检索结果-南通市图书馆

Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese:a Case-control Study

引用

Biomedical and Environmental Sciences 2015年第7期28卷 510-517页

作者： YOU Hai Fei ZHAO Jing Zhi ZHAI Yu Jia YIN Lei PANG Chao LUO Xin Ping ZHANG Ming WANG Jin Jin LI Lin Lin WANG Yan WANG Qian WANG Bing Yuan REN Yong Cheng HU Dong Sheng Department of Blood Transfusion Xijing Hospital The Fourth Military Medical University Department of Epidemiology College of Public Health Zhengzhou University Military Hospital of Henan Province Department of Public health Surveillance & Advisory Zhejiang Provincial Center for Disease Control and Prevention Shenzhen University School of medicine discipline of Public health and preventive medicine Center of Preventive Medicine Research and AssessmentHenan University of Traditional Chinese Medicine

Objective To investigate the association between low-density lipoprotein receptor-related protein 5 （LRPS） variants （rs12363572 and rs4930588） and type 2 diabetes mellitus （T2DM） in Han Chinese. Methods A total of 1842 T2DM cases （507 newly diagnosed cases and 1335 previously diagnosed cases） and 7777 controls were included in this case-control study. PCR-RFLP was conducted to detect the genotype of the two single nucleotide polymorphisms （SNPs）. Odds ratios （ORs） and 95% confidence intervals （95% CIs） were calculated to describe the strength of the association by logistic regression. Results In the study subjects, neither rs12363572 nor rs4930588 was significantly associated with T2DM, even after adjusting for relevant covariates. When stratified by body mass index （BMI）, the two SNPs were also not associated with T2DM. Among the 3 common haplotypes, only haplotype ~ was associated with reduced risk of T2DM （OR 0.820, 95% CI 0.732-0.919）. In addition, rs12363572 was associated with BMI （P〈0.001） and rs4930588 was associated with triglyceride levels （P=0.043） in 507 newly diagnosed T2DM cases but not in healthy controls. Conclusion No LRP5 variant was found to be associated with T2DM in Han Chinese, but haplotype TT was found to be associated with T2DM.

关键词： Low-density lipoprotein receptor-related protein 5 Gene polymorphism Type 2 diabetes mellitus Haplotype Metabolic characteristics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Correlates of first dose of measles vaccination delivery and uptake in Indonesia

引用

Asian Pacific Journal of Tropical medicine 2011年第2期4卷 140-145页

作者： Renae Fernandez Anu Rammohan Niyi Awofeso School of population health University of Western AustraliaAustralia School of Business Discipline of EconomicsUniversity of Western AustraliaAustralia School of Public health and Community medicine University of New South WalesAustralia

Objective:To determine health systems-related,familial,and cultural factors which influence the delivery and uptake of measles vaccination in ***:Logistic regression analysis of data collected during the 2007 Indonesian Demographic and health Survey was undertaken by the authors to investigate these *** 2007 Indonesian Demographic and health Survey dataset is a nationally representative,randomly sampled survey containing 15 065 children aged between 9 and 59 ***:72.8%of children had received the measles *** coverage was similar for males and females;however,coverage was higher amongst urban children,80.1%,compared to 68.5%in rural *** key findings of the regression analysis were congruent with the results of previous research targeting vaccination *** controlling for all other factors,maternal age,maternal education,wealth, the use of a skilled birth attendant,and postnatal check-ups were positively and significantly (Ppopulations require substantial *** health education and health systems improvements are also required.

关键词： Measles Indonesia Vaccination Rural-urban differences Maternal education

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Proteostasis failure:at the intersection between aging and Alzheimer's disease

引用

Neural Regeneration Research 2025年第11期20卷 3221-3222页

作者： Natalia Poblete Claudio Hetz Center for Geroscience Brain Health and MetabolismSantiagoChile Biomedical Neuroscience Institute Faculty of MedicineUniversity of ChileSantiagoChile Program of Cellular and Molecular Biology Institute of Biomedical SciencesFaculty of MedicineUniversity of ChileSantiagoChile Buck Institute for Research on Aging NovatoCAUSA

Lifestyle and demographics of the world's population are causing serious health problems impacting the brain,increasing the incidence of Alzheimer's disease(AD)and other types of *** we have gained important insights into the pathogenic mechanisms of AD,only palliative care is available to *** is characterized by the abnormal deposition of protein aggregates in the brain formed by amyloid β and hyper-phosphorylated,Tau in addition to neuroinflammation.

关键词： Alzheimer amyloid stasis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Association of TCF7L2 and GCG Gene Variants with Insulin Secretion,Insulin Resistance,and Obesity in New-onset Diabetes

引用

Biomedical and Environmental Sciences 2016年第11期29卷 814-817页

作者： ZHANG Lu ZHANG Ming WANG Jin Jin WANG Chong Jian REN Yong Cheng WANG Bing Yuan ZHANG Hong Yan YANG Xiang Yu ZHAO Yang HAN Cheng Yi ZHOU Jun Mei PANG Chao YIN Lei ZHAO Jing Zhi LUO Xin Ping HU Dong Sheng Department of Epidemiology and Biostatistics College of Public HealthZhengzhou UniversityZhengzhou 450000HenanChina Department of preventive medicine Shenzhen University Shenzhen University health Science Center Shenzhen 528060GuangdongChina discipline of Public health and preventive medicine Center of Preventive Medicine Research and AssessmentHenan University of Traditional Chinese MedicineZhengzhou 450016HenanChina Department of Prevention and health Care Military Hospital of Henan ProvinceZhengzhou 450052HenanChina

This cohort study was designed to evaluate the association of transcription factor 7-like 2 （TCF7L2） and proglucagon gene （GCG） variants with disordered glucose metabolism and the incidence of type 2 diabetes mellitus （T2DM） in a rural adult Chinese population. A total of 7,751 non-T2DM participants 〉18 years old genotyped at baseline were recruited. The same questionnaire interview and physical and blood biochemical examinations were performed at both baseline and follow-up. During a median 6 years of follow-up, T2DM developed in 227 participants. After adjustment for potential contributory factors, nominally significant associations were seen between 3T genotype and the recessive model of TCFTI.2 rs7903146 and increased risk of T2DM [hazard ratio （HR）=4.068, 95% confidence interval （CI）： 1.270-13.026; HR=4.051, 95% CI： 1.268-12.946, respectively]. The TT genotype of rs7903146 was also significantly associated with higher fasting plasma insulin level and the homeostasis model assessment of insulin resistance in case of new-onset diabetes. In addition, the TCF7L2 rs290487 TT genotype was associated with abdominal obesity and the GCG rs12104705 CC genotype was associated with both general obesity and abdominal obesity in case of new-onset diabetes.

关键词： TCF GCG Insulin Resistance and Obesity in New-onset Diabetes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

引用

World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen Gao Jing-Wen Li Hui Ye Xue-Zhi Zhang Jian-Xiang Liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese medicine and Integrative medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Changing Patterns of Mortality in Diabetes Mellitus Among Older Adults—China,1987-2021

引用

China CDC weekly 2023年第50期5卷 1120-1124页

作者： Chen Chen Yihao Zhao Shangjun Liu Yu Wu Shan Yang Binbin Su Xiaoying Zheng Department of population health and Aging science School of Population Medicine and Public HealthChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Department of Chronic Diseases and Multimorbidity School of Population Medicine and Public HealthChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Institute of population Research Peking UniversityBeijingChina Department of health Economics School of Population Medicine and Public HealthChinese Academy of Medical Science&Peking Union Medical CollegeBeijingChina HeSAY/Institute of population Research Peking UniversityBeijingChina

What is already known about this topic?Diabetes mellitus poses a significant public health concern for older adults in China,resulting in increased mortality *** is added by this report?This study investigates the evolving pattern of mortality associated with diabetes mellitus and analyzes the contributions of age,period,and cohort effects from 1987 to *** results demonstrate a consistent rise in diabetes mellitus mortality over the last 30 years,notably in rural *** are the implications for public health practice?This research offers valuable insights to aid policymakers in developing targeted intervention strategies that address the specific needs of higher-risk populations,such as women,older adults,and individuals in rural areas.

关键词： mortality Diabetes policy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Activities of Daily Living-Related Functional Impairment Among population Aged 65 and Older—China,2011–2050

引用

China CDC weekly 2023年第27期5卷 593-598页

作者： Binbin Su Panliang Zhong Chen Chen Yu Wu Xiaoying Zheng School of population medicine and Public health Chinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina Department of population health and Aging Science School of Population Medicine and Public HealthChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina

Summary What is already known about this topic?The elevated prevalence of functional impairment among elderly individuals in China contributes to an increased burden of *** is added by this report?This report presents a comprehensive evaluation of trends in functional impairment related to activities of daily living(ADL)among the elderly population in ***,it offers insights for future projections of these trends in this demographic *** are the implications for public health practice?Addressing the care needs and functional impairment issues among the aging population in China necessitates interdepartmental collaboration.

关键词： population demographic elderly

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association of the ADIPOQ Rs2241766 and Rs266729 Polymorphisms with Metabolic Syndrome in the Chinese population:A Meta-analysis

引用

Biomedical and Environmental Sciences 2016年第7期29卷 505-515页

作者： ZHOU Jun Mei ZHANG Ming WANG Shu WANG Bing Yuan HAN Cheng Yi REN Yong Cheng ZHANG Lu ZHANG Hong Yan YANG Xiang Yu ZHAO Yang HU Dong Sheng Department of preventive medicine Shenzhen University Health Sciences Center School of Basic medicine Shenzhen University Health Sciences Center Department of Epidemiology and health Statistics College of Public HealthZhengzhou University

Objective This meta-analysis was performed to summarize the association of the ADIPOQ rs2241766 and rs266729 polymorphisms with metabolic syndrome（MS） in the Chinese *** We searched for articles in MEDLINE via PubM ed,EMBASE,HuG E Navigator,CNKI,and Wanfang databases and calculated odds ratios（ORs） with 95% confidence intervals（CIs） to determine the strength of associations in fixed-or random-effects *** We included 21 articles in the meta-analysis：17 reports of ADIPOQ rs2241766 with 3628 cases and 3000 controls and 8 of rs266729 with 2021 cases and 2226 *** found an increased risk of MS with the ADIPOQ rs2241766 polymorphism in some genetic models（allele model：OR=1.12,95% CI：1.03-1.21;dominant model：OR=1.15,95% CI：1.04-1.28;homozygote model：OR=1.22,95% CI：1.00-1.49） but no association with the ADIPOQ rs266729 polymorphism（allele model：OR=0.98,95% CI：0.82-1.17;dominant model：OR=0.90,95% CI：0.79-1.02;recessive model：OR=1.09,95% CI：0.85-1.39;homozygote model：OR=1.03,95% CI：0.80-1.33）.Conclusion The results of this meta-analysis suggest an association between the ADIPOQ rs2241766 polymorphism and MS in the Chinese population.G allele of ADIPOQ rs2241766 increases the risk of *** designed studies with different ethnic populations and larger sample sizes are needed for assessing the relationship between ADIPOQ rs2241766 and rs266729 polymorphisms and MS in the future.

关键词： ADIPOQ Polymorphisms Metabolic syndrome Meta-analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Long-Term Patterns of Meningitis Mortality:A Continual Downward Trend and a Vulnerable Infant population—China,1987–2021

引用

China CDC weekly 2023年第34期5卷 745-750页

作者： Yu Wu Huiyun Fan Binbin Su Chao Guo Luzhao Feng Department of population health and Aging Science School of Population Medicine and Public HealthChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina APEC health Science Academy(HeSAY) Peking UniversityBeijingChina Institute of population Research Peking UniversityBeijingChina Department of Infectious Diseases School of Population Medicine and Public HealthChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina.

Summary What is already known about this topic?Meningitis,a life-threatening disease,presents a significant public health *** rate of progress in burden reduction notably lags behind other diseases that can be prevented through *** is added by this report?This research explored the changes in the mortality rate of meningitis in China over a span of 35 *** study further identified the effects of age,period,and cohort on the mortality trends.

关键词： mortality diseases vaccination

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Human semen quality and the secondary sex ratio

引用

Asian Journal of Andrology 2017年第3期19卷 374-381页

作者： Jisuk Bae Sungduk Kim Zhen Chen Michael L Eisenberg Germaine M Buck Louis Department of preventive medicine Catholic University of Daegu School of Medicine Daegu 42472 Korea Division of Intramural population health Research Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Rockvilie MD 20852 USA Department of Urology Obstetrics and Gynecology Stanford University School of Medicine Stanford CA 94305-5118 USA.

The aim of this study was to evaluate the association between semen quality and the secondary sex ratio （SSR）, defined as the ratio of male to female live births. Our study cohort comprised 227 male partners who were enrolled prior to conception in Michigan and Texas between 2005 and 2009, and prospectively followed through delivery of a singleton birth. The male partners provided a baseline and a follow-up semen sample a month apart. Semen analysis was conducted to assess 27 parameters including five general characteristics, six sperm head measures, 14 morphology measures, and two sperm chromatin stability assay measures. Modified Poisson regression models with a robust error variance were used to estimate the relative risk （RR） and 95% confidence interval （95% CI） of a male birth for each semen parameter, after adjusting for potential confounders. Of the 27 semen parameters, only the percentage of bicephalic sperm was significantly associated with the SSR （2nd VS Ist quartile, RR, 0.65, 95% CI, 0.45-0.95, P= 0.03; 4TM vs 1St quartile, RR, 0.61, 95% CI, 0.38-1.00, P 〈 0.05 before rounding to two decimal places）, suggestive of a higher percentage of bicephalic sperm being associated with an excess of female births. Given the exploratory design of the present study, this preconception cohort study suggests no clear signal that human semen quality is associated with offspring sex determination.

关键词： fertility prospective studies reproduction semen analysis sex ratio sperm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：