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Unveiling protein corona composition:predicting with resampling embedding and machine learning

Regenerative Biomaterials 2024年第1期3卷 27-33页

作者： Rong Liao Yan Zhuang Xiangfeng Li Ke Chen Xingming Wang Cong Feng Guangfu Yin Xiangdong Zhu Jiangli Lin Xingdong Zhang college of Biomedical engineering National Engineering Research Centre for BiomaterialsSichuan UniversityChengdu610065China

Biomaterials with surface nanostructures effectively enhance protein secretion and stimulate tissue *** nanoparticles(NPs)enter the living system,they quickly interact with proteins in the body fluid,forming the protein corona(PC).The accurate prediction of the PC composition is critical for analyzing the osteoinductivity of biomaterials and guiding the reverse design of ***,achieving accurate predictions remains a significant *** several machine learning(ML)models like Random Forest(RF)have been used for PC prediction,they often fail to consider the extreme values in the abundance region of PC absorption and struggle to improve accuracy due to the imbalanced data *** this study,resampling embedding was introduced to resolve the issue of imbalanced distribution in PC *** ML models were evaluated,and RF model was finally used for prediction,and good correlation coefficient(R^(2))and root-mean-square deviation(RMSE)values were *** ablation experiments demonstrated that the proposed method achieved an R^(2) of 0.68,indicating an improvement of approximately 10%,and an RMSE of 0.90,representing a reduction of approximately 10%.Furthermore,through the verification of label-free quantification of four NPs:hydroxyapatite(HA),titanium dioxide(TiO_(2)),silicon dioxide(SiO_(2))and silver(Ag),and we achieved a prediction performance with an R^(2) value>0.70 using Random ***,the feature analysis revealed that the composition of the PC is most significantly influenced by the incubation plasma concentration,PDI and surface modification.

关键词： nanoparticles protein corona machine learming resampling technique feature analysis

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Stimulated Raman scattering tomography for rapid three-dimensional chemical imaging of cells and tissue

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Advanced Photonics 2024年第2期6卷 20-31页

作者： Weiqi Wang Zhiwei Huang National University of Singapore College of Design and EngineeringOptical Bioimaging LaboratoryDepartment of Biomedical EngineeringSingapore

Three-dimensional(3D)imaging is essential for understanding intricate biological and biomedical systems,yet live cell and tissue imaging applications still face challenges due to constrained imaging speed and strong scattering in turbid ***,we present a unique phase-modulated stimulated Raman scattering tomography(PM-SRST)technique to achieve rapid label-free 3D chemical imaging in cells and *** accomplish PM-SRST,we utilize a spatial light modulator to electronically manipulate the focused Stokes beam along the needle Bessel pump beam for SRS tomography without the need for mechanical z *** demonstrate the rapid 3D imaging capability of PM-SRST by real-time monitoring of 3D Brownian motion of polystyrene beads in water with 8.5 Hz volume rate,as well as the instant biochemical responses to acetic acid stimulants in MCF-7 ***,combining the Bessel pump beam with a longer wavelength Stokes beam(NIR-II window)provides a superior scattering resilient ability in PM-SRST,enabling rapid tomography in deeper tissue *** PM-SRST technique providestwofold enhancement in imaging depth in highly scattering media(e.g.,polymer beads phantom and biotissue like porcine skin and brain tissue)compared with conventional point-scan *** also demonstrate the rapid 3D imaging ability of PM-SRST by observing the dynamic diffusion and uptake processes of deuterium oxide molecules into plant *** rapid PM-SRST developed can be used to facilitate label-free 3D chemical imaging of metabolic activities and functional dynamic processes of drug delivery and therapeutics in live cells and tissue.

关键词： stimulated Raman scattering tomography deep tissue Raman imaging spatial light modulation

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FeNi Prussian blue analogues on highly graphitized carbon nanosheets as efficient glucose sensors

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Rare Metals 2024年第6期43卷 2730-2738页

作者： Jin-Hang Xue Qiu-Hong Sun Cheng Han Yuan-Dong Yang Shao-Jie Xu Qi-Peng Li Jin-Jie Qian college of Life and Environmental Science Wenzhou UniversityWenzhou 325000China college of Chemistry and Materials engineering Wenzhou UniversityWenzhou 325000China college of Chemistry and Chemical engineering Zhaotong UniversityZhaotong 657000China

Meeting the continuous glucose monitoring requirements of individuals necessitates the research and development of sensors with high sensitivity and *** this study,a straightforward strategy was proposed for synthesizing ultra-thin oxygen-rich graphitized carbon nanosheets(denoted as GCS-O).These nanosheets are obtained by calcining a topologically two-dimensional indium-based coordination ***,the growth of FeNi Prussian blue analogue(PBA)on GCS-O effectively introduces active sites and increases the nitrogen content within the carbonaceous *** resulting FeNi-PBA/GCS-O composite exhibits excellent glucose sensing performance with a broad linear range of 1 to 1300μmol·L^(-1).Meanwhile,it also achieves a high sensitivity of 2496μA·mmol^(-1)·L·cm^(-2),a limit of detection of 100nmol·L^(-1)(S/N=3),and commendable long-term *** relatively simple synthesis process,exceptional sensitivity,and satisfactory electrochemical sensing performance of FeNi-PBA/GCS-O open up new directions for biosensor applications.

关键词： Coordination polymer Carbon nanosheet Prussian blue analogue Surface reconstruction Glucose oxidation

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Novel high-safety aeroengine performance predictive control method based on adaptive tracking weight

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Chinese Journal of Aeronautics 2024年第7期37卷 352-374页

作者： Qian CHEN Hanlin SHENG Jie ZHANG Jiacheng LI college of Energy and Power engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China college of Automation engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Increasing attention has been attracted to the dynamic performance and safety of advanced performance predictive control systems of the next-generation *** latest research demonstrates that Subspace-based Improved Model Predictive Control(SIMPC)can overcome the difficulty in solving the predictive model in MPC/NMPC ***,applying constant design parameters cannot maintain consistent control effects in all ***,the designed system relies too much on sensor-measured data,and thus it is difficult to thoroughly validate the safety of the system because of its high *** means that any potential hardware/software faults will endanger the ***,this paper first presents a novel nonlinear mapping relationship to adaptively tune the tracking weight online with the change of Power Lever Angle(PLA)and real-time relative tracking ***,without introducing additional design parameters,an Adaptive Tracking Weight-based SIMPC(ATW-SIMPC)controller is designed to improve the control performance in all operating states ***,a Primary/Backup Hybrid Control(PBHC)strategy with the ATW-SIMPC controller as the primary system and the traditional speed(Nf)controller as the backup system is proposed to ensure *** designed affiliated switching controller and the real-time monitor therein can be used to realize reasonable and smooth switching between primary/backup systems,so as to avoid bump *** PBHC system switches to the Nf controller when the ATW-SIMPC controller is wrong because of potential hardware/software faults;otherwise,the ATW-SIMPC controller keeps acting on the *** main results prove that the ATW-SIMPC controller with the optimal nonlinear mapping relationship,compared with the existing SIMPC controller,uplifts the dynamic control performance by 32%and reduces overshoots to an allowable limit,resulting in a better control effect in full *** comparison results consistently i

关键词： Aeroengine Model predictive control Hybrid system Adaptive weight Safety

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Achieving high strength and rapid degradation in Mg-Gd-Ni alloys by regulating LPSO phase morphology combined with extrusion

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Journal of Magnesium and Alloys 2024年第6期12卷 2312-2326页

作者： Kai Maa Jingfeng Wang Yinhong Peng Chaoneng Dai Yuanlang Pan Ye Wang Danqian Wang Jinxing Wang Yanlong Ma Fusheng Pan college of Materials Science and engineering Chongqing UniversityChongqing 400044PR China National engineering Research Center for Magnesium Alloys Chongqing 400044PR China college of Chemistry and Chemical engineering Chongqing UniversityChongqing 401331PR China college of Materials Science and engineering Chongqing University of TechnologyChongqing 400054PR China

In this study,Mg-13.2Gd-4.3Ni alloys containing continuous bulk-shaped long-period stacking ordered(LPSO),lamellar LPSO,and a small amount of eutectic phase were prepared,and the evolution of microstructure at different extrusion temperatures and its influence on mechanical and degradation properties as well as corrosion mechanism were *** before extrusion can effectively promote the precipitation of lamellar LPSO in ***400 with higher volume fraction of non-DRXed grains exhibited higher strength,which was mainly due to strong texture,high dislocation density,and high volume fraction of lamellar *** EX420 with higher volume fraction of DRXed grains showed higher degradation rate,which was mainly due to the higher density of grain *** EX400 exhibited excellent comprehensive properties with tensile yield strength(TYS)of 334 MPa,ultimate tensile strength(UTS)of 484 MPa and elongation(EL)of 7.4%,ultimate compressive strength(UCS)of 638 MPa and compressive yield strength(CYS)of 443 MPa,degradation rate of 86.1 mg/cm^(2)/h at 93℃in 3 wt.%KCl solution.

关键词： Mg-Gd-Ni alloys LPSO Mechanical properties Degradation rate

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A flexible multiscale algorithm based on an improved smoothed particle hydrodynamics method for complex viscoelastic flows

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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1387-1402页

作者： Jinlian REN Peirong LU Tao JIANG Jianfeng LIU Weigang LU college of Mathematical Science Yangzhou University college of Hydraulic Science and engineering Yangzhou University

Viscoelastic flows play an important role in numerous engineering fields,and the multiscale algorithms for simulating viscoelastic flows have received significant attention in order to deepen our understanding of the nonlinear dynamic behaviors of viscoelastic fluids. However, traditional grid-based multiscale methods are confined to simple viscoelastic flows with short relaxation time, and there is a lack of uniform multiscale scheme available for coupling different solvers in the simulations of viscoelastic fluids. In this paper, a universal multiscale method coupling an improved smoothed particle hydrodynamics(SPH) and multiscale universal interface(MUI) library is presented for viscoelastic flows. The proposed multiscale method builds on an improved SPH method and leverages the MUI library to facilitate the exchange of information among different solvers in the overlapping domain. We test the capability and flexibility of the presented multiscale method to deal with complex viscoelastic flows by solving different multiscale problems of viscoelastic flows. In the first example, the simulation of a viscoelastic Poiseuille flow is carried out by two coupled improved SPH methods with different spatial resolutions. The effects of exchanging different physical quantities on the numerical results in both the upper and lower domains are also investigated as well as the absolute errors in the overlapping domain. In the second example, the complex Wannier flow with different Weissenberg numbers is further simulated by two improved SPH methods and coupling the improved SPH method and the dissipative particle dynamics(DPD) method. The numerical results show that the physical quantities for viscoelastic flows obtained by the presented multiscale method are in consistence with those obtained by a single solver in the overlapping domain. Moreover, transferring different physical quantities has an important effect on the numerical results.

关键词： 35Q30 76A10 76M28 complex viscoelastic flow dissipative particle dynamics (DPD) improved smoothed particle hydrodynamics (SPH) multiscale method multiscale universal interface (MUI) O373

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Numerical simulation of transient characteristics in a bulb turbine during the load rejection process

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Journal of Hydrodynamics 2024年第1期36卷 170-183页

作者： Yue Lu Yu-quan Zhang Zhong-wei He Yuan Zheng college of Water Conservancy and Hydropower engineering Hohai UniversityNanjing210098China college of Energy and Electrical engineering Hohai UniversityNanjing210098China Huadong engineering Corporation Ltd. Hangzhou311122China

To evaluate the safety of the bulb tubular turbine,the dynamic hydraulic characteristics of a hydropower station system during the load rejection process are studied through numerical simulations and a prototype *** the developed model,a dynamic grid technology(DGT)controls the closure of the guide vane and the blade,whilst the moment balance equation and the user-defined function(UDF)provide the runner’s rotation *** 3-D transient simulation method can well predict the rotation speed and mass flow curves in the state of load *** simulation outcomes of the system performance are basically consistent with the measurement data of the *** observed,the runner is subjected to the reversely increased torque and axial force,the system is in a braking phase,and the maximum speed peaks at 144.6%of the rated ***,the internal flow of the runner is greatly affected by the closure of the guide vane,and the draft tube forms an eccentric spiral vortex *** breaks downstream,aggravating the instability of the draft ***,the transient characteristics span for the first five seconds,demonstrating the importance of establishing an efficient governing *** obtained results are useful for designing the turbine’s flow channel with a double regulating function and comprehending the turbine’s transient characteristics.

关键词： Bulb tubular turbine load rejection numerical simulation dynamic grid prototype test

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Automatic detection and assessment of crack development in ultra-high performance concrete in the spatial and Fourier domains

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Frontiers of Structural and Civil engineering 2024年第3期18卷 350-364页

作者： Jixing CAO Yao ZHANG Haijie HE Weibing PENG Weigang ZHAO Zhiguo YAN Hehua ZHU School of Safety engineering and Emergency Management Shijiazhuang Tiedao UniversityShijiazhuang 050043China college of Civil engineering and Architecture Zhejiang UniversityHangzhou 310058China college of Civil and Architectural engineering Taizhou UniversityTaizhou 318000China college of Civil engineering and Architecture Zhejiang University of TechnologyHangzhou 310014China Department of Geotechnical engineering Tongji UniversityShanghai 200092China

Automatic detection and assessment of surface cracks are beneficial for understanding the mechanical performance of ultra-high performance concrete(UHPC).This study detects crack evolution using a novel dynamic mode decomposition(DMD)*** this method,the sparse matrix‘determined’from images is used to reconstruct the foreground that contains cracks,and the global threshold method is adopted to extract the crack *** application of the DMD method to the three-point bending test demonstrates the efficiency in inspecting cracks with high ***,the geometric features,including the area and its projection in two major directions,are evaluated over *** relationship between the geometric properties of cracks and load-displacement curves of UHPC is *** to the irregular shape of cracks in the spatial domain,the cracks are then transformed into the Fourier domain to assess their *** indicate that crack patterns in the Fourier domain exhibit a distinct concentration around a central ***,the power spectral density of cracks exhibits an increasing trend over *** investigation into crack evolution in both the spatial and Fourier domains contributes significantly to elucidating the mechanical behavior of UHPC.

关键词： dynamic mode decomposition ultra-high performance concrete crack detection geometric features Fourier domain

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A projected Newton algorithm based on chemically allowed interval for chemical equilibrium computations

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Frontiers of Chemical Science and engineering 2024年第3期18卷 25-37页

作者： Hongbin Lu Shaohui Tao Xiaoyan Sun Li Xia Shuguang Xiang Institute of Process Systems engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao266042China

The chemical equilibrium equations utilized in reactive transport modeling are complex and nonlinear,and are typically solved using the Newton-Raphson *** this algorithm is known for its quadratic convergence near the solution,it is less effective far from the solution,especially for ill-conditioned *** such cases,the algorithm may fail to converge or require excessive *** address these limitations,a projected Newton method is introduced to incorporate the concept of *** method constrains the Newton step by utilizing a chemically allowed interval that generates feasible descending ***,we utilize the positive continuous fraction method as a preconditioning technique,providing reliable initial values for solving the *** numerical results are compared with those derived using the regular Newton-Raphson method,the Newton-Raphson method based on chemically allowed interval updating rules,and the bounded variable least squares method in six different test *** numerical results highlight the robustness and efficacy of the proposed algorithm.

关键词： chemical equilibrium reactive transport modeling numerical methods projected Newton method

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Recent Progress of Bionic Hierarchical Structure in the Field of Thermal Insulation Protection

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Journal of Bionic engineering 2024年第1期21卷 1-18页

作者： Yina Zhuge Fujuan Liu National engineering Laboratory for Modern Silk College of Textile and Clothing EngineeringSoochow UniversitySuzhou 215123China

Some living organisms with hierarchical structures in nature have received extensive attention in various *** hierarchical structure with multiple pores,a large number of solid-gas interfaces and tortuous conduction paths provide a new direction for the development of thermal insulation materials,making the living creatures under these extreme conditions become the bionic objects of scientific *** this review,the research progress of bionic hierarchical structure in the field of heat insulation is *** bears,cocoons,penguin feathers and wool are typical examples of heat preservation hierarchy in nature to introduce their morphological *** the same time,the thermal insulation mechanism,fractal model and several preparation methods of bionic hierarchical structures are emphatically *** application of hierarchical structures in various fields,especially in thermal insulation and infrared thermal stealth,is ***,the hierarchical structure is prospected.

关键词： Hierarchical structure Bionic Heat insulation Fractal model Cocoons

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