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In vitro activity of natural honey alone and in combination with curcuma starch against Rhodotorula mucilaginosa in correlation with bioactive compounds and diastase activity

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Asian Pacific Journal of Tropical Biomedicine 2013年第10期3卷 816-821页

作者： Moussa Ahmed Noureddine Djebli Saad Aissat Baghdad Khiati Abdelmalek Meslem Salima Bacha pharmacognosy and api-phytotherapy research laboratory Mostaganem.UniversityAlgeria

Objective:To evaluate the in vitro activity and synergism of the combinations of natural honey and curcuma starch against Rhodotorula mucilaginosa in correlation with total phenolic,flavonoid contents,and diastase ***:The Folin-Ciocalteu test was used to determine the total polyphenols content and the flavonoid content was analyzed using by the aluminum chloride *** antifungal activity of the natural honey,determined by an agar well diffusion assay and agar incorporation ***:Total phenolic content varied from(63.93±0.11)to(95.36±6.08)mg GAE/100 g honey as gallic acid *** flavonoids content varied from(5.41±0.04)to(9.94±0.54)mg CE/*** activity values were between(7.3±2.8)and(26±2.8).The zone inhibition diameter for the six honey samples without starch ranged between 6 and 20 *** starch was mixed with honey and then added to well,a zone inhibition increase diameter 7 and 21 *** percentage increase was noticed with each variety and it ranged between 5%and 62.5%.The minimal inhibitory concentrations for the six varieties of honey without starch against Rhodotorula mucilaginosa ranged between 28%and 36%(v/v).When starch was incubated with honey and then added to media,a minimal inhibitory concentration drop has been noticed with each *** ranged between 6.66%and 20%(w/v).No significant correlation was established between diastase activity and bioactive ***:The mixture of curcuma starch and honey could lead to the development of new combination antibiotics against Rhodotorula

关键词： Bioactive Compounds Diastase number Rhodotorula mucilaginosa Honey Curcuma starch

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Effect of heat treatment on antimycotic activity of Sahara honey

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Journal of Coastal Life Medicine 2014年第11期 876-881页

作者： Moussa Ahmed Saad Aissat Noureddine Djebli pharmacognosy and api-phytotherapy research laboratory Mostaganem UniversityMostaganemAlgeria

Objective:To evaluate the influence of the temperature on honey colour,polyphenol contents and antimycotic capacity and to evaluate the correlation between these ***:Sahara honey were heated up to 25,50,75 and 100℃for 15,30 and 60 min,and their colour intensity,polyphenol contents and antimycotic *** Folin-Ciocalteu test was used to determine the total polyphenol contents(TPC).The antimycotic activity was evaluated both by agar diffusion method and micro wells dilution method against the Candida albicans(***)and Candida glabrata(***).Results:Initial values for TPC in Sahara honey ranged from 0.55 to 1.14 mg of gallic acid per kg of honey,with the average value of 0.78 mg of gallic acid per kg of *** TPC values after heat-treatment were 0.54 to 1.54 with the average value of 1.49 *** minimal inhibitory concentrations before heat-treatment of Sahara honey against *** and *** ranged from 3.06%-12.5%and 50%*** heat-treatment the minimal inhibitory concentrations between 12.5%and 50%for *** and ***,*** diameters of inhibition zones of Sahara honey with 50%concentration varied from(12.67-15.00)mm by *** to(14.33-15.67)mm by *** diameters of inhibition zones after heat-treatment at 25 and 50°C for 15.30 and 60 min ranged from(2.00-18.67)mm by *** to(8.00-16.67)mm by *** significant relations between the TPC and the colour intensity of Sahara honey(r=0.99,P<0.05).Furthermore,the results showed that the TPC and colour is not correlated with the antimycotic ***:To our knowledge this is the first report on the antimycotic capacity of Sahara honey.

关键词： Sahara honey Antimycotic capacity Heat treatment

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Preliminary comparative study of anti-inlfammatory effect of unheated and heat-treated Sahara honey:In vivo approach

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Journal of Coastal Life Medicine 2015年第11期 875-878页

作者： Moussa Ahmed Saad Aissat Noureddine Djebli pharmacognosy and api-phytotherapy research laboratory Mostaganem UniversityMostaganemAlgeria

Objective:To investigate the effect of unheated and heat-treated of Sahara ***:A total of 24 Swiss albino mice weighing 25-35 g were divided into four groups(n=6).Anti-inflammatory effect was assessed at 1,2,3,4,5 and 6 h after subplantar injection of carrageenan(0.5 mL of a 1%solution in normal saline).In addition,total phenolic content was determined by modified Folin-Ciocalteu ***:The total phenolic content capacity of the Sahara honey before and after heat treatment was between 72 and 97.9 mg of gallic acid equivalents/100 g of honey *** of unheated honey(oral administration)reduced significantly(P<0.05).The carrageenan induced mice paw edema model at 1,3 and 6 h for 21.85%,5.43%and 80.43%,*** of heat-treated honey showed insignificant inhibition of carrageenan and induced paw edema at 1 h(31.16%),3 h(0.25%)and 6 h(34.19%).The 50 mg/kg diclofenac exhibited percent reduction in paw volume 16.12%,8.90%and 15.32%after 1 h,3 h and 6 h,respectively,when compared with control *** toxicity was ***:Our results suggest that unheated Sahara honey has anti-inflammatory effects by reducing the mice paw edema size while heat-treated Sahara honey decreases the antiinflammatory activity.

关键词： Sahara honey Heating Anti-inflammatory Total phenolic content

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Pharmacologically tested aldose reductase inhibitors isolated from plant sources—A concise report

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中国天然药物 2012年第5期10卷 388-400页

作者： D. K. Patel R. Kumar K. Sairam S. Hemalatha pharmacognosy research laboratory Department of Pharmaceutics Institute of Technology Banaras Hindu University

Aldose reductase (AR), a cytosolic, monomeric oxidoreductase, is a key enzyme in the polyol pathway which controls the conversion of glucose to sorbitol. The accumulation of sorbitol by the activation of AR enzymes in lens, retina, and sciatic nerves leads to the cause of diabetic defects resulting in various secondary complications, viz. retinopathy, neuropathy, nephropathy and Alzheimer's disease. Thus, reduction of the polyol pathway flux by AR inhibitors could be a potential therapeutic opening in the treatment and prevention of diabetic complications. At present, the AR inhibitors belong to two different chemical classes. One is the hydantoin derivatives, such as Sorbinil, Dilantin, and Minalrestat, and the other is the carboxylic acid derivatives, such as Epalrestat, Alrestatin, and Tolrestat. However, it is known that most of these synthethic compounds have unacceptable side-effects. Well known medicinal plants like Chrysanthemum indicum, Chrysanthemum morifolium, Prunus mume, Myrcia multiflora, Centella asiatica, and Salacia reticulata, Salacia oblonga, and Salacia chinensis exhibited potent AR inhibitory activity. The present review summarizes the list of plant material, and their isolated phytoconstituents which have been tested for their AR inhibitory activity. This litreature review covers the period to 2011, and a total of 72 plants are listed.

关键词： Aldose reductase Cataracts Enzyme Human recombinant AR Medicinal plants Phytoconstituents Polyol pathway Rat lens AR Rat lens

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Pedalium murex Linn.:An overview of its phytopharmacological aspects

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Asian Pacific Journal of Tropical Medicine 2011年第9期4卷 748-755页

作者： Dinesh Kumar Patel Damiki Laloo Rajesh Kumar Siva Hemalatha pharmacognosy research laboratory Department of PharmaceuticsInstitute of Technology.Banana Hindu University

Pedalium murex Linn(family:Pedaliaceae)(***) commonly known as Large Caltrops and Gokhru(India) is a shrub found in the Southern *** region of India and in some parts of *** parts of the plant are used to treat various ailments like,cough,cold and as an *** is reported traditionally to have an excellent cure in patients with reproductive disorders which are mainly impotency in *** emissions,gonorrhoea as well as leucorrhoea in *** plant has also benifiled in complications like urinary track disorder as well as gastro intestinal tract *** the plant is popular for the presence of a considerable amount of diosgenin and vanillin which are regarded as an important source and useful starting materials for synthesizing steroidal contraceptive drugs and isatin *** phytochemicals reported in the plant includes *** acid,caffeic acid,amino acids(glycine,histidine,tyrosine,threonine,aspartie acid and glutamic acid) and various classes of fatty acids(triacontanoic acid,*** and heptatriacontan-4-one).Pharmacologically,the plant have been investigated for antiulcerogenic. ***,aphrodisiac,antioxidant,antimicrobial and insecticidal *** all these reports it can be concluded that the plant were found to have a better profile with potential natural source for the treatment of various range of either acute or chronic *** overall database of our review article was collected from the scientific sources in regards with all the information ol the research article for *** published so far.

关键词： Pedalium murex Tissue culture Phytochemistry Ulcerogenic Aphrodisiac Nephroprotective Antioxidant Antimicrobial

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Effect of Yajieshaba,a preparation of Dai indigenous medicine,on enhanced liver detoxification

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Journal of Traditional Chinese Medicine 2015年第2期35卷 197-205页

作者： Duan Xiaohua Zheng Jin Wang Hui Cheng Haifeng Zhang Chao Yu Zepu the Key Modern research laboratory for Ethno-pharmacognosy of Yunnan Higher School Yunnan University of Traditional Chinese Medicine

OBJECTIVE:To explore the mechanistic effects of Yajieshaba(YJSB) on enhanced liver ***:The effects of YJSB on alanine aminotransferase(ALT) and aspartate aminotransferase(AST) were assayed in five acute chemical liver injury models[carbon tetrachloride(CCU),D-galactosamine(D-Glan),4-acetamidophenol(AAP),thioacetamide(TAA) and 1-naphthyl isothiocyanate(ANIT)].Sleep latency and sleep time of pentobarbital sodium were tested in control mice and CCL model miceafter oral YJSB *** effects of YJSB on drug metabolism enzymes of liver microsomes were tested in control rats and CCI_4model *** levels of cytochrome P450(CYP450) and Cyt b5 in liver microsomes were assayed using the method by Omura and Sato,and activities of erythromycin N-demethylase(ERD)and aminopyrine N-demethyl(ADM) were evaluated by Nash *** substrate-based high performance liquid chromatography(HPLC)methods were established for CYP3A4 and ***:The level of serum ALT was reduced by YJSB at 3.51 g/kg in the five models as follows:CCl_4 > D-Glan,AAP,ANIT > *** treatment did not reduce the level of serum *** at 3.51 g/kg prolonged the sleep latency in control mice and shortened the sleep time of control mice and CCl_4 model *** control rats,YJSB at 2.43 g/kg increased the levels of CYP450 and Cyt b5 and induced the activities of ERD and ADM;for liver injuries induced by CCI_4 in rats,YJSB at 2.43 g/kg increasedthe levels of CYP450 and Cyt *** results suggest that YJSB at 2.43 g/kg induces CYP3A4 and ***:These results suggest that YJSB enhanced liver detoxification and the mechanisms may be partially related to CYP3A4 and CYP1A2 induction.

关键词： Cytochrome P-450 enzyme system Chromatography high pressure liquid Liver detoxification Yajieshaba

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Evaluation of phytochemical and antioxidant activities of the different fractions of Hybanthus enneaspermus (Linn.) ***. (Violaceae).

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Asian Pacific Journal of Tropical Medicine 2011年第5期4卷 391-396页

作者： Dinesh Kumar Patel Rajesh Kumar Damiki Laloo Siva Hemalatha pharmacognosy research laboratory Department of PharmaceuticsInstitute of TechnologyBanaras Hindu UniversityVaranasi-221005.India

Objective:To investigate the naturally occurring antioxidant for the first time from the different solvent fractions of Hybanthus enneaspermus（***） Linn ***（Violaceae）. Methods:Different fractions of *** were tested for total phenolic content,and in vitro antioxidant activity was measured by total antioxidant assay,DPPH assay,reducing power, nitric oxide（NO）,hydrogen peroxide（H2O2） scavenging ***:The ethyl acetate（EA） fraction was found to have high levels of phenolic content[（212.15±0.79） mg GAE/g].The EA fraction exhibited higher total antioxidant capacity,higher percentage of DPPH radical scavenging activity[（127.07±2.29） Fg/mL],nitric oxide[（245.16±1.44）μg/mLJ,hydrogen peroxide[（227.38±7.18）μg/mL],deoxyribose[（270.61±8.72）μg/mL]and higher reducing *** was a significant correlation between total phenolic content and total antioxidant activity（r =0.972）. Conclusions:These results reveal that EA fraction of *** has strong antioxidant potential compared with other *** further study has been extended to the isolation of the possible compound that is responsible for having antioxidant property.

关键词： Hybanthus enneaspermus Antioxidant Total phenolics

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Chenopodium ambrosioides induces an endothelium-dependent relaxation of rat isolated aorta

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Journal of Integrative Medicine 2019年第2期17卷 115-124页

作者： Asmae Assaidi Ikram Dib Monique Tits Luc Angenot Said Bellahcen Nourelhouda Bouanani Abdelkhaleq Legssyer Mohammed Aziz Hassane Mekhfi Mohammed Bnouham Michel Frederich Abderrahim Ziyyat laboratory of Physiology Genetics and Ethnopharmacology Department of Biology Faculty of Sciences Mohammed I University laboratory of pharmacognosy Center for Interdisciplinary Research on the Medicines (CIRM) University of Liège

Objective: This study aims to evaluate the vasodilatory effect of Chenopodium ambrosioides on the isolated rat aorta, and to explore its mechanism of ***: The vasorelaxant effect and the mode of action of various extracts from the leaves of C. ambrosioides were evaluated on thoracic aortic rings isolated from Wistar rats. In addition, ethyl acetate and methanol fractions were analyzed, using thin-layer chromatography and high-performance liquid chromatography techniques, for their polyphenolic ***: The various active extracts of C. ambrosioides at four concentrations(10^(-3), 10^(-2), 10^(-1) and 1 mg/mL) relaxed the contraction elicited by phenylephrine, in a concentration-dependent *** effect seems to be endothelium-dependent, since the vasodilatory effect was entirely absent in denuded aortic rings. The vasorelaxant effect of the methanol fraction(MF) of C. ambrosioides at 1 mg/mL was also inhibited by atropine and tetraethylammonium. This effect remained unchanged by Nx-nitro-L-arginine methyl ester hydrochloride and glibenclamide. The preliminary phytochemical analysis showed that the leaves of C. ambrosioides are rich in phenolic and flavonoid ***: These results suggest that the MF of C. ambrosioides produces an endothelium-dependent relaxation of the isolated rat aorta, which is thought to be mediated mainly through stimulation of the muscarinic receptors, and probably involving the opening of Ca^(2+)-activated potassium channels.

关键词： Chenopodium ambrosioides Chenopodiaceae Vasorelaxation Ca^2+-activated potassium channels Thin-layer chromatography High-performance liquid chromatography Plant Complementary and alternative medicine

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An overview on antidiabetic medicinal plants having insulin mimetic property

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Asian Pacific Journal of Tropical Biomedicine 2012年第4期2卷 320-330页

作者： Patel DK Prasad SK Kumar R Hemalatha S pharmacognosy research laboratory Department of PharmaceuticsInstitute of TechnologyBanaras Hindu University

Diabetes mellitus is one of the common metabolic disorders acquiring around 2.8%of the world's population and is anticipated to cross 5.4%by the year *** long back herbal medicines have been the highly esteemed source of medicine therefore,they have become a growing part of modern,high-tech *** view of the above aspects the present review provides profiles of plants(65 species) with hypoglycaemic properties,available through literature source from various database with proper categorization according to the parts used,mode of reduction in blood glucose(insulinomimetic or insulin secretagugues activity) and active phyloconsliluents having insulin mimetics *** the review it was suggested that,plant showing hypoglycemic potential mainly belongs to the family Leguminoseae,Lamiaceae,Liliaceae,Cucurbitaceae, Asteraceae,Moraceae,Rosaceae and *** most active plants are Allium sativum. Gymnema sylvestre,Citrullus colocynthis,Trigonella foenum greacum,Momordica charantia and Ficuts *** review describes some new bioactive drugs and isolated compounds from plants such as roseoside,epigallocatechin gallate,beta-pyrazol-1-ylalanine,cinchonain Ib,leucocyandin 3-O-beta-d-galactosyl cellobioside,leucopelargonidin-3- O-alpha-L rhamuoside,glycyrrhetinic acid,dehydrotrametenolic acid,strictinin,isostrictinin,pedunculagin, epicatechin and christinin-A showing significant insulinomimetic and antidiabetic activity with more efficacy than conventional hypoglycaemic ***,from the review majorly,the antidiabetic activity of medicinal plants is attributed to the presence of polyphenols,flavonoida, terpenoids,coumarins and other constituents which show reduction in blood glucose *** review also discusses the management aspect of diabetes mellitus using these plants and their active principles.

关键词： Diabetes Insulin secretagogues Insulin mimetics Phytoconstituents Pancrease Blood glucose Insulin Beta cell Antidiabetic activity Medicinal plant Metabolic disorder Herbal medicine Diabetes mellitus Hypoglycaemic activity

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Antidiabetic and in vitro antioxidant potential of Hybanthus enneaspermus(Linn) *** in streptozotocin—induced diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2011年第4期1卷 316-322页

作者： Patel DK Kumar R Prasad SK Sairam K Hemalatha S pharmacognosy research laboratory Department of PharmaceuticsInstitute of TechnologyBanaras Hindu University

Objective:To evaluate antidiabetic and antioxidant potential of Hybanthus enneaspermus in different ***:The oral glucose tolerance test(OGTT) and normoglycemic effect of alcoholic extract of Hybanthus enneaspermus(AHE) were evaluated at a dose of 125,250 and 500mg/kg *** hypoglycemic activity and effect on body weight were tested at 250 and 500 mg/kg *** day for 21 days in Streptozotocin(STZ) induced diabetic ***,glucose uptake by hemidiaphram was also *** total polyphenolic and flavonoid were determined and their correlation with various antioxidant assays was also ***:The results showed high level of phenolic content in *** also exhibited higher total antioxidant capacity,good reducing power and a significant scavenger of reactive oxygen species like DPPH radical,nitric oxide,hydrogen peroxide and *** there was a significant increase in the body weight and decrease in the blood glucose level on treatment with the *** increased glucose uptake on isolated rat hemi-diaphragm compared to control ***:AHE reduce blood glucose level in STZ-induced diabetic *** does not show significant effect in normoglycemic study but showes significant effect in *** has significant antioxidant activity,which may be attributed to high phenolic content.

关键词： Hybanthus enneaspermus Diabetic Antioxidant Total phenol Flavonoid Flavonol Glucose uptake

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