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Studies on Enzyme Kinetics by Microchip and Related Techniques

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高等学校化学学报 2004年第Z1期25卷 165-166页

作者： James J. Bao WANG Huai-Feng ZHOU Da-Wei Ken R. Wehmeyer College of pharmaceuticals Tianjin University Tianjin 300072 China College of Pharmaceuticals Tianjin University Tianjin 300072 China College of Pharmaceuticals Tianjin University Tianjin 300072 China Procter & Gamble Pharmaceuticals 8700 Mason-Montgomery Road Mason OH 45040 USA

Both conventional and microchip-based capillary electrophoresis(CE) technologies have been used for the analysis of enzymes. Practical procedures of using CE to determine the Km and Vmax values of an enzyme have been developed. By studying the inhibition to the enzyme, it is possible to select a suitable drug candidate. When compared with the conventional CE method, single lane microchip-based method can improve the speed for the assay three times. By using multiple lane-based microchip, the speed can be further increased.

关键词： Enzyme Enzyme kinetics Inhibition Enzyme activity

Studies on Enzyme Kinetics by Microchip and Related Techniques

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Studies on Enzyme Kinetics by Microchip and Related Techniqu...

Determination of microcapsule physicochemical, structural, and mechanical properties

第二届全国微全分析系统学术会议

作者： James J.Bao Ken R.Wehmeyer College of pharmaceuticals Tianjin University Tianjin 300072 China Procter & gamble pharmaceuticals 8700 Mason-Montgomery Road Mason OH 45040 USA

关键词： Enzyme Enzyme kinetics Inhibitton Enzyme activity

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Particuology 2016年第1期14卷 32-43页

作者： Andrew Gray Stefan Egan Serafim Bakalis Zhibing Zhang School of Chemical Engineering University of Birmingham Edgbaston Birmingham B15 2IT UK Procter & gamble Newcastle-Upon-Tyne Innovation Centre Whitley Road Longbenton Newcastle-upon-Tyne NE12 9TS UK

Research into the fundamental properties of microcapsules and use of the results to develop a wide variety of products in industries such as printing, fast-moving consumer goods, construction, pharmaceuticals, and agrochemicals is a dynamic and ever-progressing field of study. For microcapsules to be effective in providing protection from harsh environments or delivering large payloads, it is essential to have a good understanding of their properties to enable quality control during formulation, storage, and applications. This review aims to outline the commonly used techniques for determining the physicochemical, struc- tural, and mechanical properties of microcapsules, and highlights the interlinked nature of these three areas with respect to the end-use industrial application. This review provides information on techniques that are well supported in the literature, and also examines microcapsule analytical techniques that will become more prevalent as a result of new technological developments or extensions from other areas of study.

关键词： Characterization Chemical composition Experimental technique Mechanical properties Microcapsule Physical structure

Bisphosphonate Use Improves in Patients With Osteopenia and Prior Fractures Following an Osteoporosis Educational Intervention:Canadian Quality Circle （CQC） National Project

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Bisphosphonate Use Improves in Patients With Osteopenia and ...

第三届国际骨质疏松及骨矿盐疾病学术会议

作者： J.F.Chiu G.Ioannidis L.Thabane A.Gafni A.Papaioannou B.Kvern A.Hodsman D.Johnstone J.D.Adachi University of Alberta Edmonton McMaster University Hamilton McMaster University Hamilton McMaster University Hamilton McMaster University Hamilton Ur University of Manitoba Winnipeg University of Western Ontario London Procter and gamble pharmaceuticals Toronto all in Canada McMaster University Hamilton

＜正＞Aim:The project was developed to improve primary care physicians’（PCPs）management of osteoporosis in accordance with the Canadian 2002 Guidelines. Methods:The study consisted of five phases: wave（?）data col...

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他汀类药物的应用与骨折的危险性

美国医学会杂志（中文版） 2002年第3期21卷 117-121页

作者：张奇 Tjeerd－PietervanStaa Department of Pharmacoepidemiology and Pharmacotherapy University of UtrechtUtrecht the Netherlands Procter and gamble pharmaceuticals Staines England Medical Research Council Environmental Epidemiology Unit University of Southampton Southampton Department of Pharmacoepidemiology and Pharmacotherapy University of UtrechtUtrecht the Netherlands Medical Research Council Environmental Epidemiology Unit University of Southampton Southampton General Hospital Southampton England

抑制肝内3-羟基-3-甲基戊二酰辅酶A(HMG-CoA)还原酶可减少胆固醇的合成,此还原酶催化HMG-CoA向甲醛戊酸的转化.他汀类药物是HMG-CoA还原酶的可逆性、竞争性抑制剂,因此目前临床将其用于高胆固醇血症的治疗1,2.

关键词：他汀类药物降血脂药骨折危险性