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Endothelial dysfunction in the kidney transplant population:Current evidence and management strategies

World Journal of Transplantation 2025年第1期15卷 24-43页

作者： Arun Prabhahar Akshey Batta Juniali Hatwal Vivek Kumar Raja Ramachandran Akash Batta Department of Telemedicine(Internal Medicine and Nephrology) Post Graduate Institute of Medical Education and ResearchChandigarh 160012India Department of Urology and Renal Transplant Neelam HospitalRajpura 140401PunjabIndia Department of Internal Medicine Post Graduate Institute of Medical Education and ResearchChandigarh 160012India Department of Nephrology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India Department of Cardiology Dayanand Medical College and HospitalLudhiana 141001PunjabIndia

The endothelium modulates vascular homeostasis owing to a variety of vasoconstrictors and *** dysfunction(ED),characterized by impaired vasodilation,inflammation,and thrombosis,triggers future cardiovascular(CV)*** kidney disease,a state of chronic inflammation caused by oxidative stress,metabolic abnormalities,infection,and uremic toxins damages the *** is also associated with a decline in estimated glomerular filtration *** kidney transplantation,endothelial functions undergo immediate but partial restoration,promising graft longevity and enhanced CV ***,the anticipated CV outcomes do not happen due to various transplant-related and unrelated risk factors for ED,culminating in poor CV health and graft *** in kidney transplant recipients is an underrecognized and poorly studied *** diseases are the leading cause of death among kidney transplant candidates with functioning *** contributes to the pathogenesis of many of the CV *** biomarkers and vasoreactivity tests are available to study endothelial *** an increasing number of transplants happening every year,and improved graft rejection rates due to the availability of effective immunosuppressants,the focus has now shifted to endothelial protection for the prevention,early recognition,and treatment of CV diseases.

关键词： Endothelial dysfunction Endothelium Cardiovascular disease Kidney transplantation Chronic kidney disease Nitric oxide Flow-mediated dilatation Nitro-glycerine-mediated dilatation Biomarkers

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Intricacies during pregnancy with gestational diabetes mellitus

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World Journal of Clinical Cases 2025年第1期13卷 62-64页

作者： Richa Rattan Rimesh Pal Parul Chawla Gupta Arvind Kumar Morya Ripunjay Prasad Department of Endocrinology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India Department of Ophthalmology Post Graduate Institute of Medical Education and ResearchChandigarh 160012PunjabIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology RP Eye InstituteDelhi 110001India

The study by Cao et al aimed to identify early second-trimester biomarkers that could predict gestational diabetes mellitus(GDM)development using advanced proteomic techniques,such as Isobaric tags for relative and absolute quantitation isobaric tags for relative and absolute quantitation and liquid chromatography-mass spectrometry liquid chromatography-mass *** analysis revealed 47 differentially expressed proteins in the GDM group,with retinol-binding protein 4 and angiopoietin-like 8 showing significantly elevated serum levels compared to *** these findings are promising,the study is limited by its small sample size(n=4 per group)and lacks essential details on the reproducibility and reliability of the protein quantification methods ***,the absence of experimental validation weakens the interpretation of the protein-protein interaction network identified through bioinformatics *** study's focus on second-trimester biomarkers raises concerns about whether this is a sufficiently early period to implement preventive interventions for *** GDM risk during the first trimester or pre-conceptional period may offer more clinical *** its limitations,the study presents valuable insights into potential GDM biomarkers,but larger,well-validated studies are needed to establish their predictive utility and generalizability.

关键词： Gestational diabetes mellitus Biomarkers Differentially expressed proteins Retinol-binding protein 4 Angiopoietin-like 8 Proteomics Lifestyle interventions Early prediction

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Actively tunable electromagnetically induced transparency in hybrid Dirac-VO2 metamaterials

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Optoelectronics Letters 2025年第1期21卷 13-20页

作者： DI Ke XIE Meng XIA Huarong CHENG Anyu LIU Yu DU Jiajia Department of Optoelectronic Engineering Chongqing University of Post and Telecommunications Chongqing Key Laboratory of Autonomous Navigation and Microsystem Chongqing University of Posts and Telecommunications Department of Automation Chongqing University of Post and Telecommunications

In this paper, we present a metamaterial structure of Dirac and vanadium dioxide（VO2） and investigate its optical properties using the finite-difference time-domain（FDTD） technique. Using the phase transition feature of VO2, the design can realize active tuning of the plasmon induced transparency（PIT） effect at terahertz frequency, thereby converting from a single PIT to a double-PIT. When VO2is in the insulating state, the structure is symmetric to obtain a single-band PIT effect. When VO2is in the metallic state, the structure turns asymmetric to realize a dual-band PIT effect. This design provides a reference direction for the design of actively tunable metamaterials. Additionally, it is discovered that the transparent window's resonant frequency and the Fermi level in this structure have a somewhat linear relationship. In addition, the structure achieves superior refractive index sensitivity in the terahertz band, surpassing 1 THz/RIU. Consequently, the design exhibits encouraging potential for application in refractive index sensors and optical switches.

关键词： Transparency

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Therapeutic potential of stem cells in subarachnoid hemorrhage

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Neural Regeneration Research 2025年第4期20卷 936-945页

作者： Hideki Kanamaru Hidenori Suzuki Department of Neurosurgery Mie University Graduate School of MedicineTsuJapan

Aneurysm rupture can result in subarachnoid hemorrhage,a condition with potentially severe consequences,such as disability and *** the acute stage,early brain injury manifests as intracranial pressure elevation,global cerebral ischemia,acute hydrocephalus,and direct blood–brain contact due to aneurysm *** may subsequently cause delayed cerebral infarction,often with cerebral vasospasm,significantly affecting patient *** complications such as brain volume loss and chronic hydrocephalus can further impact *** the mechanisms of subarachnoid hemorrhage-induced brain injury is paramount for identifying effective *** cell therapy,with its multipotent differentiation capacity and anti-inflammatory effects,has emerged as a promising approach for treating previously deemed incurable *** review focuses on the potential application of stem cells in subarachnoid hemorrhage pathology and explores their role in neurogenesis and as a therapeutic intervention in preclinical and clinical subarachnoid hemorrhage studies.

关键词： delayed cerebral ischemia early brain injury matricellular protein neurogenesis stem cell therapy subarachnoid hemorrhage

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Comparing role of ATP between acute pain in neuromyelitis optica spectrum disorder and peripheral neuropathic pain

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Neural Regeneration Research 2025年第1期20卷 184-185页

作者： Teruyuki Ishikura Tatsusada Okuno Department of Molecular Neuroscience Graduate School of MedicineOsaka UniversityOsakaJapan Department of Neurology Osaka University Graduate School of MedicineOsaka UniversityOsakaJapan

In this article, we present our previous research, which highlighted adenosine triphosphate(ATP) as the cause of neuropathic pain during the acute phase of neuromyelitis optica spectrum disorder(NMOSD). In NMOSD pathology, damageassociated molecular patterns(DAMPs), including ATP, are released from damaged astrocytes, triggering the activation of innate immune cells. ATP is a central mediator of acute pain in NMOSD.

关键词： pain acute pathology

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In vivo direct neuronal conversion as a therapeutic strategy for ischemic stroke

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Neural Regeneration Research 2025年第8期20卷 2309-2310页

作者： Takashi Irie Taito Matsuda Department of Stem Cell Biology and Medicine Graduate School of Medical SciencesKyushu UniversityFukuokaJapan Department of Neurology Neurological InstituteGraduate School of Medical SciencesKyushu UniversityFukuokaJapan

Stroke causes neuronal loss,which ultimately results in persistent neurological ***,stroke was the third-leading cause of death and disability combined in all ages in 2019,after neonatal disorders and ischemic heart *** that year,there were 12.2 million incident strokes,101 million prevalent strokes,and 143 million disability-adjusted life-years due to stroke.

关键词： neonatal death therapeutic

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Accelerating dark energy models with anisotropic fluid in Bianchi type Ⅵ_0 space-time

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Research in Astronomy and Astrophysics 2013年第2期13卷 139-158页

作者： Anirudh Pradhan Department of Mathematics Hindu Post-graduate College

Motivated by the increasing evidence for the need of a geometry that re- sembles Bianchi morphology to explain the observed anisotropy in the WMAP data, we have discussed some features of Bianchi type VI0 universes in the presence of a fluid that has an anisotropic equation of state （EoS） parameter in general relativity. We present two accelerating dark energy （DE） models with an anisotropic fluid in Bianchi type VI0 space-time. To ensure a deterministic solution, we choose the scale factor a（t） = √tnet, which yields a time-dependent deceleration parameter, representing a class of models which generate a transition of the universe from the early decelerating phase to the recent accelerating phase. Under suitable conditions, the anisotropic mod- els approach an isotropic scenario. The EoS for DE co is found to be time-dependent and its existing range for derived models is in good agreement with data from recent observations of type Ia supernovae （SNe Ia）（Knop et al. 2003）, SNe Ia data com- bined with cosmic microwave background （CMB） anisotropy and galaxy clustering statistics （Tegmark et al. 2004a）, as well as the latest combination of cosmological datasets coming from CMB anisotropies, luminosity distances of high redshift SNe Ia and galaxy clustering. For different values of n, we can generate a class of physically viable DE models. The cosmological constant A is found to be a positive decreasing function of time and it approaches a small positive value at late time （i.e. the present epoch）, which is corroborated by results from recent SN Ia observations. We also ob- serve that our solutions are stable. The physical and geometric aspects of both models are also discussed in detail.

关键词： cosmological models -- dark energy -- variable EoS parameter

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Thick Domain Walls in Lyra Geometry with Bulk Viscosity

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Communications in Theoretical Physics 2009年第2期51卷 378-384页

作者： Anirudh Pradhan Department of Mathematics Hindu Post-graduate College

In this paper, we evaluate the general solutions for plane-symmetric thick domain walls in Lyra geometry in presence of bulk viscous fluid. Expressions for the energy density and pressure of domain walls are derived in both cases of uniform and time varying displacement field β. Some physical consequences of the models are also given. Finally, the geodesic equations and acceleration of the test particle are discussed.

关键词： cosmology plane symmetric domain walls bulk viscous model Lyra geometry

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Anisotropic Bianchi Type-I Magnetized String Cosmological Models with Decaying Vacuum Energy Density A(t)

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Communications in Theoretical Physics 2011年第5期55卷 931-941页

作者： Anirudh Pradhan Department of Mathematics Hindu Post-graduate College

The present study deals with a spatially homogeneous and anisotropic Bianehi-I cosmological models representing massive strings with magnetic field and decaying vacuum energy density A. The energy-momentum tensor, as formulated by Letelier （1983）, has been used to construct massive string cosmological models for which we assume the expansion scalar in the models is proportional to one of the components of shear tensor. The Einstein＇s field equations have been solved by applying a variation law for generalized Hubble＇s parameter in Bianchi-I space-time. The variation law for Hubble＇s parameter generates two types of solutions for the average scale factor, one is of power-law type and other is of the exponential form. Using these two forms, Einstein＇s field equations are solved separately that correspond to expanding singular and non-singular models of the universe respectively. We have made a comparative study of accelerating and decelerating models in the presence of string scenario. The study reveals that massive strings dominate in the decelerating universe whereas strings dominate in the accelerating universe. The strings eventually disappear from the universe for sufficiently large times, which is in agreement with current astronomical observations. The cosmological constant A is found to be a positive decreasing function of time which is corroborated by results from recent supernovae Ia observations. The physical and geometric properties of the models have been also discussed in detail.

关键词： cosmic strings Bianchi-I universe variable cosmological constant Hubble's parameter

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Influence of magnetic field on wave propagation at liquid-microstretch solid interface

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Applied Mathematics and Mechanics(English Edition) 2011年第5期32卷 595-602页

作者： B.SINGH Department of Mathematics post graduate Government College

The reflection and refraction of a longitudinal wave at an interface between a perfectly conducting nonviscous liquid half-space and a perfectly conducting microstretch elastic solid half-space are studied. The appropriate solutions to the governing equations are obtained in both the half-spaces satisfying the required boundary conditions at the interface to obtain a system of five non-homogeneous equations in the amplitude ratios of various reflected and transmitted waves. The system is solved by a Fortran program of the Gauss elimination method for a particular example of an interface between water and aluminum-epoxy composite. Numerical values of the amplitude ratios are computed for a certain range of the incidence angle both in the presence and absence of an impressed transverse magnetic field. The effects of the presence of the transverse magnetic field on the amplitude ratios of various reflected and transmitted waves are shown graphically.

关键词： microstretch wave propagation reflection and transmission magnetic field

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