nomogram model to identify factors that predict the benefit of continued immunotherapy for hepatocellular carcinoma patients following disease progression in clinical ***:This study retrospectively analyzed the efficacy of ICIs in TBP,focusing on the Chinese population with advanced liver cancer.A nomogram was constructed based on four independent risk factors identified through Cox multivariate analysis,aiming to predict patient prognosis post-ICI *** model was validated through receiver operating characteristic(ROC)curve analysis and categorized patients into high-,intermediate-,and low-risk groups,with further validation using calibration plots and decision curve analysis(DCA).Results:The low-risk group demonstrated significantly enhanced overall survival(OS)compared to the high-risk group,with the nomogram predictions aligning closely with actual outcomes for 6-and 9-month *** model exhibited commendable predictive accuracy,achieving a C-index exceeding 0.7 in both training and validation *** DCA underscored the clinical utility of the nomogram-based prognostic model,further substantiated by the area under the ROC curve(AUC).Conclusions:The developed nomogram presents a potentially valuable tool for predicting the prognosis of HCC patients undergoing ICI therapy beyond progression,particularly within the Chinese ***,the study is constrained by its retrospective,single-center nature and necessitates further validation through large-scale,multicente

关键词： Hepatocellular carcinoma(HCC) immune checkpoint inhibitors(ICIs) novel nomogram

Comprehensive Assessment of Anxiolytic Properties in 4-HPAA Derivatives: Bridging in Vivo Validation and Molecular Docking Analyses

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Open Journal of Medicinal Chemistry 2024年第3期14卷 29-44页

作者： Kawthar Alhussieni Rami Ayoub Jamal Jilani Qais Jarrar Othman Alhussinei Vetriselvan Subramaniyan Esra Nasraldin Khalil Sharafaldin Harshini Muruganantham Jureerat Kijsomporn Ling Shing Wong Department of Applied Pharmaceutical Sciences and Clinical Pharmacy Faculty of Pharmacy Isra University Amman Jordan Department of Pharmaceutical Chemistry Faculty of Pharmacy Universiti Malaya Kuala Lumpur Malaysia Department of Medicinal Chemistry and Pharmacognosy Faculty of Pharmacy Jordan University of Science and Technology Irbid Jordan Department of Allied Medical Sciences Zarqa Private University Zarqa Jordan Department of Medical Sciences School of Medical and Life Sciences Sunway University Bandar Sunway Malaysia Department of Clinical Pharmacy and Pharmacy practice Faculty of Pharmacy Universiti Malaya Kuala Lumpur Malaysia Center for Global Research Saveetha Medical College Saveetha Institute of Medical and Technical Sciences Saveetha University Chennai India School of Nursing Metharath University Bangtoey Thailand Faculty of Health and Life Sciences INTI International University Nilai Malaysia

Anxiety is a significant mental health issue that substantially affects an individual’s quality of life. Feelings of uneasiness, irritability, and sleep disturbances characterize it. 4-Hydroxyphenyl acetic acid (4-HPAA) is identified in brain cells as a physiological byproduct of tyramine. This study hypothesizes that 4-HPAA may regulate anxiety due to its anxiolytic properties, acting as a modulator of the GABAergic system, which plays a crucial role in the pathophysiology of anxiety disorders. Our study aims to enhance the anxiolytic effects of 4-HPAA through chemical modification to improve its pharmacokinetic properties. Three derivatives, namely Isopropyl-4-hydroxy-[phenyl] acetate (IHPA), Isopropyl-4-hydroxy-[phenyl] acetate (MPAA), and 4-methoxyphenyl acetate (MPHA), have been synthesized from 4-HPAA. This assessment will use well-established animal models, specifically the Elevated Plus-Maze (EPM) and Zero Maze (EZM) tests, selected for their validity in replicating anxiety-like symptoms in animals. Chronic caffeine administration via drinking water (0.3 g/l for 14 days) was employed to induce an anxiety state for testing purposes. IHPA and MPAA demonstrated significant anxiolyticactivity when tested in the EPM and EZM experiments. Molecular docking simulations using AutoDock Vina indicated that 4-HPAA derivatives had docking scores ranging from −5.8 to −4.8 kcal/mol, compared to the standard anxiolytic medication Diazepam, which scored −7.1 kcal/mol. These scores suggest a potential for 4-HPAA derivatives to interact effectively with the Gamma-aminobutyric acid (GABA_A) receptor. In conclusion, our in vivo and in silico analyses indicate a promising anxiolytic potential for 4-HPAA derivatives.

关键词： Anxiolytics 4-HPAA Molecular Docking Elevated Plus-Maze Zero Maze Tests

Vasectomy by epithelial curettage without suture or cautery： a pilot study in humans

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Asian Journal of Andrology 2010年第3期12卷 315-321,I0008页

作者： John K. Amory John W. Jessen Charles Muller Richard E. Berger Department of Medicine Center for Research in Reproduction and Contraception University of Washington School of Medicine Seattle WA 98195 USA private practice Dentistry Seattle WA 98195 USA Department of Urology University of Washington School of Medicine Seattle WA 98195 USA

Curettage of the epithelium of the vas deferens might be a safe and effective method of male sterilization. We conducted a pilot study of vasectomy by epithelial curettage with a novel microcurette called the Vas-X in 12 normal men requesting elective sterilization. Seminal fluid analysis was obtained monthly after the procedure for 6 months. Pain was assessed by questionnaire. Three months after the procedure, all men attained sperm concentrations of less than 0.2 million sperm per mL, and seven were azoospermic. Post-procedural pain was minimal. Nine men ultimately achieved and maintained azoospermia; however, 4 to 6 months after the procedure, sperm concentrations increased in three of the 12 subjects, necessitating repeat vasectomy. Microscopic examination of the vas deferens from these failures revealed re-canalization. Vasectomy by epithelial curettage can result in effective sterilization; however, 1/4 of the subjects were not effectively sterilized by the procedure due to re-canalization of the vas deferens. Epithelial curettage will require further refinement to determine if it is a viable form of vasectomy.

关键词： male contraception male sterilization re-canalization spermatogenesis vas deferens vasectomy failure

Alzheimer’s Disease, Early Diagnosis

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Advances in Alzheimer's Disease 2020年第3期9卷 33-46页

作者： Andrisani Giovanni Andrisani Giorgia Department of Research Private Clinic “Studio Andrisani” Matera Italy private practice “Tandzorg Delft Centrum” Delft Netherland

Aim: In this review paper we propose a method to make an early diagnosis of the Alzheimer’s Disease (AD), the most common form of neurodegenerative dementia. Background: Glymphatic System (GS) is the main means of eliminating waste substances in the central nervous system (CNS);if it does not work properly, waste substances accumulate in CNS until to cause AD. Basal Forebrain is the most important component of a much broader system of cholinergic cells distributed throughout the Central Nervous System (CNS). This structure regulates attention, learning and memory and its destruction is considered responsible for the cognitive AD alterations. The characteristics of AD patients, that interest us most, are the lack of Acetylcholine, and the Orexin excess;we think that the hypothalamus produces more Orexin to stimulate cholinergic cells, indispensable for a correct CNS functioning. We want to identify these patients by detecting the Orexin excess. Early Diagnosis Model. Of course we could take a cerebrospinal fluid sample and dose Orexin but this method is risky and painful for the patient’s health, therefore unsuitable for large numbers of patients. We propose a fairly simple method for the early diagnosis of AD: if we temporarily eliminate the Orexin excess, with Dual Orexin Receptor Antagonist (DORA), i.e. Suvorexant, we can intercept the Orexin increase and demonstrate the decrease in Acetylcholine with a Functional Magnetic Resonance or a Polysomnography, many years before the AD symptoms occur.

关键词： Glymphatic System Acetilcholine Adenosine Orexin Dual Orexin Receptor Antagonist

Drug Use and Abuse among Orthopedic Ward Patients—A Revolving Cycle of Menace in Atbuth, Bauchi

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Journal of Biosciences and Medicines 2024年第9期12卷 13-20页

作者： Yusuf Stephen Shaphat Shuaibu Ibrahim Timothy Emuan Buhari Abdullahi Zailani Bukar Shehu Aminu Umar Shirama Yakubu Bababa Ibrahim Babangida Hussaini Blessing Eneh Vincent Department of Orthoepaedics and Trauma Abubakar Tafawa Balewa University Teaching Hospital Bauchi Nigeria Department of radiology Abubakar Tafawa Balewa University Teaching Hospital Bauchi Nigeria Department of Nursing Abubakar Tafawa Balewa University Teaching Hospital Bauchi Nigeria

Background: The use of drugs for purposes other than those for which they are meant to be used or in excess amounts. Psychoactive drugs are some of the drugs more commonly abused, also, antibiotics and other medications too can be misused. Drug abuse and misuse can lead to serious social, medical and emotional harm to the patients, and antibiotic resistance that makes treatment harder are also likely complications. Method: Patients in both male and female wards of the Orthoepaedics Department of ATBUTH, Bauchi were interviewed using a structured questionnaire and their responses were recorded and data were analyzed using the SPSS version 29. Results: A total of 112 patients were interviewed, 76 males and 36 females. Thirty-two (28.6%) patients had taken various kinds of unprescribed medications while on admission: 9 patients had taken unprescribed tramadol, 4 patients had taken codeine, 6 Ampiclox, 5 flagyl and about 8 patients had taken different kinds of traditional medications while on admission. Among the 32 patients, 23 (72%) are aged less than 30 years, 5 (16%) are aged between 30 and 50 years and 4 (12%) are aged above 50 years. Sixteen (50%) had such medications brought to them by relatives or friends, 10 (30%) were given by other patients on admission, 5 (15%) brought or bought the drugs by themselves while 1 (5%) were given by a non-clinical staff of the hospital. Conclusion: Drug misuse and abuse is a very serious, deleterious practice with destructive consequences in its wake, such consequences as drug dependency with all its antecedent effects, antibiotic resistance and difficulties in controlling/managing infections are but a few. So, it’s very important to both educate patients about these terrible practices and cope with the spread of them in our wards and hospitals.

关键词： Drug Abuse Misuse Dependency Resistance

Tunneled peritoneal catheters for the palliative therapy of malignant ascites

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Family Medicine and Community Health 2013年第1期1卷 17-22页

作者： YVONNE RYAN KAREN LYONS JOHN HANSEN AISLING O’GORMAN North Eastern General practice Training Scheme Department of radiology Beaumont HospitalDublin Our Lady of Lourdes Hospital DroghedaCo.Louth

Objective:Malignant ascites presents difficult management issues in the palliative care population and results in distressing symptoms and recurrent hospital *** palliative care services in Our Lady of Lourdes Hospital have been using radiologically guided tunneled peritoneal catheters for the palliative therapy of troublesome malignant *** conducted a review of this management ***:There were 10 catheters inserted in 9 patients between May 2007 and June 2011 in patients with malignant ***:There were no procedural related mortalities or major *** catheter life was 98.9 *** catheter re-hospitalization rate was 1.55 times per *** patient survival post insertion was 140 *** eight percent of patients achieved death at ***:We conclude that this is a safe and useful strategy in the management of malignant ascites in a palliative care population.

关键词： Tunneled peritoneal catheter Palliative therapy Malignant ascites