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The genomic and immunogenomic landscape of mechanics pathway informs clinical prognosis and response to mechanotherapy

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Science China(Life Sciences) 2024年第8期67卷 1549-1562页

作者： Peidong Zhang Peiwei Li Muya Tang Ryan CGimple Liang Huang Jing Yue Qiuhong Shen Yiwei Du Qian Zhang Zhengnan Yang Haihuai He Kailin Yang Linjie Zhao Shengtao Zhou Department of Obstetrics and Gynecology Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOEState Key Laboratory of BiotherapyWest China Second HospitalSichuan University and Collaborative Innovation CenterChengdu 610041China physician Scientist Training program Department of MedicineWashington University School of MedicineSt.Louis 63110USA Department of Neurosurgery State Key Laboratory of BiotherapyWest China HospitalSichuan University and Collaborative Innovation CenterChengdu 610041China Department of Radiation Oncology Taussig Cancer CenterCleveland ClinicCleveland 44106USA

Mechanics shape cell and tissue plasticity and maintain their *** cancers,mechanical signals regulate cancer hallmarks via mechanotransduction pathways,such as proliferation,metastasis and metabolic ***,comprehensive characterization of mechanotransduction pathway genes and their clinical relevance across different cancer types remains ***,we systematically portrayed the alterations of mechanotransduction pathway genes across 31 cancer types using The Cancer Genome Atlas(TCGA)*** the cancer types could be categorized into 6 subtypes based upon the transcriptional pattern of mechanics pathway *** subtype has its own unique molecular expression pattern,mutation landscapes,immune infiltrates,and patient clinical *** further found that the responses of two subtypes of cancers,one with the optimal outcome and the other with the worst prognosis,to a classical mechanotherapeutic agent(Fasudil,RhoA/ROCK inhibitor)were totally different,indicating that our cancer stratification system based upon mechanotransduction pathway genes could inform clinical responses of patients to mechanotherapeutic ***,our study provides a novel pan-cancer landscape of the mechanotransduction pathways and underscores its potential clinical significance in the prediction of clinical prognosis and therapeutic responses to mechanotherapy among cancer patients.

关键词： pan-cancer cancer mechanics multi-omics immunology

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Handheld bedside ultrasound in the diagnosis of myocarditis

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World Journal of Emergency Medicine 2024年第1期15卷 73-74页

作者： Frank Wheeler Robin Lahr James Espinosa Alan Lucerna Henry Schuitema Department of Emergency Medicine Rowan University School of Osteopathic MedicineStratford 08084USA Emergency Medicine Residency program Jeff erson HealthStratford 08084USA Department of Emergency Medicine and Associate Chief Medical Offi cer Stratford 08084USA

Myocarditis is a disease process that every emergency physician fears *** severity can be mild to life-threatening,and many cases are likely undetected because they are subclinical with nonspecifi c signs.[1]Subtle cardiac signs may be overshadowed by systemic symptoms of the underlying infectious ***,myalgias,lethargy,symptoms commonly associated with viral syndrome,can mask the life-threatening myocarditis that may be *** fact,in the United States Myocarditis Treatment Trial,almost 90%of patients reported symptoms consistent with a viral prodrome.[2]Ammirati et al[3]reported that 27%of patients with myocarditis had either reduced left ventricular ejection fraction,ventricular arrhythmias,or low cardiac ***,we present a case report,in which handheld point-of-care ultrasound was utilized at the bedside to aid in the critical diagnosis of *** the additional information provided through this imaging modality,this patient was able to be transferred to the appropriate tertiary care facility in an expeditious manner and receive possible defi nitive treatment.

关键词： diagnosis myocarditis Fever

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Cost Effective Trend in Epistaxis Management

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International Journal of Otolaryngology and Head & Neck Surgery 2023年第3期12卷 85-91页

作者： Roman Sereda Whitney Hall Department of physician assistant Medicine University of Tampa Tampa Florida USA

Background: Epistaxis affects much of the population and is a common medical complaint seen across a variety of medical settings. Current standard of care treatment includes a range of options from topical therapy to invasive intranasal device insertion in the absence of on-demand specialist involvement. Aim: The aim of this article is to not only highlight superior outcomes in patients with acute nontraumatic epistaxis that are treated with noninvasive nebulized tranexamic acid instead of more invasive options, but also monetary benefit to the community through reduced costs. Case Presentation: this case report highlights a successful epistaxis resolution with use of tranexamic acid in a 64-year-old female after she was subjected to intranasal device insertion that did not resolve bleeding. Conclusion: Nebulized tranexamic acid is a cost-effective medication that not only reduces rates of recurrence, but it also increases patient satisfaction while minimizing overall healthcare costs, and therefore should be the first choice therapy in uncomplicated epistaxis management.

关键词： Epistaxis TXA Tranexamic Acid Rhinorocket Nasal Packing

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Acceptability of self-collected human papillomavirus specimens in cervical cancer screening: A review

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World Journal of Obstetrics and Gynecology 2014年第3期3卷 90-97页

作者： Brenda L Quincy Department of physician assistant Studies School of Health Sciences Elon University

Cervical cancer morbidity and mortality is an important public health problem around the world. Some of the barriers to cervical cancer screening include the embar-rassment, discomfort, lack of privacy and time and cost associated with clinician-collected, clinic-based screen-ing with cytology or human papillomavirus tests. Self-collection of a human papillomavirus （HPV） test has been found to be generally more acceptable, less em-barrassing, more comfortable, more private and easy to do and preferred to pelvic examination for cervical cy-tology by many women worldwide. The most common-ly reported limitation to self-collection is a woman’s lack of confdence in her ability to perform it correctly. Self-collected human papillomavirus tests have been shown to be as or more sensitive than cytology or clinician-collected HPV tests. With confidence-building educa-tion about self-collection, it is likely a viable method to extend the reach of screening in high and low-resource areas around the world.

关键词： Cervical cancer Self-collected Human pap-illomavirus Acceptability

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Farmers’ Knowledge and Awareness towards the Use of Agrochemicals in Vegetable Cultivation, Fako Cameroon

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Journal of Geoscience and Environment Protection 2024年第9期12卷 215-229页

作者： Amungwa Ivan Tabikam Veronica Ebot Manga Godswill Azinwie Asongwe Elmer Kanjo Ekinzog Mantah Marian Ngwatezeh Victorine Neh Akenji Department of Environmental Science University of Buea Buea Cameroon Institute of Agricultural Research and Development (IRAD) Batoke-Limbe Cameroon GAP AG Munich Germany GIS and DTM assistant IOM-UN Yaound Cameroon South West Regional Center for Scientific Research and Innovation Buea Cameroon

Agrochemicals are contemporary, omnipresent tool used in vegetable cultivation. Farmers’ knowledge and awareness of the proper usage of agrochemicals are critical for mitigating the negative effects on human health. This cross-sectional study was aimed at assessing the usage knowledge, risk awareness of toxicological and chemical classes, proper handling and use practices for agrochemicals homologated for use in vegetable farming, and the occurrence of health-related symptoms as a result of exposure among these farmers. The study included 93 vegetable growers from agricultural hotspot towns in Fako, southwest Cameroon. The field study, ran from November 2021 to December 2023, using a questionnaire to collect information on farmers demographic, and their knowledge of pesticide classes, and the related risk of associated with the handling of agrochemicals. Results show that all vegetable farmers, particularly those engaged in agribusiness, employ pesticide inputs to maximize production. Six pesticides, two fertilizer types, and one unknown substance were identified. While 23 active compounds were found, the most utilized were abamectin, emamectin (10.46%), dimethoate (9.30%,) and ethoprophos (8.13%). Two active chemicals, dimethoate and methalaxyl, are illegal yet remain in circulation. Toxicological classes I and II, with the greatest harmful effect on human health, were the most commonly utilized (64.27%). Thirty-nine percent of farmers never use personal protection equipment when working with agrochemicals, demonstrating a significant gap in knowledge and awareness of agrochemicals and their various applications and handling procedures in the field. The government should implement an intensive specialized educational program for on-field farmers with incentives in order to promote sustainable agriculture methods that ensure environmental and human safety.

关键词： Farmers Knowledge Agrochemical Risk Awareness Vegetable Cultivation Agrochemical Use Practices Health Risk

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High Intensity Neuromuscular Electrical Stimulation to Enhance Quadriceps Strength after Anterior Cruciate Ligament Reconstruction

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中国运动医学杂志 2010年第5期29卷 593-596页

作者： Joseph A. Gallo Christopher Proulx assistant Professor/program Director Salem State College Athletic Training Education Adjunct Faculty Franklin Pierce College Physical Therapy Program assistant Professor Department of Movement Science and Leisure Studies Westfield State College

Despite the implementation of accelerated ACL reha-bilitation and improved surgical technique, persistent quadriceps weakness continues to be reported in the liter-ature following ACL reconstruction.[1-4] The literatu... 详细信息

关键词：《中国运动医学杂志》期刊摘要编辑部

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Does mindfulness meditation improve attention in attention deficit hyperactivity disorder?

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World Journal of Psychiatry 2015年第4期5卷 397-403页

作者： Vania Modesto-Lowe Pantea Farahmand Margaret Chaplin Lauren Sarro Department of Mental Health and Addiction Services Connecticut Valley Hospital Department of Psychiatry University of Connecticut School of Medicine physician assistant program Quinnipiac University Adult Outpatient Department Connecticut Mental Health Center

Attention deficit hyperactivity disorder(ADHD) manifests by high levels of inattention, impulsiveness and hyperactivity. ADHD starts in childhood and results in impairments that continue into adulthood. While hyperactivity declines over time, inattention and executive function difficulties persist, leading to functional deficits. Adolescents and adults with ADHD have pervasive impairment in interpersonal and family relationships. They may develop addiction, delinquent behavior and comorbid psychiatric disorders. Despite advances in diagnosis and treatment, persistent residual symptoms are common, highlighting the need for novel treatment strategies. Mindfulness training, derived from Eastern meditation practices, may improve self-regulation of attention. It may also be a useful strategy to augment standard ADHD treatments and may be used as a potential tool to reduce impairments in patients with residual symptoms of ADHD. Clinically, this would manifest by an increased ability to suppress task-unrelated thoughts and distractions resulting in improved attention, completion of tasks and potential improvement in occupational and social function.

关键词： Attention deficit hyperactivity disorder Mindfulness Treatment adjunct Inattention Meditation Attention

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Analysis of daily activity data from implanted cardiac defibrillators: The minimum clinically important difference and relationship to mortality/life expectancy

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World Journal of Cardiovascular Diseases 2012年第3期2卷 129-135页

作者： Michael J. Shoemaker Amy B. Curtis Eric Vangsnes Michael G. Dickinson Rajib Paul Department of Statistics Western Michigan University Kalamazoo USA Interdisciplinary Health Sciences PhD program Western Michigan University Kalamazoo USA physician assistant program Western Michigan University Kalamazoo USA Spectrum Health Frederik Meijer Heart and Vascular Institute Grand Rapids USA

Background: Daily activity is a potentially important measure for assessing prognosis in individuals with chronic heart failure (CHF), and few studies have investigated the prognostic value of daily activity measurement. The present study sought to determine whether there is an association between daily activity and mortality/mean life expectancy as predicted by the Seattle Heart Failure Model (SHFM), and to provide an estimate of the anchor-based minimum clinically important difference (MCID) for daily activity measured by single-axis accelerometers in implanted cardiac defibrillators. Methods: This study utilized a retrospective chart review of 102 medical records of patients with CHF and Medtronic? implanted cardiac defibrillators (ICDs). Mean daily activity was calculated for a two week period prior to both a baseline and follow-up routine clinical visit. Clinical characteristics from the baseline clinic visit were used for calculating SHFM estimates of mean life expectancy, 1-year mortality, and 5-year mortality. A five-point global rating scale was scored based on documented clinician impression, patient self-report, and laboratory and cardiographic tests for determining the MCID. Results: There was a moderate correlation between baseline daily activity and each of the SHFM prognostic indicators: 1-year mortality (r = 0.36, p < 0.001, 5-year mortality (r = 0.40, p < 0.001), and life expectancy (r = 0.43, p < 0.001). The MCID for a decline in daily activity was approximately 0.5 hours and was approximately 1.0 hours for improvement in daily activity. Conclusions: Although previous re- search has established the short-term predictive value of ICD-measured daily activity for CHF-related clinical events, no prior study has examined the longer-term prognostic value of ICD-based daily activity. The results of the present study suggest that low daily activity, as recorded by ICDs in patients with CHF, should prompt a more formal evaluation of prognosis using the SHFM

关键词： Heart Failure Daily Activity Prognosis Cardiac Defibrillator

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Is Preoperative Functional Status Associated with Postoperative Mortality and Morbidity in Elective Open Heart Patients?

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Health 2018年第5期10卷 654-666页

作者： A. Kate MacPhedran David B. Barker Mark L. Marbey Kieran Fogarty Eric Vangsnes Doctor of Physical Therapy program Department Gannon University Erie USA Saint Vincent Health Center Erie USA Organizational Learning and Leadership Ph.D. program Gannon University Erie USA Mason City Clinic Mason City USA Interdisciplinary Health Sciences Ph.D. program Western Michigan University Kalamazoo USA physician assistant program Western Michigan University Kalamazoo USA

Background: Cardiac surgery, even when planned, has the potential for adverse outcomes, such that several factors are taken into consideration to help surgeons and their patients discuss the potential risks weighed against the expected recovery. Preoperative functional status and its influence on cardiac surgery, if any, have not been adequately evaluated to date. This study aimed to examine the relationship between preoperative functional status and postoperative mortality and morbidity in elective open heart patients. Methods: Preoperative baseline data (n = 43 subjects) were obtained to calculate Society of Thoracic Surgeons (STS) mortality and morbidity risk scores and preoperative functional status was measured using the Late-Life Function and Disability Instrument (LLFDI). Follow-up data were abstracted at one year postoperative to calculate actual mortality and morbidity events. Ordinary least squares and negative binomial regression analyses were conducted to assess the relationship between the LLFDI preoperative score to the STS mortality and morbidity risk scores. Results: Mortality risk was significant, F (1, 39) = 4.75, p = 0.035, with an adjusted R2 = 0.086, and Function Total (measured by LLFDI) yielded a significant negative association with mortality risk, β = −0.329. Morbidity was found to be significant, F (1, 40) = 4.89, p = 0.033, with an adjusted R2 = 0.087 and Function Total yielded a significant negative association with morbidity risk, β = −0.328, as well. Estimation of the counts for postoperative complications as estimated by Function Total failed to reach significance (Wald χ2 = 0.34, p = 0.56), which provided a pseudo R2 = 0.009. Probabilities for frequencies of adverse events (major complications), therefore, could not be reliably calculated. Conclusion: Preoperative diminished functional status, as measured by the LLFDI, is associated with an increased risk of mortality and morbidity in patients undergoing elective cardiac s

关键词： Functional Status Elective Cardiac Surgery Mortality and Morbidity

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Active control of highway bridges subject to a variety of earthquake loads

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Earthquake Engineering and Engineering Vibration 2015年第2期14卷 253-263页

作者： Ryan Mitchell Young-Jin Cha Yeesock Kim Aniket Anil Mahajan Department of Civil and Environmental Engineering Worcester Polytechnic Institute (WPI) Worcester MA 01609-2280 USAGraduate Research Assistant Department of Civil Engineering University of Manitoba Winnipeg MB R3L5V6 Canada Assistant Professor Department of Civil and Environmental Engineering Worcester Polytechnic Institute (WPI) Worcester MA 01609-2280 USA Department of Civil and Environmental Engineering Worcester Polytechnic Institute (WPI) Worcester MA 01609-2280 USA Graduate Research Assistant

In this paper, a wavelet-fi ltered genetic-neuro-fuzzy(WGNF) control system design framework for response control of a highway bridge under various earthquake loads is discussed. The WGNF controller is developed by combining fuzzy logic, discrete wavelet transform, genetic algorithms, and neural networks for use as a control algorithm. To evaluate the performance of the WGNF algorithm, it is tested on a highway bridge equipped with hydraulic actuators. It controls the actuators installed on the abutments of the highway bridge structure. Various earthquakes used as input signals include an artifi cial earthquake, the El-Centro, Kobe, North Palm Springs, Turkey Bolu, Chi-Chi, and Northridge earthquakes. It is proved that the WGNF control system is effective in mitigating the vibration of the highway bridge under a variety of seismic excitation.

关键词： structural control wavelet transform genetic algor

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