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Development and validation of a novel non-invasive test for diagnosing nonalcoholic fatty liver disease in Chinese children

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World Journal of Pediatrics 2024年第4期20卷 413-421页

作者： Zhe-Wen Qin Qian-Nan Ren Hong-Xi Zhang Ya-Ru Liu Ke Huang Wei Wu Guan-Ping Dong Yan Ni Jun-Fen Fu Division of endocrinology National Clinical Research Center for Child HealthNational Children’s Regional Medical CenterThe Children’s HospitalDepartment of EndocrinologyNational Clinical Research Center for Child HealthNational Children’s Regional Medical CenterThe Children’s HospitalZhejiang University School of MedicineHangzhou310052China

With the exploding prevalence of obesity,many children are at risk of developing nonalcoholic fatty liver *** anthropometric and laboratory parameters,our study aimed to develop a model to quantitatively evaluate liver fat content(LFC)in children with *** A well-characterized cohort of 181 children between 5 and 16 years of age were recruited to the study in the endocrinology Department as the derivation *** external validation cohort comprised 77 *** assessment of liver fat content was performed using proton magnetic resonance *** and laboratory metrics were measured in all subjects.B-ultrasound examination was carried out in the external validation *** Kruskal-Wallis test,Spearman bivariate correlation analyses,univariable linear regressions and multivariable linear regression were used to build the optimal predictive *** The model was based on indicators including alanine aminotransferase,homeostasis model assessment of insulin resistance,triglycerides,waist circumference and Tanner *** adjusted R^(2)of the model was 0.589,which presented high sensitivity and specificity both in internal[sensitivity of 0.824,specificity of 0.900,area under curve(AUC)of 0.900 with a 95%confidence interval:0.783–1.000]and external validation(sensitivity of 0.918 and specificity of 0.821,AUC of 0.901 with a 95%confidence interval:0.818–0.984).Conclusions Our model based on five clinical indicators was simple,non-invasive,and inexpensive;it had high sensitivity and specificity in predicting LFC in ***,it may be useful for identifying children with obesity who are at risk for developing nonalcoholic fatty liver disease.

关键词： Biochemical markers Children Magnetic resonance spectroscopy Nonalcoholic fatty liver disease Pediatric obesity

Surface Morphology and Thermo-Electrical Energy Analysis of Polyaniline (PANI) Incorporated Cotton Fabric

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Energy Engineering 2024年第1期121卷 1-12页

作者： Md.Shohan Parvez Md.Mustafizur Rahman Mahendran Samykano Mohammad Yeakub Ali Automotive Engineering Research Group Faculty of Mechanical and Automotive Engineering TechnologyUniversiti Malaysia Pahang Al-Sultan AbdullahPekanMalaysia Department of Textile Engineering Khulna University of Engineering&Technology(KUET)KhulnaBangladesh Centre for Research in Advanced Fluid and Processes(CARIFF) Universiti Malaysia Pahang Al-Sultan AbdullahLebuhraya Tun RazakGambangMalaysia Mechanical Engineering programme Area Faculty of EngineeringUniversiti Teknologi BruneiBruneiDarussalam

With the exponential development in wearable electronics,a significant paradigm shift is observed from rigid electronics to flexible wearable ***(PANI)is considered as a dominant material in this sector,as it is endowed with the optical properties of both metal and ***,its widespread application got delineated because of its irregular rigid form,level of conductivity,and precise choice of *** PANI in textile materials can generate promising functionality for wearable *** research work employed a straightforward in-situ chemical oxidative polymerization to synthesize PANI on Cotton fabric surfaces with varying dopant(HCl)***-treatment using NaOH is implemented to improve the conductivity of the fabric surface by increasing the monomer *** research explores the morphological and structural analysis employing SEM,FTIR and *** surface resistivity was measured using a digital multimeter,and thermal stability is measured using *** successful polymerization,a homogenous coating layer is *** is revealed that the simple pre-treatment technique significantly reduces the surface resistivity of Cotton fabric to 1.27 kΩ/cm with increasing acid concentration and thermal *** electro-thermal energy can also reach up to 38.2°C within 50 s with a deployed voltage of 15 *** modified fabric is anticipated to be used in thermal regulation,supercapacitor,sensor,UV shielding,antimicrobial and other prospective functional applications.

关键词： Polyaniline cotton in-situ polymerization SEM TGA heating fabric

Incretin based therapy and pancreatic cancer:Realising the reality

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World Journal of Gastroenterology 2022年第25期28卷 2881-2889页

作者： Varun Suryadevara Ayan Roy Jayaprakash Sahoo Sadishkumar Kamalanathan Dukhabandhu Naik Pazhanivel Mohan Raja Kalayarasan Department of endocrinology Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherry 605006India Department of endocrinology All India Institute of Medical SciencesKalyani 741245West BengalIndia Department of Medical Gastroenterology Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherry 605006India Department of Surgical Gastroenterology Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherry 605006India

Incretin-based therapies like glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors help maintain the glycaemic control in patients with type 2 diabetes mellitus with additional systemic benefits and little risk of *** medications are associated with low-grade chronic pancreatitis in animal models *** incidence of acute pancreatitis was also reported in some human *** inflammation provides fertile ground for developing pancreatic carcinoma(PC).Although the data from clinical trials and population-based studies have established safety regarding PC,the pathophysiological possibility that low-grade chronic pancreatitis leads to PC *** review the existing literature and describe the relationship between incretin-based therapies and PC.

关键词： Diabetes mellitus Dipeptidyl peptidase-4 inhibitor Glucagon-like peptide-1 receptor agonist Incretin Pancreatitis Pancreatic Cancer

Treatment on Nature’s lap:Use of herbal products in the management of hyperglycemia

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World Journal of Diabetes 2023年第4期14卷 412-423页

作者： Somdatta Giri Jayaprakash Sahoo Ayan Roy Sadishkumar Kamalanathan Dukhabandhu Naik Department of endocrinology Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherry 605006India Department of endocrinology All India Institute of Medical SciencesKalyani 741245West BengalIndia

Diabetes mellitus(DM)is characterized by persistently elevated blood glucose concentration that lead to multisystem *** are about 400 medicinal plants cited to have a beneficial effect on *** must choose products wisely based on data derived from scientific ***,a major obstacle in the amalgamation of herbal medicine in modern medical practices is the lack of clinical data on its safety,efficacy and drug *** of these herbal products often underreport the side effects and other crucial intervention steps deviating from the standards set by Consolidated Standards of Reporting *** to a lack of knowledge of the active compounds present in most herbal medicines,product standardization is ***-effectiveness is another issue that needs to be kept in *** this mini-review,we focus on the antihyperglycemic effect of herbal products that are commonly used,along with the concerns stated above.

关键词： Herbal product HbA1C Diabetes mellitus Active compound Natural therapy Cost-effectiveness

Diabetes mellitus as a consequence of acute severe pancreatitis:Unraveling the mystery

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World Journal of Diabetes 2023年第8期14卷 1212-1225页

作者： Manish Manrai Anupam K Singh Chhagan Lal Birda Jimil Shah Aditya Dutta Sanjay Kumar Bhadada Rakesh Kochhar Department of Internal Medicine Armed Forces Medical CollegePune 411040MaharashtraIndia Department of Gastroenterology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Gastroenterology All India Institutes of Medical SciencesJodhpur 342001India Department of endocrinology Max HospitalNew Delhi 110017India Department of endocrinology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India

The occurrence of diabetes mellitus(DM)in pancreatitis is being increasingly recognized *** can develop not only with chronic pancreatitis but even after the first episode of acute pancreatitis(AP).The incidence of diabetes after AP varies from 18%to 23%in 3 years and reaches up to 40%over 5 *** exact pathogenesis of diabetes after AP is poorly understood and various mechanisms proposed include loss of islet cell mass,AP-induced autoimmunity,and alterations in the insulin incretin *** factors associated with increased risk of diabetes includes male sex,recurrent attacks of pancreatitis,presence of pancreatic exocrine insufficiency and level of pancreatitic *** of post-pancreatitis DM(PPDM)is often *** includes a trial of oral antidiabetic drugs in mild ***,insulin is required in uncontrolled *** the lack of awareness of this metabolic disorder after AP,this review will evaluate current information on epidemiology,risk factors,diagnosis and management of PPDM and identify the knowledge gaps.

关键词： Post-pancreatitis diabetes Diabetes of exogenous pancreas Endocrine insufficiency Acute pancreatitis Post-pancreatitis diabetes mellitus

Cell-type specific role of autophagy in the liver and its implications in non-alcoholic fatty liver disease

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World Journal of Hepatology 2023年第12期15卷 1272-1283页

作者： Sana Raza Sangam Rajak Rajani Singh Jin Zhou Rohit A Sinha Amit Goel Department of endocrinology Sanjay Gandhi Postgraduate Institute of Medical SciencesUttar PradeshLucknow 226014India Department of Hepatology Sanjay Gandhi Postgraduate Institute of Medical SciencesUttar PradeshLucknow 226014India CVMD Duke-NUS Medical SchoolSingapore 169857Singapore

Autophagy,a cellular degradative process,has emerged as a key regulator of cellular energy production and stress *** autophagy is a common phenomenon observed in several human diseases,and its restoration offers curative ***-alcoholic fatty liver disease(NAFLD),more recently renamed metabolic dysfunction-associated steatotic liver disease,is a major metabolic liver disease affecting almost 30%of the world ***,NAFLD has no pharmacological therapies available to *** regulates several hepatic processes including lipid metabolism,inflammation,cellular integrity and cellular plasticity in both parenchymal(hepatocytes)and non-parenchymal cells(Kupffer cells,hepatic stellate cells and sinusoidal endothelial cells)with a profound impact on NAFLD *** cell type-specific autophagy in the liver is essential in order to develop targeted treatments for liver diseases such as *** autophagy in specific cell types can have varying effects on liver function and pathology,making it a promising area of research for liver-related *** review aims to summarize our present understanding of cell-type specific effects of autophagy and their implications in developing autophagy centric therapies for NAFLD.

关键词： Autophagy Non-alcoholic fatty liver disease Hepatocytes Macrophages Hepatic stellate cells

Role of bisphosphonates in the management of acute Charcot foot

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World Journal of Diabetes 2018年第7期9卷 115-126页

作者： Harsh Durgia Jayaprakash Sahoo Sadishkumar Kam-alanathan Rajan Palui Kalyani Sridharan Henith Raj Department of endocrinology Jawaharlal Institute of Postgraduate Medical Education and Research

Diabetes mellitus is the most common cause of Charcot neuropathy affecting foot and ankle. Acute Charcot foot(CF) presents with a red and swollen foot in co-ntrast to the painless deformed one of chronic CF. En-hanced osteoclastogenesis plays a central role in the pathogenesis of acute CF. Many studies have shown elevated levels of bone turnover markers in patients with acute CF confirming it. These findings have led cl-inicians to use anti-resorptive agents [bisphosphonates(BP), calcitonin, and denosumab] along with immobi-lization and offloading in acute CF patients. The ma-ximum evidence among all anti-resorptive agents is available for BPs, although its quality is low. Pamidronate has been shown to reduce the markers of activity of CF like raised skin temperature, pain, edema, and bone turnover markers in the majority of studies. Intravenous BPs are known to cause acute phase reactions leading to flu-like illness following their first infusion, which can be ameliorated by oral acetaminophen. Alendronate is the only oral BP used in these patients. It needs to be taken on an empty stomach with a full glass of water to avoid esophagitis. The side-effects and contraindications to BPs should be kept in mind while treating acute CF patients with them.

关键词： Charcot foot Diabetes mellitus Charcot neuroarthropathy Bisphosphonates Pamidronate

Thyroid dysfunction and developmental anomalies in first degree relatives of children with thyroid dysgenesis

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世界儿科杂志:英文版 2016年第2期12卷 215-218页

作者： Lakshminarasimhan Sindhuja Devi Dayal Kushaljit Singh Sodhi Naresh Sachdeva Anish Bhattacharya Pediatric endocrinology Unit Department of PediatricsPostgraduate Institute of Medical Education and ResearchChandigarh Department of Radiodiagnosis Postgraduate Institute of Medical Education and ResearchChandigarh Department of endocrinology Postgraduate Institute of Medical Education and ResearchChandigarh Department of Nuclear Medicine Postgraduate Institute of Medical Education and ResearchChandigarh

Background: Familial clustering in patients withpermanent congenital hypothyroidism (CH) caused bythyroid dysgenesis (TD) has been reported in developedcountries. There is no information on familial TD fromdeveloping ***: A total of 312 first degree relativesbelonging to 80 families of children with TD (group 1)and 40 families of age-matched normal children (group2) were screened by thyroid ultrasonography, serum totalthyroxine (T4) and thyroid stimulating hormone (TSH).Results: Thyroid scintigraphy revealed agenesis in78.7% of the patients, ectopic gland in 15%, and hypoplasiain 6.2%. The mean thyroid volumes were similar in parentsand siblings of both groups. Eight (10.6%) mothers in group1 were identified to have thyroid hypoplasia as comparedwith none in group 2 (P=0.03). Serum TSH was signifi cantlyhigher in group 1 than in group 2 (P=0.004). Sixteen (7.8%)subjects (6 mothers, 5 fathers, and 5 siblings) in group 1were found to have subclinical hypothyroidism as comparedto none in group 2 (P<0.05). Four families were identifiedto have thyroid developmental anomalies and abnormalthyroid functions accounting for 5% of cases of familial TDin our ***: Thyroid developmental anomalies andthyroid function abnormalities are more frequent in firstdegree relatives of children with TD as compared with acontrol population. These findings suggest that possiblythere is a genetic component of TD in Indian patients.

关键词： congenital hypothyroidism familial occurrence first degree relatives thyroid developmental anomalies thyroid dysgenesis

Kinetic study of austenite formation during continuous heating of unalloyed ductile iron

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International Journal of Minerals,Metallurgy and Materials 2015年第1期22卷 27-31页

作者： Octvio Vazquez-Gómez Jos Antonio Barrera-Godínez Hctor Javier Vergara-Hernndez Faculty of Chemistry Metallurgical Engineering DepartmentAutonomous National University of Mexico Metallurgy Science postgraduate programme Morelia Institute of Technology

The austenite formation kinetics in unalloyed cast ductile iron was studied on the basis of dilatometry measurements, and Avrami＇s equation was used to estimate the material＇s kinetic parameters. A continuous heating transformation diagram was constructed us-ing heating rates in the range of 0.06 to 0.83℃·s^-1. As the heating rate was augmented, the critical temperatures, c1A and Aα, as well as the intercritical range, which was evaluated as the difference between the critical temperatures, α c1Δ T =A_a- A_c1 , increased. At a low heating rate, the kinetics of austenite formation was slow as a consequence of the iron＇s silicon content. The effect of heating rate on k and n, the kinetic parameters of Avrami＇s equation, was also determined. Parameter n, which is associated with nucleation sites and growth geometry, de-creased with an increase in heating rate. In addition, parameter k increased with the increase of heating rate, suggesting that the nucleation and growth rates are carbon-and silicon-diffusion controlled during austenite formation under continuous heating.

关键词： ductile iron austenite continuous heating heating rate kinetics dilatometry