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A comparative in vitro study on the effect of SGLT2 inhibitors on chemosensitivity to doxorubicin in MCF-7 breast cancer cells

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Oncology Research 2024年第5期32卷 817-830页

作者： SHAHID KARIM ALANOUD NAHER ALGHANMI MAHA JAMAL HUDA ALKREATHY ALAM JAMAL HIND A.ALKHATABI MOHAMMED BAZUHAIR AFTAB AHMAD Department of Clinical Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Biochemistry Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia Department of Biochemistry College of ScienceUniversity of JeddahJeddah21959Saudi Arabia Health Information Technology Department The Applied CollegeKing Abdulaziz UniversityJeddahSaudi Arabia pharmacovigilance and Medication Safety Unit Center of Research Excellence for Drug Research and Pharmaceutical IndustriesKing Abdulaziz UniversityJeddahSaudi Arabia

Cancer frequently develops resistance to the majority of chemotherapy *** study aimed to examine the synergistic cytotoxic and antitumor effects of SGLT2 inhibitors,specifically Canagliflozin(CAN),Dapagliflozin(DAP),Empagliflozin(EMP),and Doxorubicin(DOX),using in vitro *** precise combination of CAN+DOX has been found to greatly enhance the cytotoxic effects of doxorubicin(DOX)in MCF-7 ***,it was shown that cancer cells exhibit an increased demand for glucose and ATP in order to support their ***,when these medications were combined with DOX,there was a considerable inhibition of glucose consumption,as well as reductions in intracellular ATP and lactate ***,this effect was found to be dependent on the dosages of the *** addition to effectively inhibiting the cell cycle,the combination of CAN+DOX induces substantial modifications in both cell cycle and apoptotic gene *** work represents the initial report on the beneficial impact of SGLT2 inhibitor medications,namely CAN,DAP,and EMP,on the responsiveness to the anticancer properties of *** underlying molecular mechanisms potentially involve the suppression of the function of SGLT2.

关键词： SGLT2 Cancer Cytotoxicity ATP Cell cycle

Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy

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Acta Pharmaceutica Sinica B 2024年第2期14卷 795-807页

作者： Yongchun Pan Xiaowei Luan Fei Zeng Xuyuan Wang Shurong Qin Qianglan Lu Guanzhong He Yanfeng Gao Xiaolian Sun Xin Han Bangshun He Yujun Song Department of Laboratory Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006China College of Engineering and Applied Sciences State Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210023China State Key Laboratory of Natural Medicines Key Laboratory of Drug Quality Control and PharmacovigilanceDepartment of Pharmaceutical AnalysisChina Pharmaceutical UniversityNanjing 211198China School of Medicine&Holistic Integrative Medicine Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing University of Chinese MedicineNanjing 210023China

Recent innovations in nanomaterials inspire abundant novel tumor-targeting CRISPR-based gene ***,the therapeutic efficiency of traditional targeted nanotherapeutic strategies is limited by that the biomarkers vary in a spatiotemporal-dependent manner with tumor ***,we propose a self-amplifying logic-gated gene editing strategy for gene/H_(2)O_(2)-mediated/starvation multimodal cancer *** this approach,a hypoxia-degradable covalent-organic framework(COF) is synthesized to coat a-ZIF-8 in which glucose oxidase(GOx) and CRISPR system are *** intensify intracellular redox dyshomeostasis,DNAzymes which can cleave catalase mRNA are loaded as *** the nano system gets into the tumor,the weakly acidic and hypoxic microenvironment degrades the ZIF-8@COF to activate GOx,which amplifies intracellular H^(+)and hypoxia,accelerating the nanocarrier degradation to guarantee available CRISPR plasmid and GOx release in target *** tandem reactions deplete glucose and oxygen,leading to logic-gated-triggered gene editing as well as synergistic gene/H_(2)O_(2)-mediated/starvation ***,this approach highlights the biocomputing-based CRISPR delivery and underscores the great potential of precise cancer therapy.

关键词： CRISPRdelivery Enzymeencapsulation Logic gate Hybridmaterial Hypoxia Gene editing Precise nanomedicine Multimodal therapy

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铜基催化剂用于一氧化碳电还原为多碳产品

Science China Materials 2024年第6期67卷 1684-1705页

作者：赵雯刘娟王光滔王新天杨传举李剑王鋙葶孙晓莲林日琛左淦丞朱文磊 State Key Laboratory of Pollution Control and Resource Reuse Frontiers Science Center for Critical Earth Material CyclingState Key Laboratory of Pollution Control and Resource Reusethe Frontiers Science Center for Critical Earth Material CyclingSchool of the EnvironmentNanjing UniversityNanjing 210023China State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China State Key Laboratory of Natural Medicines Key Laboratory of Drug Quality Control and PharmacovigilanceSchool of PharmaceuticsChina Pharmaceutical UniversityNanjing 210009China Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 211189China Jiangsu Engineering Lab of Water and Soil Eco-remediation School of EnvironmentNanjing Normal UniversityNanjing 210023China

电化学二氧化碳还原(ECO_(2)R)是一种将碳和可再生能源的能量储存在多碳产品(C_(2+))的化学键中的有效途径.然而,反应涉及的复杂步骤为CO_(2)直接转化为C_(2+)设置了巨大的障碍.一种利用CO作为“中转站”,通过串联ECO_(2)R和电化学CO还... 详细信息

电化学二氧化碳还原(ECO_(2)R)是一种将碳和可再生能源的能量储存在多碳产品(C_(2+))的化学键中的有效途径.然而,反应涉及的复杂步骤为CO_(2)直接转化为C_(2+)设置了巨大的障碍.一种利用CO作为“中转站”,通过串联ECO_(2)R和电化学CO还原(ECOR)以提高生产C_(2+)的选择性和反应速率的策略引起了人们的广泛关注.本文总结了铜基电催化剂在ECOR中催化特定C_(2+)生成的设计策略.其次,从各个方面总结了催化剂工程的代表性设计策略,并介绍了电解反应器改进方面的最新进展.最后,阐述了该研究领域面临的主要挑战和未来前景.这些见解和观点将为铜基电催化剂的设计提供有益指导.

关键词： CO electroreduction Cu-based catalysts multi-car-bon products

Paper-based fluorescent devices for multifunctional assays:Biomarkers detection,inhibitors screening and chiral recognition

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Chinese Chemical Letters 2022年第9期33卷 4405-4410页

作者： Wang Li Xiaoyue Zhang Siqi Chen Yibing Ji Ruijun Li Department of Analytical Chemistry China Pharmaceutical UniversityNanjing 210009China Key Laboratory of Drug Quality Control and pharmacovigilance Ministry of EducationNanjing 210009China

The development of a single analytical platform with different functions is highly desirable but remains a challenge at ***,a paper-based device based on fluorescent carbon dots(CDs)functionalized paper/MnO_(2)nanosheets(MnO_(2)NS)hybrid devices(PCD/NS)was proposed for single-device multi-function ***_(2)NS functioned as a fluorescence quencher of CDs and recognizer of H_(2)O_(2)released from the oxidase catalyzed *** recovery would occur after the decomposition of MnO_(2)NS induced by H_(2)O_(2),by which a simple and effective strategy could be developed for fluorescence monitoring multiplex biological ***(XA)sensing,xanthine oxidase(XOD)inhibitors screening analysis and chiral recognition of glucose enantiomers were performed on PCD/NS to investigate the multifunctional application of the paper-based *** means of PCD/NS,XA could be determined in the range of 0.1–40μmol/L with a low detection of limit of 0.06μmol/*** IC_(50)value of allopurinol,the model inhibitor of XOD,was sensitively detected to be 7.4μmol/*** enantiomers were also recognized in terms of the specific fluorescence response to *** work firstly presented a paper-based device capable of biomarkers detection,inhibitors screening and chiral recognition,which enlightened a promising strategy for the construction of multifunctional devices and hold the great potential application in clinical diagnosis and drug discovery.

关键词： Paper-based devices Multifunctional Xanthine Inhibitor screening Chiral recognition

Unmodified methodologies in target discovery for small molecule drugs:A rising star

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Chinese Chemical Letters 2022年第12期33卷 4980-4988页

作者： Jiayue Tang Meng Ou Qiuling Zheng Ya Ding Key Laboratory of Drug Quality Control and pharmacovigilance Ministry of EducationChina Pharmaceutical UniversityNanjing 210009China State Key Laboratory of Natural Medicines Department of Pharmaceutical AnalysisCollege of PharmacyChina Pharmaceutical UniversityNanjing 210009China

Target discovery,involving target identification and validation,is the prerequisite for drug discovery and *** methodologies and technologies for the precise discovery and confirmation of drug targets are powerful tools in understanding the disease,looking for a drug and elucidating the mechanism of drug *** the common target identification and confirmation methods,the modified method is time-consuming and laborious,which may reduce or change the activity of natural *** unmodified methods developed in recent years without chemical modification have gradually become an important means of studying drug targets.A wide range of unmodified approaches have been reported,introducing and analyzing the recent emerging methodologies and *** review highlights the advantages and limitations of these methods for the application of drug target discovery and presents an overview of their contributions to the target discovery of small molecule *** application and future development trends of methodologies in target discovery are also prospected to provide a reference for drug target research.

关键词： Target discovery Target identification Small molecule drug Methodologies Unmodified

铜基催化剂用于一氧化碳电还原为多碳产品（英文）

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Science China Materials 2024年

作者：赵雯刘娟王光滔王新天杨传举李剑王鋙葶孙晓莲林日琛左淦丞朱文磊 Jiangsu Engineering Lab of Water and Soil Eco-remediation School of Environment Nanjing Normal University State Key Laboratory of Pollution Control and Resource Reuse Frontiers Science Center for Critical Earth Material Cycling State Key Laboratory of Pollution Control and Resource Reuse the Frontiers Science Center for Critical Earth Material Cycling School of the Environment Nanjing University Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and Environment Southeast University State Key Laboratory of Natural Medicines Key Laboratory of Drug Quality Control and Pharmacovigilance School of Pharmaceutics China Pharmaceutical University State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering Nanjing University

电化学二氧化碳还原(ECO2R)是一种将碳和可再生能源的能量储存在多碳产品(C2+)的化学键中的有效途径.然而,反应涉及的复杂步骤为CO2直接转化为C2+设置了巨大的障碍.一种利用CO作为“中转站”,通过串联ECO2R和电化学CO还原(ECOR)以提高生...

电化学二氧化碳还原(ECO2R)是一种将碳和可再生能源的能量储存在多碳产品(C2+)的化学键中的有效途径.然而,反应涉及的复杂步骤为CO2直接转化为C2+设置了巨大的障碍.一种利用CO作为“中转站”,通过串联ECO2R和电化学CO还原(ECOR)以提高生产C2+的选择性和反应速率的策略引起了人们的广泛关注.本文总结了铜基电催化剂在ECOR中催化特定C2+生成的设计策略.其次,从各个方面总结了催化剂工程的代表性设计策略,并介绍了电解反应器改进方面的最新进展.最后,阐述了该研究领域面临的主要挑战和未来前景.这些见解和观点将为铜基电催化剂的设计提供有益指导.

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Acquired hemophilia associated with vedolizumab in a patient with hemorrhagic rectocolitis

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Blood Science 2023年第1期5卷 60-61页

作者： Thomas Schiestel Regional pharmacovigilance Center Fernand Widal HospitalAPHPParisFrance

To The Editor:Hemorrhagic rectocolitis is an autoimmune disease that affects the gastrointestinal *** of the disease includes 5-aminosalicylic acid drugs such as mesalazine at first-line therapy,with a possible association of *** the case of severe inflammation,treatment with purine analogue(azathioprine),TNF-alpha inhibitor(infliximab,adalimumab),or integrin inhibitor(vedolizumab)may be initiated.

关键词： hemorrhagic drugs inflammation

When important steps for a reliable Meta-analysis are missing: the bevacizumab versus ranibizumab case

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 204-205页

作者： Valentino Conti Mauro Venegoni Ugo Moretti Corrado Barbui Regional pharmacovigilance Centre of Lombardy Regional pharmacovigilance Centre of Veneto Section of Psychiatry Department of Public Health and Community MedicineUniversity of VeronaPoliclinico GB Rossi

Dear Sir,W e have read with attention and interest the systematic review on the effectiveness and safety of bevacizumab and ranibizumab in the treatment of age-related macular degeneration(AMD)written by Zhang et al[1]and published on number of April 2014 of International Journal of *** authors,who collected data from 4randomized clinical trials(RCTs)and 11 observational

关键词： the bevacizumab versus ranibizumab case When important steps for a reliable Meta-analysis are missing than

The effect of drug position on the properties of paclitaxel-conjugated gold nanoparticles for liver tumor treatment

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Chinese Chemical Letters 2021年第3期32卷 1041-1045页

作者： Huaisong Wang Lin Wang Yueyuan Gao Ya Ding Key Laboratory of Drug Quality Control and pharmacovigilance Ministry of EducationChina Pharmaceutical UniversityNanjing 210009China

Structure-efficacy effect of small molecular drug attracts wide attentions,but it has always been ignored in nanomedicine *** reveal the efficacy modulation of nanomedicine,we developed a new type of paclitaxel(PTX)-conjugated gold nanoparticles(PTX-co njugated GNPs)to investigate the influence of drug position in controlling their in vitro properties and in vivo *** therapeutic ligands(TA-PEG-NH-N=PTX and TA-PTX=N-NH-PEG)were synthesized to conjugate PTX on the surface of GNPs at different positions,locating on the surface of gold conjugate and inserting between GNPs and polyethylene glycol(PEG,molecular weight 1000 Da),*** was found that PEG-PTX@GNPs with PTX located between GNP and PEG exhibited higher aqueous solubility,biocompatibility,and *** addition,an acid sensitive hydrazone bond has been inserted between PTX and PEG in both ligands for drug release of PTX and PTX-PEG segment,respectively,at the tumor *** release of PTX from PTX-PEG segment is based on the esterase hydrolysis of an ester bond between PTX and *** two-step drug release mechanism offers PEG-PTX@GNPs effective and sustained release behavior for desirable anticancer activity,enhanced therapeutic efficacy,and lower systematic toxicity in Hepsbearing animal models.

关键词： Gold nanoparticles Paclitaxel Drug release Tumor therapeutic efficacy Effect of drug position