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Recent progress of vaccines administration via microneedles for cancer immunotherapy

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Chinese Chemical Letters 2024年第3期35卷 96-103页

作者： Yuanzheng Chen Jiaojiao Zhu Jinsong Ding Wenhu Zhou Xiangya School of Pharmaceutical sciences Central South UniversityChangsha 410013China Key Laboratory of biological Nanotechnology of National health Commission Changsha 410008China

Therapeutic cancer vaccines have undergone a resurgence in the past *** of the high level of immune cell accumulation and abundant capillary lymphatic system in the dermis,percutaneous vaccination is considered to be an ideal treatment *** convenient administration,the recent development of microneedles(MNs)provides a safe,painless,and low-cost transdermal delivery strategy,which could bypass the first-pass metabolism of vaccines for enhanced stability and ***,the therapeutic effect of MNs-based cancer vaccines is not optimal,which is limited by the complex set of host,tumor,and environmental factors,as well as the limited vaccine loading ***,further improvements are still required to push their clinical *** this critical review,we deliberate on how to improve the therapeutic effect of MNs-based vaccines for cancer immunotherapy,summarize the recent advances in MNs-based cancer vaccination,and provide an overview of various design strategies and mechanisms for active or passive targeting delivery,aiming to develop safer,more effective,and more stable MNs-based cancer ***,we briefly describe the potential of vaccine platforms in combination with other therapies,suggest the need to design vaccines according to specific circumstances,and discuss the biosafety of repeated administration for enhancing clinical efficacy.

关键词： Transdermal delivery Microneedles Cancer vaccine Immunotherapy Nanoparticle Lymph node

重症监护疼痛观察工具印尼语版的跨文化调适及心理测量学分析

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International Journal of Nursing sciences 2024年第1期11卷 113-119页

作者： Luthfi Fauzy Asriyanto Nur Chayati Master of Nursing program Postgraduate ProgramUniversitas Muhammadiyah YogyakartaIndonesia School of Nursing Faculty of Medicine and Health SciencesUniversitas Muhammadiyah YogyakartaIndonesia

目的重症监护疼痛观察工具(Critical-care Pain Observation Tool, CPOT)是评估ICU危重症和/或意识水平下降患者疼痛最准确的方法之一。本研究旨在翻译印尼语版CPOT,并验证其效度和信度。方法研究包括初始翻译.综合翻译结果、回译、专... 详细信息

目的重症监护疼痛观察工具(Critical-care Pain Observation Tool, CPOT)是评估ICU危重症和/或意识水平下降患者疼痛最准确的方法之一。本研究旨在翻译印尼语版CPOT,并验证其效度和信度。方法研究包括初始翻译.综合翻译结果、回译、专家委员会验证.印尼语版工具验证5个步骤。2022年9月- -12月在印度尼西亚4所医院ICU中,对52例患者在翻身前、翻身过程中和翻身后15min进行疼痛评估。使用疼痛程度温度计(Faces Pain Thermometer, FPT)作为金标准来评估CPOT的校标效度。采用内容效度和校标效度评估量表的效度;采用Cronbach's a系数和评分者之间- -致性评估工具的信度。结果患者翻身过程中CPOT评分高于翻身前和翻身后。印尼语版CPOT条目水平内容效度指数为0.75~1.00,量表内容效度指数为0.93。患者CPOT与FPT评分呈正相关(0.877-0.983 ,P<0.01)。CPOT的Cronbach's a系数为0.82,评分者之间测量结果一致性水平均较高(k值范围0.739-0.834 ,P<0.01)。结论印尼语版CPOT用于评估危重症和/或意识水平降低患者的疼痛是有效和可靠的。

关键词：重症监护疼痛评估病人信度效度

Predicting major adverse cardiovascular events after orthotopic liver transplantation using a supervised machine learning model:A cohort study

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World Journal of Hepatology 2024年第2期16卷 193-210页

作者： Jonathan Soldera Leandro Luis Corso Matheus Machado Rech Vinícius Remus Ballotin Lucas Goldmann Bigarella Fernanda Tomé Nathalia Moraes Rafael Sartori Balbinot Santiago Rodriguez Ajacio Bandeira de Mello Brandão Bruno Hochhegger Post Graduate program at Acute Medicine and Gastroenterology University of South WalesCardiff CF371DLUnited Kingdom postgraduate program in Pathology Federal University of Health Sciences of Porto Alegre(UFCSPA)Porto Alegre 90050-170Brazil Department of Engineering Universidade de Caxias do SulCaxias do Sul 95070-560Brazil School of Medicine Universidade de Caxias do SulCaxias do Sul 95070-560Brazil postgraduate program in Hepatology Federal University of Health Sciences of Porto Alegre(UFCSPA)Porto Alegre 90050-170Brazil

BACKGROUND Liver transplant(LT)patients have become older and *** rate of post-LT major adverse cardiovascular events(MACE)has increased,and this in turn raises 30-d post-LT *** cardiac stress testing loses accuracy when applied to pre-LT cirrhotic *** To assess the feasibility and accuracy of a machine learning model used to predict post-LT MACE in a regional *** This retrospective cohort study involved 575 LT patients from a Southern Brazilian academic *** developed a predictive model for post-LT MACE(defined as a composite outcome of stroke,new-onset heart failure,severe arrhythmia,and myocardial infarction)using the extreme gradient boosting(XGBoost)machine learning *** addressed missing data(below 20%)for relevant variables using the k-nearest neighbor imputation method,calculating the mean from the ten nearest neighbors for each *** modeling dataset included 83 features,encompassing patient and laboratory data,cirrhosis complications,and pre-LT cardiac *** performance was assessed using the area under the receiver operating characteristic curve(AUROC).We also employed Shapley additive explanations(SHAP)to interpret feature *** dataset was split into training(75%)and testing(25%)*** was evaluated using the Brier *** followed Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis guidelines for ***-learn and SHAP in Python 3 were used for all *** supplementary material includes code for model development and a user-friendly online MACE prediction *** Of the 537 included patients,23(4.46%)developed in-hospital MACE,with a mean age at transplantation of 52.9 *** majority,66.1%,were *** XGBoost model achieved an impressive AUROC of 0.89 during the training *** model exhibited accuracy,precision,recall,and F1-score values of 0.84,0.85,0.80,and 0.79,***

关键词： Liver transplantation Major adverse cardiac events Machine learning Myocardial perfusion imaging Stress test

Long-term monitoring of cycles in Clethrionomys rutilus in the Yukon boreal forest

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Integrative Zoology 2024年第1期19卷 27-36页

作者： Charles J.KREBS Alice J.KENNEY B.Scott GILBERT Rudy BOONSTRA Department of Zoology University of British ColumbiaVancouverBritish ColumbiaCanada Renewable Resources Management program Yukon UniversityWhitehorseYukonCanada Department of biological sciences University of Toronto ScarboroughTorontoOntarioCanada

Baseline studies of small rodent populations in undisturbed ecosystems are *** report here 50 years of mon-itoring and experimentation in Yukon of a dominant rodent species in the North American boreal forest,the red-backed vole Clethrionomys *** voles breed in summer,weigh 20–25 g,and reach a maximum density of 20 to 25 per *** populations have shown consistent 3–4-year cycles for the last 50 years with the only change being that peak densities averaged 8/ha until 2000 and 18/ha since that *** the last 25 years,we have measured food resources,predator numbers,and winter weather,and for 1-year social interactions,to estimate their contribution to changes in the rate of summer increase and the rate of overwinter *** these potential limiting factors could contribute to changes in density,and we measured their relative contributions statistically with multiple *** rate of winter decline in density was related to both food supply and winter *** rate of summer increase was related to summer berry crops and white spruce cone *** measure of predator numbers was related to winter or summer changes in vole *** was a large signal of climate change effects in these *** is no density dependence in summer population growth and only a weak one in winter population *** of our results provide a clear understanding of what generates 3–4-year cycles in these voles,and the major missing piece may be an understanding of social interactions at high density.

关键词： boreal forest climate change density dependence population cycles predation winter severity

Increasing dietary fiber intake for type 2 diabetes mellitus management: A systematic review

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World Journal of Diabetes 2024年第5期15卷 1001-1010页

作者： Douglas Nitzke Juliana Czermainski Carolina Rosa Chaline Coghetto Sabrina Alves Fernandes Randhall B Carteri Department of Nutrition Centro Universitário CESUCACachoeirinha 94935-630Brazil Department of Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90430-080Brazil postgraduate program in Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil postgraduate program in Hepatology Federal University of Health Sciences of Porto Alegre(UFCSPA)Porto Alegre 90050-170Brazil

BACKGROUND Type 2 diabetes is a chronic,non-communicable disease with a substantial global impact,affecting a significant number of *** etiology is closely tied to imbalanced dietary practices and sedentary ***,increasing die-tary fiber(DF)intake has consistently demonstrated health benefits in numerous studies,including improvements in glycemic control and weight *** To investigate the efficacy of DF interventions in the management of type 2 diabetes mellitus(T2DM).METHODS A systematic literature review was conducted to explore the association between DF intake and the management of *** the inclusion and exclusion criteria,a total of 26 studies were included in this *** The main strategies implied to increased DF intake were:High DF diet plus acarbose(2 studies);DF supplements(14 studies);and high DF diets(10 studies).Overall,most studies indicated that increased DF intake resulted in im-provements in glycemic control and weight management in T2DM *** DF represents a valuable strategy in the treatment of type 2 diabetes,improving health *** intake offers the potential to improve quality of life and reduce complications and mortality associated with ***,through supplements or enriched foods,DF contributes significantly to the control of several markers such as HbA1c,blood glucose,triglycerides,low-density lipoprotein,and body weight.

关键词： Type 2 diabetes mellitus Soluble fibers Insoluble fibers Probiotics Blood glucose Nutrition

Prevalence of Latent Tuberculosis Infection [LTBI] in Prison Officers: A Systematic Review and Meta-Analysis

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Open Journal of Respiratory Diseases 2024年第1期14卷 12-24页

作者： Thiago Poss Moreira Gustavo Henrique Baraca Sanvezzo Maico Trevisol Renan William Mesquita Luiza Scalcon de Oliveira Lia Beatriz Henke de Azevedo Cleide Viviane Buzanello Martins Lirane Elize Defante Ferreto health sciences Center Faculty of Medicine Western Paraná State University Francisco Beltr&#227o Brazil health sciences Center Postgraduate Program in Applied Health Sciences Western Paraná State University Francisco Beltr&#227o Brazil

This study aimed to perform a systematic review and meta-analysis to determine the LTBI prevalence in prison officers worldwide. A systematic search was performed in PubMed, WoS, Embase, and BVS, including all articles related to LTBI prevalence and risk factors. After critical evaluation and qualitative synthesis of the identified articles, a meta-analysis was used. Five studies carried out between 2012 and 2022 were included, with a total sample size of 1718 prison officers. The overall LTBI prevalence was 50% [95% confidence interval [CI]: 48% - 52%;n = 816], with high heterogeneity between studies. Smoking [OR = 1.76;CI 95% = 1.26 - 2.46] and males [OR = 2.08;CI 95% = 1.31 - 3.31] were positively related to a higher LTBI prevalence among prison officers. Thus, preventive measures and the rapid and accurate diagnosis of new cases should be emphasized to ensure tuberculosis control, especially among risk groups such as prison officers.

关键词： Latent Tuberculosis Mycobacterium tuberculosis Meta-Analysis Prevalence Occupational Exposure

Harnessing bacteria for tumor therapy:Current advances and challenges

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Chinese Chemical Letters 2024年第2期35卷 97-106页

作者： Lina Guo Jinsong Ding Wenhu Zhou Xiangya School of Pharmaceutical sciences Central South UniversityChangsha 410013China Changsha Medical University Academician WorkstationChangsha 410219China Key Laboratory of biological Nanotechnology of National health Commission Changsha 410008China

After a century of standstill,bacteria-based tumor therapy has resurged recently benefiting from the revolution of tumor immunotherapy,which provides unique solutions to tackle the obstacles of traditional tumor *** and facultative anaerobes with active tropism can selectively colonize at tumor sites and suppress tumor growth via different mechanisms,serving as attractive tools for tumor treatment either as a monotherapy or combining with other therapies for synergistic anti-tumor *** this critical review,we introduce the recent advances of bacteria-based tumor therapy from the following ***,the general properties of bacteria are reviewed emphasizing on their structural components related to tumor immunotherapy,and the main bacteria that have been used in tumor therapy are ***,the benefits of bacteria for tumor therapy are illustrated,such as tumor targetability,deep penetration,and facile genetic engineering for attenuation,enhanced efficacy,as well as ***,anti-tumor mechanisms of bacteria are summarized,which refer to intrinsic tumoricidal activities,immune activation,bacteria metabolism,and their capability to regulate gut microbiota ***,bacteria could act as carriers to deliver various types of therapeutics to achieve combination therapy with improved *** addition,several challenges for anti-tumor applications of bacteria are discussed regarding the delivery,efficacy and safety issues,and potential solutions are also ***,the possible improvements and perspectives are discussed in the end,which provide a guideline for the design of advanced bacteria-based tumor therapeutics in the future.

关键词： Bacteria Tumor targeting Immunotherapy Combination therapy Genetic engineering Surface decoration

Immunoglobulin superfamily containing leucine-rich repeat(ISLR)negatively regulates osteogenic differentiation through the BMP-Smad signaling pathway

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Genes & Diseases 2024年第4期11卷 138-140页

作者： Lei Xiong Miaomiao Lan Chang Liu Lei Li YingYing Yu Tongtong Wang Fan Liu Kun Wang Jin Liu Qingyong Meng State Key Laboratory of Agrobiotechnology College of Biological SciencesChina Agricultural UniversityBeijing 100094China

Osteoporosis(OP)is an aging-associated condition that significantly affects the quality of life in aging humans and has few treatment *** an important marker,recombinant immunoglobulin superfamily containing leucinerich repeat(ISLR)could be used as a gene therapy for *** herein used alkaline phosphatase(ALP)and alizarin red S(ARS)staining to evaluate osteogenic differentiation potential.

关键词： Immunoglobulin alkaline herein

One-Step to Prepare Lignin Based Fluorescent Nanoparticles with Excellent Radical Scavenging Activity

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Journal of Renewable Materials 2024年第5期12卷 895-908页

作者： Xujing Zhang Hatem Abushammala Debora Puglia Binbao Lu Pengwu Xu Weijun Yang Piming Ma The Key Laboratory of Synthetic and biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi214122China Environmental health and Safety program College of Health SciencesAbu Dhabi UniversityP.O.Box 59911Abu DhabiUnited Arab Emirates Civil and Environmental Engineering Department Materials Engineering CenterPerugia UniversityUdR INSTMTerni05100Italy

Fluorescent nanomaterials have attracted much attention,due to their unique luminescent properties and promis-ing applications in biomedical *** this study,lignin basedﬂuorescent nanoparticles(LFNP)with high yield(up to 32.4%)were prepared from lignin nanoparticles(LNP)by one-pot hydrothermal method with ethylene-diamine(EDA)and citric *** and chemical structure of LFNP were investigated by SEM,FT-IR,and zeta potential,and it was found that the structure of LFNP changed with the increase of citric acid *** showed the highestﬂuorescence intensity under UV excitation at wavelengths of 375–385 nm,with emis-sion wavelengths between 454–465 nm,and exhibited strong photoluminescence ***,with the increase of citric acid content,the energy gap(ΔE)gradually decreased from 3.87 to 3.14 eV,which corresponds to the gradual enhancement ofﬂuorescence *** also exhibited excellent antioxidant activity,with DPPH free radical scavenging rate increased from 80.8%for LNP up to 96.7%for LFNP,conﬁrming the great potential of these materials for application in biomedicine and cosmetic health care.

关键词： Lignin ﬂuorescent nanoparticles bioactivity photoluminescence mechanism