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The resistance switching performance of the memristor improved effectively by inserting carbon quantum dots(CQDs)for digital information processing

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Nano Research 2024年第9期17卷 8438-8446页

作者： Tianqi Yu Jie Li Wei Lei Suhaidi Shafe Mohd Nazim Mohtar Nattha Jindapetch Paphavee van Dommelen Zhiwei Zhao Joint International Research Laboratory of Information Display and Visualization School of Electronic Science and EngineeringSoutheast UniversityNanjing 210096China Institute of nanoscience and Nanotechnology University Putra MalaysiaSerdangSelangor 43400Malaysia Department of Electrical Engineering Faculty of EngineeringPrince of Songkla UniversityHat YaiSongkhla 90112Thailand Division of Physical Science Faculty of SciencePrince of Songkla UniversityHat Yai Campus 15 KarnjanavanichHat YaiSongkhla 90110Thailand

As an emerging information device that adapts to development of the big data era,memristor has attracted much attention due to its advantage in processing massive ***,the nucleation and growth of conductive filaments often exhibit randomness and instability,which undoubtedly leads to a wide and discrete range of switching parameters,damaging the electrical performance of *** this work,a strategy of inserting carbon quantum dots(CQDs)into graphene oxide(GO)resistance layer is utilized to improve the stability of the switching parameters and the reliability of the device is *** with GO-based devices,GO/CQDs/GO-based devices exhibit a more stable resistance switching curve,low power,lower and more concentrated threshold voltage parameters with lower variation coefficient,faster switching speed,and more stable retention and *** cause-inducing performance improvement may be attributed to the local electric field generated by CQDs in resistance switching that effectively guides the formation and rupture of conductive filaments,which optimizes the effective migration distance of Ag^(+),thereby improving the uniformity of resistance ***,a convolutional neural network model is constructed to identify the CIFAR-10 data set,showing the high recognition accuracy of online and offline *** cross-kernel structure is used to further implement convolutional image processing through multiplication and accumulation *** work provides a solution to improve the performance of memristors,which can contribute to developing digital information processing.

关键词： carbon quantum dots memristor uniformity convolutional neural network convolutional image processing

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Thoracic interstitial injection of drug-liposomes in mice for treating atherosclerosis

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Nano Research 2023年第4期16卷 5311-5321页

作者： Tun Yan Huizhen Sun Yahong Shi Ya Gao Xi Lu Kai Li Yuting Zhu Qiang Zhang Tingting Li Zhongxian Li Xiaohan Zhou Yuting Guo Yinglu Ji Xiaoli Shi Dong Han College of Life Science Beijing University of Chinese MedicineBeijing 100029China CAS Center for Excellence in nanoscience National Center for Nanoscience and TechnologyBeijing 100190China College of Pharmacy Baotou Medical CollegeBaotou 10040China Hebei Key Laboratory of nanobiotechnology Yanshan UniversityQinhuangdao 066004China University of Chinese Academy of Sciences Beijing 100049China

Intervaginal space injection(ISI)is a novel mode of administration investigated over the last *** injecting nanoparticles into the intervaginal space,they can be transported along low flow resistance channels into the interstitial *** transport has a certain delivery direction,and site-specific injection can work on specific organs or *** this study,the thorax,a new ISI site in the interstitial surrounding the internal thoracic artery named the thoracic interstitial injection(tISI)was *** prove the targeting ability of the tISI,two sizes of gold nanoparticles(AuNPs)(47 and 87 nm)were administered to *** 1 h,the biodistribution of AuNPs in the tissues was measured via single particle inductively coupled plasma mass spectrometry(spICP-MS).The results showed that the concentration of AuNPs in the aorta after tISI injection was significantly higher than that after intravenous ***,fewer nanoparticles with larger particle sizes were observed to have entered the blood and were better targeted to the ***,tanshinone IIa sodium sulfonate liposomes were administered for the treatment of aortic *** proportion of aortic plaques in atherosclerotic Apoe-/-mice administered via tISI was significantly lower than that in other model animals(P<0.001).Furthermore,the proteoglycan content and CD68-positive cell count in the plaques were significantly *** vascular elastic fibers at the plaque site were thickened,and fractures were *** was,therefore,determined to be an effective strategy for the treatment of atherosclerotic aortic plaques.

关键词： thoracic intervaginal space injection(tISI) gold nanoparticle(AuNP) tanshinone IIa sodium sulfonate liposome atherosclerosis adventitia

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Nanotechnology:A New Strategy for Lung Cancer Treatment Targeting Pro-Tumor Neutrophils

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Engineering 2023年第8期27卷 106-126页

作者： Jian Zhang Shasha Jiang Shilin Li Jipeng Jiang Jie Mei Yandong Chen Yongfu Ma Yang Liu Ying Liu Department of Thoracic Surgery The First Medical Center of the Chinese PLA General HospitalBeijing 100853China School of Medicine Nankai UniversityTianjin 300071China postgraduate School Medical School of the Chinese PLABeijing 100853China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in nanoscience National Center for Nanoscience and Technology of ChinaBeijing 100190China University of Chinese Academy of Science Beijing 100049China The Great Bay Area National Institute for Nanotechnology Innovation Guangzhou 510700China

Primary and metastatic lung cancers are malignant lung tumors each with of which has a different pathogenesis,although both threaten patient *** development and progression involve communication between tumor cells and the host *** are the most abundant immune cells in the tumor microenvironment(TME);they participate in the generation of an inflammatory milieu and influence patient survival through their anti-and pro-tumor *** can be classified into various categories according to different criteria;frequent categories include N1 antitumor neutrophils and N2 immunosuppressive *** antitumor effects of neutrophils are reported to be mediated through a combination of reactive oxygen species,tumor necrosis factor-related apoptosis-inducing ligand,and receptor for advanced glycation end-products–cathepsin G association,as well as the regulation of the activities of other immune *** have also been reports that neutrophils can function as tumor promoters that contribute to lung cancer progression and metastasis by influencing processes including carcinogenesis,angiogenesis,cancer cell proliferation,and invasion ability,as well as having similar roles in the lung metastasis of other *** rapid development of nanotechnology has provided new strategies for cancer treatment targeting neutrophils.

关键词： Lung cancer Metastasis Neutrophils Tumor microenvironment Nanotechnology

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Diet as an epigenetic factor in inflammatory bowel disease

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World Journal of Gastroenterology 2023年第41期29卷 5618-5629页

作者： Karina Marangoni Gilson Dorneles Daniella Miranda da Silva Letícia Pereira Pinto Carina Rossoni Sabrina Alves Fernandes Egas Moniz School of Health and Science Caparica-AlmadaPortugalCaparica 2820-062Portugal National Institute of Sciences and Technology-Theranostics and nanobiotechnology Federal University of Uberlandia-MGBrazilUberlândia 38400-902Brazil Corporate Social Responsibility Hospital Moinhos de VentoPorto Alegre 90035-004Brazil postgraduate program in Gastroenterology Universidade Federal do Rio Grande do SulPorto Alegre 91540-000Brazil Department of Nutrition Uniasselvi-Group VitruSanta Catarina 89082-262Brazil postgraduate program in Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil Master in Physical Activity and Health Polytechnic Institute of BejaBeja 7800-000Portugal Degree in Nutrition Sciences Lusófona UniversityLisboa 1749-024Portugal

Inflammatory bowel disease(IBD)has as a main characteristic the exacerbation of the immune system against enterocytes,compromising the individual’s intestinal *** inflammatory cascade causes several nutritional deficiencies,which further compromise immunological functioning and,as a result,worsen the *** vicious cycle can be interrupted as the patient’s dietary pattern meets their needs according to their clinical condition,acting directly on the inflammatory process of IBD through the interaction of food,intestinal microbiota,and *** nutritional intervention for IBD has a crucial role in preventing and managing disease *** review addresses epigenetic modifications through dietary compounds as a mechanism for modulating the intestinal microbiota of patients with IBD.

关键词： Inflammatory bowel disease Epigenetics Nutrition Nutrigenetics

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Intelligent nanomaterials for cancer therapy:recent progresses and future possibilities

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Medical Review 2023年第4期3卷 321-342页

作者： Jing Wang Yuliang Zhao Guangjun Nie CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center of Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center of Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China GBA Research Innovation Institute for Nanotechnology Guangzhou 510700Guangdong ProvinceChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Intelligent nanomedicine is currently one of the most active frontiers in cancer therapy *** by the recent progresses of nanobiotechnology,a new generation of multifunctional nanotherapeutics and imaging platforms has remarkably improved our capability to cope with the highly heterogeneous and complicated na-ture of *** rationally designed multifunctionality and programmable assembly of functional subunits,the in vivo behaviors of intelligent nanosystems have become increasingly tunable,making them more efficient in performing sophisticated actions in physiological and path-ological *** recent years,intelligent nanomaterial-based theranostic platforms have showed great potential in tumor-targeted delivery,biological barrier circumvention,multi-responsive tumor sensing and drug release,as well as convergence with precise medication approaches such as personalized tumor *** the other hand,the increasing system complexity of anti-cancer nanomedicines also pose signiﬁcant challenges in charac-terization,monitoring and clinical use,requesting a more comprehensive and dynamic understanding of nano-bio *** review aims to brieﬂy summarize the recent progresses achieved by intelligent nanomaterials in tumor-targeted drug delivery,tumor immunotherapy and temporospatially speciﬁc tumor imaging,as well as impor-tant advances of our knowledge on their interaction with biological *** the perspective of clinical translation,we have further discussed the major possibilities provided by disease-oriented development of anti-cancer nano-materials,highlighting the critical importance clinically-oriented system design.

关键词： intelligent nanomedicine anti-cancer nano-materials tumor microenvironment tumor vaccines immunotherapy personalized medication

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Cauliflower-like nanostructured ZnV_(2)S_(4)as a potential cathode material to boost-up high capacity and durability of the aqueous zinc-ion battery

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中国化学快报:英文版 2023年第8期34卷 490-496页

作者： Mugilan Narayanasamy Balakrishnan Balan Chao Yan Subramania Angaiah School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Electro-Materials Research Laboratory Centre for Nanoscience and TechnologyPondicherry UniversityPuducherry 605014India

Owing to their unique design and development,high safety and low-cost efficient cathode is still at the forefront of research for rechargeable zinc-ion ***,the suitable cathode operating with ultrahigh capacity with a dendrite-free anode reaction mechanism remains *** this,the first archetype of a high-rate and morphologically stabled cathode material is constructed from novel cauliflower-like nano-ZnV_(2)S_(4)for aqueous zinc-ion ***,nano-ZnV_(2)S_(4)was prepared with an anion exchange reaction using ZnV2(OH)8 cauliflower-like nanostructured array as a template interestingly no morphological and shape changes were *** as-prepared nano-ZnV_(2)S_(4)electrode reveals a specific discharge capacity of 348.2 mAh/g during 0.5 A/g with enhanced rate capability and excellent capacity retention of 89.2%at 4 A/g current density even after completing 1000 cycles.

关键词： Aqueous zinc-ion battery Anion-exchange reaction High-capacity cathode Metal vanadium sulfides Nano-ZnV_(2)S_(4)

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Advancing sustainable agriculture: Enhancing crop nutrition with next-generation nanotech-based fertilizers

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Nano Research 2023年第12期16卷 13205-13225页

作者： Yiwen Liao Dawei Xu Yuhong Cao Yong-Guan Zhu State Key Laboratory of Urban and Regional Ecology Research Centre for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and TechnologyBeijing 100190China

The pressing need to enhance nutrient use efficiency(NUE)in fertilizers has become increasingly urgent in light of food insecurity and climate-related *** offers promising prospects for the development of effective and environmentally friendly alternatives in the field of *** review focuses on the impact of nanotechnology on conventional fertilizers,encompassing inorganic,organic,and microbial *** emphasize the superior attributes of nano-fertilizers compared with their conventional counterparts and explore their potential and versatility in boosting crop productivity,reducing fertilizer expenses,and mitigating detrimental environmental *** conclusion,given the significant challenges posed by food insecurity and climate change,the application of nano-fertilizers demonstrates immense potential for advancing sustainable and intelligent agricultural practices.

关键词： nanobiotechnology nano-fertilizers(NFs) nutrient use efficiency(NUE) slow release sustainable agriculture

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Ion migration in perovskite solar cells

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Journal of Semiconductors 2021年第1期42卷 1-4页

作者： Xiaoxue Ren Lixiu Zhang Yongbo Yuan Liming Ding Hunan Key Laboratory of Super Microstructure and Ultrafast Process School of Physics and ElectronicsCentral South UniversityChangsha 410083China Center for Excellence in nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The past few years have witnessed a remarkable progress of perovskite solar cells(PSCs),which can be attributed to the high light absorption coefficient,tunable bandgap,long carrier diffusion length,solution processab... 详细信息

关键词： materials. perovskite attributed

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Molecular Docking and Evaluation of Antileishmania Activity of a Ruthenium Complex with Epiisopiloturine and Nitric Oxide

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Journal of Biosciences and Medicines 2020年第5期8卷 42-53页

作者： Joabe Lima Araújo Ruan Sousa Bastos Gardênia Taveira Santos Michel Muálem de Moraes Alves Kayo Alves Figueiredo Lucas Aires de Sousa Ionara Nayana Gomes Passos Fernando Aécio de Amorim Carvalho Francisco das Chagas Alves Lima Jefferson Almeida Rocha postgraduate program in nanoscience and nanobiotechnology Department of Genetics and Morphology University of Brasília Brasília DF Brazil Research Group in Natural Sciences and Biotechnology Department of Natural Sciences/Chemistry Federal University of Maranhao Grajaú MA Brazil Research Group in Medicinal Chemistry and Biotechnology QUIMEBIO Federal University of Maranhao Sao Bernardo MA Brazil postgraduate program in Medicinal Chemistry and Molecular Modeling Federal University of Pará Belém PA Brazil Department of Nursing State University of Maranhao Colinas MA Brazil Department of Veterinary Morphophysiology Federal University of Piauí Teresina PI Brazil Department of Health Federal Institute of Education Science and Technology of Piauí Teresina PI Brazil postgraduate program in Materials Science Center for Social Sciences Health and Technology Federal University of Maranhao Imperatriz MA Brazil Department of Biochemistry and Pharmacology Federal University of Piauí Teresina PI Brazil Department of Chemistry Quantum Computational Chemistry Laboratory Federal University of Piauí Teresina PI Brazil

Leishmaniasis is an infectious disease that affects both animals and humans, caused by flagellated parasites belonging to the genus Leishmania. The disease is estimated to reach about 700,000 to 1 million people, causing the deaths of 20 to 30,000 individuals annually. Thus, the present study aims to perform molecular docking tests and evaluation of antileishmania activity in vitro of a ruthenium complex with epiisopiloturine and nitric oxide. AutoDockTools-1.5.6 software was used to perform molecular docking tests. Molecular targets were considered rigid, and Epiruno2 considered flexible. The genetic algorithm Lamarckian (AGL) with global search and pseudo-Solis and Wets with local search were the methods adopted in the docking. The most promising results of molecular interaction were achieved in the targets Pteridine reductase and UDP-glucose Pyrophosphorylase with rates of -10.68 Kcal·mol-1 and -10.51 Kcal·mol-1, respectively. This demonstrates that Epiruno2 has molecular affinity with the targets of L. major. In vitro assays prove the antileishmania activity of the complex in the face of promastigote forms with inhibition of growth, concluding through this study that the Epiruno2 complex has antileishmania activity.

关键词： Molecular Docking Simulation Neglected Diseases Leishmania major

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Living cell for drug delivery

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Engineered Regeneration 2022年第2期3卷 131-148页

作者： Yuwei Wu Yanfei Liu Ting Wang Qiao Jiang Feng Xu Zhenbao Liu Department of Pharmaceutics Xiangya School of Pharmaceutical SciencesCentral South UniversityChangsha410013Hunan ProvinceP.R.China Department of Pharmaceutical Engineering College of Chemistry and Chemical EngineeringCentral South UniversityChangsha410083Hunan ProvinceP.R.China Molecular Imaging Research Center of Central South University Changsha 410008HunanP.R.China CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190P.R.China National Clinical Research Center for Metabolic Diseases Hunan Provincial Key Laboratory of Metabolic Bone Diseasesand Department of Endocrinology and MetabolismThe Second Xiang-Ya Hospital of Central South UniversityP.R.China

The living cells have been emerged as useful platforms for drug delivery due to their advantages of good liquidity,stability,and low *** this review,we summarized the development of living cells-based drug delivery *** drug loading methods,applications,and advantages of living cell drug delivery systems were *** living cells for drug delivery,the mechanisms of action,therapeutic applications,as well as main features were summarized and *** recent research progress and challenges were *** future directions and prospects were proposed.

关键词： Drug delivery Living cells Nanomedicine Biomaterials Tumor treatment

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