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Differential regulation of JAK1 expression by ETS1 associated with predisposition to primary biliary cholangitis

Journal of Genetics and Genomics 2023年第10期50卷 807-812页

作者： Peng Jiang Chan Wang Mingming Zhang Ye Tian Weifeng Zhao Junyi Xin Yexi Huang Zhibin Zhao Wenjuan Sun Jie Long Ruqi Tang Fang Qiu Xingjuan Shi Yi Zhao Li Zhu Na Dai Lei Liu Xudong Wu Jinshan Nie Bo Jiang Youlin Shao Yueqiu Gao Jianjiang Yu Zhigang Hu Zhidong Zang Yuhua Gong Yaping Dai Lan Wang Ningling Ding Ping Xu Sufang Chen Lu Wang Jing Xu Luyao Zhang Junyan Hong Ruonan Qian Hu Li Xuan Jiang Congwei Chen Wenyan Tian Jian Wu Yuzhang Jiang Chongxu Han Kui Zhang Hong Qiu Li Li Hong Fan Liming Chen Jianqiong Zhang Zhongsheng Sun Xiao Han Zhenhua Dai Erguang Li M.Eric Gershwin Zhexiong Lian Xiong Ma Michael F.Seldin Weichang Chen Meilin Wang Xiangdong Liu Key Laboratory of Developmental Genes and Human Diseases School of Life Science and TechnologySoutheast UniversityNanjingJiangsu 210096China Institute of Translational Medicine Yangzhou University Medical CollegeYangzhouJiangsu 225009China department of Radiology&oncology The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China The First Affiliated Hospital of Soochow University SuzhouJiangsu 215006China department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjingJiangsu 210029China Author links open overlay panelYexi Huang Guangdong Provincial People's Hospital Guangdong Academy of Medical SciencesGuangzhouGuangdong 510080China department of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseasesShanghai Jiao Tong University School of Medicine Affiliated Renji HospitalShanghai 200001China department of Laboratory Medicine The Fourth Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210031China department of Gastrointestinal Endoscopy Eastern Hepatobiliary Surgery HospitalShanghai 201800China The Fifth People's Hospital Soochow UniversitySuzhouJiangsu 215007China department of Gastroenterology Jiangsu University Affiliated Kunshan HospitalKunshanJiangsu 215300China department of Gastroenterology Yixing People's HospitalYixinJiangsu 214200China department of Gastroenterology Yancheng First People's HospitalYanchengJiangsu 224005China department of Gastroenterology Taicang First People's HospitalSoochow UniversityTaicangJiangsu 215400China department of Hepatology Jingjiang Second People's HospitalJingjiangJiangsu 214500China department of Hepatology The Third People's Hospital of ChangzhouChangzhouJiangsu 213001China department of Liver Diseases Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China department of Laboratory Medicine Jiangyin People's HospitalSoutheast UniversityJiangyinJiangsu 214400China department of Labora

Primary biliary cholangitis(PBC)is an autoimmune liver disease characterized by the destruction of intrahepatic small bile ducts and progressive cholestasis,eventually leading to liver cirrhosis and hepatic failure wi... 详细信息

关键词： cholangitis biliary

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Prognostic factors affecting long-term outcomes in patients with brain metastasis from esophageal carcinoma

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Chinese Journal of Cancer Research 2020年第6期32卷 768-777页

作者： Peng Zhang Lejing Yao Ming Chen Wei Feng department of Radiology physics The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China department of Radiation oncology The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China

Objective: The incidence of brain metastasis from esophageal cancer(BMEC) has increased in recent ***, it is necessary to identify factors that affect long-term outcomes for such ***: From January 1997 to July 2018, consecutive patients(10,043 patients, 31 with brain metastasis) with esophageal cancer(EC) treated at Zhejiang Cancer Hospital were recruited for retrospective ***, clinical, and pathological variables and the survival data were ***: The median time from diagnosis of EC to diagnosis of brain metastases was 7.67(range, 0.43-55.20)months. The median survival time of BMEC patients from diagnosis of primary esophageal tumor was 16.7(range,2.33-163.30) months and the median survival time from the point of diagnosis of brain metastasis was 6.47(range,0.43-148.13) months. Univariate and multivariate analyses showed that the pathology type, EC without chemotherapy, and bone metastasis history were significantly associated with a shorter time interval between the first treatment of EC and brain metastasis. Chemotherapy history after brain metastasis, whole brain radiation therapy(WBRT) history, and surgery were significant predictors for better long-term survival ***: Our findings indicate that the use of surgery, WBRT, and chemotherapy can achieve the best therapeutic effects for BMEC patients.

关键词： Brain metastasis from esophageal cancer time to brain metastasis(TTBM) prognosis factors survival time radiotherapy chemotherapy

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The Use of Intensity Modulated radiotherapy as a Mean of Reducing Dose to Bone Marrow for Patients with Cancer Cervix Treated at Nci, Cairo, Egypt. Dosimetric Study

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Journal of Cancer Therapy 2017年第10期8卷 891-901页

作者： Mohamed Mahmoud Mahmoud Shosha Maha Hassan Shaimaa Abdelgelil Sandy Mohamed Radiation oncology department National Cancer Institute Cairo University Egypt Radiation physics Unit Shefaa Alorman Oncology Hospital Egypt Radiation physics Unit National Cancer Institute Cairo University Egypt Epidemiology and Cancer biostatistics department National Cancer Institute (NCI) Cairo University Egypt

Purpose: To test the use of Intensity Modulated radiotherapy (IMRT) to spare the bone marrow (BM) in patients treated with cancer cervix through using the bone marrow an organ at risk. Patients and methods: Thirteen patients with stage (IB2-IIIB) intact cervix cancer were included;C-T simulation was done with contrast and full bladder with slice thickness 2.5 mm. clinical Target Volume (CTV) included the cervix, uterus, upper half of the vagina, parametrium and regional lymph nodes. The CTV was expanded by 1 cm to form the Planning Target Volume (PTV). The organ at risk (OAR) included the bladder and rectum, the external contour of the pelvic bones to define the Pelvic Bone Marrow (PBM). Four plans were done for every patient with anteroposterior-posteroanterior (AP/PA), three dimensional conformal radiotherapy (3DCRT), IMRT, bone marrow-sparing intensity-modulated pelvic radiotherapy (BMS-IMRT). Results: BMS-IMRT reduced the V20, V30, V40 and V45 of the BM in comparison to 3DCRT and IMRT plans. Reduction in V20 with BMS-IMRT plan compared to 3DCRT (p 0.03). The PBM volume receiving 5, 10 and 20 Gy was lower AP/PA than BMS-IMRT (p < 0.01, p 0.001 and p 0.04 respectively). The volumes of the rectum and bladder receiving dose of 40 and 45 Gy were lower in BMS-IMRT plan compared to AP/PA and 3DCRT plans with p = 0.01 for both of them. PTV cover was better in the BMS-IMRT and IMRT plans. Conclusion: BMS-IMRT decreased the irradiated BM volume compared to other techniques. Thus using BMS-IMRT is recommended to decrease hematological toxicity and avoid treatment interruption.

关键词： IMRT BMS-IMRT OAR PBM

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The Journey of SRS: An Initial Experience of Starting Sterotactic Radiosurgery Facility at Purbanchal Cancer Hospital—First in Nepal

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International Journal of Medical physics, clinical Engineering and Radiation oncology 2023年第2期12卷 37-50页

作者： Birendra Kumar Yadav Karthik Nagamuthu Alok Thakur Kushal Rizal Umesh Kumar Sharma Ujwal Rai Dinesh Thapa Shishir Thapa Kumar Chinnappan Amit Kumar Dubey Suraj Gurung Aman Yadav Utpalkant Kumar Ranjay Kumar department of Radiation oncology Purbanchal Cancer Hospital Jhapa Nepal department of Radiology Purbanchal Cancer Hospital Jhapa Nepal Deapartment of Pathology Purbanchal Cancer Hospital Jhapa Nepal department of Neurosurgery Purbanchal Cancer Hospital Jhapa Nepal

Introduction: radiotherapy (RT) is a vital cancer treatment modality for both curative and palliative purposes. Nepal is a developing country with a population of around 30 million people. Cancer affects 100 - 120 people out of every 100,000, and the figure is increasing. The number of radiation facility machines in the country is still countable in fingers. Purbanchal Cancer Hospital, Nepal is the first comprehensive cancer facility capable of performing stereotactic radiosurgery (SRS). Our facility has cutting-edge Varian Truebeam Linear Accelerators with millennium MLC, which makes SRS and SRT’S for intracranial lesions such as small benign and malignant tumors much easier. In addition to SRS, we are the pioneers of SBRT for lung using 4DCT, interstitial & intraluminal brachytherapy, RPM Gated & DIBH modalities in Nepal. Methods & Materials: The purpose of this study is to share our experience in establishing an SRS facility in the country, which includes training the RT team on the importance of process accuracy, patient selection, patient assessment, mould preparation, and describing image data acquisition, target, and organ at risk delineation on CT and MRI images, treatment planning process, and quality assurance. Results & Discussion: The plans for all SRS and SRT cases are based on target coverage, OAR sparing, hotspot inside the target, conformity index, heterogeneity index, and dose fall off. To select the final plan, we used strict passing criteria such as a conformity index Paddick (CIPaddick) more than 0.85, a falloff between 100% and 50% of less than 5.5 mm (maximum 6 mm in irregular targets), and a hotspot inside the target between 115 to 140 percent, as per clinical standards. In addition, we determined the CILomax and CIRTOG for each case. Passing criteria for verification plans are set as minimum of 95% for a 2% percentage dose difference (% DD) and a 2-mm distance to an agreement (DTA). We also gathered demographic data from patients treated in t

关键词： Conformity Index Double Shell Positioning System Electronic Portal Imaging Device Linear Accelerator Millennium MLC Octavius Detector 1500 Setup Field

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Comparative Study of Dose Distribution Homogeneity between 3D-Brachytherapy and Intensity Modulated Radiation Therapy Techniques in Cervix Cancer Tumors

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International Journal of Medical physics, clinical Engineering and Radiation oncology 2019年第3期8卷 163-174页

作者： Mostafa Elnagger Hussein A. Motaweh Kareman Zard Cancer department Management and Research Medical Research Institute Alexandria University Alexandria Egypt physics department Faculty of Sciences Damanhour University Damanhour Egypt Medical physics department Alexandria Ayadi Almostakbl Oncology Center (AAAOC) Alexandria Egypt

Aim: The purpose of this study was to compare the dosimetric results of the techniques (3D-Brachytherapy and intensity-modulated radiotherapy IMRT) in patients with locally advanced cervical carcinoma (LACC). Method: There are 15 patients with locally advanced cervical carcinoma (LACC), after the completion of external beam radiotherapy (EBRT) for the whole pelvic irradiation 45 Gy/25 fractions, followed by 3D-Brachytherapy 24 Gy per weekly fractions and 36 Gy of IMRT per 18 fractions. Coverage of targets volume and doses received by normal tissue were compared in two techniques. Method: 15 patients of LACC treated with 3D-Brachytherapy were selected for this study. IMRT plans were also created for all the patients. 3D-Brachytherapy and IMRT plans were compared on the basis of target volume coverage, dose to Organs at risk (OAR’s), homogeneity index (HI) and conformity index (CI). Results: The results showed that D90% of HRCTV in the 3D-Brachytherapy was covered more than D90% of PTV in the IMRT of prescribed dose, the D2CC and the V60Gy values of Bladder and rectum were significantly lower than in 3D-Brachytherapy. The HI and CI in 3D-Brachytherapy were found better than IMRT. Conclusion: 3D-Brachytherapy significantly reduced the irradiated volume of OAR’s and improved dose coverage in tumor volume compared to that by IMRT.

关键词： IMRT 3D-Brachytherapy Cervical Cancer

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局部晚期宫颈癌调强和适形放疗的剂量学对比研究(英文)

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The Chinese-German Journal of clinical oncology 2013年第6期12卷 293-296页

作者： Mohamed Mahmoud Hesham A. EL-Hossiny Nashaat A. Diab Mahmoud Shosha department of Radiation oncology National Cancer InstituteCairo University department of Radiation physics National Cancer InstituteCairo University

Objective:This study was to compare 5 field conformal technique to the intensity modulated radiotherapy (IMRT) 8 fields technique in boosting locally advanced cancer cervix cases after external beam radiotherapy with respect to target volume coverage and dose to normal tissues. Methods:We conducted a single institutional comparative dosimetric analysis of 10 patients with cancer cervix who was presented to radiotherapy department in National Cancer Institute, Cairo in period between June 2012 to September 2012 and received a CRT boost in the place of planned brachytherapy after large field pelvic radiotherapy (PRT) with concurrent chemotherapy were retrospectively identified. All tumors were situated in the low central pelvis. Two plans were done for every patient; one using the 8 fields IMRT and the second one using 5 fields' 3DCRT the two techniques were then compared using dose volume histogram (DVH) analysis for the PTV, bladder, rectum and both femoral heads. Results:Comparing different DVHs, it was found that the planning target volume (PTV) was adequately covered in both plans while it was demonstrates that the 8 fields IMRT technique carried less doses reaching OARs (rectum, bladder, both femoral heads). Conclusion:From the present study, it is concluded that IMRT technique spared more efficiently OARs than CRT technique but both techniques covered the PTV adequately so whenever possible IMRT technique should be used.

关键词：肿瘤临床治疗化疗

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On the Nonequilibrium of Radiation-Induced Bystander Effects in Tumor Surface and Its Implications in Radiation Therapy

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International Journal of Medical physics, clinical Engineering and Radiation oncology 2015年第3期4卷 208-214页

作者： R. Vaitheeswaran K. J. Maria Das Philips Radiation oncology Systems Philips India Ltd. Bangalore India Research & Development Center Bharathiar University Coimbatore India department of radiotherapy Sanjay Gandhi Post Graduate Institute of Medical Sciences Lucknow India

This work aims to theoretically show the development of a nonequilibrium of radiation-induced bystander effect (RIBE) under steep dose gradient regions that typically occur in the field edges of a beam. We applied the kinetics model proposed by (McMahon et al. 2013) for in vivo conditions coupled with a hypothesis called “Layer-limited bystander signaling (LLBS)” to demonstrate 1) an enhancement in TCP (i.e. Enhanced TCP or ETCP) due to bystander signals, 2) the development of nonequilibrium of RIBE under steep dose gradient regions and 3) the reduction in ETCP in the surface of clinical Target Volume (CTV) due to the non-equilibrium of RIBE. We incorporated the elements of RIBE directly in the existing Poisson LQ model available in Pinnacle3 TPS (Version 9.10.0) to compute the percentage reduction of ETCP in the tumor surface due to nonequilibrium of RIBE. The percentage improvement in TCP obtained in tumor surface by accounting for RIBE is about 46% lower than that obtained in the interior of the tumor. This suggests that relatively more number of cancerous cells might survive in the vicinity of tumor surface. The result obtained from the study is indicative of an additional uncertainty component associated with radiation treatment. Hence, this paper suggests that the radiation treatments employing steep dose gradients could be biophysically different in many ways.

关键词： Bystander Effect TCP RIBE CTV IMRT Dose Gradients

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Planning Margins to CTV for Image-Guided Whole Pelvis Prostate Cancer Intensity-Modulated radiotherapy

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International Journal of Medical physics, clinical Engineering and Radiation oncology 2012年第2期1卷 23-31页

作者： Zhendong Wang Kelin Wang Fritz A. Lerma Bei Liu Pradip Amin Byongyong Yi Georges Hobeika Cedric Yu department of Radiation oncology University of Miami Miami FL department of Radiation oncology University of Southern California Los Angeles CA department of Radiation oncology University of Maryland Baltimore MD

Purpose: We investigated the margin recipes with different alignment techniques in the image-guided intensity-modulated radiotherapy (IMRT) of whole pelvis prostate cancer patients. Materials and Methods: Forty-eight computed tomography (CT) scans of eight prostate cancer patients were investigated. Each patient had an initial planning CT scan and 5 consecutive serial CT scans during the course of treatment, all of which were acquired using 3 mm slice separation and 0.94 mm resolution in the axial plane at 120 kVp, on a PQ 5000 CT scanner. Three different whole pelvis planning margin recipes, ranging from 3 to 13 mm, were investigated. A unique IMRT plan was created with each PTV on the initial CT scan, and was then registered to the 5 serial CT scans, by bony alignment or by prostate gland-based alignment. The dose computed on each serial CT scans was accumulated back to the initial CT scan using deformable image registration for final dosimetric evaluation of the interplay of the margin selection and alignment methods. Results: Bony alignment and prostate gland-based alignment gave very similar result to the pelvic lymphatic nodes (PLNs), regardless of its margin around. The prostate gland-based alignment greatly enhanced the coverage to the prostate and SV, especially with small margins. Meanwhile, the soft-tissue alignment also raised the incidental dose to the rectum and reduces the dose to the bladder. With small to intermediate margins, only soft-tissue alignment gave acceptable mean coverage to SV. Margin of 13mm or more was needed for PLNs to maintain good target coverage. Conclusion: We commend prostate-based alignment along with margins less than or equal to 5mm around prostate and SV, and margins greater than or equal to 13 mm around the vascular spaces.

关键词： Prostate Cancer Whole Pelvis Image Guidance IMRT Margin Alignment

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Dosimetric Evaluation of Body Contour Changes to Target Volumes and Organs at Risk for Cervix and Head and Neck radiotherapy Plans

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International Journal of Medical physics, clinical Engineering and Radiation oncology 2020年第3期9卷 96-109页

作者： Zhe Wu Jun Yan Xiaomei Chen Dong Wang Ke Liu Zhi Ming Lin Wang Boxiang Yu Ya Pang department of Radiation oncology Zigong First People’s Hospital Zigong China Institute of High Energy physics Chinese Academy of Sciences Beijing China

Purpose: To investigate how much dose discrepancy would be caused by the anatomy changes during the radiotherapy (RT) course. Methods: Ten cervical cancer and ten nasopharyngeal carcinoma (NPC) CT datasets from RT patients were enrolled. The body contour from different directions changed to simulate the weight loss or gain for cervical cancer patients, who had been treated with external-beam RT using intensity-modulated radiation therapy (IMRT) or volumetric modulated arc therapy (VMAT). Moreover, the body contour from facial and shoulder superior-inferior positional change had been also assessed for NPC patients using IMRT or VMAT. The new CT (n-CT) was generated by the body contour changes with different directions based on original CT datasets. The dosimetric parameters to target volumes and organs at risk (OARs) were evaluated in Eclipse based on n-CT. Results: The target volumes and OARs were influenced by the body contour changes. Body contour expansion resulted in coverage loss, whereas body contour shrinkage increased the dose to the OARs. These findings were generally consistent for both IMRT and VMAT plans. Over a course of research, the dose to 95% of the target volumes for cervical cancer decreased by up to 2.83% per cm for IMRT and 2.87% per cm for VMAT (P Conclusions: The RT staff could determine whether resimulation and replaning or not according to which body contour directions were changed.

关键词： Dosimetry Body Contour Change Cervical Cancer Nasopharyngeal Carcinoma IMRT

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clinical trials for treating recurrent head and neck cancer with boron neutron capture therapy using the Tsing-Hua Open Pool Reactor

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Cancer Communications 2018年第1期38卷 393-399页

作者： Ling-Wei Wang Yen-Wan Hsueh Liu Fong-In Chou Shiang-Huei Jiang department of oncology Taipei Veterans General HospitalNo.201Section 2Shih-Pai RoadTaipei 11217TaiwanChina School of Medicine National Yang Ming UniversityTaipei 11217TaiwanChina Institute of Nuclear Engineering and Science National Tsing Hua UniversityHsin-ChuTaiwanChina Nuclear Science and Technology Development Center National Tsing Hua UniversityHsin-ChuTaiwanChina

Head and neck(HN)cancer is an endemic disease in Taiwan,*** recurrent HN cancer after full-dose irradia-tion poses a therapeutic challenge,and boron neutron capture therapy(BNCT)may be a solution that could provide durable local control with tolerable *** Tsing-Hua Open Pool Reactor(THOR)at National Tsing-Hua University in Hsin-Chu,provides a high-quality epithermal neutron source for basic and clinical BNCT *** first clinical trial,entitled“A phase I/II trial of boron neutron capture therapy for recurrent head and neck cancer at THOR”,was carried out between 2010 and 2013.A total of 17 patients with 23 recurrent HN tumors who had received high-dose photon irradiation were enrolled in the *** fructose complex of l-boronophenylalanine was used as a boron carrier,and a two-fraction BNCT treatment regimen at 28-day intervals was used for each *** was acceptable,and although the response rate was high(12/17),re-recurrence within or near the radiation site was *** obtain better local control,another clinical trial entitled“A phase I/II trial of boron neutron capture therapy combined with image-guided intensity-modulated radiotherapy(IG-IMRT)for locally recurrent HN cancer”was initiated in *** first administration of BNCT was performed according to our previous protocol,and IG-IMRT was initiated 28 days after *** of May 2017,seven patients have been treated with this *** treatment-related toxicity was similar to that previously observed with two BNCT *** patients had a complete response,but locoregional recurrence was the major cause of failure despite initially good *** clinical trials combining BNCT with other local or systemic treatments will be carried out for recurrent HN cancer patients at THOR.

关键词： Head and neck cancer Boron neutron capture therapy Tsing-Hua Open Pool Reactor Boronophenylalanine

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