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A systematic review of progenitor survival and maturation in Parkinsonian models

Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd pharmacology&therapeutics and galway neuroscience Center University of GalwayGalwayIreland

Stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged from<1% to 500% of cells transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

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The loaded matrix:neurotrophin-enriched hydrogels for stem cell brain repair in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2315-2316页

作者： Giulia Comini Eilis Dowd pharmacology&therapeutics University of GalwayGalwayIreland

More than 200 years after Parkinson's disease was first described by the English surgeon whose name would eventually be given to the condition,available treatments remain purely symptomatic,leaving a critical unmet cl... 详细信息

关键词： clinical loaded eventually

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Neuroinflammation as a therapeutic target in Huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani H.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand pharmacology and therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George Huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. Huntington's disease(HD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： Huntington inflammation Medicine

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Glial response in the midcingulate cortex in Huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani H.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand pharmacology and therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

Huntington’s disease(HD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying HD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： Huntington degeneration cortex

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Brain repair for Parkinson's disease:is the answer in the matrix?

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Neural Regeneration Research 2018年第7期13卷 1187-1188页

作者： Niamh Moriarty Eilís Dowd pharmacology & therapeutics and galway neuroscience centre National University of Ireland

Two hundred years after James Parkinson first described the cardinal motor symptoms of the disorder that would later bear his name,there is still an irrefutable need for a therapy that targets the underlying pathophys... 详细信息

关键词： Brain repair for Parkinson’s disease:is the answer in the matrix

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Is EAAT2 a potential therapeutic intervention target for Alzheimer's disease?

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Neural Regeneration Research 2023年第8期18卷 1721-1722页

作者： Oliver WG Wood Jason HY Yeung Andrea Kwakowsky centre for Brain Research Department of Anatomy and Medical ImagingFaculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand pharmacology and therapeutics School of MedicineGalway Neuroscience CentreOllscoil na Gaillimhe-University of GalwayGalwayIreland

Alzheimer's disease(AD)is the most common form of dementia worldwide,impairing memory and cognitive functions due to widespread neuronal *** global incidence of this neurodegenerative disorder is predicted to increase... 详细信息

关键词： Alzheimer death EAAT2

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Metabotropic glutamate receptor 1 alpha:a unique receptor variant with variable implications for Alzheimer’s disease pathogenesis

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Neural Regeneration Research 2023年第10期18卷 2196-2197页

作者： Jason HY Yeung Andrea Kwakowsky centre for Brain Research Department of Anatomy and Medical ImagingFaculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand pharmacology and therapeutics School of MedicineGalway Neuroscience CentreOllscoil na Gaillimhe-University of GalwayGalwayIreland

Alzheimer’s disease (AD) is the leading neurodegenerative disorder *** this,there is minimal effective therapeutics proven to reduce or prevent the progression of this *** is the main excitatory neurotransmitter with... 详细信息

关键词： Alzheimer Metab pathogenesis

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Central CB2 receptors in inflammation-driven neurodegeneration： dysregulation and therapeutic potential

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Neural Regeneration Research 2016年第9期11卷 1409-1410页

作者： Ruth M. Concannon Eilis Dowd pharmacology & therapeutics and galway neuroscience centre National University of Ireland Galway Ireland

In recent times there has been an intensification of interest in the pathological role of neuroinflammation in neurodegenerative disease. Neuroprotective strategies to slow, halt or reverse neuro- degeneration have not proven fruitful clinically, and the notion of a multi-hit hypothesis in the progression of neurodegenerative disease has steered focus towards other contributory pathological factors, particularly neuroinflammation. Neuroinflammation is believed to sustain the neurodegenerative pathology, forming a cy- clical and self-sustaining pathological process, with dying neurons activating microglia, which, once activated, can release several fac- tors that kill further neurons （reviewed in Blandini, 2013）.

关键词： Central CB2 receptors in inflammation-driven neurodegeneration CB

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Gastrointestinal radiation injury:Symptoms,risk factors and mechanisms

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World Journal of Gastroenterology 2013年第2期19卷 185-198页

作者： Abobakr K Shadad Frank J Sullivan Joseph D Martin Laurence J Egan Department of Gastroenterology University Hospital GalwayUniversity Hospital Galway34562 GalwayIreland Department of pharmacology and therapeutics School of MedicineUniversity Hospital Galway34562 GalwayIreland Department of Radiation Oncology National University of Ireland GalwayUniversity Hospital Galway34562 GalwayIreland

Ionising radiation therapy is a common treatment modality for different types of cancer and its use is expected to increase with advances in screening and early detection of *** injury to the gastrointestinal tract is important factor working against better utility of this important therapeutic *** survivors can suffer a wide variety of acute and chronic symptoms following radiotherapy,which significantly reduces their quality of life as well as adding an extra burden to the cost of health *** accurate diagnosis and treatment of intestinal radiation injury often represents a clinical challenge to practicing physicians in both gastroenterology and *** the growing recognition of the problem and some advances in understanding the cellular and molecular mechanisms of radiation injury,relatively little is known about the pathophysiology of gastrointestinal radiation injury or any possible susceptibility factors that could aggravate its *** aims of this review are to examine the various clinical manifestations of post-radiation gastrointestinal symptoms,to discuss possible patient and treatment factors implicated in normal gastrointestinal tissue radiosensitivity and to outline different mechanisms of intestinal tissue injury.

关键词： Radiation enteritis Radiation proctitis Symptoms Pathophysiology Risk factors

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Gastrointestinal radiation injury:Prevention and treatment

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World Journal of Gastroenterology 2013年第2期19卷 199-208页

With the recent advances in detection and treatment of cancer,there is an increasing emphasis on the efficacy and safety aspects of cancer *** therapy is a common treatment for a wide variety of cancers,either alone or in combination with other *** radiation injury to the gastrointestinal tract is a frequent side effect of radiation therapy and a considerable proportion of patients suffer acute or chronic gastrointestinal symptoms as a *** side effects often cause morbidity and may in some cases lower the efficacy of radiotherapy *** injury to the gastrointestinal tract can be minimised by either of two strategies:technical strategies which aim to physically shift radiation dose away from the normal intestinal tissues,and biological strategies which aim to modulate the normal tissue response to ionising radiation or to increase its resistance to *** considerable improvement in the safety of radiotherapy treatment has been achieved through the use of modern optimised planning and delivery techniques,biological techniques may offer additional further *** agents have been used to prevent or minimize the severity of gastrointestinal injury induced by ionising radiation exposure,including biological,chemical and pharmacological *** this review we aim to discuss various technical strategies to prevent gastrointestinal injury during cancer radiotherapy,examine the different therapeutic options for acute and chronic gastrointestinal radiation injury and outline some examples of research directions and considerations for prevention at a pre-clinical level.

关键词： Radiation enteritis Radiation proctitis Prevention Treatment Gastrointestinal radiation injury

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