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A Study of the TPS Based Beam-Matching Concept for Medical Linear Accelerators at a Tertiary Hospital

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International Journal of Medical physics, clinical Engineering and Radiation oncology 2024年第1期13卷 16-25页

作者： Ntombela N. Lethukuthula Rovetto J. Nicolas Nethwadzi C. Lutendo Mpumelelo Nyathi department of Radiation oncology Steve Biko Academic Hospital Pretoria South Africa department of Medical physics University of Pretoria Pretoria South Africa department of Medical physics Sefako Makgatho Health Sciences University Ga-Rankuwa South Africa

The flexibility in radiotherapy can be improved if patients can be moved between any one of the department’s medical linear accelerators (LINACs) without the need to change anything in the patient’s treatment plan. For this to be possible, the dosimetric characteristics of the various accelerators must be the same, or nearly the same. The purpose of this work is to describe further and compare measurements and parameters after the initial vendor-recommended beam matching of the five LINACs. Deviations related to dose calculations and to beam matched accelerators may compromise treatment accuracy. The safest and most practical way to ensure that all accelerators are within clinical acceptable accuracy is to include TPS calculations in the LINACs matching evaluation. Treatment planning system (TPS) was used to create three photons plans with different field sizes 3 × 3 cm, 10 × 10 cm and 25 × 25 cm at a depth of 4.5 cm in Perspex. Calculated TPS plans were sent to Mosaiq to be delivered by five LINACs. TPS plans were compared with five LINACs measurements data using Gamma analyses of 2% and 2 mm. The results suggest that for four out of the five LINACs, there was generally good agreement, less than a 2% deviation between the planned dose distribution and the measured dose distribution. However, one specific LINAC named “Asterix” exhibited a deviation of 2.121% from the planned dose. The results show that all of the LINACs’ performance were within the acceptable deviation and delivering radiation dose consistently and accurately.

关键词： radiotherapy Beam-Matching Linear Accelerator Dosimetry

LncRNA HOTAIR promotes DNA damage repair and radioresistance by targeting ATR in colorectal cancer

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oncology Research 2024年第8期32卷 1335-1346页

作者： HAIQING HU HAO YANG SHUAISHUAI FAN XUE JIA YING ZHAO HONGRUI LI department of Endoscopic Center Peking University Cancer Hospital(Inner Mongolia Campus)&Affiliated Cancer Hospital of Inner Mongolia Medical UniversityHuhhot010020China department of Radiation oncology Peking University Cancer Hospital(Inner Mongolia Campus)&Affiliated Cancer Hospital of Inner Mongolia Medical UniversityKey Laboratory of Radiation Physics and Biology of Inner Mongolia Medical UniversityPeking University Cancer Hospital(Inner Mongolia Campus)&Affiliated Cancer Hospital of Inner Mongolia Medical UniversityHuhhot010020China Graduate School Inner Mongolia Medical UniversityHuhhot010020China

Long non-coding RNAs(lncRNAs)have been implicated in cancer progression and drug resistance ***,there is evidence that lncRNA HOX transcript antisense intergenic RNA(HOTAIR)is involved in colorectal cancer(CRC)*** present study aimed to examine the functional role of lncRNA HOTAIR in conferring radiotherapy resistance in CRC cells,as well as the underlying *** relative expression levels of HOTAIR were examined in 70 pairs of CRC tumor and para-cancerous tissues,as well as in radiosensitive and radioresistant *** correlations between HOTAIR expression levels and clinical features of patients with CRC were assessed using the Chi-square *** assays such as cell proliferation,colony formation and apoptosis assays were conducted to determine the radiosensitivity in CRC cells with HOTAIR silencing after treatment with different doses of *** pull-down assay andﬂuorescence in situ hybridization(FISH)were used to determine the interaction between HOTAIR and DNA damage response mediator ataxia-telangiectasia mutated-and Rad3-related(ATR).HOTAIR was signiﬁcantly upregulated in CRC tumor tissues,especially in radioresistant tumor *** elevated expression of HOTAIR was correlated with more advanced histological grades,distance metastasis and the poor prognosis in patients with *** HOTAIR suppressed the proliferation and promoted apoptosis and radiosensitivity in CRC *** knockdown also inhibited the tumorigenesis of CRC cells and enhanced the sensitivity to radiotherapy in a mouse xenograft ***,the data showed that HOTAIR could interact with ATR to regulate the DNA damage repair signaling *** HOTAIR impaired the ATR-ATR interacting protein(ATRIP)complex and signaling in cell cycle ***,the present results indicate that lncRNA HOTAIR facilitates the DNA damage response pathway and promotes radioresistance in CRC cells by targeting ATR.

关键词： LncRNA HOTAIR CRC radioresistance DNA damage repair ATR

Progress in heavy ion cancer therapy at IMP and future development

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Malignancy Spectrum 2024年第2期1卷 91-98页

作者： Qiang Li Xinguo Liu Zhongying Dai Pengbo He Yuanyuan Ma Guosheng Shen Xiaodong Jin Fei Ye Xiaogang Zheng Ting Zhao Hui Zhang Zheng Li Bingwen Zou Yuehu Pu Weiqiang Chen Institute of Modern physics Chinese Academy of SciencesLanzhouGansuChina Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences LanzhouGansuChina Gansu Provincial Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine LanzhouGansuChina University of Chinese Academy of Sciences BeijingChina Division of Thoracic Tumor Multimodality Treatment and department of Radiation oncology Cancer CenterWest China HospitalSichuan UniversityChengduSichuanChina Medical Equipment Innovation Research Center West China HospitalSichuan UniversityChengduSichuanChina

Basic research on heavy ion cancer therapy such as radiobiology, medicalphysics, and therapeutic technique has been conducted at the Institute ofModern physics (IMP), Chinese Academy of Sciences since 1995. Based on theachievements acquired in the basic research and the requirements for a heavyion accelerator for radiotherapy purposes, a dedicated heavy ion therapy facilitynamed Heavy Ion Medical Machine (HIMM) was designed at IMP andconstructed in Wuwei, China. The HIMM facility consists of two electroncyclotron resonance ion sources, one cyclotron as the injector and onesynchrotron as the main accelerator, and four different treatment roomsequipped with passive or active beam delivery systems, and accelerates carbonions up to 400 MeV/u. After the performance inspection of HIMM organized bythe National Medical Device Inspection Center, preclinical tests like cell andanimal radiobiological experiments and dosimetric verification using anthropomorphicphantoms for elucidating the biophysical properties of the carbon ionbeams provided by HIMM were carried out. According to the Chinese medicaldevice regulations, a clinical trial in which 46 tumor patients were recruited andtwo hospitals participated was conducted in the HIMM facility, aiming atevaluating the treatment safety and short-term efficacy of the medical *** success of the clinical trial helped the HIMM facility be authorized by theChinese government as a class III medical device. In this paper, all the aspectsmentioned above are introduced and discussed, and implications for futureimprovements are also given.

关键词： heavy ion cancer therapy clinical trial performance inspection dosimetric verification medical device

Postoperative radiotherapy for thymus salivary gland carcinoma:A case report

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World Journal of clinical Cases 2022年第26期10卷 9484-9492页

作者： Rui Deng Nan-Jing Li Liang-Liang Bai Shi-Hong Nie Xiao-Wen Sun Yong-Sheng Wang clinical Trial Center National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Innovative DrugsDepartment of Thoracic OncologyWest China HospitalSichuan UniversityCheng Du 610041Sichuan ProvinceChina department of Radiation oncology Cancer CenterWest China HospitalSichuan UniversityCheng Du 610041Sichuan ProvinceChina

BACKGROUND Salivary gland cancer is a rare disease in which cancer cells form in the tissues of the salivary *** mostly occurs in the glands that have secretion functions,such as the parotid gland,sublingual gland and submandibular *** is very rare when it occurs in other nonsecreting ***,we report one case of salivary gland carcinoma occurring in the thymus and discuss related diagnoses and treatment *** SUMMARY One 33-year-old middle-aged man presented with a thymus mass without any clinical symptoms when he underwent regular physical ***,the patient was admitted to the hospital for further *** tomography(CT)showed that there was a mass of 3 cm×2.8 cm×1.5 cm in the thymus *** patient had no symptom of discomfort or tumor-related medical history *** completing the preoperative examinations,it was confirmed that the patient had indications for *** surgeon performed a transthoracoscope"thymectomy+pleural mucostomy"for *** the operation,the tumor tissue was quickly frozen,and the symptomatic section showed a malignant *** final pathological result suggested thymus salivary gland carcinoma-mucoepidermoid carcinoma(MEC).In the second month after surgery,we performed local area radiotherapy for the patient,with a total radiation dose of 50.4 Gy/*** 12 mo of surgery,the patient underwent positron emission tomography-CT examination,which indicated that there was no sign of tumor recurrence or *** 16 mo of operation,CT scan re-examination showed that there was no sign of tumor recurrence or *** of the time of publication,the patient was followed up for one and a half *** had no sign of tumor recurrence and continued to *** The incidence of MEC in the thymus is low,and its diagnosis needs to be combined with clinical features and imaging *** analysis plays a key role in the diagnosis of the *** w

关键词： Thymic tumor Salivary gland carcinoma Mucoepidermoid carcinoma Postoperative radiotherapy Case report

三维适形放疗和调强放疗在治疗儿童后颅窝提升伴高危成神经管细胞瘤的剂量学比较研究(英文)

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The Chinese-German Journal of clinical oncology 2013年第11期12卷 540-545页

作者： Saad El Din I Abd El AAl H Makaar W Mashhour K El Beih D Hashem W department of clinical oncology and radiotherapy Kasr Al-Ainy HospitalCairo UniversityCairo Egypt physics section in department of clinical oncology and radiotherapy Kasr Al-Ainy Hospital Cairo UniversityCairo Egypt

Objective: The work is a comparative study between two modalities of radiation therapy, the aim of which is to compare 3D conformal radiation therapy(3D-CRT) and intensity modulated radiation therapy(IMRT) in treating posterior fossa boost in children with high risk medulloblastoma; dosimetrically evaluating and comparing both techniques as regard target coverage and doses to organs at risk(OAR). Methods: Twenty patients with high risk medulloblastoma were treated by 3D-CRT technique. A dosimetric comparison was done by performing two plans for the posterior fossa boost, 3D-CRT and IMRT plans, for the same patient using Eclipse planning system(version 8.6). Results: IMRT had a better conformity index compared to 3D-CRT plans(P value of 0.000). As for the dose homogeneity it was also better in the IMRT plans, yet it hasn't reached the statistical significant value. Also, doses received by the cochleae, brainstem and spinal cord were significantly less in the IMRT plans than those of 3D-CRT(P value < 0.05). Conclusion: IMRT technique was clearly able to improve conformity and homogeneity index, spare the cochleae, reduce dose to the brainstem and spinal cord in comparison to 3DCRT technique.

关键词：放射治疗剂量学风险三维 CRT技术 Eclipse 均匀性指数计划系统

Study of copper-cysteamine based X-ray induced photodynamic therapy and its effects on cancer cell proliferation and migration in a clinical mimic setting

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Bioactive Materials 2022年第1期7卷 504-514页

作者： Xiangyu Chen Jiayi Liu Ya Li Nil Kanatha Pandey Taili Chen Lingyun Wang Eric Horacio Amador Weijun Chen Feiyue Liu Enhua Xiao Wei Chen department of Radiology The Second Xiangya Hospital of Central South UniversityChangshaHunanChina department of physics The University of Texas at ArlingtonArlingtonTX76019USA department of oncology Xiangya HospitalCentral South UniversityChangshaHunan Province410011China department of oncology The Second Xiangya Hospital of Central South UniversityChangshaHunanChina

Copper-cysteamine as a new generation of sensitizers can be activated by light,X-rays,microwaves,or ultrasound to produce reactive oxygen species.X-ray induced photodynamic therapy(X-PDT)has been studied extensively;however,most of the studies reported so far were conducted in the laboratory,which is not conducive to the clinical translation *** this contribution,for the first time,we investigated the treatment efficiency of copper-cysteamine(Cu-Cy)based X-PDT by mimicking the clinical conditions with a clinical linear accelerator and building deep-seated tumor models to study not only the effectiveness but also its effects on the cell migration and proliferation in the level of the cell,tissue,and *** results showed that,without X-ray irradiation,Cu-Cy nanoparticles(NPs)had a low toxicity in HepG2,SK-HEP-1,Li-7,and 4T1 cells at a concentration below 100 mg/***,for the first time,it was observed that Cu-Cy mediated X-PDT can inhibit the proliferation and migration of these cell lines in a dose-dependent *** markers of migration and cell proliferation,proliferating cell nuclear antigen(PCNA)and E-cadherin,from tumor tissue in the X-PDT group were remarkably different from that of the control ***,the MRI assessment showed that the Cu-Cy based X-PDT inhibited the growth of deeply located tumors in mice and rabbits(pclinical application prospect in X-PDT to improve the efficiency of radiotherapy(RT)for deep-seated tumors and effectively inhibit tumor cell proliferation and migration.

关键词： Copper-cysteamine Nanoparticle Photodynamic therapy X-ray Cell migration Proliferation

Hi'CT:a pixel sensor-based device for ion tomography

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Nuclear Science and Techniques 2023年第7期34卷 231-241页

作者： Yi-Lun Chen Hong-Kai Wang Shi-Yu Zhang Hai-Bo Yang Cheng-Xin Zhao Institute of Modern physics Chinese Academy of SciencesLanzhou 730000China department of Radiation oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516003China

Carbon ions,commonly referred to as particle therapy,have become increasingly popular in the last *** predicting the range of ions in tissues is important for the precise delivery of doses in heavy-ion *** uncertainty is currently the largest contributor to dose uncertainty in normal tissues,leading to the use of safety margins in treatment *** potential method is the direct relative stopping measurement(RSP)with ***-ion CT(Hi′CT),a compact segmented full digital tomography detector using monolithic active pixel sensors,was designed and evaluated using a 430 MeV/u high-energy carbon ion pencil beam in *** precise position of the individual carbon ion track can be recorded and reconstructed using a 30μm×30μm small pixel pitch *** types of customized image reconstruction algorithms were developed,and their performances were evaluated using three different modules of CAT-PHAN 600-series *** RSP measurement accuracy of the tracking algorithm for different types of materials in the CTP404 module was less than 1%.In terms of spatial resolution,the tracking algorithm could achieve a 20%modulation transfer function normalization value of CTP528 imaging results at 5 lp/cm,which is significantly better than that of the fast imaging algorithm(3 lp/cm).The density resolution obtained using the tracking algorithm of the customized CTP515 was approximately 10.5%.In conclusion,a compact digital Hi'CT system was designed,and its nominal performance was evaluated in a *** RSP resolution and image quality provide potential feasibility for scanning most parts of an adult body or pediatric patient,particularly for head and neck tumor treatment.

关键词： Heavy-ion imaging Computed tomography Silicon pixel detectors Monte Carlo Phantoms radiotherapy Image-guided Tracking

Computed tomography-based radiomic to predict resectability in locally advanced pancreatic cancer treated with chemotherapy and radiotherapy

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World Journal of Gastrointestinal oncology 2022年第3期14卷 703-715页

作者： Gabriella Rossi Luisa Altabella Nicola Simoni Giulio Benetti Roberto Rossi Martina Venezia Salvatore Paiella Giuseppe Malleo Roberto Salvia Stefania Guariglia Claudio Bassi Carlo Cavedon Renzo Mazzarotto department of Radiation oncology University of Verona Hospital TrustVerona 37126Italy department of Medical physics University of Verona Hospital TrustVerona 37126Italy department of General and Pancreatic Surgery Pancreas InstituteUniversity of Verona Hospital TrustVerona 37126Italy

BACKGROUND Surgical resection after neoadjuvant treatment is the main driver for improved survival in locally advanced pancreatic cancer(LAPC).However,the diagnostic performance of computed tomography(CT)imaging to evaluate the residual tumour burden at restaging after neoadjuvant therapy is low due to the difficulty in distinguishing neoplastic tissue from fibrous scar or *** this context,radiomics has gained popularity over conventional imaging as a complementary clinical tool capable of providing additional,unprecedented information regarding the intratumor heterogeneity and the residual neoplastic tissue,potentially serving in the therapeutic decision-making *** To assess the capability of radiomic features to predict surgical resection in LAPC treated with neoadjuvant chemotherapy and *** Patients with LAPC treated with intensive chemotherapy followed by ablative radiation therapy were retrospectively *** thousand six hundred and fifty-five radiomic features were extracted from planning CT inside the gross tumour *** extracted features and clinical data contribute to create and validate the predictive model of resectability *** were repeatedly divided into training and validation *** discriminating performance of each model,obtained applying a LASSO regression analysis,was assessed with the area under the receiver operating characteristic curve(AUC).The validated model was applied to the entire dataset to obtain the most significant *** Seventy-one patients were included in the *** age was 65 years and 57.8%of patients were *** patients underwent induction chemotherapy followed by ablative radiotherapy,and 19(26.8%)ultimately received surgical *** the first step of variable selections,a predictive model of resectability was developed with a median AUC for training and validation sets of 0.862(95%CI:0.792-0.921)and 0.853(95%CI:0.706-0.960),respectivel

关键词： Computed tomography Radiomics Predictive model Resectability Locally advanced pancreatic cancer Radiation oncology

Adjuvant Pelvic radiotherapy *** Chemoradiotherapy for High-Risk StageⅠ-ⅡEndometrial Carcinoma

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clinical oncology and cancer resexreh 2012年第3期9卷 168-171页

作者： Hend Ahmed El-Hadaad Hanan Ahmed Wahba Anas Mohamed Gamal Tamer Dawod department of clinical oncology and Nuclear Medicine Mansoura University Gynecology and Obstetrics Mansoura University Medical physics Mansoura University

Objective To explore if the addition of adjuvant chemotherapy with paclitaxel and carboplatin to radiotherapy confers an advantage for overall survival(OAS),and progression free survival(PFS);to assess the incidence of relapses over standard pelvic radiotherapy; and to evaluate the related toxicity in high-risk stageⅠ-Ⅱendometrial carcinoma Methods Medical records were reviewed to identify high-risk stageⅠ-Ⅱendometrial carcinoma cases treated in the clinical oncology and Nuclear Medicine department between 2002 and 2008 with adjuvant radiotherapy alone(armⅠ)(57 patients) or with sequential carboplatin(AUC5-6) and paclitaxel(135-175 mg/m^2) with radiotherapy(armⅡ)(51 patients).radiotherapy was performed through the four-field box technique at doses of 45-50 Gy(1.8 Gy/day×5 days/week). Results The toxicity was manageable and predominantly hematologic with a grade 3 neutropenia and thrombocytopenia in 9.8% and 6% of the patients in armⅠand armⅡ,respectively,without febrile *** patients experienced hair loss. Chemoradiotherapy arm was associated with a lower incidence rate of relapse(9.8% vs.22.7% ).After a median follow-up period of 48 months,the 5-year OAS and PFS rates for chemoradiotherapy-treated patients were significantly more favorable than those who did not receive chemotherapy(P=0.02 and 0.03,respectively).In armⅠ,the OAS and PFS rates were 73.7% and 66.7% compared with those in armⅡ,whose rates were 90.2% and 84.3% . Conclusions Adjuvant chemoradiation with paclitaxel and carboplatin improved the survival rates and decreased the recurrence rates in patients with high-risk stageⅠ-Ⅱendometrial *** was associated with an acceptable rate of toxicity. However,a prospective study with a larger number of patients is needed to define a standard adjuvant treatment for high-risk stageⅠ-Ⅱendometrial carcinoma.

关键词：子宫内膜癌化疗风险放疗盆腔放射治疗中性粒细胞序贯