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Asian Pacific Journal of Tropical Biomedicine 2011年第4期1卷 316-322页

作者： Patel DK Kumar R Prasad SK Sairam K Hemalatha S pharmacognosy research laboratory Department of PharmaceuticsInstitute of TechnologyBanaras Hindu University

Objective:To evaluate antidiabetic and antioxidant potential of Hybanthus enneaspermus in different ***:The oral glucose tolerance test(OGTT) and normoglycemic effect of alcoholic extract of Hybanthus enneaspermus(AHE) were evaluated at a dose of 125,250 and 500mg/kg *** hypoglycemic activity and effect on body weight were tested at 250 and 500 mg/kg *** day for 21 days in Streptozotocin(STZ) induced diabetic ***,glucose uptake by hemidiaphram was also *** total polyphenolic and flavonoid were determined and their correlation with various antioxidant assays was also ***:The results showed high level of phenolic content in *** also exhibited higher total antioxidant capacity,good reducing power and a significant scavenger of reactive oxygen species like DPPH radical,nitric oxide,hydrogen peroxide and *** there was a significant increase in the body weight and decrease in the blood glucose level on treatment with the *** increased glucose uptake on isolated rat hemi-diaphragm compared to control ***:AHE reduce blood glucose level in STZ-induced diabetic *** does not show significant effect in normoglycemic study but showes significant effect in *** has significant antioxidant activity,which may be attributed to high phenolic content.

关键词： Hybanthus enneaspermus Diabetic Antioxidant Total phenol Flavonoid Flavonol Glucose uptake

Diabetes mellitus:An overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity

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Asian Pacific Journal of Tropical Biomedicine 2012年第5期2卷 411-420页

作者： Patel DK Kumar R Laloo D Hemalatha S pharmacognosy research laboratory Department of PharmaceuticsInstitute of TechnologyBanaras Hindu University

Diabetes mellitus is not a single disease but is a group of metabolic disorders affecting a huge numlier of population in the *** is mainly characterized by chronic hyperglycemia,resulting from defects in insulin secretion or insulin *** is predicated that the number of diabetes person in the world could reach upto 366 million by the year *** though the cases of diabetes are increasing day by day,except insulin and oral hypoglycemic drugs no other way of treatment has been successfully developed so ***,the objective of the present review is to provide an insight over the pathophysiological and etiological aspects of diabetes mellitus along with the remedies available for this metabolic *** review also contains brief idea about diabetes mellitus and the experimental screening model with their relevant mechanism and significance mainly used *** and streptozotocin are mainly used for evaluating the antidiabetic activity of a particular *** review contain list of medicinal plants which have been tested for their antidiabetic activity in the alloxan induced diabetic rat *** the available data in the literature,it was found that plant having antidiabetic activity is mainly due to the presence of the secondary ***,the information provided in this review will help the researchers for the development of an alternative methods rather than insidin and oral hypoglycemic agents for the treatment of diabetes niellitus,which will minimize the complication associated with the diabetes and related disorder.

关键词： Aldose reductase Alloxan Antioxidant Diabetes mellitus Insulin Phytoconstituents Streptozotocin Oral hypoglycemic agents

Pedalium murex Linn(Pedaliaceae) fruits:a comparative antioxidant activity of its different fractions

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Asian Pacific Journal of Tropical Biomedicine 2011年第5期1卷 395-400页

作者： DK Patel R Kumar SK Prasad S Hemalatha pharmacognosy research laboratory Department of PharmaceuticsInstitute of TechnologyBanaras Hindu University

Objective:To examine the antioxidant activity and total phenolic content of different solvent fractions of Pedulium murex(***)Linn fruits(Family:Pedaliaceae)as well as the correlation between the total antioxidant capacity and total phenolic ***:In the present study,the antioxidant activities of *** were evaluated using six in-vitro assays,namely total antioxidant assay,DPPH assay,reducing power,nitric oxide scavenging,hydrogen peroxide scavenging and deoxyribose scavenging assays,and total phenol contents were also ***:The ethyl acetate(EA)fraction was found to have high levels of phenolic content(298.72±2.09 mg GAE/g).The EA fraction exhibit higher total antioxidant capacity,higher percentage of DPPH radical scavenging activity(135.11±2.95μg/mL),nitric oxide(200.57±4.5lμg/mL),hydrogen peroxide(2I7.91±6.12μg/mL),deoxyribose(250.01±4.68μg/mL)and higher reducing *** coefficient(r^2=0.914)was found to be significant between total phenolic content and total antioxidant ***:In general,the results indicate that the EA fractions are rich in phenolic antioxidants with potent free radical scavenging activity implying their importance to human health.

关键词： Pedalium murex Antioxidant activity Total phenolics Different solvent fraction In vitro assay Scavenging activity

Evaluation of in vitro aldose reductase inhibitory potential of different fraction of Hybanthus enneaspermus Linn ***

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Asian Pacific Journal of Tropical Biomedicine 2012年第2期2卷 134-139页

作者： Patel DK Kumar R Kumar M Sairarn K Hemalatha S pharmacognosy research laboratory Department of PharmaceuticsInstitute of TechnologyBanaras Hindu University

Objective:To evaluate the aldose reductase inhibitory(ARI)activity of different fractions of Hybanthus enneaspermus for potential use in diabetic ***:Total phenol and flavonoid content of different fractions was *** activity of different fractions in rat lens was investigated in ***:The results showed significant level of phenolic and flavonoid content in ethyl acetate fraction[total phenol(212.15±0.79 mg/g),total flavonoid(39.11±2.27mg/g)]and aqueous fraction[total phenol(140.62±0.57mg/g),total flavonoid(26.07±1.49 mg/g)]as compared with the chloroform fraction[total phenol(68.56±0.51mg/g),total flavonoid(13.41±0.82mg/g)]and petrolium ether fraction[total phenol(36.68±0.43mg/g),total flavonoid(11.55±1.06mg/g)].There was a significant difference in the ARI activity of each fraction,and it was found to be the highest in ethyl acetate fraction[IC_(50)(49.26±1.76μg/mL)]followed by aqueous extract[IC_(50)(70.83±2.82μg/mL)]and it was least in the petroleum ether fraction[IC_(50)(118.89±0.71μg/mL)].Chloroform fraction showed moderate activity[IC_(50)(98.52±1.80μg/mL)].Conclusions:Different fractions showed significanct amount of ARI activity,where in ethyl acetate fraction it was found to be maximum which may be due to its high phenolic and flavonoid *** extract after further evaluation may be used in the treatment of diabetic cataract.

关键词： Hybanthus enneaspermus Total phenol Total flavonoid Rat lens Aldose reductase Diabetic cataract Different fractions

Flavonoid chemical composition and antidiabetic potential of Brachychiton acerifolius leaves extract

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Asian Pacific Journal of Tropical Biomedicine 2017年第5期7卷 389-396页

作者： Aisha Hussein Abou Zeid Mohamed Ali Farag Manal Abdel Aziz Hamed Zeinab Abdel Aziz Kandil Radwa Hassan El-Akad Hanaa Mohamed El-Rafie pharmacognosy Department National Research Centre pharmacognosy Department College of PharmacyCairo University Therapeutic Chemistry Department National Research Centre

Objective:To evaluate Brachychiton acerifolius leaf extracts as antidiabetic potential agent and to identify the main active constituents using bioactivity guided ***:In vitro antioxidant activity was evaluated for *** different extracts using DPPH assay and vitamin C as *** activity was then determined using STZ-induced rats treated daily with ethyl acetate and 70% ethanol leaf extracts for4 weeks at a dose of 200 g/kg body weight against gliclazide reference *** glucose,a-amylase,lipid profile,liver function enzymes and oxidative stress markers were assessed along with histopathological study for liver and pancreatic *** and structural elucidation of active compounds were made using Diaion and Sephadex followed by spectral ***:The results indicated that ethyl acetate and ethanol leaf extracts exhibited the strongest antioxidant activity compared to that of vitamin C(IC500.05,0.03 and 12 mg/m L,respectively).Both extracts showed potent anti-hyperglycemic activity evidenced by a significant decrease in serum glucose levels by 82.5% and 80.9% and a-amylase by45.2% and 53.6%,as compared with gliclazide 68% and 59.4%,*** of ethanol extract resulted in the isolation of 9 flavonoids including apigenin-7-O-arhamnosyl(1/2)-b-D-glucuronide,apigenin-7-O-b-D-glucuronide,apigenin-7-O-b-Dglucoside and ***:This study highlights the potential use of *** leaf extract enriched in flavones for the treatment of diabetes that would warrant further clinical trials investigation.

关键词： STZ-induced diabetes Diaion fractionation Flavonoid glucuronides Brachychiton acerifolius

Multi-targeting cytotoxic drug leads from mushrooms

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Asian Pacific Journal of Tropical Medicine 2019年第12期12卷 531-536页

作者： MVNL Chaitanya Asha Jose P Ramalingam SC Mandal P Narendra Kumar Phytomedicine&Phytochemistry Division Raghavendra Institute of Pharmaceutical Education&Research(RIPER)(AUTONOMOUS)campusAnantapuramuAPIndia Department of Pharmacology Karpagam College of PharmacyOthakkalmadapamCoimbatore 32TamilnaduIndia RERDS-CPR Raghavendra Institute of Pharmaceutical Education&Research(RIPER)(AUTONOMOUS)AnantapuramuAPIndia pharmacognosy and phytotherapy research laboratory Division of PharmacognosyDepartment of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India School of Crop Production Technology Suranaree University of TechnologyThailand

Due to genetic and epigenetic mechanisms, cancer have become a resistant disease and there is a need for new molecules having multiple targeting action that promotes apoptosis. Phytomolecules having multiple targeting anticancer activity are in high demand and there is less documentation or information available on these metabolites. It is evident that mushrooms are became the store houses of new anticancer molecules and mushrooms like Agaricus blazei, Antrodia camphorate, Albatrellus confluens, Bolteus badius, Cordyceps militaris, Clitocybe maxima, Funalia trogii, Grifola frondosa, and Inocybe umbrinella, are some of the medicinal mushrooms reported for their cytotoxic activity. Cytotoxic molecules like lentinan, grifolin, illudin-S, psilocybin, ganoderic acid, theanine, and hispolon, have been isolated from various mushroom species. However, studies have been limited only to in vitro cytotoxic mechanisms and very few trials have been conducted to prove the clinical efficacy of these drug leads. Hence, the current review focuses on new anticancer metabolites isolated from various mushrooms having multiple targeting mechanisms in cancer. However, an extensive research is needed to define the biosynthesis and clinical mechanism of these multiple acting metabolites. This review provides a platform for researchers new anticancer drugs and to bring out potent multiple acting anticancer newer drugs.

关键词： Cancer Phytomolecules Multiple targeting Anticancer Drugs Leads

Fatty acids of Pleurotus florida mushroom:Potential molecules for blood glucose control

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Food Bioscience 2022年第2期46卷 395-402页

作者： Shefali Madaan Sanaa Ismael Abdul Jabar Bibhu Prasad Panda Microbial&Pharmaceutical Biotechnology laboratory Department of Pharmacognosy and PhytochemistrySchool of Pharmaceutical Education and ResearchJamia HamdardNew DelhiIndia

In Vitro-In Vivo antidiabetic effect of Pleurotus florida mycelia was evaluated using enzymes,yeast cell and in streptozotocin induced type 2 diabetic(T2D)animal *** mycelia was prepared by submerged fermentation *** fungal biomass was organically extracted using mixture of ethanol and *** extractives yield of 14.3%w/w was obtained in hydroalcoholic solvent with dielectric constant-δvalue of 78.2(EX78).*** mycelia extract(EX 78)shows higher antioxidant power with 86.87%free radical scavenging activity and with 75.29 reducing ***-vitroα-amylase inhibition,α-glucosidase inhibition and glucose uptake activity of EX 78 shows higher *** *** mycelia extract(EX 78)is also found to be effective in controlling of blood glucose and insulin level in streptozotocin-nicotinamide induced T2D *** blood glucose was reduced to 216±6.21 mg/dl from 357±0.34 mg/dl and the insulin level was increased to 0.423±0.006 ng per mL from 0.164±0.03 ng/mL in *** treated *** higher fatty acids,C20-eicosane;C24-tetracosane and C30-squalene present in *** mycelium extract was found to be effective in inhibiting human intestinalα-glucosidase and pancreaticα-*** *** mushroom is found to be effective in controlling high blood glucose elevated liver and cardiac *** of this mushroom is suitable for controlling blood glucose level in person with hyperglycaemia.

关键词： Pleurotus florida Oyster mushroom Bioactive molecules Hyperglycaemia Type 2 diabetic

Monoterpene and tetrahydronaphthene derivatives from Senecio argunensis

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Chinese Chemical Letters 2009年第5期20卷 598-600页

作者： Chao Feng Zhang Ning Li Lin Li Mian Zhang research Department of pharmacognosy China Pharmaceutical University Nanjing 210038 China

Two new compounds, senarguines A and B, were isolated from Senecio argunensis. They were respectively identified as （Z）-3- ethylidene-9-hydroxyl-9-methyl-6,7-dioxaspiro [4.4] nonane-5,8-dione （1） and 3,6,6-trimeth... 详细信息

关键词： Compositae Senecio argunensis Senarguine A Senarguine B

The brain-derived neurotrophic factor in neuronal plasticity and neuroregeneration: new pharmacological concepts for old and new drugs

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Neural Regeneration research 2018年第6期13卷 983-984页

作者： Solomon Habtemariam Herbal Analysis Services UK & pharmacognosy research Laboratories University of Greenwich

Neurotrophins：Neurotrophins are peptides or proteins that are known to regulate neuronal viability,development,and function Beyond synaptic plasticity,neurotrophins protect neurons from apoptosis and also promote neu... 详细信息

关键词： The brain-derived neurotrophic factor in neuronal plasticity and neuroregeneration new pharmacological concepts for old and new drugs

Optimization of vinegar-steaming process for Wuweizi (Fructus Schisandrae Chinensis) with response surface method

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Journal of Traditional Chinese Medicine 2013年第5期33卷 682-685页

作者： Yan Zhang Kangwei Li Kuan Yang Xing Fan Mengxin Zhang Teaching and research Section of pharmacognosy of Pharmacy Department Xi'an Medical University

OBJECTIVE:To optimize the vinegar-steaming process of Wuweizi(Fructus Schisandrae Chinensis)using the response surface method(RSM)based on the Box-Behnken ***:A regression model was constructed with the response variables,the content of Deoxyschizandrin,and the three explanatory factors:length of steaming time,the quantity of vinegar and length of moistening time to evaluate the effects on the processing of Wuweizi(Fructus SchisandraeChinensis).RESULTS:There was a linear relationship between the content of Deoxyschizandrin and the three explanatory *** the steaming time was5.49 h,with 2.365 g of vinegar added and a moistening time of 4.13 h,the content of Deoxyschizandrin reached the maximum predicted value of0.1076%,and under the conditions the average content of Deoxyschizandrin was 0.1058%.CONCLUSION:The correlation coefficient of thenonlinear mathematical model was relatively high and the model matched the data well,potentially providing a method for the study of the steaming process.

关键词： Processing Wuweizi(Fructus SchisandraeChinensis) Vinegar-steaming Regression analysis Response surface method Correlation coefficient