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Metabolic reprogramming: a new option for the treatment of spinal cord injury

Neural Regeneration research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen Chao Yu Kaishun Xia Biao Yang Ronghao Wang Yi Li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang Jingkai Wang Qixin Chen Chengzhen Liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical research center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National center for Microscopy and Imaging research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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population,development,and environment in India

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Chinese Journal of population,Resources and Environment 2013年第4期11卷 367-374页

作者： C.M.Lakshmana Institute for Social and economic Change(ISEC)population research Centre

High population growth and continued economic development have caused serious environmental damage in the Asia Pacific ***,the recent experience is that the pace of environmental degradation is faster in developing countries than in developed *** this end,the study seeks to assess the impact of population pressure on India's environment,with particular reference to the degradation of natural endowments like land and water resources and the resultant environmental pollution in the six regions of *** rapid economic growth and expansion of infrastructure development in recent decades have not come without serious environmental consequences particularly in the southern,northern,and western *** in the eastern,north-eastern,and central regions of the country,environmental damage has been mainly due to rapid population growth.

关键词： India population poverty urbanization development environment

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THE STRATEGIC TRANSITION OF SPATIAL DISTRIBUTION IN CHINA'S URBANIZATION AND THE MEASURES CONCERNED

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Journal of Geographical Sciences 1990年第1期1卷 50-60页

作者： Wang Sijun population research center Hangzhou University

Three economic zones are explored in terms of spatial distribution of urbanization with reference to past experiences and the existing relevant *** are made to draw an overall plan for the purpose of adjustment.

关键词： urbanization economic zones

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On the Process of Peasant Workers' Transformation to Urban Residents

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Chinese Journal of population,Resources and Environment 2008年第1期6卷 63-71页

作者： Liu Chuanjiang Dong Yanfang Wang Jing center for economic Development research Wuhan University Wuhan Hubei 430072 China center for population Resource and Environment Economy Research Wuhan University Wuhan Hubei 430072 China

The unique two-stage "Chinese path" of China’s ru-ral-urban migration, which cannot be fully explained by classical theories of economic development, makes us to give peasant workers’ transformation to urban residents a top priority. On the basis of fully explaining peasant workers’ transformation to urban residents, a method for measuring its process has been advanced and then confirmed with the data of March in 2005 from surveys to peasant workers in Wuhan. Finally, the suggestions of acceler-ating peasant workers’ transformation to urban residents to pro-mote the construction of a harmonious society have been drawn from the analysis.

关键词： rural-urban migration peasant workers' transformation to urban residents process of peasant workers' transformation to urban residents

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THE ECOGEOGRAPHIC DISTRIBUTION OF THE population IN THE YANGTZE RIVER VALLEY

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Journal of Geographical Sciences 1991年第4期 16-26页

作者： Zhang Dixiang Institute of population research Economic College of Wuhan University

The total population of the Yangtze River Valley(YRV)was 190 million by the end of 1949 and it amounted to 377 million in 1987,an increase of 95.95 percent in 38years,averaging 1.82 percent *** population density increased from 106.4 persons per km2 in 1949 to 208.6persons per km2 in *** ecogeographic distribution of the population and the analysis of the reasons accountable for its development and changes in the YRV are presented in this paper.

关键词： population distribution ecogeography Yangtze River Valley

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Better nutrition, healthier mind? Experimental evidence from primary schools in rural northwestern China

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Journal of Integrative Agriculture 2019年第8期18卷 1768-1779页

作者： LIU Xiao-yue ZHAO Qi-ran CHEN Qi-hui center for Food and Health economic research College of Economics and Management China Agricultural University

Malnutrition and mental health problems are both prevalent among rural students in China. To provide a better understanding of the functional linkage between these two problems, this study estimates the causal effect of improved nutrition on rural students’ mental health status, exploiting a randomized controlled trial involving 6 044 fourth and fifth graders in rural northwestern China. Estimation results show that a nutrition subsidy provided by the project significantly improved students’ mental health status(measured by their anxiety scale). However, an add-on incentive provided to school principals, which was tied to anemia reduction, almost entirely offset the beneficial impact of the nutrition subsidy. These findings suggest that to improve students’ mental health in rural China, not only direct subsidies, such as low-priced school meals, but also correct incentives, especially those tied closely to students’ mental health outcomes, should be provided.

关键词： malnutrition mental health randomized controlled trial rural China

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ON WEAK MINIMUM ABERRATION AND NUMBER OF CLEAR TWO-FACTOR INTERACTION COMPONENTS IN s_Ⅳ～(m-p) DESIGNS

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Acta Mathematica Scientia 2010年第1期30卷 240-246页

作者：杨贵军 Department of Statistics and China center for economic Statistics research Tianjin University of Finance and Economics

This article obtains some theoretical results on the number of clear two-factor interaction components and weak minimum aberration in an sm-pIVdesign, by considering the number of not clear two-factor interaction comp... 详细信息

关键词： clear two-factor interaction component weak minimum aberration, resolu-tion wordlength pattern

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Adverse Childhood Experiences and Depressive Symptoms Trajectories Among Middle-Aged and Elderly—China,2011–2018

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China CDC weekly 2022年第27期4卷 588-592,I0003-I0007页

作者： Jiajia Li Shiqi Lin Lijun Pei Institute of population research/China center on population Health and Development Peking UniversityBeijingChina.

Summary What is already known about this topic?Previous studies in western populations have found consistent relationships between adverse childhood experiences and the development of mood and anxiety disorders,especially depressive symptoms in adolescence and *** is added by this report?This study used a longitudinal design and analytic method to model depressive symptom trajectories from 2011 to 2018 among the middle-aged and elderly in *** study also investigated the association between adverse childhood experiences and adulthood depressive symptoms in the Chinese *** are the implications for public health practice?Future public policy could consider early prevention and intervention on adverse childhood experiences to prevent adult depressive ***,it is essential to create safe,stable,and nurturing environments for children’s development.

关键词： prevention Middle policy

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Parental and Social Factors’Contribution to Adverse Pregnancy Outcomes with Urban-Rural Disparities—Four Provinces,China,2011–2020

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China CDC weekly 2023年第16期5卷 353-357页

作者： Ning Zhang Jianli Ye Xiaoping Pan Jilei Wu National center for Women and Children’s Health Chinese Center for Disease Control and PreventionBeijingChina Institute of population research/China center on population Health and Development Peking UniversityBeijingChina

Summary What is already known about this topic?The prevalence of adverse pregnancy outcomes(APOs)exhibits a disparity between urban and rural areas,which is commonly associated with various factors,such as demographic and socio-environmental ***,the specific contribution of each factor has not yet been *** is added by this report?This study demonstrates that the primary factors contributing to urban-rural differences in the prevalence of APOs are population structure,parental age,parity,and regional *** are the implications for public health practice?Future prevention and control measures should be directed toward considering population structure and regional *** interventions will enhance the efficiency of public health services.

关键词： prevention pregnancy Rural

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