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Mechanisms of phototherapy of Alzheimer’s disease during sleep and wakefulness:the role of the meningeal lymphatics

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Frontiers of Optoelectronics 2023年第3期16卷 57-76页

作者： Semyachkina‑Glushkovskaya Oxana Shirokov Alexander Blokhina Inna Fedosov Ivan Terskov Andrey Dubrovsky Alexander Tsoy Maria Elovenko Daria Adushkina Viktoria Evsukova Arina Telnova Valeria Tzven Anna Krupnova Valeria Manzhaeva Maria Dmitrenko Alexander Penzel Thomas Kurths Jürgen Institute of Physics Humboldt UniversityBerlin 12489Germany Department of Biology Saratov State UniversitySaratov 410012Russia Institute of Biochemistry and Physiology of Plants and Microorganisms Russian Academy of SciencesSaratov 410049Russia Charité–Universitätsmedizin Berlin Berlin 10117Germany Department of Complexity Scienc Potsdam Institute for Climate Impact ResearchPotsdam 14473Germany

With the increase in the aging population,the global number of people with Alzheimer’s disease(AD)progressively increased *** situation is aggravated by the fact that there is no the efective pharmacological therapy of ***(PBM)is non-pharmacological approach that has shown very promising results in the therapy of AD in pilot clinical and animal ***,the mechanisms of therapeutic efects of PBM for AD are poorly *** this study on mice,we demonstrate that photodynamic efects of 5-aminolevulenic acid and laser 635 nm cause reduction of network of the meningeal lymphatic vessels(MLVs)leading to suppression of lymphatic removal of beta-amyloid(Aβ)from the right lateral ventricle and the *** the original protocol of PBM under electroencephalographic monitoring of wakefulness and sleep stages in non-anesthetized mice,we discover that the 7-day course of PBM during deep sleep *** provides better restoration of clearance of Aβfrom the ventricular system of the brain and the *** results shed light on the mechanism of PBM and show the stimulating efects of PBM on the brain lymphatic drainage that promotes transport of Aβvia the lymphatic *** efects of PBM on the brain lymphatics in sleeping brain open a new niche in the study of restorative functions of sleep as well as it is an important informative platform for the development of innovative smart sleep technologies for the therapy of AD.

关键词： Alzheimer’s disease Photobiomodulation Brain lymphatics Sleep Mechanisms

Avian responses to an extreme weather event:The case of the‘Filomena’snowstorm in Madrid(central Spain)

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Avian research 2024年第2期15卷 180-186页

作者： Carlos Lazaro Carlos Sanchez-García Fabian Casas E.Jorge Tizado Department of research Fundacion Artemisan13001 Ciudad RealSpain Department of Zoology Faculty of SciencesUniversity of GranadaGranadaSpain Department of Biodiversity and Environmental Management Universidad de Leon24401 PonferradaSpain

Cold spells and severe weather may have detrimental effects in wild birds,but owing to the stochastic nature of these events,it is not always possible to measure their *** January 2021,a strong snowstorm known as‘Filomena’affected Spain,mainly the region of Madrid(Central Spain),which was fully covered with snow and suffered freezing temperatures for a *** bird surveys conducted in the winter-spring of 2020 and 2021(before and after Filomena)at same locations,we addressed the possible impact of the cold spell in three widespread gamebirds:Wood Pigeon(Columba palumbus),Eurasian Magpie(Pica pica)and Red-legged Partridge(Alectoris rufa).No significant abundance differences were found between years for none of the species and hunting pressure was only significantly reduced for Partridges,hence this species may have been negatively affected by *** suggest that in response to Filomena,Pigeons conducted partial migration in search of better conditions,while Magpies aggregated in certain areas of Madrid and Partridges endured the harsh conditions within their home *** results highlight the importance to alleviate negative impacts of extreme weather events in wild birds through management actions,especially for sedentary species.

关键词： Alectoris rufa climate change Cold spell Columba palumbus Migration Pica pica Winter

Ground-based and additional science support for SMILE

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Earth and Planetary Physics 2024年第1期8卷 275-298页

作者： J.A.Carter M.Dunlop C.Forsyth K.Oksavik E.Donovon A.Kavanagh S.E.Milan T.Sergienko R.C.Fear D.G.Sibeck M.Connors T.Yeoman X.Tan M.G.G.T.Taylor K.McWilliams J.Gjerloev R.Barnes D.D.Billet G.Chisham A.Dimmock M.P.Freeman D.-S.Han M.D.Hartinger S.-Y.W.Hsieh Z.-J.Hu M.K.James L.Juusola K.Kauristie E.A.Kronberg M.Lester J.Manuel J.Matzka I.McCrea Y.Miyoshi J.Rae L.Ren F.Sigernes E.Spanswick K.Sterne A.Steuwer T.Sun M.-T.Walach B.Walsh C.Wang J.Weygand J.Wild J.Yan J.Zhang Q.-H.Zhang Planetary Sciences Group School of Physics and AstronomyUniversity of LeicesterUniversity RoadLeicesterLE17RHUK Rutherford Appleton Laboratory Space Science Technology Facilities CouncilOxfordshireUK School of Space and Environment Beihang UniversityBeijing 100191China Key Laboratory of Space Environment Monitoring and Information Processing Ministry of Industry and Information TechnologyBeijing 100017China Department of Space and climate Physics UCLMullard Space Science LaboratoryHolmbury St.MaryDorkingSurreyRH56NTUK Birkeland Centre for Space Science Department of Physics and Technology.University of BergenBergenNorway Department of Physics and Astronomy University of Calgary2500 University DriveCalgaryAlbertaCanada T2N 1N4 British Antarctic Survey CambridgeUK Swedish Institute of Space Physics KirunaSweden West Highfield Campus University of SouthamptonUniversity RoadSO171BJUK Goddard Space Flight Center NASAGreenbeltMarylandUSA Athabasca University AthabascaCanada ESTEC European Space AgencyNetherlands University of Saskatchewan SaskatoonCanada The Johns Hopkins University Applied Physics Laboratory LaurelMarylandUSA Swedish Institude of Space Physics UppsalaSE 75121Sweden Tongji University Shanghai 200092China Center for Space Plasma Physics Space Science Institute4765 Walnut Street Suite BBoulderColorado80301USA Polar research Institute of China Shanghai 200136China Finnish Meteorological Institute(FMI) Finland Department of Earth and Environmental Sciences(Geophysics) Ludwig Maximilian University of Munich(LMU)MunichTheresienstr.41MunichD-80333Germany Canadian Space Agency MontrealCanada GFZ German research Centre for Geosciences PotsdamGermany Nagoya University Institute for Space Earth Environment ResearchCenter for Integrated Data ScienceNagoyaAichiJP 464-8601 Northumbria University Newcastle upon TyneTyne and WearUK NE18ST National Space Science Center Chinese Academy SciencesBeijing 100190China Arctic Geophysics University Centre in Svalbard

The joint European Space Agency and Chinese Academy of Sciences Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission will explore global dynamics of the magnetosphere under varying solar wind and interplanetary magnetic field conditions,and simultaneously monitor the auroral response of the Northern Hemisphere *** these large-scale responses with medium and fine-scale measurements at a variety of cadences by additional ground-based and space-based instruments will enable a much greater scientific impact beyond the original goals of the SMILE ***,we describe current community efforts to prepare for SMILE,and the benefits and context various experiments that have explicitly expressed support for SMILE can offer.A dedicated group of international scientists representing many different experiment types and geographical locations,the Ground-based and Additional Science Working Group,is facilitating these *** include constructing an online SMILE Data Fusion Facility,the discussion of particular or special modes for experiments such as coherent and incoherent scatter radar,and the consideration of particular observing strategies and spacecraft *** anticipate growing interest and community engagement with the SMILE mission,and we welcome novel ideas and insights from the solar-terrestrial community.

关键词： magnetosphere ionosphere magnetosphere-ionosphere coupling ground-based experimentation SMILE conjunctions missions

Recent advances in intermediate-temperature CO_(2) capture: Materials,technologies and applications

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Journal of Energy Chemistry 2024年第3期90卷 435-452,I0010页

作者： Chengbo Zhao Leiming Wang Liang Huang Nicholas M.Musyoka Tianshan Xue Jabor Rabeah Qiang Wang Engineering research Center for Water Pollution Source Control&Eco-remediation College of Environmental Science and EngineeringBeijing Forestry UniversityBeijing 100083China State Key Laboratory of Efficient Production of Forest Resources Beijing Forestry UniversityBeijing 100083China China Machinery Huanyu Certification and Inspection Co. Ltd.Beijing 102609China Nottingham Ningbo China Beacons of Excellence research and Innovation Institute University of Nottingham Ningbo ChinaNingbo 315100ZhejiangChina Institute of Atmospheric Environment Chinese Research Academy of Environmental SciencesBeijing 100012China Leibniz-Institut für Katalyse e.V. Albert-Einstein-Str.29aRostock D-18059Germany

Carbon capture,utilization and storage(CCUS) is widely recognized as a vital strategy for mitigating the impact of human induced climate *** various CO_(2) adsorbents,intermediate-temperature solid adsorbents have garnered significant attention due to their potential applications in hydrogen utilization,specifically in the water gas shift,steam reforming and gasification *** processes are crucial for achieving carbon *** laboratory-level studies have showcased the high adsorption capacity of these materials via various synthesis and modification methods,their practical application in complex industrial environments remains challenging,impeding the commercialization *** review aims to critically summarize the recent research progress made in intermediatetemperature(200-400℃) solid CO_(2) adsorbents,particularly focusing on indicators such as cyclability,gas selectivity,and formability,which play vital roles in industrial application ***,we provide an overview of laboratory-level advanced technologies specifically tailored for industrial ***,we highlight several industrial-ready advanced technologies that can pave the way for overcoming the challenges associated with large-scale *** insights provided by this review aim to assist researchers in identifying the most relevant research directions for industrial *** promoting advances in the application of solid adsorbents,we strive to facilitate the ultimate goal of achieving carbon neutrality.

关键词： Intermediate-temperature CO_(2) capture MgO LDHs Industrialization

Rice Heat Tolerance Breeding: A Comprehensive Review and Forward Gaze

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Rice science 2024年第4期31卷 375-400,I0022页

作者： Ravindran Lalithambika VISAKH Sreekumar ANAND Sukumaran Nair ARYA Behera SASMITA Uday Chand JHA Rameswar Prasad SAH Radha BEENA Department of Genetics and Plant Breeding College of AgricultureVellayaniKerala Agricultural UniversityThiruvananthapuramKerala 695522India Crop Improvement Division Indian Council of Agricultural Research-National Rice Research InstituteCuttackOdisha 7530006India Department of Plant Breeding and Genetics Indian Institute of Pulse ResearchKanpur 208024India Department of Plant Physiology College of AgricultureVellayaniKerala Agricultural UniversityThiruvananthapuramKerala 695522India

The yield potential of rice is seriously affected by heat stress due to climate change. Since rice is a staple food globally, it is imperative to develop heat-resistant rice varieties. Thus, a thorough understanding of the complex molecular mechanisms underlying heat tolerance and the impact of high temperatures on various critical stages of the crop is needed. Adoption of both conventional and innovative breeding strategies offers a long-term advantage over other methods, such as agronomic practices, to counter heat stress. In this review, we summarize the effects of heat stress, regulatory pathways for heat tolerance, phenotyping strategies, and various breeding methods available for developing heat-tolerant rice. We offer perspectives and knowledge to guide future research endeavors aimed at enhancing the ability of rice to withstand heat stress and ultimately benefit humanity.

关键词： genetic mechanism high-temperature stress molecular breeding genomics selection

Diff erences in pigment circadian rhythmicity in greenand red-leafed tree species in the sun and shade

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Journal of Forestry research 2023年第3期34卷 693-704页

作者： Ermes Lo Piccolo Giulia Lauria Giulia Bongi Lucia Guidi Marian Brestic Damiano Remorini Rossano Massai Marco Landi Department of Agriculture Food and EnvironmentUniversity of PisaVia del Borghetto 8052124 PisaItaly Centre for climate Change impact CIRSECUniversity of PisaVia del Borghetto 8052124 PisaItaly Department of Plant Physiology Slovak University of AgricultureA.Hlinku 2Nitra 94976Slovakia

Light fl ux and quality are crucial factor for setting endogenous plant circadian *** the daily rhythmicity of leaf chlorophyll content is an eff ective method to monitor the plant physiological endogenous clock in response to environmental signals such as light availability/***,we used a leaf-clip sensor to monitor diurnal rhythms in the content of chlorophyll and fl avonoids such as fl avonols and anthocyanins in three green-(Ailanthus altissima,Tilia platyphyllos and Platanus×acerifolia)and two red-leafed(Acer platanoides *** King and Prunus cerasifera ***)tree species,adapted to sun(L)or shade(S).Signifi cant diff erences in chlorophyll content(Chl)and its variations during the day were observed among treatments in all the analyzed species.S-plants had more Chl than L-plants irrespective of leaf color,and Chl variations were more distinct during the day than in *** particular,contents were lowest in the morning(9:00)and in the middle of the day(at 12:00 and 15:00),and the highest at dusk(21:00).The less evident trends in Chl variation in L-plants were attributed to a decrease in Chl content in high light,which likely masked any increases in the shaded counterparts during the *** fl avonol levels did not vary no notably during the *** sun-exposed red leaves,anthocyanins partially screened mesophyll cells from incident light,and its levels were similar to the Chl dynamics in the shaded *** study provides new bases for further work on endogenous rhythms of plant pigments and improves our understanding of plant physiology in the context of day/night rhythmicity.

关键词： Anthocyanins Chlorophylls Circadian clock Flavonols Shade syndrome

Slowing down critical transitions via Gaussian white noise and periodic force

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Science China(Technological Sciences) 2019年第12期62卷 2144-2152页

作者： MA JinZhong XU Yong XU Wei LI YongGe KURTHS Jirge Department of Applied Mathematics Northwestern Polytechnical UniversityXi'an 710072China MIIT Key Laboratory of Dynamics and Control of Complex Systems Northwestern Polytechnical UniversiyXi'an 710072China Center for Mathematical Sciences&School of Mathematics and Statistics Huazhong University of Science and TechmologyWuhan 430074China potsdam Institute for climate impact research Potsdam 14412Germany Department of Physics Humboldt UniversityBerlin 12489Germany

Stochastic perturbations and periodic excitations are generally regarded as sources to induce critical transitions in complex systems. However, we find that they are also able to slow down an imminent critical transition. To illustrate this phenomenon, a periodically driven bistable eutrophication model with Gaussian white noise is introduced as a prototype class of real *** residence probability(RP) is presented to measure the possibility that the given system stays in the oligotrophic state versus Gaussian white noise and periodic force. Variations in the mean first passage time(MFPT) and the mean velocity(MV) of the first right-crossing process are also calculated respectively. We show that the frequency of the periodic force can increase the MFPT while reduce the MV under different control parameters. Nevertheless, the noise intensity or the amplitude may result in an increase of the RP only in the case of control parameters approaching the critical values. Furthermore, for an impending critical transition, an increase of the RP appears with the interaction between the amplitude and noise intensity or the combination of the noise intensity and frequency, while the interaction of the frequency and amplitude leads to an extension of the MFPT or a decrease of the MV. As a result, an increase of the RP and MFPT, and a decrease of the MVobtained from our results claim that it is possible to slow down an imminent critical transition via Gaussian white noise and periodic force.

关键词： critical transition slowing down bistable eutrophication model Gaussian white noise periodic force residence probability mean first passage time mean velocity

Nurses'attitude toward patients'safety climate during COVID-19 pandemic:a cross-sectional study

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Frontiers of Nursing 2024年第1期11卷 39-46页

作者： Asra Nassehi Kobra Ghorbanzadeh Somaye Moayedi Javad Jafari Parvin Mahmoodi Mojtaba Jafari Department of Nursing Bam University of Medical SciencesBamIran Department of Nursing Khalkhal University of Medical SciencesKhalkhalIran Community Nursing research Center Department of NursingZahedan University of Medical SciencesZahedanIran Clinical Care research Center Department of NursingNursing and Midwifery SchoolKurdistan University of Medical SciencesSanandajIran

Objective:Patient safety is a fundamental factor in improving the quality of care provided in ***,it is considered a significant parameter by all healthcare organizations around the *** present study was conducted to investigate the attitude of nurses toward the patient safety climate during the Coronavirus Disease 2019(COVID-19)pandemic in the southeast of ***:This is a cross-sectional descriptive *** all the nurses working in one of the hospitals in the southeast of Iran,171 nurses participated in the study through convenience sampling *** survey was conducted between June 1 and July 30,2020.A 2-part questionnaire including demographic information and an assessment of nurses'attitudes toward patients'safety climate was used for data collection in *** content validity of the scale is(0.77)and reliability was re-calculated and confirmed by the present study with Cronbach's alpha(α=0.9).Data were analyzed by SPSS 20(IBM Corporation,Armonk,New York,United States)using descriptive and analytical statistical ***:The mean score of safety climates was 3.2±5.20(out of 5 scores).The results showed that among all dimensions of the safety climate,only the education dimension was statistically significant between males and females(Pclimate and its dimensions according to the people's position only in the dimension of supervisors'attitude(Pclimate(Pclimate was at a relatively favorable *** the impact of nurses'attitudes on the safety climate of patients,its improvement seems *** is recommended to design training courses and educate nurses in order to promote a p

关键词： COVID-19 Iran nurses patient safety climate

Spatial-temporal patterns and evolution of carbon storage in China's terrestrial ecosystems from 1980 to 2020

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Science China Earth Sciences 2024年

作者： Shaojian WANG Shijie ZHOU Chuanglin FANG School of Geography and Planning Sun Yat-sen University Institute of Geographic Sciences and Natural Resources research Chinese Academy of Sciences

Analyzing the changes in carbon storage in terrestrial ecosystems caused by land use changes is a crucial part of exploring the carbon cycle. In addition, enhancing carbon storage in terrestrial ecosystems is an effective and environmentally friendly measure to sequester anthropogenic carbon emissions, which is significant for achieving carbon neutrality and curbing global climate change. This paper uses land use data and carbon density tables with the InVEST model to obtain a carbon storage distribution map of China. It further applies land use response elasticity coefficients, Theil index multi-stage nested decomposition, and spatial autocorrelation analysis to examine the spatial-temporal patterns, causes of changes, and evolution characteristics of carbon storage in terrestrial ecosystems from 1980 to 2020. The results show that the temporal changes in China’s carbon storage generally present an inverted S-curve, with an initial rapid decline followed by a slower decrease. Spatially, it features high levels in the northeast, low levels in the northwest, and a uniform distribution in the central and southern *** disturbance of land use type changes on terrestrial ecosystem carbon storage has been effectively mitigated. The significant reduction in grassland area in the Southwest region is the main source of carbon storage loss during the study period, and the encroachment of construction land on arable land in large urban agglomerations is one of the important causes of carbon storage loss. The Theil index multi-stage nested decomposition results indicate that the overall difference in carbon storage in China has decreased, while differences among cities within provinces and among counties within cities have increased. The influence of natural factors on the distribution of carbon storage is weakening, whereas the impact of human activities is becoming more profound, enhancing its influence on the spatial distribution of carbon storage in China. From 1980

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