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The brain-derived neurotrophic factor in neuronal plasticity and neuroregeneration: new pharmacological concepts for old and new drugs

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Neural Regeneration research 2018年第6期13卷 983-984页

作者： Solomon Habtemariam herbal analysis services uk & pharmacognosy research laboratories University of Greenwich

Neurotrophins：Neurotrophins are peptides or proteins that are known to regulate neuronal viability,development,and function Beyond synaptic plasticity,neurotrophins protect neurons from apoptosis and also promote neu... 详细信息

关键词： The brain-derived neurotrophic factor in neuronal plasticity and neuroregeneration new pharmacological concepts for old and new drugs

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The African Moringa is to change the lives of millions in Ethiopia and far beyond

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Asian Pacific Journal of Tropical Biomedicine 2016年第4期6卷 355-356页

作者： Solomon Habtemariam pharmacognosy research laboratories and herbal analysis services uk

Dear Editor,I vividly recall one of my medicinal plant collection trips in the southern regions of Ethiopia back in 1986.Besides collecting few plants of interest,we were asking the locals to show us medicinal plants ... 详细信息

关键词： Moringa African branches lives minutes millions collection medicinal usage collecting

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Protection effect of the anthraquinones, cassiatorin and aurantio-obtusin from seeds of Senna tora against cowpea weevil attack

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Asian Pacific Journal of Tropical Biomedicine 2018年第2期8卷 98-105页

作者： Valentine Chi Mbatchou Rita Akosua Dickson Isaac Kingsley Amponsah Abraham Yeboah Mensah Solomon Habtemariam Department of Applied Chemistry and Biochemistry University for Development Studies Navrongo Campus Department of pharmacognosy Faculty of Pharmacy and Pharmaceutical Sciences Kwame Nkrumah University of Science and Technology pharmacognosy research laboratories & herbal analysis services uk University of Greenwich

Objetive: To explore the potential insecticidal, ovipositor deterrent and antifeedant effects of ethyl acetate extract of the seeds of Senna tora(Syn. Cassia tora) against cowpea weevil(Callosobruchus maculatus).Method: The activities were evaluated using standard protocols.In these bioassays, the cowpea seeds were used directly as an insect feed. The activity of the extract and isolated compounds were tested at concentrations of 100, 200 and 300 μg/mL and compared to neem oil and cinnamaldehyde(as standard positive controls). Phytochemical analysis of the ethyl acetate extract was done through a number of chromatographic techniques and the structures of the isolated compounds were established through comprehensive spectroscopic analysis including 2 D-NMR and ESI-MS studies.Results: Fractionation of the active ethyl acetate extract resulted in the isolation of one known anthraquinone,aurantio-obtusin(1) and a novel compound that was named as cassiatorin(2). Compounds1 and 2 showed comparable insect antifeedant properties with the positive controls while their insecticidal and ovipositor deterrent effects were far superior to the standard controls.Conclusions: It is thus concluded that Senna tora extracts and the isolated compounds(1 and2) may be employed in the postharvest management of stored cowpea seeds and as other crop protectants.

关键词： Senna tora Cassia tora Cassiatorin Aurantio-obtusin Insecticidal Ovipositor deterrent Antifeedant Cowpea weevil

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Antioxidant,anti-alpha-glucosidase and pancreatic beta-cell protective effects of methanolic extract of Ensete superbum Cheesm seeds

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Asian Pacific Journal of Tropical Biomedicine 2017年第2期7卷 121-125页

作者： Solomon Habtemariam George Kabakasseril Varghese pharmacognosy research laboratories&herbal analysis services Medway School of ScienceUniversity of GreenwichChatham-MaritimeKent ME4 4TBUK Department of Botany St.Berchmans'CollegeChanganasseryKottayam 686101KeralaIndia

Objective: To investigate the antioxidant, anti-a-glucosidase and pancreatic b-cell protective potential of Ensete superbum(E. superbum) seeds.Methods: A variety of in vitro assays including radical scavenging, reducing power potential, phenolic content determination, a-glucosidase assay and pancreatic b-cell(1.4E7 cells) viability were employed for assessing the effect of methanolic extract of E. superbum seeds.Results: The radical scavenging and reducing power effects comparable with the standard rutin were obtained while the enzyme inhibitory activity of the extract was 68-fold better than the standard antidiabetic drug, acarbose. The seed extract of E. superbum was packed-full of polyphenols with mean percentage gallic acid equivalent value of(38.2 ± 1.8)(n = 3). The protection of pancreatic cells from massive onslaught of hydrogen peroxide was far superior to that obtained for rutin.Conclusions: The reputed antidiabetic therapeutic uses of the seeds extract of E. superbum may be justified on the basis of inhibition of carbohydrate enzymes, antioxidant effects and pancreatic b-cell protection.

关键词： Ensete superbum Musaceae Seeds Antioxidant Pancreatic beta-cell protection Alpha-glucosidase inhibition

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