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CD8+T cell metabolic flexibility elicited by CD28-ARS2 axisdriven alternative splicing of PKM supports antitumor immunity

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Cellular & Molecular Immunology 2024年第3期21卷 260-274页

作者： G.Aaron Holling Colin A.Chavel Anand P.Sharda Mackenzie M.Lieberman Caitlin M.James Shivana M.Lightman Jason H.Tong Guanxi Qiao Tiffany R.Emmons Thejaswini Giridharan Shengqi Hou Andrew M.Intlekofer Richard M.Higashi Teresa W.M.Fan Andrew N.Lane Kevin H.Eng Brahm H.Segal Elizabeth A.Repasky Kelvin P.Lee Scott H.Olejniczak department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA department of Medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environmental Systems biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA department of Cancer Genetics and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA present address:University of Colorado Boulder BoulderCO 80309USA present address:Dana Farber Cancer Institute BostonMA 02215USA present address:Massachusetts Institute of Technology BostonMA 02139USA present address:Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

Metabolic flexibility has emerged as a critical determinant of CD8+T-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap-binding complex(CBC)adaptor protein ARS2 on mature T *** doing so,we discovered a novel signaling axis that endows activated CD8+T cells with flexibility of glucose ***2 upregulation driven by CD28 signaling reinforced splicing factor recruitment to pre-mRNAs and affected approximately one-third of T-cell activation-induced alternative splicing *** these effects,the CD28-ARS2 axis suppressed the expression of the M1 isoform of pyruvate kinase in favor of PKM2,a key determinant of CD8+T-cell glucose utilization,interferon gamma production,and antitumor effector ***,PKM alternative splicing occurred independently of CD28-driven PI3K pathway activation,revealing a novel means by which costimulation reprograms glucose metabolism in CD8+T cells.

关键词： Immunometabolism mRNA splicing CD8 T cells ARS2 PKM2

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Trend of Developing Aqueous Liquid and Gel Electrolytes for Sustainable,Safe,and High‑Performance Li‑Ion Batteries

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Nano-Micro Letters 2024年第1期16卷 17-34页

作者： Donghwan Ji Jaeyun Kim School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences&Technology(SAIHST)Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Biomedical Institute for Convergence at SKKU(BICS) Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Institute of Quantum biophysics(IQB) Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea present address:department of NanoEngineering University of California San DiegoLa JollaSan DiegoCA 92093USA

Current lithium-ion batteries(LIBs)rely on organic liquid electrolytes that pose significant risks due to their flammability and *** potential for environmental pollution and explosions resulting from battery damage or fracture is a critical ***-based(aqueous)electrolytes have been receiving attention as an alternative to organic ***,a narrow electrochemicalstability window,water decomposition,and the consequent low battery operating voltage and energy density hinder the practical use of aqueous ***,developing novel aqueous electrolytes for sustainable,safe,high-performance LIBs remains *** Review first commences by summarizing the roles and requirements of electrolytes–separators and then delineates the progression of aqueous electrolytes for LIBs,encompassing aqueous liquid and gel electrolyte development trends along with detailed principles of the *** aqueous electrolytes are progressed based on strategies using superconcentrated salts,concentrated diluents,polymer additives,polymer networks,and artificial passivation layers,which are used for suppressing water decomposition and widening the electrochemical stability window of water of the *** addition,this Review discusses potential strategies for the implementation of aqueous Li-metal batteries with improved electrolyte–electrode interfaces.A comprehensive understanding of each strategy in the aqueous system will assist in the design of an aqueous electrolyte and the development of sustainable and safe high-performance batteries.

关键词： Lithium-ion battery(LIB) Aqueous electrolyte Gel electrolyte Electrochemical stability window Li dendrite

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Exploring unconventional attributes of red blood cells and their potential applications in biomedicine

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Protein & Cell 2024年第5期15卷 315-330页

作者： Alkmini T.Anastasiadi Vasiliki-Zoi Arvaniti Krystalyn E.Hudson Anastasios G.Kriebardis Constantinos Stathopoulos Angelo D’Alessandro Steven L.Spitalnik Vassilis L.Tzounakas department of biochemistry School of MedicineUniversity of Patras26504 PatrasGreece department of Pathology and Cell Biology Columbia University Irving Medical CenterNew York CityNY 10032USA Laboratory of Reliability and Quality Control in Laboratory Hematology(HemQcR) Department of Biomedical SciencesSchool of Health&Caring SciencesUniversity of West Attica(UniWA)12243 EgaleoGreece department of biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus13001 AuroraCOUSA present address:Institute for Fundamental Biomedical Research(IFBR) Biomedical Sciences Research Center“Alexander Fleming”Vari11527 AthensGreece

We need to talk about red blood *** cells are defined as cells containing distinct nuclei and other membranous ***,red blood cells(RBCs)lack a nucleus and organelles—perhaps to limit the generation of reactive oxygen species(Zhang et al.,2011)—and are filled with hemoglobin(Hb).This oxygen carrier is limited to the cytosol by the cell membrane and cytoskeleton,which maintain cellular integrity and deformability as RBCs pass through narrow capillaries(Gratzer,1994)to perform their primary function of gas exchange.

关键词： membranous maintain

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The biosynthetic pathway of the hallucinogen mescaline and its heterologous reconstruction

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Molecular Plant 2024年第7期17卷 1129-1150页

作者： Paula Berman Luis Alejandro de Haro Ana-Rita Cavaco Sayantan Panda Younghui Dong Nikolay Kuzmich Gabriel Lichtenstein Yoav Peleg Hila Harat Adam Jozwiaki Jianghua Cai Uwe Heinig Sagit Meir Ilana Rogachev Asaph Aharoni department of Plant and Environmental Sciences Weizmann Institute of ScienceRehovot 7610001Israel Life Sciences Core Facilities Weizmann Institute of ScienceRehovot 7610001Israel The Maurice and Vivienne Wohl Institute for Drug Discovery Weizmann Institute of ScienceRehovot 7610001Israel present address:department of Cell and Metabolic Biology Leibniz Institute of Plant BiochemistryWeinberg 306120 Halle(Saale)Germany department of Molecular&Cellular Pharmacology University of Miami Miler School of MedicineMiamiFL 33136USA department of Botany and Plant Sciences University of California RiversideRiversideCA 92521USA Laboratory of Plant Hormones and Development Regulation of Chongqing School of Life SciencesChongqing UniversityChongqing 401331China

Mescaline,among the earliest identified natural hallucinogens,holds great potential in psychotherapy ***,despite the existence of a postulated biosynthetic pathway for more than half a century,the specific enzymes involved in this process are yet to be *** this study,we investigated the cactus Lophophora williamsii(Peyote),the largest known natural producer of the phenethylamine *** employed a multi-faceted approach,combining de novo whole-genome and transcriptome sequencing with comprehensive chemical profiling,enzymatic assays,molecular modeling,and pathway engineering for pathway *** identified four groups of enzymes responsible for the six catalytic steps in the mescaline biosynthetic pathway,and an N-methyltransferase enzyme that N-methylates all phenethylamine intermediates,likely modulating mescaline levels in ***,we reconstructed the mescaline biosynthetic pathway in both Nicotiana benthamiana plants and yeast cells,providing novel insights into several challenges hindering complete heterologous mescaline *** together,our study opens up avenues for exploration of sustainable production approaches and responsible utilization of mescaline,safeguarding this valuable natural resource for future generations.

关键词： mescaline Lophophora williamsi Peyote biosynthetic pathway de novo genome sequencing mo-lecular modeling

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Volumetric lattice Boltzmann method for pore-scale mass diffusionadvection process in geopolymer porous structures

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2126-2136页

作者： Xiaoyu Zhang Zirui Mao Floyd W.Hilty Yulan Li Agnes Grandjean Robert Montgomery Hans-Conrad zur Loye Huidan Yu Shenyang Hu Purdue University IndianapolisIN46202USA Pacific Northwest National Laboratory RichlandWA99352USA CEA DESISECDMRCUniv.MontpellierMarcouleFrance department of Chemistry and biochemistry University of South CarolinaColumbiaSC29208USA

Porous materials present significant advantages for absorbing radioactive isotopes in nuclear waste *** improve absorption efficiency in nuclear waste treatment,a thorough understanding of the diffusion-advection process within porous structures is essential for material *** this study,we present advancements in the volumetric lattice Boltzmann method(VLBM)for modeling and simulating pore-scale diffusion-advection of radioactive isotopes within geopolymer porous *** structures are created using the phase field method(PFM)to precisely control pore *** our VLBM approach,we introduce a concentration field of an isotope seamlessly coupled with the velocity field and solve it by the time evolution of its particle population *** address the computational intensity inherent in the coupled lattice Boltzmann equations for velocity and concentration fields,we implement graphics processing unit(GPU)*** of the developed model involves examining the flow and diffusion fields in porous ***,good agreement is observed for both the velocity field from VLBM and multiphysics object-oriented simulation environment(MOOSE),and the concentration field from VLBM and the finite difference method(FDM).Furthermore,we investigate the effects of background flow,species diffusivity,and porosity on the diffusion-advection behavior by varying the background flow velocity,diffusion coefficient,and pore volume fraction,***,all three parameters exert an influence on the diffusion-advection *** background flow and diffusivity markedly accelerate the process due to increased advection intensity and enhanced diffusion capability,***,increasing the porosity has a less significant effect,causing a slight slowdown of the diffusion-advection process due to the expanded pore *** comprehensive parametric study provides valuable insights into the kinetics of isotope

关键词： Volumetric lattice Boltzmann method(VLBM) Phase field method(PFM) Pore-scale diffusion-advection Nuclear waste treatment Porous media flow Graphics processing unit(GPU) parallelization

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Innovative insights into extrachromosomal circular DNAs in gynecologic tumors and reproduction

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Protein & Cell 2024年第1期15卷 6-20页

作者： Ning Wu Ling Wei Zhipeng Zhu Qiang Liu Kailong Li Fengbiao Mao Jie Qiao Xiaolu Zhao State Key Laboratory of Female Fertility Promotion Center for Reproductive MedicineDepartment of Obstetrics and GynecologyCenter for Reproductive MedicinePeking University Third HospitalBeijing 100191China National Clinical Research Center for Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China Key Laboratory of Assisted Reproduction(Peking University) Ministry of EducationBeijing 100191China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing 100191China Institute of Medical Innovation and Research Peking University Third HospitalBeijing 100191China Cancer Center Peking University Third HospitalBeijing 100191China department of biochemistry and biophysics Beijing Key Laboratory of Protein Posttranslational Modifications and Cell FunctionSchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Beijing Advanced Innovation Center for Genomics Beijing 100191China Peking-Tsinghua Center for Life Sciences Peking UniversityBeijing 100191China

Originating but free from chromosomal DNA,extrachromosomal circular DNAs(eccDNAs)are organized in circular form and have long been found in unicellular and multicellular *** biogenesis and function are poorly understood as they are characterized by sequence homology with linear DNA,for which few detection methods are *** advances in high-throughput sequencing technologies have revealed that eccDNAs play crucial roles in tumor formation,evolution,and drug resistance as well as aging,genomic diversity,and other biological processes,bringing it back to the research *** mechanisms of eccDNA formation have been proposed,including the breakage-fusion-bridge(BFB)and translocation-deletion-amplification *** tumors and disorders of embryonic and fetal development are major threats to human reproductive *** roles of eccDNAs in these pathological processes have been partially elucidated since the first discovery of eccDNA in pig sperm and the double minutes in ovarian cancer *** present review summarized the research history,biogenesis,and currently available detection and analytical methods for eccDNAs and clarified their functions in gynecologic tumors and *** also proposed the application of eccDNAs as drug targets and liquid biopsy markers for prenatal diagnosis and the early detection,prognosis,and treatment of gynecologic *** review lays theoretical foundations for future investigations into the complex regulatory networks of eccDNAs in vital physiological and pathological processes.

关键词： extrachromosomal circular DNAs gynecologic tumors reproduction liquid biopsy non-invasive prena-tal testing

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A perspective on functionalizing colloidal quantum dots with DNA

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Nano Research 2013年第12期6卷 853-870页

作者： Anirban Samanta Zhengtao Dengt Yan Liu Hao Yan Center for Single Molecule biophysics the Biodesign Institute & Department of Chemistry and Biochemistry Arizona State University. TempeArizona 85281 USA present address: MIT Synthetic Biology Center Boston MA USA

This perspective provides an overview of the techniques that have been developed for the conjugation of DNA to colloidal quantum dots （QDs）, or semiconductor nanocrystals. Methods described include： ligand exchange at the QD surface, covalent conjugation of DNA to the QD surface ligands, and one-step DNA functionalization on core QDs or during core/shell QD synthesis in aqueous solution, with an emphasis on tile most recent progress in our lab. We will also discuss emerging trends in DNA-functionalized QDs for potential applications.

关键词： colloidal quantum dots semiconductor nanocrystals DNA conjugation ligand exchange covalent bond core/shell

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SWI1 Is Required for Meiotic Chromosome Remodeling Events

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Molecular Plant 2008年第4期1卷 620-633页

作者： Kingsley A. Boateng Xiaohui Yang Fuqui Dong Heather A. Owen Christopher A. Makaroff department of Chemistry and biochemistry Miami University Oxford OH 45056 USA present address: department of Biological Sciences University of Wisconsin-Milwaukee Milwaukee Wl 53211 USA

The Arabidopsis dsy10 mutant was previously identified as being defective in the synapsis of meiotic chromosomes resulting in male and female sterility. We report here the molecular analysis of the mutation and show that it represents a T-DNA insertion in the third exon of the SWll gene. Four mutations have now been identified in SWI1, several of which exhibit different phenotypes. For example, the swil- 1 and dyad mutations only affect meiosis in megasporocytes, while the swil-2 and dsy10 mutations block both male and female meiosis. Furthermore, as part of a detailed cytological characterization of dsy10 meiocytes, we identified several differences during male meiosis between the swil-2 and dys10 mutants, including variations in the formation of axial elements, the distribution of cohesin proteins and the timing of the premature loss of sister chromatid cohesion. We demonstrate that dsy10 represents a complete loss-of-function mutation, while a truncated form of SWll is expressed during meiosis in swil-2 plants. We further show that dys10 meiocytes exhibit alterations in modified histone patterns, including acetylated histone H3 and dimethylated histone H3-Lysine 4.

关键词： Arabidopsis meiosis sister chromatid cohesion chromatin remodeling histone.

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Two-Step Processing of AtFtsH4 Precursor by Mitochondrial Processing Peptidase in Arabidopsis thaliana

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Molecular Plant 2012年第6期5卷 1417-1419页

作者： Beata Kmiec Adam Urantowka Marcin Lech Hanna Janska department of Biotechnology University of Wroclawul.Przybyszewskiego 63/7751–148 WroclawPoland present address:department of biochemistry and biophysics Stockholm UniversitySE-10691 StockholmSweden

Dear Editor, Most mitochondrial proteins are encoded by the nuclear genome and posttranslationally imported to mitochondria. The correct targeting is often ensured by an N-terminal exten- sion designated presequence. Upon import, the presequence is cleaved off in a reaction termed processing. Most of our knowledge regarding mitochondrial processing comes from analyses performed in Saccharomyces cerevisiae. In yeast, the mitochondrial processing peptidase （MPP） is responsible for processing of the majority of mitochondrial precursors, with a fraction of them undergoing a second step of processing, car- ried out by either metalloproteases （Octl/MIP, Icp55） or serine proteases （Imp, Pcpl）（reviewed in Teixeira and Glaser, 2012）. Unusual two-step processing in which both processing steps are carried out by MPP has been reported for yeast and human frataxin （Branda et al., 1999） and for Neurospora crassa mito- chondrial ATP synthase subunit 9 （Schmidt et al., 1984）.

关键词： CLEAVAGE YEAST

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Assembly of JAZ–JAZ and JAZ–NINJA complexes in jasmonate signaling

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Plant Communications 2023年第6期4卷 296-312页

作者： X.Edward Zhou Yaguang Zhang Jian Yao Jie Zheng Yuxin Zhou Qing He Javier Moreno Vinh QLam Xiaoman Cao Koichi Sugimoto Leidy Vanegas-Cano Leena Kariapper Kelly Suino-Powell Yuanye Zhu Scott Novick Patrick R.Griffin Feng Zhang Gregg A.Howe Karsten Melcher department of Structural Biology Van Andel InstituteGrand RapidsMI 49503USA Key Laboratory of Pesticide College of Plant ProtectionNanjing Agricultural UniversityNanjingChina MSU-DOE Plant Research Laboratory Michigan State UniversityEast LansingMI 48824USA department of Molecular Medicine UF Scripps Biomedical ResearchJupiterFL 33458USA Plant Resilience Institute Michigan State UniversityEast LansingMI 48824USA department of biochemistry and Molecular Biology Michigan State UniversityEast LansingMI 48824USA present address:Institute of Botany Jiangsu Province and Chinese Academy of SciencesNanjing 210014China present address:Tsukuba-Plant Innovation Research Center University of TsukubaTsukubaIbaraki 305-8572Japan

Jasmonates(JAs)are plant hormones with crucial roles in development and stress *** activate MYC transcription factors by mediating the proteolysis of MYC inhibitors called JAZ *** the absence of JA,JAZ proteins bind and inhibit MYC through the assembly of MYC–JAZ–Novel Interactor of JAZ(NINJA)–TPL repressor ***,JAZ and NINJA are predicted to be largely intrinsically unstructured,which has precluded their experimental structure *** a combination of biochemical,mutational,and biophysical analyses and AlphaFold-derived ColabFold modeling,we characterized JAZ–JAZ and JAZ–NINJA interactions and generated models with detailed,high-confidence domain *** demonstrate that JAZ,NINJA,and MYC interface domains are dynamic in isolation and become stabilized in a stepwise order upon complex *** contrast,most JAZ and NINJA regions outside of the interfaces remain highly dynamic and cannot be modeled in a single *** data indicate that the small JAZ Zinc finger expressed in Inflorescence Meristem(ZIM)motif mediates JAZ–JAZ and JAZ–NINJA interactions through separate surfaces,and our data further suggest that NINJA modulates JAZ *** study advances our understanding of JA signaling by providing insights into the dynamics,interactions,and structure of the JAZ–NINJA core of the JA repressor complex.

关键词： JAZ protein NINJA AlphaFold ColabFold MYC hydrogen-deuterium exchange

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