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Strengthening the Construction of the Talent Team and Promoting the High-Quality Development of disease Prevention and Control

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China CDC weekly 2024年第38期6卷 986-988页

作者： Qingfeng Chen Ying Cui Hao Chen Chengyu Lai Yuan Wang Kaixuan Liu Yuhui Zhou Office of Policy and Planning research Chinese Center for Disease Control and PreventionBeijingChina Chinese center for disease Control and Prevention BeijingChina

Talent is essential for development,and career development strategies should prioritize talent cultivation(1–2).China’s CDC workforce comprises a diverse,multidisciplinary team of disease prevention and control *** workforce includes personnel from various CDC agencies,public medical institutions,township health centers,and community health service *** the development of this pool of talent is crucial for enhancing the quality of disease prevention and control systems and forms the foundation of a robust public health infrastructure(3).On December 25,2023,the State Council released the Guideline on Promoting the High-Quality Development of disease Prevention and Control,outlining a comprehensive strategy for strengthening the CDC’s talent *** paper analyzes this policy to clarify the historical context,principal actions,and future trajectory of workforce development within China’s CDC.

关键词： prevention policy strengthening

Strengthening Organizational Support Is Essential for the High-Quality Development of disease Prevention and Control Initiatives

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China CDC weekly 2024年第38期6卷 982-985页

作者： Ying Cui Qingfeng Chen Hao Chen Kaixuan Liu Yuan Wang Chengyu Lai Zhi Zeng Jun Yan Office of Policy and Planning research Chinese Center for Disease Control and PreventionBeijingChina Chinese center for disease Control and Prevention BeijingChina

Organizational security in public health encompasses structural and supportive measures designed to ensure public health security and effectively prevent and control disease *** measures include organizational leadership,investment mechanisms,information technology support,scientific research,and international exchange and *** prevention and control is often described as an“invisible war”,emphasizing the need for preparedness and proactive measures(1).As the adage states,“Before soldiers and horses move,food and grass go first,”highlighting the critical role of a robust organizational security foundation for successful disease prevention and control *** foundation is essential for promoting high-quality development within the *** its 14th Five-Year Plan period,the Chinese government has implemented policies to bolster organizational *** this commitment,on December 25,2023,the State Council issued the“Guiding Opinions on Promoting the High-Quality Development of disease Prevention and Control.”

关键词： prevention measures foundation

China’s Initiatives and Achievements in Enhancing the Professional Capabilities of CDCs

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China CDC weekly 2024年第38期6卷 979-981页

作者： Hao Chen Ying Cui Kaixuan Liu Chengyu Lai Yuan Wang Qingfeng Chen Zhi Zeng Yang Mei Office of Policy and Planning research Chinese Center for Disease Control and PreventionBeijingChina Chinese center for disease Control and Prevention BeijingChina.

Capacity building is essential for developing a robust disease control and prevention system(1).Recognizing this,on December 25,2023,the General Office of China’s State Council issued the“Guidelines for Promoting the High-Quality Development of disease Control and Prevention”(hereinafter referred to as the“Guidelines”)(2),emphasizing the need to enhance six key professional capabilities within the disease control and prevention *** Guidelines provide a foundational framework for the future growth and enhancement of centers for disease control and prevention(CDCs).

关键词： Professional prevention system.

Comparison of Three Influenza Surveillance Data Sources for Timely Detection of Epidemic Onset — Chengdu City, Sichuan Province and Beijing Municipality, China, 2017–2023

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China CDC weekly 2024年第36期6卷 918-923,I0004-I0006页

作者： Mingyue Pan Ying Shen Yao Wang Lu Long Xunbo Du Ying Sun Daitao Zhang Hui Yao Yonghong Liu Peng Yang Quanyi Wang Xiaoli Wang Liang Wang Beijing center for disease Prevention and Control BeijingChina Beijing research center for Respiratory Infectious diseases BeijingChina Chengdu center for disease Control and Prevention Chengdu CitySichuan ProvinceChina

What is already known about this topic?The syndromic surveillance system,exemplified by the influenza-like illness(ILI)surveillance system,has long been crucial in providing early warnings of influenza *** is added by this report?The analysis revealed that employing reported influenza case data from the nationwide Notifiable Infectious diseases Reporting Information System(NIDRIS)enhanced the early detection of influenza epidemics,particularly within the context of multiple respiratory pathogens circulating *** are the implications for public health practice?The NIDRIS,characterized by its extensive coverage,obligatory reporting,high specificity,and real-time data transmission,offers a valuable tool for the effective early detection of influenza *** this system could enhance preparedness and responses to such health crises,potentially mitigating their impact on public health.

关键词： nationwide system specificity

Effects of loneliness and isolation on cardiovascular diseases:a two sample Mendelian Randomization Study

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Journal of Geriatric Cardiology 2024年第3期21卷 340-348页

作者： Jia-Yin CAI Xin WANG Cong-Yi ZHENG Xue CAO Zhen HU Run-Qing GU Yi-Xin TIAN Ye TIAN Lan SHAO Lin-Feng ZHANG Zeng-Wu WANG Division of Prevention and Community Health National Center for Cardiovascular DiseaseNational Clinical Research Center of Cardiovascular DiseaseState Key Laboratory of Cardiovascular DiseaseFuwai HospitalPeking Union Medical College&Chinese Academy of Medical SciencesBeijingChina

BACKGROUND Loneliness and isolation are associated with multiple cardiovascular diseases(CVDs),but there is a lack of research on whether they were causally *** conducted a Mendelian Randomization(MR)study to explore causal relationships between loneliness and isolation and multiple *** Single nucleotide polymorphisms associated with loneliness and isolation were identified from a genome-wide association study(GWAS)of 455,364 individuals of European ancestry in the IEU GWAS *** data for 15 CVDs were also obtained from the IEU GWAS *** used three MR methods including inverse variance weighting,MR-Egger,and weighted median estimation to assess the causal effect of exposure on ***'s Q test and MR-Egger intercept test were used to evaluate the heterogeneity and *** MR analysis showed that loneliness and isolation were significantly associated with essential hypertension(OR=1.07,95%CI:1.03-1.12),atherosclerotic heart disease(OR=1.04;95%CI:1.02-1.06),myocardial infarction(OR=1.02;95%CI:1-1.04)and angina(OR=1.04;95%CI=1.02-1.06).No heterogeneity and pleiotropy effects were found in this *** Causal relationship of loneliness and isolation with CVDs were found in this study.

关键词： diseases cardiovascular angina

Regulations of m^(6)A and other RNA modifications and their roles in cancer

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Frontiers of Medicine 2024年第4期18卷 622-648页

作者： Xin-Hui Chen Kun-Xiong Guo Jing Li Shu-Hui Xu Huifang Zhu Guang-Rong Yan Biomedicine research center Guangdong Provincial Key Laboratory of Major Obstetric DiseaseGuangdong Provincial Clinical Research Center for Obstetrics and GynecologyState Key Laboratory of Respiratory Diseasethe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150China

RNA modification is an essential component of the epitranscriptome,regulating RNA metabolism and cellular *** types of RNA modifications have been identified to date;they include N^(6)-methyladenosine(m^(6)A),N^(1)-methyladenosine(m1A),5-methylcytosine(m5C),N^(7)-methylguanosine(m^(7)G),N^(6),2′-O-dimethyladenosine(m^(6)Am),N4-acetylcytidine(ac^(4)C),*** modifications,mediated by regulators including writers,erasers,and readers,are associated with carcinogenesis,tumor microenvironment,metabolic reprogramming,immunosuppression,immunotherapy,chemotherapy,etc.A novel perspective indicates that regulatory subunits and post-translational modifications(PTMs)are involved in the regulation of writer,eraser,and reader functions in mediating RNA modifications,tumorigenesis,and anticancer *** this review,we summarize the advances made in the knowledge of different RNA modifications(especially m^(6)A)and focus on RNA modification regulators with functions modulated by a series of factors in cancer,including regulatory subunits(proteins,noncoding RNA or peptides encoded by long noncoding RNA)and PTMs(acetylation,SUMOylation,lactylation,phosphorylation,etc.).We also delineate the relationship between RNA modification regulator functions and carcinogenesis or cancer ***,inhibitors that target RNA modification regulators for anticancer therapy and their synergistic effect combined with immunotherapy or chemotherapy are discussed.

关键词： RNA modification writers erasers readers regulatory subunits PTMs cancer

Magnitude and direction of temperature variability affect hospitalization for myocardial infarction and stroke:population-based evidence from Guangzhou,China

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Frontiers of Environmental Science & Engineering 2024年第3期18卷 1-11页

作者： Zhou Yang Murui Zheng Ze-Lin Yan Hui Liu Xiangyi Liu Jie-Qi Jin Jiagang Wu Chun-Quan Ou State Key Laboratory of Organ Failure research Department of BiostatisticsGuangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public HealthSouthern Medical UniversityGuangzhou 510515China Guangzhou center for disease Control and Prevention Guangzhou 510440China

Relationships between nonoptimal temperatures and cardiovascular disease(CVD)mortality have been well ***,evidence of the association between temperature variability(TV)and CVD morbidity is *** study aimed to quantify the risk and burden of CVD-related hospitalization associated with the magnitude and direction of *** on meteorology and population-based hospitalizations for myocardial infarction(MI)and stroke were collected in Guangzhou,China,from 2013 to *** temperature variability(HTV)was measured as the standard deviation of hourly temperature records over specific exposure *** direction(upward or downward)of HTV was defined as the average daily mean temperature change relative to that of the previous day during the exposure ***-Poisson regression was applied to assess the impact of HTV after adjusting for the daily mean temperature,and the hospitalization fractions attributable to HTV were calculated.A 1℃-increase in HTV was significantly associated with a 2.24%and 1.72%increase in hospitalizations for MI and hemorrhagic stroke(HS)at lag 0–1 d,respectively,and a 1.55%increase in hospitalizations for ischemic stroke(IS)at lag 0–3 *** the study period,5.99%,4.64%,and 4.53%of MI,HS,and IS hospitalizations,respectively,were attributable to *** upward TV exerts acute effects on CVD hospital admissions,whereas the impact of downward TV generally *** findings highlight the importance of the magnitude and direction of temperature fluctuations,in addition to the mean level,in assessing the adverse health impacts of temperature variations.

关键词： Hourly temperature variability Cardiovascular Hospitalization Direction China

The key mediator of diabetic kidney disease:Potassium channel dysfunction

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Genes & diseases 2024年第4期11卷 188-200页

作者： Jia Guo Chaojie Zhang Hui Zhao Yufan Yan Zhangsuo Liu Nephrology research center The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney disease in Henan Province ZhengzhouHenan 450052China research center for Kidney disease ZhengzhouHenan 450052China

Diabetic kidney disease is a leading cause of end-stage renal disease,making it a global public health *** molecular mechanisms underlying diabetic kidney disease have not been elucidated due to its complex ***,exploring these mechanisms from new perspectives is the current focus of research concerning diabetic kidney *** channels are important proteins that maintain the physiological functions of cells and *** ion channels,potassium channels stand out,because they are the most common and important channels on eukaryotic cell surfaces and function as the basis for cell *** potassium channel abnormalities have been found to be closely related to diabetic kid-ney disease progression and genetic susceptibility,such as K_(ATP),K_(ca),K_(ir),and K_(v).In this review,we summarized the roles of different types of potassium channels in the occurrence and devel-opment of diabetic kidney disease to discuss whether the development of DKD is due to potas-sium channel dysfunction and present new ideas for the treatment of DKD.

关键词： Channel dysfunction Diabetic kidney disease End-stage renal disease lon channel Potassium

Trends in Fruit and Vegetable Intake Among the Labor Force Population—China,2010-2018

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China CDC weekly 2024年第18期6卷 401-407,I0008页

作者： Lan Wang Mei Zhang Xiao Zhang Zhenping Zhao Chun Li Mengting Yu Taotao Xue Feng Tan Limin Wang Division of Chronic disease and Risk Factor Surveillance National Center for Chronic and Non-communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Chinese center for disease Control and Prevention BeijingChina

Introduction:This research investigates trends pertaining to the prevalence of low fruit and vegetable consumption among the labor force population in *** study considered data derived from four nationally representative cross-sectional ***:The data under review for this study was derived from the China Chronic disease and Risk Factor Surveillance(CCDRFS)carried out in 2010,2013,2015,and 2018,*** utilized a food frequency questionnaire to evaluate the quantity and frequency of fruit and vegetable *** estimated prevalence of low fruit and vegetable consumption was calculated for each survey,while considering factors such as sex,age,location,and socioeconomic status(SES).Participants’SES was ascertained via latent class analysis,serving to identify distinct classes based on criteria such as education,occupation,and household income per *** regression was deployed to determine the statistical significance of ***:From 2010 to 2018,there was a notable increase in the average daily consumption of vegetables and fruits among the working population,rising from 418.6 g/day to 491.8 g/day(P0.05 for trend).Conclusion:Over the past nine years,there has been a notable decline in the prevalence of low fruit and vegetable consumption among the labor force population in ***,the comparatively deficient intake of fruits and vegetables evident among individuals of lower SES warrants further attention.

关键词： intake occupation utilized