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Ultrastable in-situ silver nanoparticle dressing for effective prevention and treatment of wound infection in emergency

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Engineered Regeneration 2024年第1期5卷 111-123页

作者： Wei Wang Ziwei Hu Wanying Mo Min Ouyang Shihao Lin Xiang Li Chengxinqiao Wang Feng Yu Yupeng Wang Dongfang Zhou Key Laboratory of Mental Health of the Ministry of Education NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China institute of Otolaryngology Head and neck surgery Guangzhou Red Croee Hospital of Jinan UniversityGuangzhou 510282China c Department of orthopaedics and traumatology Zhujiang HospitalSouthern Medical UniversityGuangzhou 510282China

The use of antibacterial dressings is crucial in the prevention and treatment of wound infection in emergency ***,the efficacy of dressings is compromised by long-term storage or exposure to harsh ***,an ultrastable in-situ silver nanoparticle dressing(AgSNP@CD)was prepared for effective prevention and treatment of wound infection in *** fabrication process of AgSNP@CD is simple,suitable for large-scale *** to the strong interaction between the in-situ synthesized AgNPs and the cotton fabric,AgSNP@CD owned remarkable stability,thus retaining its antimicrobial efficacy even after long-term storage(up to 2 years)and under extreme conditions(damp heat,low temperatures,low-oxygen,water immersion,acid-alkali erosion).Both in vitro and in vivo results demonstrated the extraordinary antibacterial efficacy and stability of AgSNP@CD,facilitating infection prevention and wound healing in extreme *** particular,AgSNP@CD exhibited a superior treatment effect on severe bacteria-infected trauma and can prevent the occur-rence of sepsis *** exceptional stability and antibacterial efficacy of AgSNP@CD under complex and extreme conditions make it a well-suited dressing strategy for the prevention and treatment of wound infection in emergency.

关键词： Bacteria-infected wounds Silver nanoparticle dressing Ultra stability Infection prevention In emergency

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游泳短纤维鼻滴剂用于鼻脑药物传递

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Science Bulletin 2024年第14期69卷 2153-2155页

作者：徐臆茹丁涛陈信良 The International Peace Maternity and Child Health Hospital School of MedicineShanghai Jiao Tong UniversityShanghai 200030China Shanghai Key Laboratory of Embryo Original Diseases Shanghai 200030China Department of orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

The brain,the most vital and intricate organ in the human body,governs neural *** within the brain is protected by the blood–brain barrier(BBB),a unique and highly regulated semi-permeable membrane[1].Due to the BBB obstruction,traditional drug delivery methods,such as oral administration or intravenous injection,often fail to efficiently deliver drugs to the brain[2].

关键词：药物传递 drugs injection

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Does topical vancomycin prevent fracture-related infections in closed fractures undergoing open reduction and internal fixation?A randomised controlled trial

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Chinese Journal of traumatology 2024年第2期27卷 71-76页

作者： Mohit Gandhi Gopisankar Balaji Jagdish Menon Ruben Raj Thomas Department of orthopaedics Jawaharlal Institute of Postgraduate Medical Education and ResearchPondicherryIndia Department of Preventive and Social Medicine Jawaharlal Institute of Postgraduate Medical Education and ResearchPondicherryIndia

Purpose:The role of topical vancomycin in fracture-related infection(FRI)is *** few studies have reported their efficacy in open and high-risk extremity *** study aimed to assess topical vancomycin's role in reducing FRI in closed fractures undergoing open surgical intervention with an ***:This prospective randomized cohort study was carried out between February 2021 to January *** with isolated closed fractures,who were planned for open reduction and internal fixation within 2 weeks from the time of injury were included for this *** data collected included age,gender,socioeconomic status,mechanism of injury,diagnosis,Tscherne classification,and time interval to take up for *** were randomized into the intervention and control groups using the block randomization *** control group received only systemic antibiotic prophylaxis,whereas the intervention group received topical application of vancomycin powder in the surgical wound alongside systemic antibiotic *** primary outcome measure was the incidence of FRI among these *** and radiological findings and culture reports(in cases with infection)were recorded during the post-operative period and at 6 weeks of *** relevant statistical calculations were done using STATA statistical/data analysis-parallel edition version 16.0(StataCorp LLC).The quantitative variables like age and duration of the surgery were assessed for normalcy by Shapiro-Wilk W *** independent samples t-test with equal variances was applied to the age ***'s exact test was used for the analysis of the primary outcome measure(presence of FRI following surgery),and"Risk of FRI"and"Risk difference"between the 2 groups was *** strength of the association between qualitative variables was assessed using the Fisher's exact and Chi-square tests,***:There were 88 patients included in this *** statistical si

关键词： Infections Antibiotics Vancomycin Fractures

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静电纺纤维滴鼻液实现脑室内给药

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Science Bulletin 2024年第9期69卷 1249-1262页

作者：王娟王秋云符一飞卢敏陈亮刘志恒付晓晗杜习羽于布为陆菡崔文国 Department of orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Anesthesiology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Anesthesiology Shenzhen Second People’s HospitalThe First Afﬁliated Hospital of Shenzhen UniversityShenzhen 518035China Department of Anesthesiology Huadong Hospital Afﬁliated to Fudan UniversityShanghai 200040China

Adequate drug delivery across the blood–brain barrier(BBB) is a critical factor in treating central nervous system(CNS) disorders. Inspired by swimming fish and the microstructure of the nasal cavity, this study is the first to develop swimming short fibrous nasal drops that can directly target the nasal mucosa and swim in the nasal cavity, which can effectively deliver drugs to the brain. Briefly, swimming short fibrous nasal drops with charged controlled drug release were fabricated by electrospinning, homogenization,the π-π conjugation between indole group of fibers, the benzene ring of leucine-rich repeat kinase 2(LRRK2) inhibitor along with charge-dipole interaction between positively charged poly-lysine(PLL)and negatively charged surface of fibers;this enabled these fibers to stick to nasal mucosa, prolonged the residence time on mucosa, and prevented rapid mucociliary clearance. In vitro, swimming short fibrous nasal drops were biocompatible and inhibited microglial activation by releasing an LRRK2 inhibitor. In vivo, luciferase-labelled swimming short fibrous nasal drops delivered an LRRK2 inhibitor to the brain through the nasal mucosa, alleviating cognitive dysfunction caused by sepsis-associated encephalopathy by inhibiting microglial inflammation and improving synaptic plasticity. Thus, swimming short fibrous nasal drops is a promising strategy for the treatment of CNS diseases.

关键词： Nasal drops Electrospun short fibers Nasal mucosa Intraventricular administration Brain diseases

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Case of gout with inflammatory low back pain

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Rheumatology & Autoimmunity 2024年第3期4卷 192-193页

作者： Sabarinath Mahadevan Balakrishnan Navaneethakrishnan Mahabaleshwar Mamadapur Department of Rheumatology O.M.Health Care ClinicChennaiTamilnaduIndia Department of Rheumatology Madras Institute of Orthopaedics and Traumatology HospitalChennaiTamilnaduIndia Department of Clinical Immunology and Rheumatology JSS Medical College and HospitalJSS Academy of Higher ResearchMysoreKarnatakaIndia

A 50-year-old male patient with a history of chronic tophaceous gout presented with low back pain and bilateral shoulder,hip,knee,and buttock pain for 1 *** had nocturnal exacerbations of buttock pain and significant early morning stiffness,which improved with nonsteroidal anti-inflammatory agents(NSAIDs).On examination,he had multiple hard,lobulated tophaceous deposits over the bilateral elbow,hand,leg,and *** was no ulcer or discharge from tophi(Figure 1A).He had restriction of movements in the lower back and bilateral positive faber test localized to the back.

关键词： gout gouty sacroiliitis Tophi

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Advances and challenges in hydrogel microspheres for biomedical applications

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Biomaterials Translational 2024年第3期5卷 203-204页

作者： Yiting Lei Hélder A Santos Wenguo Cui Department of Orthopaedic Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine ChongqingChina Orthopaedic research Laboratory of Chongqing Medical University ChongqingChina Department of Biomaterials and Biomedical Technology The Personalized Medicine Research Institute(PRECISION)University Medical Center GroningenUniversity of GroningenGroningenthe Netherlands Drug research Program Division of Pharmaceutical Chemistry and TechnologyFaculty of PharmacyUniversity of HelsinkiHelsinkiFinland Department of orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Hydrogel microspheres,with their high water content and tunable physicochemical properties,have emerged as a promising class of materials for a myriad of biomedical applications.1 These microscale particles,which can be fabricated from both natural and synthetic polymers,exhibit diverse properties and bear a striking resemblance to the native extracellular matrix.2 This makes them highly suitable as substrates for cell culture,templates for tissue engineering,and vehicles for drug and protein delivery.

关键词： template striking microspheres

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Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications

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Military Medical research 2024年第1期11卷 50-79页

作者： Shuai Liu Jiang-Ming Yu Yan-Chang Gan Xiao-Zhong Qiu Zhe-Chen Gao Huan Wang Shi-Xuan Chen Yuan Xiong Guo-Hui Liu Si-En Lin Alec McCarthy Johnson V.John Dai-Xu Wei Hong-Hao Hou Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering the Fifth Affiliated HospitalSchool of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510900China Department of Orthopedics Tongren HospitalShanghai Jiao Tong UniversityShanghai 200336China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033GuangdongChina Engineering research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011ZhejiangChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of orthopaedics and traumatology Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Functional Materials Terasaki Institute for Biomedical InnovationLos AngelesCA 90064USA Mary&Dick Holland Regenerative Medicine Program College of MedicineUniversity of Nebraska Medical CenterOmahaNE 68130USA Zigong Affiliated Hospital of Southwest Medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigong 643002SichuanChina Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an 710127China

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative *** contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative *** paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future *** highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ***,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE ***,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

关键词： Biomimic Scaffold Biosynthesis Natural biomaterial Tissue engineering

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Diamond-Like Carbon Depositing on the Surface of Polylactide Membrane for Prevention of Adhesion Formation During Tendon Repair

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Nano-Micro Letters 2024年第9期16卷 478-499页

作者： Yao Xiao Zaijin Tao Yufeng Ju Xiaolu Huang Xinshu Zhang Xiaonan Liu Pavel A.Volotovski Chao Huang Hongqi Chen Yaozhong Zhang Shen Liu Department of orthopaedics Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China Shanghai Tongji Hospital 389 Xincun RdShanghai 200065People’s Republic of China Key Laboratory for Thin Film and Microfabrication of Ministry of Education Research Institute of Micro/Nano Science and TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Orthopedic Trauma Department Belarus Republic Scientific and Practical Center for Traumatology and OrthopedicsKizhevatova str.60/4220024 MinskBelarus Shanghai Haohai Biological Technology Limited Liability Company 1386 Hongqiao RdShanghai 200336People’s Republic of China Department of General Surgery Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China Shanghai Key Laboratory for High Temperature Materials and Precision Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Post-traumatic peritendinous adhesion presents a significant challenge in clinical *** study proposes the use of diamond-like carbon(DLC)deposited on polylactic acid(PLA)membranes as a biophysical mechanism for anti-adhesion barrier to encase ruptured tendons in tendon-injured *** results indicate that PLA/DLC composite membrane exhibits more efficient anti-adhesion effect than PLA membrane,with histological score decreasing from 3.12±0.27 to 2.20±0.22 and anti-adhesion effectiveness increasing from 21.61%to 44.72%.Mechanistically,the abundant C=O bond functional groups on the surface of DLC can reduce reactive oxygen species level effectively;thus,the phosphorylation of NF-κB and M1 polarization of macrophages are ***,excessive inflammatory response augmented by M1 macrophage-originated cytokines including interleukin-6(IL-6),interleukin-1β(IL-1β),and tumor necrosis factor-α(TNF-α)is largely *** biocompatibility evaluation,PLA/DLC membrane is slowly absorbed within tissue and displays prolonged barrier effects compared to traditional PLA *** studies show the DLC depositing decelerates the release of degradation product lactic acid and its induction of macrophage M2 polarization by interfering esterase and PLA ester bonds,which further delays the fibrosis *** was found that the PLA/DLC membrane possess an efficient biophysical mechanism for treatment of peritendinous adhesion.

关键词： Diamond-like carbon Reactive oxygen species scavenging Foreign body reaction Biodegradation Antioxidant Peritendinous adhesion

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Detection of angiospastic disorders in the microcirculatory bed using laser diagnostics technologies

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Journal of Innovative Optical Health Sciences 2018年第1期11卷 65-79页

作者： Irina N.Makovik Andrey V.Dunaev Victor V.Dremin Alexander I.Krupatkin Viktor V.Sidorov Lyudmila S.Khakhicheva Vadim F.Muradyan Olga V.Pilipenko Ilya E.Rafailov Karina S.Litvinova Biomedical Photonics Instrumentation Group Scientic-Educational Centre of"Biomedical Engineering"Orel State University named after I.S.Turgenev Orel 302026 Russian Federation priorov central research institute of traumatology and orthopaedics moscow 127299 Russian Federation SPE"LAZMA"Ltd Moscow 125252Russian Federation Orel Regional Clinical Hospital Orel 302028 Russian Federation School of Engineering and Applied Sciences Aston institute of Photonic Technologies Aston University BirminghamB47ETUK Optoelectronics and Biomedical Photonics Group Aston institute of Photonic Technologies Aston University BirminghamB47ETUK Aston Medical School Aston University BirminghamB47ETUK

The evaluation of the microcirculatory bed functional state and the identification of angiospastic disorders with related complications,when the pathological changes are reversible,have an important role in medical *** aim of this study was to evaluate the possibility of using optical noninvasive methods and the cold pressor test to solve this problem.A total of 33 patients with rheumatological diseases and 32 healthy volunteers were included in the *** Doppler flowmetry,tissue reflectance oximetry and pulse oximetry were used as optical noninvasive *** parameters were recorded before,immediately after and 20 min after the cold pressor *** on the measured parameters,the complex parameters of the microcirculatory bed were calculated.A detailed statistical analysis of the parameter changes for each individual in the two groups displayed diverse microcirculatory bed parameter responses upon cold exposure,with differing recovery of parameters after *** diagnostic criteria were proposed for the identification of angiospastic *** to the proposed criteria,27 people of the volunteers group were confirmed to not display any *** the patient group,however,18 people were observed to have a relatively normal functional state of the microcirculatory bed,while 15 people were observed to have a possible tendency to *** highlight the diferences between a relatively normal state and presence of angiospastic disorders,statistical analysis of experimental data was carried out,which revealed significant *** analysis of data with angiospastic disorders identified a relationship between their diagnoses and the results of labo-ratory ***,the evaluation of combined noninvasive optical diagnostic method use,the cold pressor test and proposed diagnostic criteria showed a positive *** approach can be used to detect the presence of possible angiospastic disorders and related complications,as

关键词： Noninvasive diagnostics laser Doppler flowmetry tissue relctance oximetry pulse oximetry cold pressor test microcirculatory bed angiospasm

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Materials evolution of bone plates for internal fixation of bone fractures:A review

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Journal of Materials Science & Technology 2020年第1期36卷 190-208页

作者： Junlei Li Ling Qin Ke Yang Zhijie Ma Yongxuan Wang Liangliang Cheng Dewei Zhao Department of orthopaedics Affiliated Zhongshan Hospital of Dalian UniversityDalian116001China Musculoskeletal research Laboratory of Department of orthopaedics&traumatology The Chinese University of Hong KongHong Kong SARChina Center for Translational Medicine research and Development Institute of Biomedical EngineeringChinese Academy of SciencesShenzhen518055China institute of Metal research Chinese Academy of SciencesShenyang110016China

Bone plates play a vital role in bone fracture healing by providing the necessary mechanical fixation for fracture fragments through modulating biomechanical microenvironment adjacent to the fracture *** treatment effect has been achieved for fixation of bone fracture with conventional bone plates,which are made of stainless steel or titanium ***,several limitations still exist with traditional bone plates including loosening and stress shielding due to significant difference in modulus between metal material and bone tissue that impairs optimal fracture ***,due to demographic changes and non-physiological loading,the population suffering from refractory fractures,such as osteoporosis fractures and comminuted fractures,is increasing,which imposes a big challenge to traditional bone plates developed for normal bone fracture ***,optimal fracture treatment with adequate fixation implants in terms of materials and design relevant to special conditions is *** this review,the complex physiological process of bone healing is introduced,followed by reviewing the development of implant design and biomaterials for bone ***,we discuss recent development of hybrid bone plates that contains bioactive elements or factors for fracture healing enhancement as a promising *** includes biodegradable Mg-based alloy used for designing bone screw-plates that has been proven to be beneficial for fracture healing,an innovative development that attracts more and more *** paper also indicates that the tantalum bone plates with porous structure are also emerging as a new fracture internal fixation *** reduction of the stress shielding is verified to be useful to accelerate bone fracture *** application of biodegradable metals may also avoid a second operation for implant *** developments in biometals and their design for orthopedic bone plates are expected to improve the

关键词： Bone plate Biomaterials Biodegradable materials Titanium Magnesium Porous tantalum

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