检索结果-南通市图书馆

Zoological Research 2022年第2期43卷 237-240页

作者： Yong-Gang Yao behalf of the Construction Team of the KIZ Primate Facility National Research facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility) and National Resource Center for Non-Human PrimatesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province and KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China 不详

Some 10 years ago, in early 2012, we started discussing the establishment of the National Research facility for Phenotypic and Genetic Analysis of Model Animals(Primate Facility).Even though the Primate Facility is st... 详细信息

关键词： moment passing Even

Obituary:Prof.Yun Zhang(1963-2023)-A scientist focused on toxins and their underlying mechanisms to decipher human diseases

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2024年第1期45卷 230-232页

作者： Wenhui Lee Ren Lai the Key Laboratory of Bioactive Peptides of Yunnan Province Engineering Laboratory of Peptides of Chinese Academy of SciencesKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesNational Resource Centre for Non-Human PrimatesKunming Primate Research CentreNational Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Sino-African Joint Research CentreNew Cornerstone Science InstituteKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China

Prof.Yun Zhang was born on 9 July 1963 in Kunming,Yunnan,China,during a tumultuous period which he often referenced.Throughout his life,he harbored a steadfast belief in using knowledge to unravel the mysteries of human diseases.His educational journey was marked by frequent changes in schools due to his parents’occupational relocations.However,despite these challenges,he consistently displayed diligence and was admitted to the East China University of Science and Technology,Shanghai,after completing high school in 1980.He remained an active and loyal member of the School of Biotechnology at the university.

关键词： admitted harbor mechanisms

Brain developmental and cortical connectivity changes in transgenic monkeys carrying the human-specific duplicated gene SRGAP2C

在线全文

学校读者我要写书评

暂无评论

National Science Review 2023年第11期10卷 45-60页

作者： Xiaoyu Meng Qiang Lin Xuerui Zeng Jin Jiang Min Li Xin Luo Kaimin Chen Haixu Wu Yan Hu Cirong Liu Bing Su State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of Sciences National Resource Center for Non-Human primates Kunming Primate Research Centerand National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility)Kunming Institute of ZoologyChinese Academy of Sciences Kunming College of Life Science University of Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology Institute of NeuroscienceCAS Key Laboratory of Primate NeurobiologyChinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences

Human-specific duplicated genes contributed to phenotypic innovations during the origin of our own species, such as an enlarged brain and highly developed cognitive abilities. While prior studies on transgenic mice carrying the human-specific SRGAP2C gene have shown enhanced brain connectivity, the relevance to humans remains unclear due to the significant evolutionary gap between humans and rodents. In this study,to investigate the phenotypic outcome and underlying genetic mechanism of SRGAP2C, we generated transgenic cynomolgus macaques(Macaca fascicularis) carrying the human-specific SRGAP2C gene.Longitudinal MRI imaging revealed delayed brain development with region-specific volume changes,accompanied by altered myelination levels in the temporal and occipital regions. On a cellular level, the transgenic monkeys exhibited increased deep-layer neurons during fetal neurogenesis and delayed synaptic maturation in adolescence. Moreover, transcriptome analysis detected neotenic expression in molecular pathways related to neuron ensheathment, synaptic connections, extracellular matrix and energy metabolism. Cognitively, the transgenic monkeys demonstrated improved motor planning and execution skills. Together, our findings provide new insights into the mechanisms by which the newly evolved gene shapes the unique development and circuitry of the human brain.

关键词： SRGAP2C transgenic monkey brain evolution brain development neurogenesis neoteny

Monkeypox,wild animals,and potential big problem

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Zoological Research 2022年第4期43卷 612-614页

作者： Tian-Zhang Song Yong-Tang Zheng Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China National Resource Center for Non-Human primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China

A new outbreak of monkeypox virus(MPV)is currently occurring in several regions of the world.Since the beginning of May 2022,3040 cases have been reported to the World Health Organization(WHO)globally.Outside of its usual“endemic”base in Africa,the virus has so far been detected in 47 countries,including in Europe,America,Oceania,and Asia,where monkeypox is uncommon or previously unreported.On 25 June 2022,the WHO Emergency Committee declared that the outbreak does not currently constitute a Public Health Emergency of International Concern,but unanimously acknowledged the emergency nature of the event and that controlling further spread will require a vigorous response.Recently,new cases of MPV infection have been confirmed in Korea,Singapore,and Taiwan,China.Thus,a better understanding of MPV and enhanced surveillance are essential for preventing disease recurrence.

关键词： globally Taiwan currently

Design methods for antimicrobial peptides with improved performance

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2023年第6期44卷 1095-1114页

作者： James Mwangi Peter Muiruri Kamau Rebecca Caroline Thuku Ren Lai Key Laboratory of Bioactive Peptides of Yunnan Province Engineering Laboratory of Peptides of Chinese Academy of SciencesKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesNational Resource Centre for Non-Human PrimatesKunming Primate Research CentreNational Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Sino-African Joint Research CentreNew Cornerstone Science InstituteKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China Centre for Evolution and Conservation Biology Southern Marine Science and Engineering Guangdong LaboratoryGuangzhouGuangdong 511458China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China

The recalcitrance of pathogens to traditional antibiotics has made treating and eradicating bacterial infections more difficult.In this regard,developing new antimicrobial agents to combat antibiotic-resistant strains has become a top priority.Antimicrobial peptides(AMPs),a ubiquitous class of naturally occurring compounds with broadspectrum antipathogenic activity,hold significant promise as an effective solution to the current antimicrobial resistance(AMR)crisis.Several AMPs have been identified and evaluated for their therapeutic application,with many already in the drug development pipeline.Their distinct properties,such as high target specificity,potency,and ability to bypass microbial resistance mechanisms,make AMPs a promising alternative to traditional antibiotics.Nonetheless,several challenges,such as high toxicity,lability to proteolytic degradation,low stability,poor pharmacokinetics,and high production costs,continue to hamper their clinical applicability.Therefore,recent research has focused on optimizing the properties of AMPs to improve their performance.By understanding the physicochemical properties of AMPs that correspond to their activity,such as amphipathicity,hydrophobicity,structural conformation,amino acid distribution,and composition,researchers can design AMPs with desired and improved performance.In this review,we highlight some of the key strategies used to optimize the performance of AMPs,including rational design and de novo synthesis.We also discuss the growing role of predictive computational tools,utilizing artificial intelligence and machine learning,in the design and synthesis of highly efficacious lead drug candidates.

关键词： Antimicrobial resistance Antimicrobial peptides Design methods Peptidomimetics Artificial intelligence

Characterization of tree shrew telomeres and telomerase

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2021年第7期48卷 631-639页

作者： Jian Sun Wenjing Liu Yongbo Guo Hailin Zhang Dewei Jiang Ying Luo Rong Liu Ceshi Chen Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences&Yunnan Province National Resource Center for Non-Human PrimatesKunming Primate Research CenterNational Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyKunmingYunnan 650201China Kunming College of Life Sciences University of Chinese Academy SciencesKunmingYunnan 650204China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Laboratory of Molecular Genetics of Aging&Tumor Medical FacultyKunming University of Science and TechnologyKunmingYunnan 650500China

The use of tree shrews as experimental animals for biomedical research is a new practice.Several recent studies suggest that tree shrews are suitable for studying cancers,including breast cancer,glioblastoma,lung cancer,and hepatocellular carcinoma.However,the telomeres and the telomerase of tree shrews have not been studied to date.Here,we characterize telomeres and telomerase in tree shrews.The telomere length of tree shrews is approximately 23 kb,which is longer than that of primates and shorter than that of mice,and it is extended in breast tumor tissues according to Southern blot and flow-fluorescence in situ hybridization(FISH)analyses.Tree shrew spleen,bone marrow,testis,ovary,and uterus show high telomerase activities,which are increased in breast tumor tissues by telomeric repeat amplification protocol assays.The telomere length becomes shorter,and telomerase activity decreases with age.The tree shrew TERT and TERC are more highly similar to primates than to rodents.These findings lay a solid foundation for using tree shrews to study aging and cancers.

关键词： Tree shrews Telomere TERT TERC Breast cancer

Bioactive peptides from scorpion venoms:therapeutic scaffolds and pharmacological tools

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2023年第1期21卷 19-35页

作者： Peter Muiruri Kamau ZHONG Jian YAO Bing LAI Ren LUO Lei Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesNational Resource Center for Non-Human PrimatesKunming Primate Research CenterNational Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Sino-African Joint Research Centerand Engineering Laboratory of PeptidesKunming Institute of ZoologyKunming 650107China Kunming College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Reproductive Medicine Affiliated Jinling HospitalNanjing Medical UniversityNanjing 210002China Department of Gynecology Women’s Hospital of Nanjing Medical UniversityNanjing 210004China Center for Evolution and Conservation Biology Southern Marine Science and Engineering Guangdong LaboratoryGuangzhou 511458China

Evolution and natural selection have endowed animal venoms,including scorpion venoms,with a wide range of pharmacological properties.Consequently,scorpions,their venoms,and/or their body parts have been used since time immemorial in traditional medicines,especially in Africa and Asia.With respect to their pharmacological potential,bioactive peptides from scorpion venoms have become an important source of scientific research.With the rapid increase in the characterization of various components from scorpion venoms,a large number of peptides are identified with an aim of combating a myriad of emerging global health problems.Moreover,some scorpion venom-derived peptides have been established as potential scaffolds helpful for drug development.In this review,we summarize the promising scorpion venoms-derived peptides as drug candidates.Accordingly,we highlight the data and knowledge needed for continuous characterization and development of additional natural peptides from scorpion venoms,as potential drugs that can treat related diseases.

关键词： Scorpion venoms Scorpion venom-derived peptides Pharmacological properties Drug development

Dynamic coding in the hippocampus during navigation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zoological Research 2022年第6期43卷 1023-1025页

作者： Jia-Li Long Li Lu Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China National Research facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility) Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China

Spatial navigation, which enables animals to move in an oriented way, is a complex, dynamic behavior fundamental for everyday survival. Animals navigate their environments using cognitive maps, which are internal representations of external space acquired by the brain through integration of multisensory cues. Deficits in spatial navigation skills are often preclinical signs of Alzheimer’s disease in seniors and neurodevelopmental disorders in children and adolescents(Coughlan et al., 2018;Faedda et al., 2022).

关键词： Alzheimer everyday

Exploring the primate genome:Unraveling the mysteries of evolution and human disease

在线全文

学校读者我要写书评

暂无评论

The Innovation 2023年第4期4卷 21-22页

作者： Yaoxi He Yafei Mao State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China National Resource Center for Non-Human primates Kunming Primate Research Centerand National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunming 650107China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200230China Center for Genomic Research International Institutes of MedicineThe Fourth Affiliated HospitalZhejiang UniversityYiwu 322000China

Nonhuman primates(NHPs),our closest relatives,represent one of the most successful lineages of adaptive radiation in mammals.The primate order contains several hundred species living in varied ecological niches with phenotypic diversity.However,what we know about NHPs is still limited because of genome diversity.To address this gap,the primate Genome Project(PGP)consortium recently made a comprehensive sequencing effort.

关键词： evolution prima relatives

Age-associated changes in amyloid-β and formaldehyde concentrations in cerebrospinal fluid of rhesus monkeys

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zoological Research 2020年第4期41卷 444-448页

作者： Zhen-Hui Li Xia-Ping He Hao Li Rong-Qiao He Xin-Tian Hu Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life Science University of the Chinese Academy of SciencesKunmingVt/nnan 650204China School of Basic Medical Sciences Dali UniversityDaliYunnan 671000China CAS Center for Excellence in Brain Science Chinese Academy of SciencesShanghai 200031China Kunming primate Research Center and National Research facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility) Chinese Academy of SciencesKunmingYunnan 650223China State Key Laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of ScienceBeijing 100101China

DEAR EDITOR,Rhesus monkeys(Macaca mulatta)are valuable experimental animals for studies on neurodegenerative diseases due to their evolutionarily close relationship to humans(Zhang et al.,2014).Rhesus monkeys also display similar hallmarks of aging and neurodegeneration as humans,including formation of senile plaques in the brain(Beckman et al.,2019;Paspalas et al.,2018).

关键词： al. senile amyloid