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Power output correction model of narrow linewidth ring fiber laser filtered with whispering gallery mode resonator

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Chinese Optics Letters 2024年第3期22卷 60-64页

作者：王子云徐在斌崔继文谭久彬 center of Ultra-precision Optoelectronic Instrument Harbin Institute of TechnologyHarbin 150080China Key laboratory of Ultra-precision Intelligent Instrumentation Ministry of Industry and Information TechnologyHarbin Institute of TechnologyHarbin 150080China

A whispering gallery mode resonator(WGMR)filter can narrow laser linewidth while significantly changing the output power characteristics of fiber laser *** is found that traditional laser output power model is *** report a correction model of a narrow linewidth fiber laser filtered with a WGMR to analyze its *** believe that the loss of the laser system and the threshold gain increase caused by the WGMR filter lead to the predominate amplified spontaneous emission during the original laser *** to that,we assume the correction coefficient is an exponential decay related to the Er-doped fiber length in the large loss situation,and we verify it *** a result,the correction model is valid for WGMR-filtered fiber laser.

关键词： whispering gallery resonator filter narrow linewidth fiber laser power output correction model

Design of a high frequency accuracy heterodyne laser source working in a wide temperature range

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Chinese Optics Letters 2024年第4期22卷 83-88页

作者：杨宏兴王彦殷子淇胡鹏程杨睿韬李婧 center of Ultra-precision Optoelectronic Instrument Harbin Institute of TechnologyHarbin 150080China Key laboratory of Ultra-precision Intelligent Instrumentation(Harbin Institute of Technology) Ministry of Industry and Information TechnologyHarbin 150080China

To ensure the frequency accuracy of a heterodyne laser source in the ambient temperature range of-20℃ to 40℃, a duallongitudinal-mode thermally stabilized He–Ne laser based on non-equilibrium power locking was designed. The ambient adaptive preheating temperature setting scheme ensured the laser could operate normally in the range of-20℃ to40℃. The non-equilibrium power-locked frequency stabilization scheme compensated for the frequency drift caused by different stabilization temperatures. The experimental results indicated that the frequency accuracy of the laser designed in this study could reach 5.2 × 10^(-9)in the range of-20℃ to 40℃.

关键词： He–Ne laser frequency accuracy ambient adaptability non-equilibrium power locking

Strong field ionization of molecules on the surface of nanosystems

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Chinese Physics B 2024年第4期33卷 25-34页

作者：曲棋文孙烽豪王佳伟高健李辉吴健 State Key laboratory of precision Spectroscopy East China Normal UniversityShanghai 200241China Chongqing Key laboratory of precision Optics Chongqing Institute of East China Normal UniversityChongqing 401121China Collaborative Innovation center of Extreme Optics Shanxi UniversityTaiyuan 030006China CAS center for Excellence in Ultra-Intense Laser Science Shanghai 201800China

Besides the diverse investigations on the interactions between intense laser fields and molecular systems,extensive research has been recently dedicated to exploring the response of nanosystems excited by well-tailored femtosecond laser *** to the fact that nanostructures hold peculiar effects when illuminated by laser pulses,the underlying mechanisms and the corresponding potential applications can make significant improvements in both fundamental research and development of novel *** this review,we provide a summarization of the strong field ionization occurring on the surface of *** molecules attached to the nanoparticle surface perform as the precursor in the ionization and excitation of the whole nanosystem,the fundamental processes of which are yet to be *** discuss the influence on nanoparticle constituents,geometric shapes and sizes,as well as the specific waveforms of the excitation laser *** intriguing characteristics observed in surface ion emission reflect how enhanced near field affects the localized ionizations and nanoplasma expansions,thereby paving the way for further precision controls on the light-and-matter interactions in the extreme spatial temporal levels.

关键词： nanoparticle femtosecond laser field local field enhancement

β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture

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Bone Research 2024年第2期12卷 302-313页

作者： Jie Huang Tong Wu Yi-Rong Jiang Xuan-Qi Zheng Huan Wang Hao Liu Hong Wang Hui-Jie Leng Dong-Wei Fan Wan-Qiong Yuan Chun-Li Song Department of Orthopedics Peking University Third Hospital100191 BeijingChina Beijing Key laboratory of Spinal Disease 100191 BeijingChina Engineering Research center of Bone and Joint precision medicine 100191 BeijingChina

The autonomic nervous system plays a crucial role in regulating bone metabolism,with sympathetic activation stimulating bone resorption and inhibiting bone *** found that fractures lead to increased sympathetic tone,enhanced osteoclast resorption,decreased osteoblast formation,and thus hastened systemic bone loss in ovariectomized(OVX)***,the combined administration of parathyroid hormone(PTH)and theβ-receptor blocker propranolol dramatically promoted systemic bone formation and osteoporotic fracture healing in OVX *** effect of this treatment is superior to that of treatment with PTH or propranolol *** vitro,the sympathetic neurotransmitter norepinephrine(NE)suppressed PTH-induced osteoblast differentiation and mineralization,which was rescued by ***,NE decreased the PTH-induced expression of Runx2 but enhanced the expression of Rankl and the effect of PTH-stimulated osteoblasts on osteoclastic differentiation,whereas these effects were reversed by ***,PTH increased the expression of the circadian clock gene Bmal1,which was inhibited by NE-βAR ***1 knockdown blocked the rescue effect of propranolol on the NE-induced decrease in PTHstimulated osteoblast *** together,these results suggest that propranolol enhances the anabolic effect of PTH in preventing systemic bone loss following osteoporotic fracture by blocking the negative effects of sympathetic signaling on PTH anabolism.

关键词： blocker metabolism inhibited

High-speed PGC demodulation model and method with subnanometer displacement resolution in a fiber-optic micro-probe laser interferometer

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Photonics Research 2024年第5期12卷 921-931页

作者： YISI DONG WENWEN LI JiNRAN ZHANG WENRUI LUo HAIJIN FU XU XING PENGCHENG HU YONGKANG DONG JIUBIN TAN center of Ultra-precision Optoelectronic Instrument Harbin Institute of TechnologyHarbin 150080China Key laboratory of Ultra-precision Intelligent Instrumentation(Harbin Institute of Technology) Ministry of Industry and Information TechnologyHarbin 150080China National Key laboratory of Science and Technology on Tunable Laser Harbin Institute of TechnologyHarbin 150001China

As the key of embedded displacement measurement,a fiber-optic micro-probe laser interferometer(FMI)is of great interest in developing high-end equipment as well as precision ***,conventional phasegenerated carrier(PGC)approaches are for low-speed scenes and local error analysis,usually neglecting the global precision analysis and dynamic effect of system parameters under high-speed measurement,thus hindering their broad *** present a high-speed PGC demodulation model and method to achieve subnanometer displacement measurement precision in *** model includes a global equivalent resolution analysis and revelation of the demodulation error *** this model,the failure issues regarding the PGC demodulation method under high speed and large range are ***,an ultra-precision PGC demodulation algorithm based on the combination of static and dynamic delay adaptive regulation is proposed to enable high-speed and large-range displacement *** this paper,the proposed model and algorithm are validated through simulation and experimental *** results demonstrate a displacement resolution of 0.1 nm with a standard deviation of less than 0.5 nm when measuring at a high velocity of 1.5 m/s—nearly a tenfold increase of the latest study.

关键词： interferometer fiber displacement

MiR-4465-modified mesenchymal stem cell-derived small extracellular vesicles inhibit liver fibrosis development via targeting LOXL2 expression

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第7期25卷 594-604页

作者： Yanjin WANG Yifei CHEN Fuji YANG Xiaolong YU Ying CHU Jing ZHOU Yongmin YAN Jianbo XI Department of laboratory medicine Wujin Hospital Affiliated with Jiangsu UniversityJiangsu UniversityChangzhou 213017China Department of laboratory medicine School of MedicineJiangsu UniversityZhenjiang 212013China Changzhou Key laboratory of Molecular Diagnostics and precision Cancer medicine Wujin Clinical College of Xuzhou Medical UniversityChangzhou 213017China

Liver fibrosis is a significant health burden,marked by the consistent deposition of ***,the currently available treatment approaches for this condition are far from *** oxidase-like protein 2(LOXL2)secreted by hepatic stellate cells(HSCs)is a crucial player in the cross-linking of matrix collagen and is a significant target for treating liver *** stem cell-derived small extracellular vesicles(MSC-sEVs)have been proposed as a potential treatment option for chronic liver *** studies have found that MSC-sEV can be used for microRNA delivery into target cells or *** is currently unclear whether microRNA-4465(miR-4465)can target LOXL2 and inhibit HSC ***,it is uncertain whether MSC-sEV can be utilized as a gene therapy vector to carry miR-4465 and effectively inhibit the progression of liver *** study explored the effect of miR-4465-modified MSC-sEV(MSC-sEVmiR-4465)on LOXL2 expression and liver fibrosis *** results showed that miR-4465 can bind specifically to the promoter of the LOXL2 gene in ***,MSC-sEVmiR-4465 inhibited HSC activation and collagen expression by downregulating LOXL2 expression in ***-sEVmiR-4465 injection could reduce HSC activation and collagen deposition in the CCl4-induced mouse ***-sEVmiR-4465 mediating via LOXL2 also hindered the migration and invasion of HepG2 *** conclusion,we found that MSC-sEV can deliver miR-4465 into HSC to alleviate liver fibrosis via altering LOXL2,which might provide a promising therapeutic strategy for liver diseases.

关键词： Mesenchymal stem cell(MSC) Small extracellular vesicle(sEV) MicroRNA-4465(miR-4465) Hepatic stellate cell(HSC) Liver fibrosis

Coherent link between a Ti:sapphire comb and a 1.5μm laser via nonlinear interaction in photonic crystal fiber

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Photonics Research 2024年第2期12卷 350-355页

作者： YUAN YAO HAOSEN SHI GUANG YANG BO LI CONGYU WANG HONGFU YU LONGSHENG MA YANYI JIANG State Key laboratory of precision Spectroscopy East China Normal UniversityShanghai 200062China Collaborative Innovation center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Optical clock networks have distinct advantages for the dissemination of time/frequency,geodesy,and fundamental *** realize such a network,the telecom band and optical atomic clocks have to be coherently *** the telecom band and optical atomic clocks reside in a distinct spectral region,second-harmonic generation is usually introduced to bridge the large frequency *** this paper,we introduce a new method to coherently link a 1550 nm continuous wave laser with a Ti:sapphire mode-locked laser-based optical frequency *** coupling the 1550 nm continuous wave laser light and the Ti:sapphire comb light together into a photonic crystal fiber,nonlinear interaction takes place,and new comblike frequency components related to the 1550 nm laser frequency are generated in the visible ***,we can detect beat notes between two combs in the visible region with a signal-to-noise ratio of more than 40 dB in a resolution bandwidth of300 *** this signal,we realize an optical frequency divider for converting the frequency of optical clocks in the visible region to the telecom band at 1.55μ*** out-of-loop measurement shows that the additional noise and uncertainty induced in optical frequency conversion are 5×10^(-18)at 1 s averaging time and 2.2×10^(-19),respectively,which are limited by the uncompensated light path fluctuation but fulfill precision measurement using state-of-the-art optical clocks.

关键词： fiber interaction nonlinear

Manipulating the electron dynamics in the non-sequential double ionization process of Ar atoms by an orthogonal two-color laser field

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Chinese Physics B 2024年第6期33卷 338-345页

作者：王鹏昭钱丽洁孙真荣杨岩 State Key laboratory of precision Spectroscopy East China Normal UniversityShanghai 200241China Collaborative Innovation center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Electron dynamics during non-sequential double ionization(NSDI) is one of the most attractive areas of research in the field of laser–atom or laser–molecule interaction. Based on the classic two-dimensional model, we study the process of NSDI of argon atoms driven by a few-cycle orthogonal two-color laser field composed of 800 nm and 400 nm laser pulses. By changing the relative phase of the two laser pulses, a localized enhancement of NSDI yield is observed at 0.5πand 1.5π, which could be attributed to a rapid and substantial increase in the number of electrons returning to the parent ion within extremely short time intervals at these specific phases. Through the analysis of the electron–electron momentum correlations within different time windows of NSDI events and the angular distributions of emitted electrons in different channels, we observe a more pronounced electron–electron correlation phenomenon in the recollision-induced ionization(RII) channel. This is attributed to the shorter delay time in the RII channel.

关键词： non-sequential double ionization electron dynamics few-cycle orthogonal two-color laser field

Manipulating the Phase Transition Behavior of Dual Temperature-Responsive Block Copolymers by Adjusting Composition and Sequence

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Chinese Journal of Polymer Science 2024年第2期42卷 176-187,I0006页

作者： Zhi Zou Xiang Xu Hai-Tao Zhao Jian-Nan Cheng Wei-Wei He Li-Fen Zhang Zhen-Ping Cheng Suzhou key laboratory of Macromolecular Design and precision Synthesis Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationState and Local Joint Engineering Laboratory for Novel Functional Polymeric MaterialsCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou215123China State Key laboratory of Radiation medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of JiangsuSoochow UniversitySuzhou215123China

Temperature-responsive polymers have garnered significant attention due to their ability to respond to external *** this work,dual temperature-responsive block copolymers are synthesized via reversible addition-fragmentation chain transfer polymerization(RAFT)polymerization utilizing zwitterionic monomer methacryloyl ethyl sulfobetaine(SBMA) and N-isopropyl acrylamide(NIPAAm) as *** thermal responsive behaviors can be easily modulated by incorporating additional hydrophobic monomer benzyl acrylate(BN) or hydrophilic monomer acrylic acid(AA),adjusting concentration or pH,or varying the degree of polymerization of the block chain *** cloud points of the copolymers are determined by UV-Vis spectrophotometry,and these copolymers exhibit both controlled upper and lower critical solu bility temperatures(LCST and UCST) in aqueous *** study analyzes and summarizes the influencing factors of dual temperature responsive block copolymers by exploring the effects of various conditions on the phase transition temperature of temperature-sensitive polymers to explore the relationship between their properties and environment and structure to make them more selective in terms of temperature application range and regulation *** is very interesting that the introduction of poly-acrylic acid(PAA) segments in the middle of di-block copolymer PSBMA_(55)-b-PNIPAAm_(80) to form PSBMA_(55)-b-PAA_(x)-b-PNIPAAm_(80) results in a reversal of temperature-responsive behaviors from 'U'(LCST UCST) type,while the copolymer PSBMA_(55)-b-P(NIPAAm_(80)-co-AA_(x)) *** work provides a clue for tuning the phase transition behavior of polymers for manufacture of extreme smart materials.

关键词： Temperature responsive polymers High critical solubility temperature(UCST) Low critical solubility temperature(LCST) Block copolymers