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Three Co(Ⅱ) Coordination Polymers Incorporated with a Bent Connector: Crystal Structures and Magnetic Properties

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Chinese Journal of Structural Chemistry 2019年第4期38卷 587-596页

作者： LIU Han-Fu LI Hai-Ye YAO Peng-Fei SHU Chun-Yue HUANG Fu-Ping School of Chemistry and pharmacy Guangxi Normal University College of pharmacy Guilin Medical University

Based on the bent ligand 1 H-3-(3-pyridyl)-5-(4-pyridyl)-1,2,4-triazole(3,4?-Hbpt) with Co(Ⅱ) ions as well as a series of polycarboxylate co-ligands, three new coordination polymers were yielded, namely, {[Co(op)(3,4?-Hbpt)(H_2O)_3]?2 H_2O}n(1), [Co(cyc)(3,4′-Hbpt)(H_2O)]n(2) and [Co(pro)(3,4′-Hbpt)(H_2O)]n(3)(here, op = o-phthalic anion, cyc = 1,1-cyclobutanedicarboxylic anion, pro = propanedioic anion). In cooperation with the auxiliary polycarboxylate co-ligands, a variety of Co(Ⅱ) coordination networks, such as 1-D chain 1 and 2-D layer 2 and 3 have been assembled. The magnetic behaviors of compounds 1～3 were studied. All of them indicated the existence of interesting spin-canting behavior.

关键词： Co(Ⅱ) complexes bent connector spin canting behavior

Evaluation of directly observed treatment short courses at a secondary health institution in Ibadan,Oyo State,Southwestern Nigeria

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Asian Pacific Journal of Tropical Medicine 2013年第12期6卷 952-959页

作者： Olajire A.Adegoke Olalekan A.Orokotan Department of Pharmaceutical Chemistry Faculty of PharmacyUniversity of IbadanIbadanNigeria Department of Clinical pharmacy and pharmacy Administration Faculty of PharmacyUniversity of IbadanIbadanNigeria

Objective:To evaluate the success rate of tuberculosis intervention programme at a specialist hospital in(?)badan,Nigeria through a retrospective study as well as carry out physicochemical evaluation of anti-tuberculous agents as a way of eliminating drug-related ***:The retrospective study involved the use of quarterly tuberculosis central register at the Government Chest Hospital,(?)badan between 1st quarter(2003)to 4th quarter(2009).Relevant data were extracted from these register with the aid of data collection *** basic physicochemical analyses of the drugs given to the patients were also carried out using the International Pharmacopoeia ***:All the drugs examined for their physicochemical properties passed the International Pharmacopeia recommended tests.A total number of 1 260 patients enrolled at the hospital were assessed through case *** comprises of 59.4%males of which69.23%new cases were also *** was a significant(P0.05).Failure rates in all categories were higher in males than females(P>0.05).Conclusions:More enlightenment and counseling is still required to meet up with the target for TB control.

关键词： Tuberculosis DOTS therapy Success rate Anti-TB drugs Physicochemical evaluation

Physical characterization of meloxicam-β-cyclodextrin inclusion complex pellets prepared by a fluid-bed coating method

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Particuology 2009年第1期7卷 1-8页

作者： Yi Lu Xingwang Zhang Jie Lai Zongning Yin Wei Wu School of pharmacy Fudan University Shanghai China West China School of pharmacy Sichuan University Chengdu china

Meloxicam-β-cyclodextrin （ME-β-CD） inclusion complex was prepared by a fluid-bed coating technique upon solvent removal and simultaneous depositing onto the surface of nonpareil pellets and using PVP K30 as a binding agent to facilitate good coating. The resultant pellets were spherical and intact in shape with good flowability and friability. SEM analysis showed that the pellets were smooth and had a tightly coated inclusion complex layer. In vitro dissolution of the inclusion complex pellets in pH 7.4 phosphate buffer was dramatically enhanced at an ME/CD ratio of 1/1. DSC and powder X-ray diffractometry proved the absence of crystallinity in the ME/CD inclusion complexes. Moreover, Fourier transform-infrared spectrometry together with Raman spectrometry indicated that the thiazole ring of ME was possibly included in the cavity of β-CD.

关键词： Meloxicam Inclusion complex β-Cyclodextrin Fluid-bed Pellets Dissolution Characterization

Synthesis of Zinc Oxide Nanoparticles with Good Photocatalytic Activities under Stabilization of Bovine Serum Albumin

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Journal of Wuhan University of Technology(Materials Science) 2017年第5期32卷 1061-1066页

作者：陈稚 SHUAI Li ZHENG Bodan WU Dudu School of pharmacy Guangdong Medical University School of pharmacy South Central University for Nationalities

Zinc oxide nanoparticles were synthesized using bovine serum albumin as stabilizers through a facile one-pot strategy in aqueous media. The morphology and crystal phase of the zinc oxide nanoparticles were determined by transmission electron microscopy, X-ray diffractograms, and Fourier transform infrared spectroscopy. The synthesized ZnO nanoparticles exhibited strong absorption and photoluminescence properties in the visible wavelength region based on the fluorescence and UV-visible spectroscopy. Based on the results, the zinc oxide nanoparticles could effectively degrade the organic dyes through the mediation of the hydroxyl radical under visible light irradiation. Furthermore, the zinc oxide nanoparticles show good recycling stability during the photocatalytic experiments. These results suggested that the as-prepared zinc oxide nanoparticles might be used as a potential photocatalyst to efficiently treat the organic pollutants.

关键词： zinc oxide bovine serum albumin nanoparticles photocatalysis rhodamine B

Development of carrier-free nanocrystals of poorly water-soluble drugs by exploring metastable zone of nucleation

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Acta Pharmaceutica Sinica B 2019年第1期9卷 118-127页

作者： Xiaoting Ren Jianping Qi Wei Wu Zongning Yin Tonglri Li Yi Lu Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of Pharmacy Sichuan University Department of Pharmaceutics School of Pharmacy Fudan University Department of Industrial and Physical pharmacy College of Pharmacy Purdue University

There has been increasing interest in research and development of nanocrystals for the delivery of poorly water-soluble drugs that can be directly produced from solution. Compared with traditional carrier-based or encapsulation designs, drug nanocrystals circumvent possible side-effects due to carrier polymers and poor stability issues associated with encapsulation. The production of carrier-free nanocrystals requires careful control of nucleation and thus a thorough understanding of the relevant solution's metastable zone. A solution may stay supersaturated without forming any nuclei and become metastable. The maximal degree of supersaturation is known as the metastable zone width. When nucleation is triggered directly from the metastable zone, it helps to produce homogeneous nuclei leading to uniform nanocrystals. Herein, we report a study in which the solubility and metastable limit of paclitaxel(PTX) in ethanol aqueous solution were measured at 40 °C. A wide range of metastable compositions were studied to prepare carrier-free PTX nanocrystals with particle size smaller than250 nm and PDI less than 0.25. Compared with the raw material, dissolution rate of PTX nanocrystals was significantly increased. The study enables production of high-quality drug nanocrystals for treating patients.

关键词： Nanocrystals Metastable zone Nucleation Sonication Dissolution Paclitaxel

Use of stimulatory responsive soft nanoparticles for intracellular drug delivery

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Nano Research 2023年第5期16卷 6974-6990页

作者： Krystal A Hughes Bishal Misra Maryam Maghareh Sharan Bobbala Department of Pharmaceutical Sciences West Virginia University School of PharmacyMorgantownWV 26505USA Department of Clinical pharmacy West Virginia University School of PharmacyMorgantownWV 26505USA

Drug delivery has made tremendous advances in the last *** therapies are increasingly common,with intracellular delivery highly impactful and sought *** drug delivery systems have limitations due to imprecise and non-targeted release *** way this can be addressed is through using stimuli-responsive soft nanoparticles,which contain materials with an organic backbone such as lipids and *** choice of biomaterial is essential for soft nanoparticles to be responsive to internal or external *** nanoparticle must retain its integrity and payload in non-targeted physiological conditions while responding to particular intracellular environments where payload release is *** internal and external factors could stimulate the intracellular release of drugs from *** stimuli include pH,oxidation,enzymes,while external stimuli include ultrasound,light,electricity,magnetic *** responsive soft nanoparticulate systems specifically utilized to modulate intracellular delivery of drugs are explored in this review.

关键词： nanoparticles biomaterials stimuli-responsive targeted delivery intracellular drug delivery

Beneficial effects of Houttuynia cordata polysaccharides on “two-hit” acute lung injury and endotoxic fever in rats associated with anti-complementary activities

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Acta Pharmaceutica Sinica B 2018年第2期8卷 218-227页

作者： Yan Lu Yun Jiang Lijun Ling Yunyi Zhang Hong Li Daofeng Chen Department of Pharmacognosy School of Pharmacy Fudan University Department of Pharmacology School of Pharmacy Fudan University

Houttuynia cordata Thunb. is a traditional herb used for clearing heat and eliminating toxins,and has also been used for the treatment of severe acute respiratory syndrome(SARS). In vitro, the crude H. cordata polysaccharides(CHCP) exhibited potent anti-complementary activity through both the classical and alternative pathways by acting on components C3 and C4 of the complement system without interfering with the coagulation system. This study was to investigate the preventive effects of CHCP on acute lung injury(ALI) induced by hemorrhagic shock plus lipopolysaccharide(LPS) instillation(two-hit)and LPS-induced fever in rats. CHCP significantly attenuated pulmonary injury in the "two-hit" ALI model by reducing pulmonary edema and protein exudation in bronchoalveolar lavage fluid(BALF). In addition, it reduced the deposit of complement activation products in the lung and improved oxidantantioxidant imbalance. Moreover, CHCP administration inhibited fever in rats, reduced the number of leukocytes and restored serum complement levels. The inhibition on the inappropriate activation of complement system by CHCP may play an important role in its beneficial effects on inflammatory diseases. The anti-complementary polysaccharides are likely to be among the key substances for the heatclearing function of H. cordata.

关键词： Houttuynia cordata Polysaccharides Fever Acute lung injury Anti-complementary

New triazole derivatives containing substituted 1,2,3-triazole side chains:Design,synthesis and antifungal activity

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Chinese Chemical Letters 2017年第4期28卷 913-918页

作者： Hai-Jiang Chen Yan-Juan Jiang Yong-Qiang Zhang Qi-Wei Jing Na Liu Yan Wang Wan-Nian Zhang Chun-Quan Sheng School of pharmacy Fujian University of Traditional Chinese Medicine School of pharmacy Second Military Medical University School of pharmacy East China University of Science and Technology

In order to discover new generation of triazole antifungal agents,a series of novel antifungal triazoles were designed and synthesized by structural simplification of our previously identified triazolepiperdine-heterocycle lead *** target compounds showed good antifungal activity with a broad *** particular,compound 71 was highly active against Candida albicans and Candida ***,compound 71 showed potent in vivo antifungal efficacy in the Caenorhabditis *** infection model.

关键词： Triazole derivatives Antifungal activities Click reaction Molecular docking CYP51

Houttuynia cordata polysaccharide alleviated intestinal injury and modulated intestinal microbiota in H1N1 virus infected mice

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Chinese Journal of Natural Medicines 2019年第3期17卷 187-197页

作者： CHEN Mei-Yu LI Hong LU Xiao-Xiao LING Li-Jun WENG Hong-Bo SUN Wei CHEN Dao-Feng ZHANG Yun-Yi Department of Pharmacology School of Pharmacy Fudan University Department of Pharmacognosy School of Pharmacy Fudan University

Houttuynia cordata polysaccharide(HCP) is extracted from Houttuynia cordata, a key traditional Chinese medicine. The study was to investigate the effects of HCP on intestinal barrier and microbiota in H1N1 virus infected mice. Mice were infected with H1N1 virus and orally administrated HCP at a dosage of 40 mg×kg^(–1)×d^(–1). H1N1 infection caused pulmonary and intestinal injury and gut microbiota imbalance. HCP significantly suppressed the expression of hypoxia inducible factor-1α and decreased mucosubstances in goblet cells, but restored the level of zonula occludens-1 in intestine. HCP also reversed the composition change of intestinal microbiota caused by H1N1 infection, with significantly reduced relative abundances of Vibrio and Bacillus, the pathogenic bacterial genera. Furthermore, HCP rebalanced the gut microbiota and restored the intestinal homeostasis to some degree. The inhibition of inflammation was associated with the reduced level of Toll-like receptors and interleukin-1β in intestine, as well as the increased production of interleukin-10. Oral administration of HCP alleviated lung injury and intestinal dysfunction caused by H1N1 infection. HCP may gain systemic treatment by local acting on intestine and microbiota. This study proved the high-value application of HCP.

关键词： H1N1 influenza virus Houttuynia cordata Inflammation Intestinal Barrier Microbiota Polysaccharide