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Optimized Three-Dimensional Cardiovascular Magnetic Resonance Whole Heart Imaging Utilizing Non-Selective Excitation and Compressed Sensing in Children and Adults with Congenital Heart Disease

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Congenital Heart Disease 2023年第3期18卷 279-294页

作者： Ingo Paetsch Roman Gebauer Christian Paech Frank-Thomas Riede Sabrina Oebel Andreas Bollmann Christian Stehning Jouke Smink Ingo Daehnert Cosima Jahnke Department of Electrophysiology Heart Center Leipzig at University of LeipzigLeipzigGermany Department of Pediatric Cardiology Heart Center Leipzig at University of LeipzigLeipzigGermany philips research Laboratories HamburgGermany philips Medical Systems BestThe Netherlands

Background:In congenital heart disease(CHD)patients,detailed three-dimensional anatomy depiction plays a pivotal role for diagnosis and therapeutical decision ***,the present study investigated the applicability of an advanced cardiovascular magnetic resonance(CMR)whole heart imaging approach utilizing nonselective excitation and compressed sensing for anatomical assessment and interventional guidance of CHD patients in comparison to conventional dynamic CMR ***:86 consecutive pediatric patients and adults with congenital heart disease(age,1 to 74 years;mean,35 years)underwent CMR imaging including a freebreathing,ECG-triggered 3D nonselective SSFP whole heart acquisition using compressed SENSE(nsWHcs).Anatomical assessability and signal intensity ratio(SIR)measurements were compared with conventional dynamic 3D-/4D-MR ***:The most frequent diagnoses were partial anomalous pulmonary venous drainage(17/86,20%),transposition of the great arteries(15/86,17%),tetralogy of Fallot(12/86,14%),and a single ventricle(7/86,8%).Image quality of nsWHcs was rated as excellent/good in 98%of *** resulted in a reliable depiction of all large thoracic vessels(anatomic assessability,99%–100%)and the proximal segments of coronary arteries and coronary sinus(>90%).nsWHcs achieved a homogenously distributed SIR in all cardiac cavities and thoracic vessels without a significant difference between pulmonary and systemic circulation(10.9±3.5 and 10.6±3.4;p=0.15),while 3D angiography showed significantly increased SIR for targeted ***-targeted circulation(PA-angiography,15.2±8.1 vs.5.8±3.6,p<0.001;PV-angiography,7.0±3.9 vs.17.3±6.8,p<0.001).Conclusions:The proposed nsWHcs imaging approach provided a consistently high image quality and a homogeneous signal intensity distribution within the pulmonary and systemic circulation in pediatric patients and adults with a wide spectrum of congenital heart *** enabled detailed anatomi

关键词： Cardiovascular magnetic resonance imaging congenital heart disease whole heart imaging nonselective SSFP compressed SENSE MR angiography

Investigating the relationship between intracranial atherosclerotic plaque remodelling and diabetes using high-resolution vessel wall imaging

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World Journal of Diabetes 2024年第1期15卷 72-80页

作者： Yong-Qian Mo Hai-Yu Luo Han-Wen Zhang Yu-Feng Liu Kan Deng Xiao-Lei Liu Biao Huang Fan Lin Department of Radiology Peking University Shenzhen HospitalShenzhen 518000Guangdong ProvinceChina Department of Ultrasound Peking University Shenzhen HospitalShenzhen 518000Guangdong ProvinceChina The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510282Guangdong ProvinceChina Department of Radiology The First Affiliated Hospital of Shenzhen UniversityHealth Science CenterShenzhen Second People’s HospitalShenzhen 518036Guangdong ProvinceChina research Department Philips HealthcareGuangzhou 518000Guangdong ProvinceChina Department of Radiology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Intracranial atherosclerosis,a leading cause of stroke,involves arterial plaque *** study explores the link between plaque remodelling patterns and diabetes using high-resolution vessel wall imaging(HR-VWI).AIM To investigate the factors of intracranial atherosclerotic remodelling patterns and the relationship between intracranial atherosclerotic remodelling and diabetes mellitus using *** Ninety-four patients diagnosed with middle cerebral artery or basilar artery INTRODUCTION Intracranial atherosclerotic disease is one of the main causes of ischaemic stroke in the world,accounting for approx-imately 10%of transient ischaemic attacks and 30%-50%of ischaemic strokes[1].It is the most common factor among Asian people[2].The adaptive changes in the structure and function of blood vessels that can adapt to changes in the internal and external environment are called vascular remodelling,which is a common and important pathological mechanism in atherosclerotic diseases,and the remodelling mode of atherosclerotic plaques is closely related to the occurrence of *** remodelling(PR)is an outwards compensatory remodelling where the arterial wall grows outwards in an attempt to maintain a constant lumen *** a long time,it was believed that the degree of stenosis can accurately reflect the risk of ischaemic stroke[3-5].Previous studies have revealed that lesions without significant luminal stenosis can also lead to acute events[6,7],as summarized in a recent meta-analysis study in which approximately 50%of acute/subacute ischaemic events were due to this type of lesion[6].research[8,9]has pointed out that the PR of plaques is more dangerous and more likely to cause acute ischaemic *** studies[10-13]have found that there are specific vascular remodelling phenomena in the coronary and carotid arteries of diabetic ***,due to the deep location and small lumen of intracranial arteries and limitations of i

关键词： High-resolution vessel wall imaging Intracranial atherosclerosis Vascular remodelling Magnetic resonance imaging

Li-intercalation in Silicon Anodes:A Challenging Route Towards 3D-Integrated All-solid-state Batteries

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复旦学报（自然科学版） 2007年第5期46卷 688-页

作者： P.H.L.Notten L.Baggetto R.A.H.Niessen D.Danilov Eindhoven University of Technology philips research Laboratories

1 Results Micro-batteries are expected to become more and more important in numerous small-sized devices,like medical implantables,biosensors,hearing aids and autonomous network *** for these electronic applications is that they have to operate autonomously and *** to these requirements thin film power sources need to be rechargeable,mechanically stable for a long period of time and have a long cycle *** the average energy consumption of these future devices will be rathe...

关键词： Li-ion batteries 3D-integration All-solid-state

Optimal C-arm angulation during transcatheter aortic valve replacement: Accuracy of a rotational C-arm computed tomography based three dimensional heart model

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World Journal of Cardiology 2016年第10期8卷 606-614页

作者： Verena Veulemans Sabine Mollus Axel Saalbach Max Pietsch Katharina Hellhammer Tobias Zeus Ralf Westenfeld Jürgen Weese Malte Kelm Jan Balzer Department of Medicine Division of Cardiology Pulmonary Diseases Vascular Medicine University Hospital Düsseldorf philips research europe Philips GmbH Innovative Technologies Research Laboratories

AIMTo investigate the accuracy of a rotational C-arm CT-based 3D heart model to predict an optimal C-arm configuration during transcatheter aortic valve replacement (TAVR).METHODSRotational C-arm CT (RCT) under rapid ventricular pacing was performed in 57 consecutive patients with severe aortic stenosis as part of the pre-procedural cardiac catheterization. With prototype software each RCT data set was segmented using a 3D heart model. From that the line of perpendicularity curve was obtained that generates a perpendicular view of the aortic annulus according to the right-cusp rule. To evaluate the accuracy of a model-based overlay we compared model- and expert-derived aortic root *** all 57 patients in the RCT cohort diameter measurements were obtained from two independent operators and were compared to the model-based measurements. The inter-observer variability was measured to be in the range of 0°-12.96° of angular C-arm displacement for two independent operators. The model-to-operator agreement was 0°-13.82°. The model-based and expert measurements of aortic root diameters evaluated at the aortic annulus (r = 0.79, P < 0.01), the aortic sinus (r = 0.93, P < 0.01) and the sino-tubular junction (r = 0.92, P < 0.01) correlated on a high level and the Bland-Altman analysis showed good agreement. The interobserver measurements did not show a significant *** segmentation of the aortic root using an anatomical model can accurately predict an optimal C-arm configuration, potentially simplifying current clinical workflows before and during TAVR.

关键词： Aortic stenosis Imaging modalities Degenerative valve disease Transcatheter aortic valve replacement

Plasmonics for solid-state lighting: enhanced excitation and directional emission of highly efficient light sources

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Light(Science & Applications) 2013年第1期2卷 163-169页

作者： Gabriel Lozano Davy J Louwers Said RK Rodrı´guez Shunsuke Murai Olaf TA Jansen Marc A Verschuuren Jaime Gomez Rivas Center for Nanophotonics FOM Institute AMOLFc/o Philips Research LaboratoriesEindhovenThe Netherlands philips research Laboratories EindhovenThe Netherlands Department of Material Chemistry Graduate School of EngineeringKyoto UniversityKyotoJapan COBRA research Institute Eindhoven University of TechnologyEindhovenThe Netherlands

Light sources based on reliable and energy-efficient light-emitting diodes (LEDs) are instrumental in the development of solid-statelighting (SSL). Most research efforts in SSL have focused on improving both the intrinsic quantum efficiency (QE) and the stability oflight emitters. For this reason, it is broadly accepted that with the advent of highly efficient (QE close to 1) and stable emitters, thefundamental research phase of SSL is coming to an end. In this study, we demonstrate a very large improvement in SSL emission (above70-fold directional enhancement for p-polarized emission and 60-fold enhancement for unpolarized emission) using nanophotonicstructures. This is attained by coupling emitters with very high QE to collective plasmonic resonances in periodic arrays of aluminumnanoantennas. Our results open a new path for fundamental and applied research in SSL in which plasmonic nanostructures are able tomold the spectral and angular distribution of the emission with unprecedented precision.

关键词： diffraction fluorescence LED nanophotonics plasmonics

Altered small-world,functional brain networks in patients with lower back pain

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Science China(Life Sciences) 2018年第11期61卷 1420-1424页

作者： Jing Liu Feng zhang Xiufen Liu Zhizheng Zhuo Juan Wei Minyi Du Queenie Chan Xiaoying Wang Dongxin Wang Department of Radiology Peking University First HospitalBeijing 100034China Department of Anesthesiology Peking University First HospitalBeijing 100034China philips Healthcare Beijing 100600China philips research China Shanghai 200040China philips Healthcare Hong KongChina

In this study, we aimed to investigate the functional network changes that occur in patients with lower back pain(LBP). We also investigated the link between LBP and the small-world properties of functional networks within the brain. Functional MRI(fMRI) was performed on 20 individuals with LBP and 17 age and gender-matched normal controls during the resting state. The severity of the pain in the individuals with LBP ranged from 5 to 8 on a 0–10 scale, with 0 indicating no pain. Network-based statistics were performed to investigate the differences between the brain networks of individuals with LBP and those of normal controls. Several small-world parameters of brain networks were calculated, including the clustering coefficient, characteristic path length, local efficiency, and global efficiency. These criteria reflect the overall network efficiency. The brain networks in the individuals with LBP due to herniation of a lumbar disc demonstrated a significantly longer characteristic path length as well as a lower clustering coefficient, global efficiency, and local efficiency compared to those in control subjects. We found that LBP patients tended to have unstable and inefficient brain networks when compared with healthy controls. In addition, LBP individuals showed significantly decreased functional connectivity in the anterior cingulate cortex, middle cingulate cortex, post cingulate cortex, inferior frontal gyrus, middle temporal gyrus, occipital gyrus, postcentral gyrus, precentral gyrus, supplementary motor area, thalamus, fusiform, caudate, and cerebellum. We believe that these regions may be involved in the pathophysiology of lower back pain.

关键词： small-world network brain functional networks resting-state fMRI low back pain

Recent Advances in ^(19)Fluorine Magnetic Resonance Imaging with Perfluorocarbon Emulsions

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Engineering 2015年第4期1卷 475-489页

作者： Anne H.Schmieder Shelton D.Caruthers Jochen Keupp Samuel A.Wickline Gregory M.Lanza Division of Cardiology Washington University School of Medical Toshiba Medical research Institute USA Inc. Department of Biomedical Engineering Washington University philips research hamburg

The research roots of 19fluorine （19F） magnetic resonance imaging （MRI） date back over 35 years. Over that time span, 1H imaging flourished and was adopted worldwide with an endless array of applications and imaging approaches, making magnetic resonance an indispensable pillar of biomedical diagnostic imaging. For many years during this timeframe, 19F imaging research continued at a slow pace as the various attributes of the technique were explored. However, over the last decade and particularly the last several years, the pace and clinical relevance of 19F imaging has exploded. In part, this is due to advances in MRI instrumentation, ~gF/1H coil designs, and ultrafast pulse sequence development for both preclinical and clinical scanners. These achievements, coupled with interest in the molecular imaging of anatomy and physiology, and combined with a cadre of innovative agents, have brought the concept of ~gF into early clinical evaluation. In this review, we attempt to provide a slice of this rich history of research and development, with a particular focus on liquid perfluorocarbon compound-based agents.

关键词： fluorine magnetic resonance imaging (MRI) dual-tuned coil perfluorocarbon angiogenesis cell labeling

Curved digital X-ray detectors

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npj Flexible Electronics 2020年第1期4卷 185-192页

作者： Albert JJMvan Breemen Matthias Simon Olivier Tousignant Santhosh Shanmugam Jan-Laurens van der Steen Hylke B.Akkerman Auke Kronemeijer Walter Ruetten Rob Raaijmakers Lex Alving Jan Jacobs Pawel E.Malinowski Florian De Roose Gerwin H.Gelinck Holst Centre/TNO EindhovenThe Netherlands philips research EindhovenThe Netherlands philips Healthcare BestThe Netherlands imec LeuvenBelgium Department of Applied Physics Technical University EindhovenEindhovenThe Netherlands Teledyne Dalsa EindhovenThe Netherlands

A curved image sensor on plastic foil has been developed for cone beam computed tomography(CBCT)X-ray *** image sensor of about 6×8 cm^(2) size has been built on a thin polyimide foil with an indium gallium zinc oxide(IGZO)backplane and an organic photodetectors(OPD)frontplane.A flexible cesium iodide(CsI)scintillator has been attached to the optical sensor with 480×640 pixels of 126µm *** current density of the OPD was low with less than 10^(−7) mA/cm^(2) at−2 V,while an external quantum efficiency(EQE)of about 50%was reached in the visible wavelength range matched to the scintillator *** image quality of the digital X-ray detector allowed for 3D reconstruction images of a bone phantom on a rotating stage with a lab *** curved detector with 32 cm curvature radius opens up the path for very compact CBCT gantries with largely reduced footprint.

关键词： curved curvature allowed

Energy Efficient Switch Policy for Small Cells

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China Communications 2015年第1期12卷 78-88页

作者： GAN Xiaoying WANG Luyang FENG Xinxin LIU Jing YU Hui ZHANG Zhizhong LIU Haitao Department of Electrical Engineering Shanghai Jiao Tong University The State Key Laboratory of Integrated Services Networks Xidian University Lighting Department Philips Research China

Switch policy is essential for small cells to properly serve variable number of users in an energy efficient ***,frequently switching small cell base stations(SBSs) may increase the network operating cost,especially when there is an nonnegligible start-up energy *** this end,by observing the variety of user number,we focus on the design of a switch policy which minimize the cumulative energy consumption.A given user transmission rate is guaranteed and the capability of SBSs are limited as *** to the knowledge on user number variety,we classify the energy consumption problem into two *** complete information case,to minimize the cumulative energy consumption,an offline solution is proposed according to critical segments.A heuristic algorithm for incomplete information case(HAIIC) is proposed by tracking the difference of cumulative energy *** upper bound of the Energy Consumption Ratio(ECR) for HAIIC is derived as *** addition,a practical Q-learning based probabilistic policy is *** results show that the proposed HAIIC algorithm is able to save energy efficiently.

关键词： heterogeneous network small cell switch policy Q-learning