检索结果-南通市图书馆

Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks

引用

Signal Transduction and Targeted Therapy 2022年第1期7卷 243-257页

作者： Louisa Ruhl Isabell Pink Jenny F.Kiihne Kerstin Beushausen Jana Keil Stella Christoph Andrea Sauer Lennart Boblitz Julius Schmidt Sascha David Hans-Martin Jack Edith Roth Markus Cornberg Thomas F.Schulz Tobias Welte Marius M.Hoper Christine S.Falk Institute of Transplant Immunology MHHDHanoverGermany Department of pneumology MHHDHanoverGermany Department of Intensive Care Medicine University of ZurichCHZurichSwitzerland division of Molecular Immunology Internal Medicine IIINikolaus-Fiebiger-Center of Molecular MedicineFriedrich-Alexander University Erlangen-NurnbergDErlangenGermany Department of Gastroenterology Hepatology and Endocrinology MHHDHanoverGermany Center for Individualized Infection Medicine CiiM HanoverGermany lnstitute of Virology MHHDHanoverGermany German Center for Infection Research DZIFTTU-IICHMarburgGermany Excellence Cluster 2155 RESIST MHHHanoverGermany German Center for Lung Diseases DZL/BREATH MarburgGermany

The systemic processes involved in the manifestation of life・threatening COVID-19 and in disease recovery are still incompletely understood,despite investigations focusing on the dysregulation of immune responses after SARS-CoV-2 *** define hallmarks of severe COVID-19 in acute disease(n=58)and in disease recovery in con valesce nt patie nts(n=28)from Han nover Medical School,we used flow cytometry and proteomics data with unsupervised clustering *** our observational study,we combined analyses of immune cells and cytokine/chemokine networks with endothelial activation and *** patients displayed an altered immune signature with prolonged lymphopenia but the expansion of granulocytes and plasmablasts along with activated and terminally differentiated T and NK cells and high levels of SARS-CoV-2-specific *** core signature of seven plasma proteins revealed a highly inflammatory microenvironment in addition to endothelial injury in severe *** within this sign ature were associated with either disease progression or *** summary,our data suggest that besides a strong inflammatory response,severe COVID-19 is driven by endothelial activation and barrier disruption,whereby recovery depends on the regeneration of the endothelial integrity.

关键词： cytokine networks signature

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Initial clinical experience using the Echo Navigator~-system during structural heart disease interventions

引用

World Journal of Cardiology 2015年第9期7卷 562-570页

作者： Jan Balzer Tobias Zeus Katharina Hellhammer Verena Veulemans Silke Eschenhagen Eva Kehmeier Christian Meyer Tienush Rassaf Malte Kelm division of Cardiology Pneumology and Angiology Department of Medicine University Hospital Duesseldorf

AIM: To present our initial clinical experience using this innovative software solution for guidance of percutaneous structural heart disease ***: Left atrial appendage, atrial septal defect and paravalvular leak closure, transaortic valve repair and Mitra Clip procedures were performed in the catheter laboratory under fluoroscopic and echocardiographic guidance. The two-dimensional and three-dimensional images generated by the transesophageal echocardiography probe were interfaced with the fluoroscopic images in real-time using the Echo Navigator-***:The application of the novel image fusion technology was safe and led to a better appreciation of multimodality imaging guidance due to improved visualization of the complex relationship between catheter devices and anatomical ***:The Echo Navigator-system is a feasible and safe tool for guidance of interventional procedures in structural heart *** innovative technology may improve confidence of interventional cardiologists in targeting and positioning interventional devices in order to increase safety,accuracy,and efficacy of percutaneous interventions in the catheter laboratory.

关键词： Fusion imaging Interventional guidance Percutaneou

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A serum microRNA signature for enhanced selection of people for lung cancer screening

引用

Cancer Communications 2022年第11期42卷 1222-1225页

作者： Haixin Yu Janhavi R.Raut Megha Bhardwaj Yan Zhang Evelin Sandner Ben Schöttker Bernd Holleczek Petra Schrotz-King Hermann Brenner division of Clinical Epidemiology and Aging Research German Cancer Research Center(DKFZ)Heidelberg 69120Baden-WürttembergGermany Medical Faculty Heidelberg University of HeidelbergHeidelberg 69120Baden-WürttembergGermany division of Preventive Oncology German Cancer Research Center(DKFZ)and National Center for Tumor Diseases(NCT)Heidelberg 69120Baden-WürttembergGermany German Cancer Consortium(DKTK) German Cancer Research Center(DKFZ)Heidelberg 69120Baden-WürttembergGermany pneumology and Thoracic Oncology Robert-Bosch KrankenhausKlinik SchillerhoeheGerlingen 70839Baden-WürttembergGermany Network Aging Research University of HeidelbergBergheimer Straße 20Heidelberg 69115Baden-WürttembergGermany Saarland Cancer Registry Präsident-Baltz-Straße 5Saarbrucken 66119SaarlandGermany

Dear editor,Lung cancer(LC)is the leading cause of cancer-related mortality globally[1].Earlier detection by screening can substantially reduce LC mortality[2,3],but should be focused on those at highest risk[4].Risk stratification for LC screening,which is mostly based on smoking history[5],is far from perfect[6].Therefore,additional criteria to better define those at highest risk of LC are needed to enhance the efficiency and cost-effectiveness of LC *** risk prediction models incorporating classical LC risk factors[7].

关键词： mortality cancer signature

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development

引用

Genomics, Proteomics & Bioinformatics 2018年第3期16卷 162-171页

作者： Andreas Keller Tobias Fehlmann Nicole Ludwig Mustafa Kahraman Thomas Laufer Christina Backes Claus Vogelmeier Caroline Diener Frank Biertz Christian Herr Rudolf A. Jorres Hans-Peter Lenhof Eckart Meese Robert Bals Clinical Bioinformatics Saarland University 66123 Saarbriieken Germany Department of Human Genetics Saarland University Hospital 66421 Homburg Germany Hummingbird Diagnostics GmbH 69120 Heidelberg Germany Department of Internal Medicine Division for Pulmonary Diseases Philipps University of Marburg 35043 Marburg Germany Institute for Biostatistics Hannover Medical School 30625 Hanover Germany Department of Internal Medicine V- Pulmonology AlIergology Intensive Care Medicine Saarland University Hospital 66421 Homburg Germany Institute and Outpatient Clinic for Occupational Social and Environmental Medicine Comprehensive Pneumology Center Munich (CPC-M) Ludwig-Maximilians-University Munich Member of the German Center for Lung Research ( DZL) 80539 Munich Germany Bioinformatics Saarland University 66123 Saarbrucken Germany Center for Bioinformatics Saarland University 66123 Saarbrucken Germany

Chronic obstructive pulmonary disease （COPD） significantly increases the risk of developing cancer. Biomarker studies frequently follow a case-control set-up in which patients diagnosed with a disease are compared to controls. Longitudinal cohort studies such as the COPD-centered German COPD and SYstemic consequences-COmorbidities NETwork （COSYCONET） study provide the patient and biomaterial base for discovering predictive molecular markers. We asked whether microRNA （miRNA） profiles in blood collected from COPD patients prior to a tumor diagnosis could support an early diagnosis of tumor development independent of the tumor type. From 2741 participants of COSYCONET diagnosed with COPD, we selected 534 individuals including 33 patients who developed cancer during the follow-up period of 54 months and 501 patients who did not develop cancer, but had similar age, gender and smoking history. Genome-wide miRNA profiles were generated and evaluated using machine learning techniques. For patients developing cancer we identified nine miRNAs with significantly decreased abundance （two-tailed unpaired t-test adjusted for multiple testing P 〈 0.05）, including members of the miR-320 family. The identified miRNAs regulate different cancer-related pathways including the MAPK pathway （P - 2.3 × 10 -5）. We also observed the impact of confounding factors on the generated miRNA profiles, underlining the value of our matched analysis. For selected miRNAs, qRT-PCR analysis was applied to validate the results. In conclusion, we identified several miRNAs in blood of COPD patients, which could serve as candidates for biomarkers to help identify COPD patients at risk of developing cancer.

关键词： microRNA Cancer COPD Lung Biomarker COSYCONET

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cell Cycle-based myocardial repair

Cell Cycle-based myocardial repair

引用

2012年中美临床和转化医学国际论坛心脑血管病分会论坛（延吉）暨第十二届全国心血管药理学术会议和中俄药理国际研讨会

作者： Loren Field Mark Soonpaa Sean Reuter Gerd Hasenfuss Karl Toischer Krannert Institute of Cardiology/Department of Medicine Indiana UniversityIndianapolisUSA Herz Zentrum Gttingen/Department of Cardiology and pneumology Georg-August-UniversittGttingenGermany

Progressive cardiomyocyte loss is a unifying theme in congestive heart *** in humans and mice revealed remarkably similar albeit low levels of cardiomyocyte cell cycle activity in un-injured *** injury can result in a transient increase in cardiomyocyte cell cycle induction,which in some cases results in increased cardiomyocyte multi-nucleation and/or ploidy in the absence of an overt increase in cardiomyocyte *** potential theraputic value of cell cycle induction is evident in

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

慢性肾脏病患者铁剂应用的争议：来自改善全球肾脏病预后组织(KDIGO)会议的结论

引用

肾脏病与透析肾移植杂志 2016年第4期25卷 363-370页

作者： Iain C.Macdougall Andreas J.Bircher Kai-Uwe Eckardt Gregorio T.Obrador Carol A.Pollock Peter Stenvinkel Dorine W.Swinkels Christoph Wanner Gü nter Weiss Glenn M.Chertow 陈佩玲(翻译) 龚德华(审校) Department of Renal Medicine King's College Hospital London UK Allergy Unit Dermatology Clinic University Hospital Basel Basel Switzerland Department of Nephrology and Hypertension Friedrich-Alexander-Universitat Erlangen-Numberg Erlangen Germany Universidad Panamericana School of Medicine Mexico City Mexico University of Sydney Sydney Australia Royal North Shore Hospital Sydney Australia division of Renal Medicine Department of Clinical Science Intervention and Technology Karolinska University Hospital Stockholm Sweden Department of Laboratory Medicine Translational Metabolic Laboratory Radboud University Medical Center Nijmegen the Netherlands Renal division University Hospital of Wiirzburg Wiirzburg Germany Department of Internal Medicine VI Infectious Disease Immunology Rheumatology Pneumology Medical University of Innsbruck Innsbruck Austria division of Nephrology Stanford University School of Medicine Palo Alto California USA 南京军区南京总医院肾脏科国家肾脏疾病临床医学研究中心全军肾脏病研究所南京210016 不详

慢性肾脏病和终末期肾病患者常需补铁治疗。但近年来铁剂的使用逐年增加,带来了铁超载、氧化应激和超敏反应等新问题,并可能促进感染的发生,其使用的安全性受到关注。为此,改善全球肾脏病预后组织(KDIGO)召开专家组会议,全面评估铁剂使... 详细信息

慢性肾脏病和终末期肾病患者常需补铁治疗。但近年来铁剂的使用逐年增加,带来了铁超载、氧化应激和超敏反应等新问题,并可能促进感染的发生,其使用的安全性受到关注。为此,改善全球肾脏病预后组织(KDIGO)召开专家组会议,全面评估铁剂使用的利和弊,并且提供合理使用方案以减轻急性反应及其他毒副作用。

关键词：慢性肾脏病超敏反应感染铁超载氧化应激

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

冠状动脉内自体骨髓细胞移植有益于调节心率变异性

引用

世界核心医学期刊文摘（心脏病学分册） 2007年第11期3卷 44-页

作者： Schueller P.O. Meyer C. Brehm M. 刘相飞 Department of Internal Medicine Division of Cardiology Pneumology and Angiology Heinrich-Heine-University 40225 Duesseldorf Germany

冠状动脉内自体骨髓细胞移植在心率自主性调节方面的作用尚未得以阐明。因此,作者在23例透壁心肌梗死后行冠状动脉内干细胞治疗的患者及23例未行干细胞治疗的患者中观察了心率变异性(HRV)

关键词：冠状动脉内自体骨髓细胞心率变异性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ventilator associated pneumonia following liver transplantation:Etiology,risk factors and outcome

引用

World Journal of Transplantation 2016年第2期6卷 389-395页

作者： Antonio Siniscalchi Lucia Aurini Beatrice Benini Lorenzo Gamberini Stefano Nava Pierluigi Viale Stefano Faenza division of Anesthesiology Depart-ment of General Surgery of Sant’Orsola HospitalUniversity of Bologna Department of Specialist Diagnostic and Experimental MedicinePneumology and Respiratory Intensive Care UnitSant’Orsola HospitalUniversity of Bologna Clinic of Infectious Diseases Department of Internal Medicine Geriatrics and Nephrologic DiseasesUniversity of Bologna

AIM: To determine the incidence, etiology, risk factors and outcome of ventilator-associated pneumonia(VAP) in patients undergoing orthotopic liver transplantation(OLT).METHODS: This retrospective study considered 242 patients undergoing deceased donor OLT. VAP was diagnosed according to clinical and microbiological criteria. RESULTS: VAP occurred in 18(7.4%) patients, with an incidence of 10 per 1000 d of mechanical ventilation(MV). Isolated bacterial etiologic agents were mainly Enterobacteriaceae(79%). Univariate logistic analysis showed that model for end-stage liver disease(MELD) score, pre-operative hospitalization, treatment with terlipressin, Child-Turcotte-Pugh score, days of MV and red cell transfusion were risk factors for VAP. Multivariateanalysis, considering significant risk factors in univariate analysis, demonstrated that pneumonia was strongly associated with terlipressin usage, pre-operative hospitalization, days of MV and red cell transfusion. Mortality rate was 22% in the VAP group vs 4% in the group without VAP. CONCLUSION: Our data suggest that VAP is an important cause of nosocomial infection during postoperative period in OLT patients. MELD score was a significant risk factor in univariate analysis. Multiple transfusions, treatment with terlipressin, preoperative hospitalization rather than called to the hospital while at home and days of MV constitute important risk factors for VAP development.

关键词： Liver transplantation Ventilator associated pneumonia Perioperative period Infection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

MDCT in the diagnostic algorithm in patients with symptomatic atrial fibrillation

引用

World Journal of Radiology 2011年第2期3卷 41-46页

作者： Christian Sohns Dirk Vollmann Lars Luethje Marc Dorenkamp Joachim Seegers Jan D Schmitto Markus Zabel Silvia Obenauer Department of Cardiology and pneumology Heart CenterGeorg-August-University GoettingenD-37077 GoettingenGermany division of Cardiac Surgery Brigham and Women's HospitalHarvard Medical SchoolBostonMA 02115United States Department of Diagnostic and Interventional Radiology Medical FacultyUniversity DusseldorfD-40225 DusseldorfGermany

Atrial fibrillation(AF) is the most common supraventricular arrhythmia and a major cause of *** foci originating within the pulmonary veins(PVs) are an important cause of both paroxysmal and persistent AF.A variety of endovascular and surgical techniques have been used to electrically isolate the PV from the left *** venography for localization of the PV ostium can be difficult to perform during the ablation *** the anatomy of the PV is patientspecific,non-invasive imaging techniques may provide useful diagnostic information prior to the intended *** this context,multidetector computed tomography(MDCT) visualization of the left atrial and PV anatomy prior to left atrial ablation and PV isolation is becoming increasingly *** imaging provides pre-procedural information on the left atrial anatomy,including atrial size and venous attachments,and it may identify potential post-procedural complications,such as pulmonary vein stenosis or cardiac ***,we review the relevant literature and present the current"state-of-the-art"of left atrial anatomy,PV ostia as well as the clinical aspects of refractory AF with MDCT imaging protocols and procedural aspects of PV ablation.

关键词： Atrial fibrillation Multidetector computed tomography Pulmonary veins Pulmonary vein ablation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sensorineural Hearing Loss in Multidrug-Resistant Tuberculosis Patients in Kinshasa (Democratic Republic of Congo): Prospective Cohort Study of Therapeutic Regimen with Aminoglycoside versus Bedaquiline

引用

Journal of Tuberculosis Research 2023年第3期11卷 109-119页

作者： Mireille A. Mpwate Eddy M. Mbambu Christian N. Matanda Gabriel M. Lema Michel K. Kaswa Murielle L. Aloni Nicole M. Anshambi Fabrice M. Matuta Luc L. Lukasu Dominique M. Mupepe Serge K. Mpwate Pierre Z. Akilimali Zacharie M. Kashongwe Richard N. Matanda Department of Otorhinolaryngology University Clinics of Kinshasa Kinshasa 11 University of Kinshasa Kinshasa Democratic Republic of Congo National Tuberculosis Control Program in the Democratic Republic of Congo Kinshasa Democratic Republic of Congo Provincial Coordination for the Fight against Tuberculosis Kinshasa Democratic Republic of Congo Multidrug-Resistant Tuberculosis Unit “Centre d’Excellence Damien” Damien Foundation Kinshasa Democratic Republic of Congo division of Cardiology Department of Internal Medicine University Clinics of Kinshasa Kinshasa 11 University of Kinshasa Kinshasa Democratic Republic of Congo Department of Anatomy-Pathology University Clinics of Kinshasa Kinshasa 11 University of Kinshasa Kinshasa Democratic Republic of Congo Kinshasa School of Public Health Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo pneumology Unit Department of Internal Medicine University Clinics of Kinshasa Kinshasa 11 University of Kinshasa Kinshasa Democratic Republic of Congo

Context: Multidrug-resistant tuberculosis (MDR-TB) remains a major public health problem in developing countries such as the Democratic Republic of Congo (DRC), which continues to face the emergence of MDR-TB cases. Because of the ototoxic effects of AGs, the World Health Organization (WHO) has recommended the introduction of the bedaquiline regimen. However, very few data are available regarding the susceptibility of bedaquiline to induce hearing loss, hence the present study set out to compare the AG-based regimen and the bedaquiline-based regimen in the occurrence of hearing loss in MDR-TB patients. Methods: This is a prospective multicenter cohort study that included 335 MDR-TB patients, performed in Kinshasa (DRC) during the period from January 2020 to January 2021. Sociodemographic, clinical, biological and audiometric data were analyzed using Stata 17. Repeated-measures analysis of variance was used to compare changes in the degree of hearing loss over time between the two groups of patients on AG and bedaquiline regimens. The double-difference method was estimated using regression with fixed-effects. A p value < 0.05 was considered the threshold for statistical significance. Results: The degree of hearing loss was similar between the two groups at the first month [AGs (28 dB) vs BDQ (30 dB);p = 0.298]. At six months, the mean degree of hearing loss was significantly greater in the aminoglycoside regimen group [AGs (60.5 dB) vs BDQ (44 dB);p < 0.001]. The double difference was significant, with a greater increase in hearing loss in the AGs group (diff-in-diff 18.3;p < 0.001). After adjustment for age and serum albumin, the group receiving the AG-based regimen had a 2-point greater worsening than those with bedaquiline at the sixth month (diff-in-diff 19.8;p Conclusion: Hearing loss is frequent with both treatment regimens, but more marked with the Aminoglycoside-based regimen. Thus, bedaquiline should also benefit for audiometric monitoring in future MDR-TB p

关键词： Multidrug-Resistant Tuberculosis Aminoglycosides Bedaquiline Hearing Loss

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：