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International Journal of Mining Science and Technology 2013年第1期23卷 113-119页

作者： Mena Rodrigo Zio Enrico Kristjanpoller Fredy Arata Adolfo European Foundation for New Energy-Electricity of France at Central School of Paris-Supelec Paris 92295 France Energy Department Polytechnic of Milan Milan 20133 Italy Department of Industrial Engineering Federico Santa Maria Technical University Valparaiso 2390123 Chile Industrial Engineering School Pontifical Catholic University of Valparaiso Valparaiso 2340025 Chile

We present a novel system productivity simulation and optimization modeling framework in which equipment availability is a variable in the expected productivity function of the system. The framework is used for allocating trucks by route according to their operating performances in a truck-shovel system of an open-pit mine, so as to maximize the overall productivity of the fleet. We implement the framework in an originally designed and specifically developed simulator-optimizer software tool. We make an application on a real open-pit mine case study taking into account the stochasticity of the equipment behavior and environment. The total system production values obtained with and without considering the equipment reliability, availability and maintainability (RAM) characteristics are compared. We show that by taking into account the truck and shovel RAM aspects, we can maximize the total production of the system and obtain specific information on the production availability and productivity of its components.

关键词： Simulation Optimization Reliability Productivity Open-pit Truck allocation

Identifying representative days of solar irradiance and wind speed in Brazil using machine learning techniques

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Energy and AI 2024年第1期15卷 151-170页

作者： Rafaela Ribeiro Bruno Fanzeres Industrial Engineering Department Pontifical Catholic University of Rio de Janeiro(PUC-Rio)22451-900Rio de JaneiroRJBrazil

The investment levels in electricity production capacity from variable Renewable Energy Sources have substantially grown in Brazil over the last decades,following the worldwide-seeking-goal of a carbon-neutral economy and the country’s incentives in diversifying its generation *** a long-term perspective,the current non-storable capability of renewable energy sources requires an adequate uncertainty characterization over the *** this context,the main objective of this work is to provide a thorough descriptive analytics of the time-linked hourly-based daily dynamics of wind speed and solar irradiance in the main resourceful regions of *** on unsupervised Machine Learning methods,we focus on identifying similar days over the years,Representative Days,that can depict the fundamental underlying behaviour of each *** analysis is based on a historical dataset of different sites with the highest potential and installed capacity of each source spread over the country:three in the Northeast and one in the South Regions,for wind speed;and three in the Northeast and one in the Southeast Regions,for solar *** use two Partitioning Methods(𝐾-Means and𝐾-Medoids),the Hierarchical Ward’s Method,and a Model-Based Method(Self-Organizing Maps).We identified that wind speed and solar irradiance can be effectively represented,respectively,by only two representative days,and two or three days,depending on the region and method(segments data with respect to the intensity of each source).Analysis with higher Representative Days highlighted important hidden patterns such as different wind speed modulations and solar irradiance peak-hours along the days.

关键词： Partitioning clustering methods Hierarchical clustering methods Model-based clustering methods Representative days Solar irradiance Wind speed

Survival and maturation rates of the African rodent, Mastomys natalensis: density-dependence and rainfall

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Integrative Zoology 2007年第4期2卷 220-232页

作者： Vincent SLUYDTS Laurent CRESPIN Stephen DAVIS Mauricio LIMA Herwig LEIRS Evolutionary Biology Group University of AntwerpAntwerpBelgium Danish Pest Infestation Laboratory Department of Integrated Pest ManagementFaculty of Agricultural SciencesUniversity of AarhusKongens LyngbyDenmark Center for Advances Studies in Ecology and Biodiversity Pontifical Catholic University of ChileSantiagoChile IRD UMR CBGP(INRA/IRD/Cirad/Montpellier SupAgro)Montferrier-sur-Lez CedexFrance

Survival and maturation rates of female Mastomys natalensis were analysed based on a ten-year monthlycapture-recapture data set. We investigated whether direct and delayed density dependent and independent (rainfall)variables accounted for the considerable variation in demographic traits. It was estimated that seasonal and annualcovariates accounted for respectively 29 and 26% of the total variation in maturation rates and respectively 17 and11% of the variation in survival rates. Explaining the between-year differences in maturation rates with annual pastrainfall or density did not improve the model fit. On the other hand we showed that maturation rates were correlatednegatively with density the previous month and positively to cumulative rainfall over the past three *** estimates of both adults and subadults varied seasonally, with higher estimates during the increase phase(dry season). The subadults were characterised by a very high survival rate (> 0.95) during this phase. In thedecrease phase only minor differences were found between survival rates of subadults and adults. We found that39% of the between-year variation in survival can be explained by accumulated rainfall over the past year.

关键词： capture-recapture Mastomys maturation multistate model survival

Diabetes mellitus contribution to the remodeling of the tumor microenvironment in gastric cancer

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 1997-2012页

作者： Armando Rojas Cristian Lindner Iván Schneider Ileana Gonzàlez Hernan Araya Erik Morales Milibeth Gómez Nelson Urdaneta Paulina Araya Miguel Angel Morales Biomedical Research Lab. Medicine FacultyCatholic University of MauleTalca 34600000Chile Department of Clinical Sciences Medicine FacultyCatholic University of MauleTalca 34600000Chile Servicio de Oncología Hospital Regional de TalcaTalca 34600000Chile Servicio de Anatomía Patologica Hospital Regional de TalcaTalca 34600000Chile Department of Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Compelling pieces of evidence derived from both clinical and experimental research has demonstrated the crucial contribution of diabetes mellitus(DM)as a risk factor associated with increased cancer incidence and mortality in many human neoplasms,including gastric cancer(GC).DM is considered a systemic inflammatory disease and therefore,this inflammatory status may have profound effects on the tumor microenvironment(TME),particularly by driving many molecular mechanisms to generate a more aggressive *** is an active driver in the modification of the behavior of many cell components of the TME as well as altering the mechanical properties of the extracellular matrix(ECM),leading to an increased ECM ***,DM can alter many cellular signaling mechanisms and thus favoring tumor growth,invasion,and metastatic potential,as well as key elements in regulating cellular functions and cross-talks,such as the microRNAs network,the production,and cargo of exosomes,the metabolism of cell stroma and resistance to *** the present review,we intend to highlight the mechanistic contributions of DM to the remodeling of TME in GC.

关键词： Diabetes mellitus Gastric cancer Tumor microenvironment Hyperglycemia Chronic inflammation

Emerging and multifaceted potential contributions of polyphenols in the management of type 2 diabetes mellitus

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World Journal of Diabetes 2024年第2期15卷 154-169页

作者： Ileana González Cristian Lindner Ivan Schneider Erik Diaz Miguel Angel Morales Armando Rojas Biomedical Research Laboratories Faculty of MedicineCatholic University of MauleTalca 34600000Chile Department of Radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile Centre of Primary Attention South Metropolitan Health ServiceSantiago 3830000Chile Faculty of Medicine Catholic University of MauleTalca 3460000Chile Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Type 2 diabetes mellitus(T2DM)is recognized as a serious public health concern with a considerable impact on human life,long-term health expenditures,and substantial health *** this context,the use of dietary polyphenols to prevent and manage T2DM is widely *** dietary compounds exert their beneficial effects through several actions,including the protection of pancreatic islet β-cell,the antioxidant capacities of these molecules,their effects on insulin secretion and actions,the regulation of intestinal microbiota,and their contribution to ameliorate diabetic complications,particularly those of vascular *** the present review,we intend to highlight these multifaceted actions and the molecular mechanisms by which these plant-derived secondary metabolites exert their beneficial effects on type 2 diabetes patients.

关键词： Polyphenols Antioxidants Oxidative stress Type 2 diabetes mellitus Health benefits

Revolution and Restoration： The Revolution of Quito （Ecuador） Within the Independence Process of Latin America

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Sociology Study 2015年第2期5卷 146-156页

作者： Juan J. Paz-y-Mino Cepeda pontifical catholic university of Ecuador Ecuador

The Revolution of Quito （1808-1812） in many aspects pioneered the way during the Latin American independence process. After the independence of Haiti （1804） and at its initial stage, the Sovereign Junta in Quito, founded in 1809, took action together with the revolutionary movements of Chuquisaca and La Paz. Controlled, its members persecuted and finally killed, the Revolution of Quito passed from a loyalty to an independence movement which resulted in the creation of the new State of Quito. The defeat of the Revolution of Quito restored the old regime. In the middle of this process, the threat of the Holy Alliance, which was born at the Congress of Vienna （1814-1815）, has particular significance for Quito and Latin America as it was the third attempt of a Spanish conquest The celebrations of the bicentenaries of the independence of Latin American countries have given a reason to value the concepts which the region developed during its anticolonial struggle, the first of its kind in the world and at the dawn of capitalism. G. W. F. Hegel always perceived Latin America as an ＂echo of a foreign Life＂. He never understood nor visited Latin America. He could not understand that another ＂spirit of the people＂ existed here which did not have a place in his elaborate universal history. And as has happened in the past, today Latin America is once again a pioneering region when it comes to setting the foundations for what should become its second independence, an idea which has been revived by the Latin American governments associated with the New Left.

关键词： Revolution of Quito Congress of Vienna independence of Latin America second independence spirit of the people

Wnt signaling in the nervous system and in Alzheimer＇s disease

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Journal of Molecular Cell Biology 2014年第1期8卷 64-74页

作者： Nibaldo C. Inestrosa Lorena Varela-Nallar Center for Aging and Regeneration (CARE) Department of Cell and Molecular Biology Faculty of Biological Sciences Pontifical Catholic University of ChileSantiago Chile Center for Biomedical Research Faculty of Biological Sciences and Faculty of Medicine AndrOs Bello University Santiago Chile

Wnts comprise a large family of proteins that have shown to be part of a signaling cascade that regulates several aspects of develop- ment including organogenesis, mid brain development as welt as stem cell proliferation. Wnt signaling pathway plays different roles in the development of neuronal circuits and also in the adult brain, where it regulates synaptic transmission and plasticity. It has been also implicated in various diseases including cancer and neurodegenerative diseases, reflecting its relevance in fundamental biological pro- cesses. This review summarizes the progress about Wnts function in mature nervous system with a focus on Alzheimer＇s disease （AD）. We discuss the prospects of modulating canonical and non-canonical Wnt signaling as a strategy for neuroprotection. This will include the potential of Wnts to：（i） act as potent regulators of hippocampai synapses and impact in learning and memory; （ii） regulate adult neurogenesis; and finally （iii） control AD pathogenesis.

关键词： Wnt glutamate Alzheimer's disease synapses dendritic spines neuroprotection

RAGE in Cancer Lung： the End of a Long and Winding Road is in Sight

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中国肺癌杂志 2018年第9期21卷 655-657页

作者： Armando ROJAS Ileana GONZALEZ Paulina ARAYA Biomedical Research Laboratories Medicine Faculty Catholic University of Maule Talca Chile

Introduction The receptor of advanced glycation end-products (RAGE),is a type I single-pass transmembrane protein, member of the multi-ligand immunoglobulin superfamily molecule, which was discovered in 1992, on accou... 详细信息

关键词：糖基化终产物受体肿瘤医学研究

TWO ALGORITHMS FOR LC^1 UNCONSTRAINED OPTIMIZATION

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Journal of Computational Mathematics 2000年第6期18卷 621-632页

作者： Wen-yu Sun R.J.B.de Sampaio Jin-Yun Yuan School of Mathematics and Computer Science Nanjing Normal UniversityNanjing 210097China Applied Informatics Program Pontifical Catholic University of ParanaCuritibaPR81611-970Brazil Department of Mathematics Federal University of ParanaCuritibaPR81531-990Brazil

Presents two algorithms for LC unconstrained optimization problems which use the second order Dini upper directional derivative. Simplicity of the methods to use and perform; Discussion of related properties of the it... 详细信息

关键词： nonsmooth optimization directional derivative Newton-like method convergence trust region method

Father Prepared, Committed, and Involved in His Child’s Birth: The Experience of Early Father-Child Skin to Skin Contact at Birth

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Open Journal of Obstetrics and Gynecology 2021年第7期11卷 853-867页

作者： Claudia Uribe-Torres Mónica Muñoz Serrano Luiza Hoga Nursing College Medical School Pontifical Catholic University of Chile Santiago Chile Nursing College University of S&atilde o Paulo S&atilde o Paulo Brazil

Although the figure of the father has progressively gained a place in birth, it is still displaced and in the mere role of a companion. Objective: To understand the experience of fathers who have prepared to get actively involved in birth and to undergo the experience of early physical contact with their newborns. Method: A qualitative Action-Research (AR) design was carried out, which considered the antenatal educational intervention of 12 fathers together with their pregnant partners. After delivery, individual interviews were conducted in depth to collect the paternal experience at birth. Results: The central emerging theme developed during AR was “Paternal role and early bonding with the child”, whereas the experience was comprehended in two central themes related to the meaning of the father-child encounter-contact: “The impact of the face-to-face encounter with the child”;“The first physical contact with the child, a key moment”. Conclusion: The fathers who were prepared and involved from pregnancy and at birth attribute a special meaning to the father-child relationship which generated since the first encounter, allowing them to feel, enjoy and commit to care.

关键词： Antenatal Preparation Birth Paternal Role Father-Child Relationship