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Impact of microplastics and nanoplastics on liver health:Current understanding and future research directions

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World Journal of Gastroenterology 2024年第9期30卷 1011-1017页

作者： Chun-Cheng Chiang Hsuan Yeh Ruei-Feng Shiu Wei-Chun Chin Tzung-Hai Yen School of Medicine University of PittsburghPittsburghPA 15213United States pittsburgh Liver research Center University of PittsburghPittsburghPA 15213United States division of Experimental Pathology Department of PathologyUniversity of PittsburghPittsburghPA 15213United States division of Endocrinology Department of PediatricsUniversity of PittsburghPittsburghPA 15213United States Center of Excellence for The Oceans National Taiwan Ocean UniversityKeelung 20224Taiwan Institute of Marine Environment and Ecology National Taiwan Ocean UniversityKeelung 20224TaiwanChina Department of Materials Science and Engineering University of California MercedMercedCA 95343United States Department of Nephrology Clinical Poison CenterChang Gung Memorial HospitalTaoyuan 333TaiwanChina College of Medicine Chang Gung UniversityTaoyuan 333TaiwanChina

With continuous population and economic growth in the 21st century,plastic pollution is a major global issue.However,the health concern of microplastics/nanoplastics(MPs/NPs)decomposed from plastic wastes has drawn public attention only in the recent decade.This article summarizes recent works dedicated to understanding the impact of MPs/NPs on the liver-the largest digestive organ,which is one of the primary routes that MPs/NPs enter human bodies.The interrelated mechanisms including oxidative stress,hepatocyte energy re-distribution,cell death and autophagy,as well as immune responses and inflammation,were also featured.In addition,the disturbance of microbiome and gut-liver axis,and the association with clinical diseases such as metabolic dysfunction-associated fatty liver disease,steatohepatitis,liver fibrosis,and cirrhosis were briefly discussed.Finally,we discussed potential directions in regard to this trending topic,highlighted current challenges in research,and proposed possible solutions.

关键词： Microplastics Nanoplastics Liver Reactive oxidative species Cell death Autophagy Innate immunity Metabolic dysfunction-associated fatty liver disease Gut-liver axis

High-yield and rapid isolation of extracellular vesicles by flocculation via orbital acoustic trapping:FLOAT

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Microsystems & Nanoengineering 2024年第1期10卷 313-323页

作者： Joseph Rufo Peiran Zhang Zeyu Wang Yuyang Gu Kaichun Yang Joseph Rich Chuyi Chen Ruoyu Zhong Ke Jin Ye He Jianping Xia Ke Li Jiarong Wu Yingshi Ouyang Yoel Sadovsky Luke P.Lee Tony Jun Huang Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNCUSA Department of Biomedical Engineering Duke UniversityDurhamNCUSA Department of Obstetrics Gynecologyand Reproductive SciencesMagee-Womens Research InstituteUniversity of PittsburghPittsburghPAUSA Department of Microbiology and Molecular Genetics School of MedicineUniversity of PittsburghPittsburghPAUSA Renal division and division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Department of Bioengineering Department of Electrical Engineering and Computer ScienceUniversity of CaliforniaBerkeleyBerkeleyCAUSA Department of Biophysics Institute of Quantum BiophysicsSungkyunkwan UniversitySuwonKorea

Extracellular vesicles(EVs)have been identified as promising biomarkers for the noninvasive diagnosis of various diseases.However,challenges in separating EVs from soluble proteins have resulted in variable EV recovery rates and low purities.Here,we report a high-yield(>90%)and rapid(<10 min)EV isolation method called FLocculation via Orbital Acoustic Trapping(FLOAT).The FLOAT approach utilizes an acoustofluidic droplet centrifuge to rotate and controllably heat liquid droplets.By adding a thermoresponsive polymer flocculant,nanoparticles as small as 20 nm can be rapidly and selectively concentrated at the center of the droplet.We demonstrate the ability of FLOAT to separate urinary EVs from the highly abundant Tamm-Horsfall protein,addressing a significant obstacle in the development of EV-based liquid biopsies.Due to its high-yield nature,FLOAT reduces biofluid starting volume requirements by a factor of 100(from 20 mL to 200µL),demonstrating its promising potential in point-of-care diagnostics.

关键词： trapping utilize separating

Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics:The Study of Muscle,Mobility and Aging(SOMMA)

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Journal of Sport and Health Science 2024年第5期13卷 621-630页

作者： Yujia(Susanna)Qiao Terri L.Blackwell Peggy M.Cawthon Paul M.Coen Steven R.Cummings Giovanna Distefano Samaneh Farsijani Daniel E.Forman Bret H.Goodpaster Stephen B.Kritchevsky Theresa Mau Frederico G.S.Toledo Anne B.Newman Nancy W.Glynn Department of Epidemiology School of Public HealthUniversity of PittsburghPittsburghPA 15261USA San Francisco Coordinating Center California Pacific Medical Center Research InstituteSan FranciscoCA 94143USA Department of Epidemiology and Biostatistics University of CaliforniaSan FranciscoCA 94143USA Translational research Institute AdventHealthOrlandoFL 32804USA Department of Medicine(Geriatrics and Cardiology) University of Pittsburghand GeriatricsResearchEducationand Clinical Center(GRECC)VA Pittsburgh Healthcare SystemPittsburghPA 15261USA Department of Internal Medicine Section on Gerontology and Geriatric MedicineWake Forest School of MedicineWinston-SalemNC 27109USA division of Endocrinology and Metabolism Department of MedicineUniversity of PittsburghPittsburghPA 15261USA

Background:Skeletal muscle energetics decline with age,and physical activity(PA)has been shown to offset these declines in older adults.Yet,many studies reporting these effects were based on self-reported PA or structured exercise interventions.Therefore,we examined the associations of accelerometry-measured and self-reported PA and sedentary behavior(SB)with skeletal muscle energetics and explored the extent to which PA and sedentary behavior would attenuate the associations of age with muscle energetics.Methods:As part of the Study of Muscle,Mobility and Aging,enrolled older adults(n=879),810(age=76.4±5.0 years old,mean±SD;58%women)had maximal muscle oxidative capacity measured ex vivo via high-resolution re spirometry of permeabilized myofibers(maximal oxidative phosphorylation(maxOXPHOS))and in vivo by ^(31)phosphorus magnetic resonance spectroscopy(maximal adenosine triphosphate(ATP_(max))).Accelerometry-measured sedentary behavior,light activity,and moderate-to-vigorous PA(MVPA)were assessed using a wrist-worn ActiGraph GT9X over 7 days.Self-reported sedentary behavior,MVPA,and all PA were assessed with the Community Healthy Activities Model Program for Seniors(CHAMPS)questionnaire.Linear regression models with progressive covariate adjustments evaluated the associations of sedentary behavior and PA with muscle energetics,as well as the attenuation of the age/muscle energetics association by MVP A and sedentary behavior.As a sensitivity analysis,we also examined activPAL-measured daily step count and time spent in sedentary behavior and their associations with muscle energetics.Results:Every 30 min/day more of ActiGraph-measured MVPA was associated with 0.65 pmol/(s×mg)higher maxOXPHOS and 0.012 mM/s higher ATP_(max)after adjusting for age,site/technician,and sex(p<0.05).Light activity was not associated with maxOXPHOS or ATP_(max).Meanwhile,every 30 min/day spent in ActiGraph-measured sedentary behavior was associated with 0.39 pmol/s×mg lower maxOXPHOS and0.006 mM/s lower ATP_(max)(p<0.05).Only associatio

关键词： Aging Exercise Mitochondria

Omics approaches in asthma research:Challenges and opportunities

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第1期2卷 1-9页

作者： Molin Yue Shiyue Tao Kristina Gaietto Wei Chen Department of Biostatistics School of Public HealthUniversity of PittsburghPittsburghPA 15224USA division of Pediatric Pulmonary Medicine UPMC Children’s Hospital of PittsburghUniversity of PittsburghPittsburghPA 15224USA

Asthma,a chronic respiratory disease with a global prevalence of approximately 300 million individuals,presents a significant societal and economic burden.This multifaceted syndrome exhibits diverse clinical phenotypes and pathogenic endotypes influenced by various factors.The advent of omics technologies has revolutionized asthma research by delving into the molecular foundation of the disease to unravel its underlying mechanisms.Omics technologies are employed to systematically screen for potential biomarkers,encompassing genes,transcripts,methylation sites,proteins,and even the microbiome components.This review provides an insightful overview of omics applications in asthma research,with a special emphasis on genetics,transcriptomics,epigenomics,and the microbiome.We explore the cutting-edge methods,discoveries,challenges,and potential future directions in the realm of asthma omics research.By integrating multi-omics and non-omics data through advanced sta-tistical techniques,we aspire to advance precision medicine in asthma,guiding diagnosis,risk assessment,and personalized treatment strategies for this heterogeneous condition.

关键词： Asthma Genomics Transcriptomics Epigenomics Metagenomics Multi-omics integration

Reinforcing effects of polypropylene on energy absorption and fracturing of cement-based tailings backfill under impact loading

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 650-664页

作者： Jiajian Li Shuai Cao Erol Yilmaz School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory of High-Efficient mining and Safety of Metal Mines of Ministry of Education University of Science and Technology BeijingBeijing 100083China Department of Civil Engineering Geotechnical DivisionRecep Tayyip Erdogan UniversityFenerRize TR53100Turkey

Polypropylene(PP)fiber-reinforced cement-based tailings backfill(FRCTB)is a green compound material with superior crack resistance and has good prospects for application in underground mining.However,FRCTB exhibits susceptibility to dynamic events,such as impact ground pressure and blast vibrations.This paper investigates the energy and crack distribution behavior of FRCTB under dynamic impact,considering the height/diameter(H/D)effect.Split Hopkinson pressure bar,industrial computed tomography scan,and scanning electron microscopy(SEM)experiments were carried out on six types of FRCTB.Laboratory outcomes confirmed fiber aggregation at the bottom of specimens.When H/D was less than 0.8,the proportion of PP fibers distributed along theθangle direction of80°-90°increased.For the total energy,all samples presented similar energy absorption,reflectance,and transmittance.However,a rise in H/D may cause a rise in the energy absorption rate of FRCTB during the peak phase.A positive correlation existed between the average strain rate and absorbed energy per unit volume.The increase in H/D resulted in a decreased crack volume fraction of FRCTB.When the H/D was greater than or equal to 0.7,the maximum crack volume fraction of FRCTB was observed close to the incidence plane.Radial cracks were present only in the FRCTB with an H/D ratio of 0.5.Samples with H/D ratios of 0.5 and 0.6 showed similar distributions of weakly and heavily damaged areas.PP fibers can limit the emergence and expansion of cracks by influencing their path.SEM observations revealed considerable differences in the bonding strengths between fibers and the FRCTB.Fibers that adhered particularly well to the substrate were attracted together with the hydration products adhering to surfaces.These results show that FRCTB is promising as a sustainable and green backfill for determining the design properties of mining with backfill.

关键词： cement-based tailings fiber-reinforced backfills fracture energy absorption impact loading

Review of current coal rib control practices

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Underground Space 2023年第2期9卷 53-75页

作者： Dogukan Guner Samuel Nowak Taghi Sherizadeh Maurice Sunkpal Khaled Mohamed Yuting Xue Department of mining and Explosives Engineering Missouri University of Science and TechnologyRollaMO 65409USA CDC NIOSH Pittsburgh Mining Research DivisionPittsburghPA 15236USA

The instability of coal ribs in underground mines continues to result in the injuries and fatalities of mine workers.The proper esti-mation and evaluation of primary and secondary support for coal ribs is still a challenging problem in the field of ground control science and requires further research and study.Although mining operations have various support design criteria and support methodologies for strata control,most rib support designs are still based on experience and local practices.This review study is intended to summarize the currently applied practices for rib support and control in various countries and mining conditions.Firstly,critical parameters that con-trol the amount and type of required rib support are considered and evaluated.The study revealed that among these parameters that control the stability of coal ribs,mining depth,rib height,cleat orientation/condition,and coal strength are the most significant param-eters.Secondly,current rib support application methods were also summarized.Similar to rock mass classification systems,some studies proposed a rib control rating system for practical estimation of the current rib condition and to estimate primary support requirements.These studies are classified and summarized into two groups(categorical and empirical)based on the required inputs and methodologies.Empirically based coal rib rating systems were closely examined,and the usefulness and intuitive aspects of each rating system were com-pared.This comprehensive literature review demonstrates that the Australian rating system,Analysis and Design of Rib Support(ADRS),and the new U.S.rating system,Coal Pillar Rib Rating(CPRR),are highly applicable for their regions.

关键词： Coal rib Ground control Rib support Rib control techniques ADRS CPRR

Analysis of global and local stress changes in a longwall gateroad

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International Journal of mining Science and Technology 2018年第1期28卷 127-135页

作者： I.B.Tulu G.S.Esterhuizen D.Gearhart T.M.Klemetti K.M.Mohamed D.W.H.Su Department of mining Engineering West Virginia University NIOSH Pittsburgh Mining Research Division

A numerical-model-based approach was recently developed for estimating the changes in both the horizontal and vertical loading conditions induced by an approaching longwall face.In this approach, a systematic procedure is used to estimate the model's inputs.Shearing along the bedding planes is modeled with ubiquitous joint elements and interface elements.Coal is modeled with a newly developed coal mass model.The response of the gob is calibrated with back analysis of subsidence data and the results of previously published laboratory tests on rock fragments.The model results were verified with the subsidence and stress data recently collected from a longwall mine in the eastern United States.

关键词： Longwall mining Gateroad design Flac3D Horizontal angle Gob loading Hollow inclusion cells

Coal rib response during bench mining: A case study

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International Journal of mining Science and Technology 2018年第1期28卷 107-113页

作者： Morgan M.Sears John Rusnak Mark Van Dyke Gamal Rashed Khaled Mohamed Michael Sloan Ground Control Branch NIOSH Pittsburgh Mining Research Division

In 2016, room-and-pillar mining provided nearly 40% of underground coal production in the United States.Over the past decade, rib falls have resulted in 12 fatalities, representing 28% of the ground fall fatalities in U.S.underground coal mines.Nine of these 12 fatalities(75%) have occurred in room-andpillar mines.The objective of this research is to study the geomechanics of bench room-and-pillar mining and the associated response of high pillar ribs at overburden depths greater than 300 m.This paper provides a definition of the bench technique, the pillar response due to loading, observational data for a case history, a calibrated numerical model of the observed rib response, and application of this calibrated model to a second site.

关键词： Deep cover Bench mining Thick seam Retreat mining Rib response Rib support

Ground response to high horizontal stresses during longwall retreat and its implications for longwall headgate support

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International Journal of mining Science and Technology 2019年第1期29卷 27-33页

作者： Peter Zhang Dave Gearhart Mark Van Dyke Daniel Su Essie Esterhuizen Berk Tulu NIOSH Pittsburgh Mining Research Division(PMRD) Department of mining Engineering West Virginia University

Roof falls in longwall headgate can occur when weak roof and high horizontal stress are present. To prevent roof falls in the headgate under high horizontal stress, it is important to understand the ground response to high horizontal stress in the longwall headgate and the requirements for supplemental roof support. In this study, a longwall headgate under high horizontal stress was instrumented to monitor stress change in the pillars, deformations in the roof, and load in the cable bolts. The conditions in the headgate were monitored for about six months as the longwall face passed by the instrumented site.The roof behavior in the headgate near the face was carefully observed during longwall retreat.Numerical modeling was performed to correlate the modeling results with underground observation and instrumentation data and to quantify the effect of high horizontal stress on roof stability in the longwall headgate. This paper discusses roof support requirements in the longwall headgate under high horizontal stress in regard to the pattern of supplemental cable bolts and the critical locations where additional supplemental support is necessary.

关键词： Longwall mining Longwall headgate High horizontal stress Supplemental support