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Role of pulmonary perfusion magnetic resonance imaging for the diagnosis of pulmonary hypertension:A review

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World Journal of Radiology 2023年第9期15卷 256-273页

作者： Miriam Lacharie Adriana villa Xenios Milidonis Hadeer Hasaneen Amedeo Chiribiri Giulia Benedetti Oxford Centre of Magnetic Resonance Imaging University of OxfordOxford OX39DUUnited Kingdom Department of Diagnostic and Interventional Radiology German Oncology CentreLimassol 4108Cyprus Deep Camera MRG CYENS Centre of ExcellenceNicosiaCyprusNicosia 1016Cyprus School of Biomedical Engineering&Imaging Sciences King's College LondonLondon WC2R 2LSUnited Kingdom School of Biomedical Engineering and Imaging Sciences Kings Coll LondonDiv Imaging SciSt Thomas HospitalLondon WC2R 2LSUnited Kingdom Department of Cardiovascular Imaging and Biomedical Engineering King’s College LondonLondon WC2R 2LSUnited Kingdom

Among five types of pulmonary hypertension,chronic thromboembolic pulmonary hypertension(CTEPH)is the only curable form,but prompt and accurate diagnosis can be *** tomography and nuclear medicine-based techniques are standard imaging modalities to non-invasively diagnose CTEPH,however these are limited by radiation exposure,subjective qualitative bias,and lack of cardiac functional *** review aims to assess the methodology,diagnostic accuracy of pulmonary perfusion imaging in the current literature and discuss its advantages,limitations and future research scope.

关键词： Pulmonary perfusion MRI Pulmonary hypertension Dynamic contrast enhanced magnetic resonance imaging Chronic thromboembolic pulmonary hypertension Computed tomography pulmonary angiography Chronic thromboembolic disease

儿童全地形车(ATV)损伤对全国范围入院治疗的影响

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世界核心医学期刊文摘（儿科学分册） 2006年第A10期2卷 62-62页

作者： Killingsworth J.B. Tilford J.M. Parker J.G. M.E. Aitken 高蕊 Department of Pediatrics Arkansas Children' s Hospital 800 Marshall St Slot 512- 26 Little Rock AR 72202- 3591 United States Dr.

Objective. All- terrain vehicle (ATV) injuries among children represent a significant and growing problem. Although state level analyses have characterized some aspects of pediatric ATV- related injuries, little information on the national impact on hospitalization is available. This study was designed to characterize more fully the patterns of injury, hospital length of stay, and hospital charges associated with ATV- related injuries, with a nationally representative sample. Methods. Analyses were based on the 1997 and 2000 Healthcare Cost and Utilization Project Kids’ Inpatient Database (KID). The KID is the only national, all- payer database of hospital discharges for children. KID data were weighted to represent all discharges from general hospitals in the United States. Discharges with external cause- of- injury codes consistent with off- road ATV related injuries were selected, and the affected population was described. Nationally representative rates of ATV- related injuries were calculated, and changes between 1997 and 2000 were documented. Results. An estimated 5292 children were hospitalized because of ATV- related injuries during the 2- year period, and hospitalizations increased 79.1% between 1997 and 2000. Rates of ATV- related hospitalization were highest among adolescent white male subjects, consistent with previous studies. Most patients had hospital lengths of stay of 8 days. Injury severity varied considerably, with more than one third of patients sustaining moderate to severe injuries. Approximately 1% of hospitalizations resulted in in- hospital deaths. Total hospital charges for this injury mechanism were ＄ 74 367 677 for the 2- year study period. Most of these charges were paid by private insurers. Conclusions. This study provides evidence supporting recent substantial increases in childhood ATV- related injuries. The hospitalization impact of ATV- related injuries among children is considerable. Our data

关键词： ATV 全地形车综合医院入院率出院病例住院情况损伤严重程度内估计入院患者损伤率

新生儿静脉注射带状疱疹免疫球蛋白后水痘带状疱疹病毒抗体浓度测定及其免疫球蛋白制剂的安全性

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世界核心医学期刊文摘（儿科学分册） 2005年第11期1卷 15-15页

作者： Murgua-De-Sierra T. villa-Guillén M. villanueva-Garca D. 朱新菊 Division of Neonatology Hospital Infantil de México Federico Gómez Dr. Mérquez #162 Col Doctores CP 06720 Mexico City Mexico

Aims: 1) To assess the safety of intravenous varicella zoster virus hyperimmune globulin G (IV-VZVIG) in neonates; 2) measure varicella zoster virus-specific IgG antibody (VZVIG) changes in newborn IV-VZVIG recipients. Methods: Eighteen neonatal intensive care unit (NICU) neonates with varicella exposure were given 1 ml/kg (43 International Units (IU)/kg) Varitect(r) IV-VZVIG. Serum VZVIG titers were assayed in neonatal recipients 0, 1, 7, 14, 21, 28, and 35 d after IV-VZVIG. Also, serum samples for VZV-IgM antibody determinations were obtained at 4 wk post-infusion. Results: No varicella developed in the 18 infants. Infusion of 1 ml/kg (43 IU/kg) IV-VZVIG was generally safe. The IV-VZVIG dose resulted in seroconversion of a non-immune newborn. Five infants had low basal VZVIG titers, and two of them had a 0.6-log10 increase at 24 h post-infusion. Neonatal VZVIG titers (mean ±SEM in log10) before IV-VZVIG and after by 1, 7, 14, 21, 28, and 35 d were 2.22 ±0.15, 2.17 ±0.17, 2.02 ±0.12, 0.87 ±0.2, 1.09 ±0.19, 2.33 ±0.07, and 2.16 ±0.1, respectively. Conclusions: One ml/kg (43 IU/kg) IV-VZVIG was generally safe. Our neonatal mean VZV-immune status did not significantly increase after the 1 ml/kg (43 IU/kg) IVVZVIG dose, although no varicella developed and it caused a VZV-specific seroconversion.

关键词：水痘带状疱疹病毒抗体浓度测定免疫球蛋白制剂抗体滴度超免疫球蛋白 IgG 注射量内接触血清转换

Building a global schistosomiasis alliance:an opportunity to join forces to fight inequality and rural poverty

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Infectious Diseases of Poverty 2017年第1期6卷 558-563页

作者： Lorenzo Savioli Marco Albonico Daniel G.Colley Rodrigo Correa-Oliveira Alan Fenwick Will Green Narcis Kabatereine Achille Kabore Naftale Katz Katharina Klohe Philip TLoVerde David Rollinson JRussell Stothard Louis-Albert Tchuem Tchuente Johannes Waltz Xiao-Nong Zhou Global Schistosomiasis Alliance GenevaSwitzerland Center for Tropical Diseases Sacro Cuore Hospital-WHO Collaborating Centre on strongyloidiasis and other intestinal parasitic infectionsNegrarVeronaItaly Schistosomiasis Consortium for Operational Research and Evaluation The University of GeorgiaAthensGeorgiaUSA Centro de Pesquisas ReneRachou-Fiocruz Belo HorizonteBrazil and Universidade Federal de Ouro PretoOuro PretoBrazil Department of Infectious Disease Epidemiology SCIImperial CollegeLondonUK Trinity College Cambridge CambridgeUK Imperial College London LondonUK RTI International WashingtonDCUSA Research Center Rene Rachou-Oswaldo Cruz Foundation Belo HorizonteBrazil Global Schistosomiasis Alliance MunichGermany University of Texas Health Science Center San AntonioTXUSA Life Sciences Department The Natural History MuseumLondonUK Department of Parasitology Liverpool School of Tropical MedicineLiverpool L35QAUK Centre for Schistosomiasis&Parasitology YaoundeCameroon Global Schistosomiasis Alliance LondonUK National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention ShanghaiChina

Schistosomiasis,one of the 17 neglected tropical diseases listed by the World Health Organization,presents a substantial public health and economic *** the 261 million people requiring preventive chemotherapy for schistosomiasis in 2013,92%of them lived in sub-Saharan Africa and only 12.7%received preventive ***,in 2010,the WHO reported that schistosomiasis mortality could be as high as 280000 per year in Africa *** May 2012 delegates to the sixty-fifth World Health Assembly adopted resolution WHA65.21 that called for the elimination of schistosomiasis,and foresees the regular treatment of at least 75%of school age children in at-risk *** resolution urged member states to intensify schistosomiasis control programmes and to initiate elimination campaigns where *** this,in June 2015,schistosomiasis was indicated to have the lowest level of preventive chemotherapy implementation in the spectrum of neglected tropical *** was also highlighted as the disease most lacking in *** is perhaps unsurprising,given that it was also the only NTD with access to drug donations but without a coalition of stakeholders that collaborates to boost commitment and *** a consequence,and to ensure that the WHO NTDs Roadmap Targets of 2012 and World Health Assembly Resolution WHA65.21 are met,the Global Schistosomiasis Alliance(GSA)has been set *** and representative,the GSA aims to be a partnership of endemic countries,academic and research institutions,international development agencies and foundations,international organizations,non-governmental development organizations,private sector companies and advocacy and resource mobilisation ***,the GSA calls for a partnership to work for the benefit of endemic countries by addressing health inequity and rural poverty.

关键词： Neglected tropical diseases Schistosomiasis Global Schistosomiasis Alliance Elimination

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医源性卵巢过度刺激综合征患者中不存在卵泡刺激素受体的活动性变异

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世界核心医学期刊文摘（妇产科学分册） 2005年第10期1卷 20-20页

作者： D'Alva C.B Serafini P Motta E B.B. Mendonca 李跃萍 hospital Das Cl inicas Laboratorio de Hormonios e Genetica Molecular LIM/42 Av. Dr. E. C. A. 155 2 A. Bl. 6 CEP 05403- 900 S.ao Paulo-SP Brazil.Dr

Objective: To analyzethe FSH receptor gene in women with iatrogenic ovarian hyperstimulation syndrome (OHSS). Design: Clinical and molecular studies. Setting: University hospital and private clinic. Patient(s): Twenty- nine women who developed moderate or severe OHSS after ovulation induction for *** addition, 50 fertile normal women were used as controls. Intervention(s): Peripheral blood was used for DNA extraction. The exons 4, 7, 9, and 10 of the FSH receptor gene were amplified by polymerase chain reaction (PCR) followed by automatic direct sequencing. Main Outcome Measure(s): Hormonal results and automatic sequencing analysis. Result(s): Thirteen patients developed moderate OHSS and 16 patients developed the severe form of the syndrome. Automatic sequencing revealed no activating mutations in all patients studied. We found two known polymorphisms in linkage disequilibrium, Ala307Thr and Ser680Asn, in 79.3% of the patients (44.8% in heterozygous and 34.5% in homozygous state). These polymorphisms were found with similar frequency in the 50 normal fertile women. Conclusion(s): We conclude that the FSH receptor genotype did not play a significant role in the risk of iatrogenic OHSS in this cohort.

关键词：卵泡刺激素体外受精受体基因诱导排卵分子学聚合酶链反应教学医院外显子基因纯合态连锁不平衡

FungalTraits:a user-friendly traits database of fungi and fungus-like stramenopiles

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Fungal Diversity 2020年第2期107卷 I0001-I0016页

作者： Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates Petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald Pfister Hans-Otto Baral Helle Järv Hugo Madrid Jenni Nordén Jian-Kui Liu Julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin David Hyde Marcelo Sandoval-Denis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni Thomas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ahto Agan Alexandre Reis Machado Andrés Argüelles-Moyao Andrew Detheridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César Marín Daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-Peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks Laszlo Irinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew PNelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust Olesya Dulya Peter Johnston Petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renata dos Santos Chikowski Renato L.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Torda Varga Wei Li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.Mikryukov Yongzhong Lu Yosuke Matsuda Yumiko Miyamoto Urm Institute of Ecology and Earth Sciences University of Tartu14A Ravila50411 TartuEstonia Natural History Museum University of Tartu46 Vanemuise Str51003 TartuEstonia Gothenburg Global Biodiversity Centre Box 46140530 GothenburgSweden Department of Biological and Environmental Sciences University of GothenburgGothenburgSweden Department of Soil and Environment Swedish University of Agricultural SciencesBox 701475007 UppsalaSweden Department of Forest Mycology and Plant Pathology Swedish University of Agricultural SciencesBox 702675007 UppsalaSweden Section for Genetics and Evolutionary Biology(EvoGene) Department of BiosciencesUniversity of OsloP.O.Box 1066BlindernNO-0316 OsloNorway University of Hawaiʻi at Mānoa 3190 Maile WaySt.John 102HonoluluHIUSA Department of Biology University of CopenhagenUniversitetsparken 152100 CopenhagenØDenmark Purdue University Northwest WestvilleIN 46391USA Institute of Microbiology Czech Academy of SciencesVidenska 108314220 Praha 4Czech Republic GLOBE Institute University of CopenhagenØster Farimagsgade 5KH7.2.321353 CopenhagenDenmark Dipartimento di Scienze della Vita e Biologia dei Sistemi Universitàdi TorinoViale Mattioli 2510125 TorinoItaly Department of Organismic and Evolutionary Biology and Farlow Library and Herbarium Harvard University22 Divinity AveCambridgeMA 02138USA Blaihofstr.42 72074 TübingenGermany SYNLAB Estonia Veerenni 53aTallinn 11313Estonia Escuela de Tecnología Médica Universidad Santo TomásLos Carreras 753OsornoChile Centro de Genómica y Bioinformática Universidad MayorCamino La Pirámide 5750HuechurabaSantiagoChile Norwegian Institute for Nature Research(NINA) Sognsveien 680855 OsloNorway School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Evolutionary Biology Faculty of BiologyBiological and Chemical Research CentreUniversity of Warsawul.Zwirki i Wigury 10102-089 WarsawPoland Department of Botany Swedish Museum of

The cryptic lifestyle of most fungi necessitates molecular identification of the guild in environmental *** the past decades,rapid development and affordability of molecular tools have tremendously improved insights of the fungal diversity in all ecosystems and ***,in spite of the progress of molecular methods,knowledge about functional properties of the fungal taxa is vague and interpretation of environmental studies in an ecologically meaningful manner remains *** order to facilitate functional assignments and ecological interpretation of environmental studies we introduce a user friendly traits and character database FungalTraits operating at genus and species hypothesis *** the information from previous efforts such as FUNGuild and FunFun together with involvement of expert knowledge,we reannotated 10,210 and 151 fungal and Stramenopila genera,*** resulted in a stand-alone spreadsheet dataset covering 17 lifestyle related traits of fungal and Stramenopila genera,designed for rapid functional assignments of environmental *** order to assign the trait states to fungal species hypotheses,the scientific community of experts manually categorised and assigned available trait information to 697,413 fungal ITS *** the basis of those sequences we were able to summarise trait and host information into 92,623 fungal species hypotheses at 1%dissimilarity threshold.

关键词： Fungal traits Trophic modes Function Guild Bioinformatics High-throughput sequencing Community ecology

Systematic and other reviews: Criteria and complexities

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2021年第3期7卷 236-239页

作者： Robert T.Sataloff Matthew L.Bush Rakesh Chandra Douglas Chepeha Brian Rotenberg Edward W.Fisher David Goldenberg Ehab Y.Hanna Joseph E.Kerschner Dennis H.Kraus John H.Krouse Daqing Li Michael Link Lawrence R.Lustig Samuel H.Selesnick Raj Sindwani Richard J.Smith James R.Tysome Peter C.Weber D.Bradley Welling Department of Otolaryngology-Head and Neck Surgery Drexel University College of MedicinePhiladelphiaPennsylvaniaUSA Department of Otolaryngology University of KentuckyLexingtonKentuckyUSA Department of Otolaryngolosy Vanderbilt University Medical CenterNashvilleTennesseeUSA Faculty of Medicine Deportment of Otolaryngology-Head and Neck SurseryUniversity of TorontoTorontoOntarioCanada Department of Otolaryngology·Head and Neck Surgery Western UniversityTorontoOntarioCanada Department of Otolaryngology Cambridge University PressCambridgeUK Department of Otolaryngology-Head and Neck Surgery Pennsylvania State University College of MedicineHersheyPennsylvaniaUSA Department of Head and Neck Surgery The University of Texas M.D.Anderson Cancer CenterHoustonTexasUSA Department of Otolaryngology Medical College of WisconsinMilwaukeeWisconsinUSA Department of Otolaryngology-Head and Neck Surgery Northwell HealthNew YorkNew YorkUSA Department of Otolaryngology University of Texas Rio Grande Valley School of MedicineBrownsvilleTexasUSA Department of Otorhinolaryngology·Head and Neck Surgery Hospital of the University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Department of Radiation Oncology Mayo ClinicRochesterMinnesotaUSA Department of Otolaryngology Columbia University Medical CenterNew YorkNew YorkUSA Department of Otolarynsology Weill Cornell Medical College of Cornell UniversityNew YorkNew YorkUSA Cleveland Clinic Head and Neck InstituteClevelandOhioUSA Department of Otolaryngology·Head and Neck Surgery The University of Iowa Hospitals and ClinicsIowa CityIowaUSA Department of Otolarynsolosy Cambridge University Hospitals NHS Foundation TrustCambridgeUK Mount Sinai Health System New YorkNew YorkUSA Department of Otolaryngology·Head and Neck Surgery Harvard UniversityCambridgeMassachusettsUSA

Review articles can be extremely *** synthesize information for readers,often provide clarity and valuable insights into a topic;and good review articles tend to be cited *** articles do not require Institutional Review Board(IRB)approval if the data reviewed are public(including private and government databases)and if the articles reviewed have received IRB approval previously.

关键词： approval insight valuable